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Vitamin B 12 Associated Neurological Diseases

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Late diagnosis of Lesch-Nyhan disease complicated with end-stage renal disease and tophi burst: a case report.

Cahyani Gita Ambarsari, Daffodilone Cahyadi, Lenny Sari, Oryza Satria, Felly Sahli, Thyrza Laudamy Darmadi, Agustina Kadaristiana,

Background: Lesch-Nyhan disease (LND) is a rare X-linked recessive inborn error of purine metabolism. Late diagnosis of LND may cause significant morbidity. LND cases have never been reported in Indonesia.Case report: A 15-year-old male who had been diagnosed with cerebral palsy was referred to our hospital due to renal failure ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):113-121]

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Association between vitamin D levels and mortality in hemodialysis patients: a cohort study.

Maryanne Machado da Silva Canhos, Rogério Carvalho de Oliveira, Luis Gustavo Modelli de Andrade, Jacqueline Costa Teixeira Caramori, Pasqual Barretti, Luis Cuadrado Martin,

Introduction: Low vitamin D levels are associated with mortality in hemodialysis (HD) patients; however, the serum vitamin D thresholds are unclear. This study aimed to identify the vitamin D level below which mortality increases in HD patients.Methods: A cohort of HD patients enrolled from January 2014 to January 2017 was ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):225-233]

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Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders.

Baruh Polis, Abraham O Samson,

Alzheimer's disease is an incurable chronic neurodegenerative disorder and the leading cause of dementia, imposing a growing economic burden upon society. The disease progression is associated with gradual deposition of amyloid plaques and the formation of neurofibrillary tangles within the brain parenchyma, yet severe dementia is the culminating phase of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1460-1470]

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Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases.

Jose A Fernández-Albarral, Rosa de Hoz, Ana I Ramírez, Inés López-Cuenca, Elena Salobrar-García, María D Pinazo-Durán, José M Ramírez, Juan J Salazar,

Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant, anxiolytic, hypolipidemic, anti-atherogenic, anti-hypertensive, antidiabetic, and anti-cancer properties. In addition, saffron has remarkable beneficial properties, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1408-1416]

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Activating Sirt1 by resveratrol suppresses Nav1.7 expression in DRG through miR-182 and alleviates neuropathic pain in rats.

Qianqian Jia, Wenze Dong, Liwei Zhang, Xiaochun Yang,

Neuropathic pain is clinically unsatisfactorily treated because of unclear mechanisms. The present study aims to explore the concrete mechanisms underlying the alleviation of resveratrol-activated silent information regulator 1 (Sirt1) to chronic constriction injury (CCI)-induced neuropathic pain. CCI surgery was conducted to the unilateral sciatic nerve of male Sprague-Dawley rats to ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):69-78]

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Protective effects of grape seed procyanidin on isoflurane-induced cognitive impairment in mice.

Xiangdan Gong, Lizhi Xu, Xin Fang, Xin Zhao, Ying Du, Hao Wu, Yue Qian, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu,

Context: Oxidative imbalance-induced cognitive impairment is among the most urgent clinical concerns. Isoflurane has been demonstrated to impair cognitive function via an increase in oxidative stress. GSP has strong antioxidant capacities, suggesting potential cognitive benefits.Objective: This study investigates whether GSP pre-treatment can alleviate isoflurane-induced cognitive dysfunction in mice.Materials and methods: ... Read more >>

Pharm Biol (Pharmaceutical Biology)
[2020, 58(1):200-207]

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LIM kinases in synaptic plasticity and their potential as therapeutic targets.

Eva Halasz, Ellen Townes-Anderson, Weiwei Wang,

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1471-1472]

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Vitamin B12 measurements across neurodegenerative disorders.

Nijee S. Luthra, Ariane H. Marcus, Nancy K. Hills, Chadwick W. Christine,

BackgroundVitamin B12 deficiency causes a number of neurological features including cognitive and psychiatric disturbances, gait instability, neuropathy, and autonomic dysfunction. Clinical recognition of B12 deficiency in neurodegenerative disorders is more challenging because it causes defects that overlap with expected disease progression. We sought to determine whether B12 levels at the ... Read more >>

J Clin Mov Disord (Journal of Clinical Movement Disorders)
[2020, 7:]

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Higher vitamin B12 level at Parkinson's disease diagnosis is associated with lower risk of future dementia.

Stuart J McCarter, Cole Stang, Pierpaolo Turcano, Michelle M Mielke, Farwa Ali, James H Bower, Rodolfo Savica,

INTRODUCTION:To determine whether vitamin B12 level at Parkinson's disease (PD) diagnosis predicts time to develop dementia. METHODS:We utilized a population-based cohort of Parkinsonism patients to examine the relationship between serum vitamin B12 at the time of PD diagnosis and dementia risk. Receiver operating curves were calculated for vitamin B12 cutoffs ... Read more >>

Parkinsonism Relat. Disord. (Parkinsonism & related disorders)
[2020, 73:19-22]

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Vitamin B12 deficiency as a cause of severe neurological symptoms in breast fed infant - a case report.

