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Viral Pneumonia

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Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2.

Jianhui Nie, Qianqian Li, Jiajing Wu, Chenyan Zhao, Huan Hao, Huan Liu, Li Zhang, Lingling Nie, Haiyang Qin, Meng Wang, Qiong Lu, Xiaoyu Li, Qiyu Sun, Junkai Liu, Changfa Fan, Weijin Huang, Miao Xu, Youchun Wang,

Pseudoviruses are useful virological tools because of their safety and versatility, especially for emerging and re-emerging viruses. Due to its high pathogenicity and infectivity and the lack of effective vaccines and therapeutics, live SARS-CoV-2 has to be handled under biosafety level 3 conditions, which has hindered the development of vaccines ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):680-686]

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Inhibition of SARS-CoV 3CL protease by flavonoids.

Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim,

There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):145-151]

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Peste des petits ruminants in large ruminants, camels and unusual hosts.

Aziz-Ul- Rahman, Kuldeep Dhama, Qasim Ali, Irshad Hussain, Muhammad Oneeb, Umar Chaudhary, Jonas Johansson Wensman, Muhammad Zubair Shabbir,

Since its first report in 1942, peste-des-petits-ruminants virus (PPRV) has caused several epidemics in a wide range of susceptible hosts around the world. In the last 30 years, the evidence of natural and experimental infections and virus isolation were reported from novel but unusual hosts such as camel, cattle, buffalo, dogs, ... Read more >>

Vet Q (The veterinary quarterly)
[2020, 40(1):35-42]

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[The Effects and Management of Viral Pneumonia on Lung Cancer Patients].

Yanhong Yao, Ming Lu, Yan'e Liu, Baoshan Cao,

The worldwide epidemic of three coronaviruses and one influenza virus in 21st century have seriously threatened human health. Infection with these viruses can cause respiratory symptoms. The patients with lung cancer are more susceptible to viral infection and have a worse prognosis due to the advanced age and the systemic ... Read more >>

Zhongguo Fei Ai Za Zhi (Zhongguo fei ai za zhi = Chinese journal of lung cancer)
[2020, :]

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Retrospective Analysis of 61 Cases of Children Died of Viral Pneumonia.

X B Chen, S H Du, J C Lu, X H Tan, D R Li, X Yue, Q Wang, H J Wang, D F Qiao,

Abstract:Objective To retrospectively analyze the forensic and pathological postmortem examination and clinical data of children who died of viral pneumonia in identification of cause of death cases and to discuss the clinical characteristics and pathological features of viral pneumonia in children, in order to provide reference to pathological diagnosis of ... Read more >>

Fa Yi Xue Za Zhi (Fa yi xue za zhi)
[2020, 36(2):]

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Cross-species transmission of the newly identified coronavirus 2019-nCoV.

Wei Ji, Wei Wang, Xiaofang Zhao, Junjie Zai, Xingguang Li,

The current outbreak of viral pneumonia in the city of Wuhan, China, was caused by a novel coronavirus designated 2019-nCoV by the World Health Organization, as determined by sequencing the viral RNA genome. Many initial patients were exposed to wildlife animals at the Huanan seafood wholesale market, where poultry, snake, ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, 92(4):433-440]

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Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China.

Yueying Pan, Hanxiong Guan, Shuchang Zhou, Yujin Wang, Qian Li, Tingting Zhu, Qiongjie Hu, Liming Xia,

ObjectivesThe purpose of this study was to observe the imaging characteristics of the novel coronavirus pneumonia.MethodsSixty-three confirmed patients were enrolled from December 30, 2019 to January 31, 2020. High-resolution CT (HRCT) of the chest was performed. The number of affected lobes, ground glass nodules (GGO), patchy/punctate ground glass opacities, patchy ... Read more >>

Eur Radiol (European radiology)
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[CT imaging features of patients with different clinical types of coronavirus disease 2019 (COVID-19)].

Qi Zhong, Zhi Li, Xiaoyong Shen, Kaijin Xu, Yihong Shen, Qiang Fang, Feng Chen, Tingbo Liang,

OBJECTIVE:To analyze the CT findings of patients with different clinical types of coronavirus disease 2019 (COVID-19). METHODS:A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were included and divided into 4 groups according to the clinical staging based on Diagnosis and treatment of novel coronavirus pneumonia (Trial ... Read more >>

Zhejiang Da Xue Xue Bao Yi Xue Ban (Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences)
[2020, 49(1):0]

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A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome.