Cezary Dubaj, Katarzyna Czyż, Wanda Furmaga-Jabłońska,

BACKGROUND:Vitamin B12 (cobalamin, cbl) deficiency in children is rare and may occurs in exclusively breast fed infants of mothers on vegetarian or vegan diet with lack of appropriate supplementation. The clinical manifestation of vitamin B12 deficiency include neurological disorders, megaloblastic anemia and failure to thrive. Routine and commonly used laboratory ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):40]

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Nitrous oxide and vitamin B12 in sickle cell disease: Not a laughing situation.

Camille Desprairies, Apolline Imbard, Bérengère Koehl, Mathie Lorrot, Jean Gaschignard, Julie Sommet, Samia Pichard, Laurent Holvoet, Albert Faye, Malika Benkerrou, Jean-François Benoist, Manuel Schiff,

Nitrous oxide (N2O) is widely used as an anesthetic or an analgesic. N2O prolonged and recurrent administration is known to affect vitamin B12 metabolism with subsequent clinical consequences. We report herein the case of a 13-year-old girl with sickle cell disease exhibiting severe neurological and biochemical signs of functional vitamin ... Read more >>

Mol Genet Metab Rep (Molecular genetics and metabolism reports)
[2020, 23:100579]

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Low Vitamin B12 Levels: An Underestimated Cause Of Minimal Cognitive Impairment And Dementia.

Shazia Jatoi, Abdul Hafeez, Syeda Urooj Riaz, Aijaz Ali, Muhammad Ishaq Ghauri, Maham Zehra,

Background Vitamin B12 deficiency is linked to impaired cognition and memory along with a sensation of tingling and numbness, an outcome of poor myelination. Elevated methylmalonic acid and serum homocysteine levels are markers of Vitamin B12 deficiency. Elevated homocysteine levels are also often associated with Alzheimer's disease and stroke. We ... Read more >>

Cureus (Cureus)
[2020, 12(2):e6976]

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Homocysteine: Its Possible Emerging Role in At-Risk Population Groups.

Elena Azzini, Stefania Ruggeri, Angela Polito,

Increased plasma homocysteine is a risk factor for several pathological disorders. The present review focused on the role of homocysteine (Hcy) in different population groups, especially in risk conditions (pregnancy, infancy, old age), and on its relevance as a marker or etiological factor of the diseases in these age groups, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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Adult-onset methylenetetrahydrofolate reductase deficiency.

Daniela Vieira, Cristina Florindo, Isabel Tavares de Almeida, Maria Carmo Macário,

Severe hyperhomocysteinemia (>100 µmol/L) is often associated with inborn errors of homocysteine metabolism. It manifests typically in neonatal period with developmental delay, hypotonia, feeding problems or failure to thrive. Adult-onset forms are rare and include less severe manifestations. Early diagnosis is crucial because effective treatment is available. A 23-year-old man ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(3):]

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Cladribine Treatment Improved Homocysteine Metabolism and Increased Total Serum Antioxidant Activity in Secondary Progressive Multiple Sclerosis Patients.

Anna Jamroz-Wiśniewska, Jerzy Bełtowski, Grażyna Wójcicka, Halina Bartosik-Psujek, Konrad Rejdak,

Hyperhomocysteinemia plays a crucial role in the pathogenesis of many diseases of the central nervous system (CNS). The nervous system is particularly sensitive to high homocysteine (Hcy) level mainly due to its prooxidative and cytotoxic effects. Cladribine, a drug recently registered for the treatment of multiple sclerosis (MS), possesses additionally ... Read more >>

Oxid Med Cell Longev (Oxidative Medicine and Cellular Longevity)
[2020, 2020:]

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Clinical-radiological dissociation in a patient with nitrous oxide-induced subacute combined degeneration: a case report.

Jiwei Jiang, Xiuli Shang,

BACKGROUND:Several recent studies have reported subacute combined degeneration (SCD) induced by nitrous oxide (N2O) abuse. However, the association between the evolution of dynamic neuroimaging and clinical manifestations has not been reported in patients with N2O-induced SCD. CASE PRESENTATION:We described the case of a 24-year-old man who developed SCD with inverted ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):99]

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Serum levels of Homocysteine, Vitamin B12 and Folate in Patients with Multiple Sclerosis: an Updated Meta-Analysis.