Shibo Jiang, Shuai Xia, Tianlei Ying, Lu Lu,

Cell. Mol. Immunol. (Cellular and Molecular Immunology)
[0, :1-1]

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Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue.

Kun-Ling Shen, Yong-Hong Yang,

World J Pediatr (World Journal of Pediatrics)
[0, :1-3]

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Hypothesis for potential pathogenesis of SARS-CoV-2 infection--a review of immune changes in patients with viral pneumonia.

Ling Lin, Lianfeng Lu, Wei Cao, Taisheng Li,

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with droplets and contact as the main means of transmission. Since the first case appeared in Wuhan, China, in December 2019, the outbreak has gradually spread nationwide. Up to now, according to official ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, :1-14]

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Brief report of the first cured 2019-nCoV pneumonia patient in West China Hospital.

En-Qiang Chen, Li-Chun Wang, Guang-Min Tang, Yao Yang, Min-Jin Wang, Rong Deng, Fang Chen, Meng-Lan Wang, Ya-Chao Tao, Ping Feng, Hong Tang,

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[0, :1-3]

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The potential added value of FDG PET/CT for COVID-19 pneumonia.

Yan Deng, Lei Lei, Yue Chen, Wei Zhang,

Eur. J. Nucl. Med. Mol. Imaging (European Journal of Nuclear Medicine and Molecular Imaging)
[2020, :]

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Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT.

Harrison X Bai, Ben Hsieh, Zeng Xiong, Kasey Halsey, Ji Whae Choi, Thi My Linh Tran, Ian Pan, Lin-Bo Shi, Dong-Cui Wang, Ji Mei, Xiao-Long Jiang, Qiu-Hua Zeng, Thomas K Egglin, Ping-Feng Hu, Saurabh Agarwal, Fangfang Xie, Sha Li, Terrance Healey, Michael K Atalay, Wei-Hua Liao,

Background Despite its high sensitivity in diagnosing COVID-19 in a screening population, chest CT appearances of COVID 19 pneumonia are thought to be non-specific. Purpose To assess the performance of United States (U.S.) and Chinese radiologists in differentiating COVID-19 from viral pneumonia on chest CT. Methods A total of 219 ... Read more >>

Radiology (Radiology)
[2020, :200823]

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Active or latent tuberculosis increases susceptibility to COVID-19 and disease severity

Yongyu Liu, Lijun Bi, Yu Chen, Yaguo Wang, Joy Fleming, Yanhong Yu, Ye Gu, Chang Liu, Lichao Fan, Xiaodan Wang, Moxin Cheng,

Importance: Risk factors associated with COVID-19, the viral pneumonia originating in Wuhan, China, in Dec 2019, require clarification so that medical resources can be prioritized for those at highest risk of severe COVID-19 complications. Infection with M. tuberculosis (MTB), the pathogen that causes TB and latently infects ~25% of the ... Read more >>

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SARS-CoV-2: What do we know so far?

Pratik Hemant Khedkar, Andreas Patzak,

We are living in times where a viral disease has brought normal life in much of the world to a halt. Named after its causative agent, coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus recently renamed as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 manifests as dry ... Read more >>

Acta Physiol (Oxf) (Acta physiologica (Oxford, England))
[2020, :e13470]

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A Comparison of Demographic, Epidemiological and Clinical Characteristics of Hospital Influenza-related Viral Pneumonia Patients

Lingling Tang, Bin Fu, Zhengjie Wu, Lingtong Huang, Zhaohui Chai, Peidong Zheng, Qinmiao Sun, Haiting Feng,

<title>Abstract</title> <p> Background The comparison of the demographic, epidemiological, and clinical characteristics of hospital human influenza (influenza A (H1N1) pdm09, H3N2, and B) -related and hospitalized avian-origin influenza A (H7N9)-related viral pneumonia patients has not been reported. Methods A retrospective study was conducted in hospitalized influenza-related viral pneumonia ... Read more >>

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2019 Novel Coronavirus (COVID-19) Pneumonia with Hemoptysis as the Initial Symptom: CT and Clinical Features.