Xuanting Li, Junliang Yuan, Jinming Han, Wenli Hu,

Background: Multiple sclerosis (MS) is a demyelinating and disabling inflammatory disease of the central nervous system. MS is triggered by complex environmental factors which mostly affect genetically the susceptible young people. Emerging data has suggested that changes of homocysteine (Hcy), Vitamin B12 and folate serum levels may be associated with ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(6):751-761]

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Successful Treatment of Human Immunodeficiency Virus-Associated Highly Active Antiretroviral Therapy-Resistant Vacuolar Myelopathy with Intravenous Immunoglobulin.

Lidiia N Prakhova, Aleksandr G Ilves, Svetlana N Kizhlo, Zhanna I Savintseva,

For the first time, human immunodeficiency virus (HIV)-associated vacuolar myelopathy (VM) was detailed in an autopsy-based study of 89 cases in 1985. This condition is the most common cause for spinal cord lesions in HIV patients. VM's pathogenic mechanism remains unclear; however, it is assumed that the disease can be ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2020, 23(2):220-222]

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Type XIX collagen: a promising biomarker from the basement membranes.

Ana C Calvo, Laura Moreno, Leticia Moreno, Janne M Toivonen, Raquel Manzano, Nora Molina, Miriam de la Torre, Tresa López, Francisco J Miana-Mena, María J Muñoz, Pilar Zaragoza, Pilar Larrodé, Alberto García-Redondo, Rosario Osta,

Among collagen members in the collagen superfamily, type XIX collagen has raised increasing interest in relation to its structural and biological roles. Type XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member, one main subclass of collagens in this superfamily. This collagen contains a triple helix composed of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):988-995]

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Vegetarian diet and incidence of total, ischemic, and hemorrhagic stroke in 2 cohorts in Taiwan.

Tina H T Chiu, Huai-Ren Chang, Ling-Yi Wang, Chia-Chen Chang, Ming-Nan Lin, Chin-Lon Lin,

OBJECTIVE:To determine how a vegetarian diet affects stroke incidence in 2 prospective cohorts and to explore whether the association is modified by dietary vitamin B12 intake. METHODS:Participants without stroke in the Tzu Chi Health Study (cohort 1, n = 5,050, recruited in 2007-2009) and the Tzu Chi Vegetarian Study (cohort ... Read more >>

Neurology (Neurology)
[2020, 94(11):e1112-e1121]

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A Patient with Combined CADASIL and MTHFR Homozygosity.

Sidonie Ibrikji, Tarek El Halabi, Bassem Yamout,

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an inherited disorder caused by a mutation in the NOTCH 3 gene, characterized by early onset of subcortical lacunar infarcts in the absence of vascular risk factors and cerebral microbleeds. Homozygosity for the factor Methylenetetrahydrofolate Reductase (MTHFR) is also ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:4980847]

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Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice.

Pedram Honarpisheh, Caroline R Reynolds, Maria P Blasco Conesa, Jose F Moruno Manchon, Nagireddy Putluri, Meenakshi B Bhattacharjee, Akihiko Urayama, Louise D McCullough, Bhanu P Ganesh,

Amyloid plaques in Alzheimer's disease (AD) are associated with inflammation. Recent studies demonstrated the involvement of the gut in cerebral amyloid-beta (Aβ) pathogenesis; however, the mechanisms are still not well understood. We hypothesize that the gut bears the Aβ burden prior to brain, highlighting gut-brain axis (GBA) interaction in neurodegenerative ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(5):]

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Elevated cerebrospinal fluid homocysteine is associated with blood-brain barrier disruption in amyotrophic lateral sclerosis patients.

Yonghua Wu, Xu Yang, Xiaogang Li, Haining Wang, Tiancheng Wang,

OBJECTIVES:Homocysteine (Hcy) has been shown to be relevant in the pathogenesis of amyotrophic lateral sclerosis (ALS). Although the CSF Hcy changes were explored in patients with ALS previously, the outcomes were inconsistent, and the permeability of the blood-brain barrier (BBB) may involve in the process. The aim of this study ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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Vitamin B12 and folate concentrations in recent-onset type 2 diabetes and the effect of metformin treatment.

Georgia Kanti, Evrim Anadol-Schmitz, Pavel Bobrov, Klaus Strassburger, Sabine Kahl, Oana P Zaharia, Theresia Sarabhai, Yanislava Karusheva, Volker Burkart, Daniel F Markgraf, Sandra Trenkamp, Dan Ziegler, Julia Szendroedi, Michael Roden, ,

CONTEXT:Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance. Metformin can decrease vitamin B12 and folate concentrations. OBJECTIVE:To examine (i) effects of short-term metformin treatment on serum holotranscobalamin (holoTC) and folate and (ii) their association with insulin sensitivity ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, :]

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