Fengxia Shi, Quanbo Yu, Wei Huang, Chaochao Tan,

Recently, some global cases of 2019 novel coronavirus (COVID-19) pneumonia have been caused by second- or third-generation transmission of the viral infection, resulting in no traceable epidemiological history. Owing to the complications of COVID-19 pneumonia, the first symptom and imaging features of patients can be very atypical and early diagnosis ... Read more >>

Korean J Radiol (Korean journal of radiology)
[2020, :]

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[Diagnosis and treatment recommendation for pediatric coronavirus disease-19].

Zhimin Chen, Junfen Fu, Qiang Shu, Yinghu Chen, Chunzhen Hua, Fubang Li, Ru Lin, Lanfang Tang, Tianlin Wang, Wei Wang, Yingshuo Wang, Weize Xu, Zihao Yang, Sheng Ye, Tianming Yuan, Chenmei Zhang, Yuanyuan Zhang,

Zhejiang Da Xue Xue Bao Yi Xue Ban (Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences)
[2020, 49(1):1-8]

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A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility.

Qiong Wang, Ye Qiu, Jin-Yan Li, Zhi-Jian Zhou, Ce-Heng Liao, Xing-Yi Ge,

Virol Sin (Virologica Sinica)
[0, :1-3]

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A Fully Automatic Deep Learning System for COVID-19 Diagnostic and Prognostic Analysis

Shuo Wang, Yunfei Zha, Weimin Li, Qingxia Wu, Xiaohu Li, Meng Niu, Meiyun Wang, Xiaoming Qiu, Hongjun Li, He Yu, Wei Gong, Yan Bai, Li Li, Yongbei Zhu, Liusu Wang, Jie Tian,

Coronavirus disease 2019 (COVID-19) has spread globally, and medical resources become insufficient in many regions. Fast diagnosis of COVID-19, and finding high-risk patients with worse prognosis for early prevention and medical resources optimization is important. Here, we proposed a fully automatic deep learning system for COVID-19 diagnostic and prognostic analysis ... Read more >>

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Clinical features and dynamics of viral load in imported and non-imported patients with COVID-19.

Tianmin Xu, Cong Chen, Zhen Zhu, Manman Cui, Chunhua Chen, Hong Dai, Yuan Xue,

OBJECTIVES:To compare the clinical characteristics and the dynamics of viral load between the imported and non-imported patients with COVID-19. DESIGN AND METHODS:Data from 51 laboratory-confirmed patients were retrospectively analyzed. RESULTS:The incubation period in the tertiary group was longer than that in the imported and secondary groups (both P < 0.05). Fever was ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, :]

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[Efficient management of novel coronavirus pneumonia by efficient prevention and control in scientific manner].

Z C Gao,

At the end of 2019, sporadic and clustered case with "pneumonia of unknown origin" emerged in Wuhan, Hubei province. The causative pathogen was quickly confirmed as "2019-nCoV" . The epidemic soon spread throughout the country and became a pandemic in over a month. Government and medical institutions across the country ... Read more >>

Zhonghua Jie He He Hu Xi Za Zhi (Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases)
[2020, 43(3):163-166]

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CT image of novel coronavirus pneumonia: a case report.

Xiangmin Zhang, Wei Song, Xingli Liu, Liang Lyu,

ObjectiveKnowledge of CT characteristics of COVID-19 pneumonia might be helpful to the early diagnosis and treatment of patients, and to control the spread of infection.MethodsThe chest CT images of the patient were collected to describe the CT manifestations and characteristics, and they were compared with the previous studies.ResultsMultiple patchy ground-glass ... Read more >>

Jpn J Radiol (Japanese journal of radiology)
[0, :1-2]

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Predicting the microbial cause of community-acquired pneumonia: can physicians or a data-driven method differentiate viral from bacterial pneumonia at patient presentation?

Claire Lhommet, Denis Garot, Leslie Grammatico-Guillon, Cassandra Jourdannaud, Pierre Asfar, Christophe Faisy, Grégoire Muller, Kimberly A Barker, Emmanuelle Mercier, Sylvie Robert, Philippe Lanotte, Alain Goudeau, Helene Blasco, Antoine Guillon,

BACKGROUND:Community-acquired pneumonia (CAP) requires urgent and specific antimicrobial therapy. However, the causal pathogen is typically unknown at the point when anti-infective therapeutics must be initiated. Physicians synthesize information from diverse data streams to make appropriate decisions. Artificial intelligence (AI) excels at finding complex relationships in large volumes of data. We ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):62]

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