Full Text Journal Articles about
Viral Meningitis

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Hypertrophic pachymeningitis in a southern Chinese population: a retrospective study

Li Feng, Xuewen Xiao, Dongni Fu,

<title>Abstract</title> <p> <bold>Background </bold>Hypertrophic pachymeningitis (HP) is a fibrotic disorder featuring a thickening of the dura matter. Most HP studies were from Caucasian population and only a few studies of HP are available in China. In this study, we investigated the causes, clinical and imaging features and therapeutic ... Read more >>

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Metagenomic Next-Generation Sequencing for Diagnosis of Infectious Encephalitis and Meningitis: A Large, Prospective Case Series of 213 Patients.

Xiao-Wei Xing, Jia-Tang Zhang, Yu-Bao Ma, Mian-Wang He, Guo-En Yao, Wei Wang, Xiao-Kun Qi, Xiao-Yan Chen, Lei Wu, Xiao-Lin Wang, Yong-Hua Huang, Juan Du, Hong-Fen Wang, Rong-Fei Wang, Fei Yang, Sheng-Yuan Yu,

Purpose: We assessed the performance of metagenomic next-generation sequencing (mNGS) in the diagnosis of infectious encephalitis and meningitis. Methods: This was a prospective multicenter study. Cerebrospinal fluid samples from patients with viral encephalitis and/or meningitis, tuberculous meningitis, bacterial meningitis, fungal meningitis, and non-central nervous system (CNS) infections were subjected to ... Read more >>

Front Cell Infect Microbiol (Frontiers in Cellular and Infection Microbiology)
[2020, 10:88]

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CD8 T Cells and STAT1 Signaling Are Essential Codeterminants in Protection from Polyomavirus Encephalopathy.

Taryn E Mockus, Colleen S Netherby-Winslow, Hannah M Atkins, Matthew D Lauver, Ge Jin, Heather M Ren, Aron E Lukacher,

JC polyomavirus (JCPyV), a human-specific virus, causes the aggressive brain-demyelinating disease progressive multifocal leukoencephalopathy (PML) in individuals with depressed immune status. The increasing incidence of PML in patients receiving immunotherapeutic and chemotherapeutic agents creates a pressing clinical need to define biomarkers to stratify PML risk and develop anti-JCPyV interventions. Mouse ... Read more >>

J. Virol. (Journal of virology)
[2020, 94(8):]

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Escherichia coli: a rare cause of meningitis in immuno-competent adult.

Maryam Zafar, Abubakar Tauseef, Muhammad Sohaib Asghar, Narmin Khan, Nabeeha Farooqui, Mustafa Dawood, Tanvir Alam, Durre Naman,

A 35-year-old male of Asian ethnicity presented with complaints of high-grade fever, severe headache, vomiting, generalized seizures, deteriorated conscious level and neck stiffness. After all baseline workup Computed Tomography (CT) scan of the brain was done, which turned out to be unremarkable. CT scan was then followed by lumbar puncture ... Read more >>

J Community Hosp Intern Med Perspect (Journal of community hospital internal medicine perspectives)
[2020, 10(1):69-72]

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Repeated viral meningitis in a newborn.

Abdulaziz Alhazmi, Mouna Lazrek, Enagnon Kazali Alidjinou, Ilka Engelmann, Isabelle Schuffenecker, Francois Dubos, Didier Hober,

Human enteroviruses (EV) are the most common cause of viral meningitis in children. Human parechoviruses (HPeV) are increasingly being recognized as a cause of central nervous system (CNS) infections and sepsis-like disease in children. Both viruses belong to Picornaviridae family. The clinical picture in EV and HPeV infections is usually ... Read more >>

J. Neurovirol. (Journal of neurovirology)
[2020, :]

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Impact of decreasing cerebrospinal fluid enterovirus PCR turnaround time on costs and management of children with suspected enterovirus meningitis.

Mohammad Alghounaim, Chelsea Caya, MinGi Cho, Marc Beltempo, Cedric P. Yansouni, Nandini Dendukuri, Jesse Papenburg,

To estimate the impact of implementing in-hospital enterovirus (EV) polymerase chain reaction (PCR) testing of cerebrospinal fluid (CSF) with same-day turn-around-time (TAT) on length-of-stay (LOS), antibiotic use and on cost per patient with suspected EV meningitis, compared with testing at an outside reference laboratory. A model-based analysis using a retrospective ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[0, :1-10]

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Implementation of the FilmArray ME panel in laboratory routine using a simple sample selection strategy for diagnosis of meningitis and encephalitis.

Susanne Pfefferle, Martin Christner, Martin Aepfelbacher, Marc Lütgehetmann, Holger Rohde,

BACKGROUND:Infectious meningitis is a serious disease and patient outcome relies on fast and reliable diagnostics. A syndromic panel testing approach like the FilmArray ME can accelerate diagnosis and therefore decrease the time to pathogen specific therapy. Yet, its clinical utility is controversial, mainly because of a remaining uncertainty in correct ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):170]

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[Cytotoxic lesion of the corpus callosum (CLOCC) in a context of viral meningitis].

H Hoëffelin, P Marchetti, J Khamis, P Reginster,

We report the case of a young patient of 16 years admitted in the emergency department for headache, nausea and vomiting, of brutal installation. After clinico-biological confrontation, the diagnosis of viral meningitis (aseptic) was made. During the initial assessment several complementary examinations and various brain imaging exams (CT, MRI) were ... Read more >>

Rev Med Liege (Revue medicale de Liege)
[2020, 75(2):78-82]

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What is AIDS in the Amazon and the Guianas in the 90-90-90 era?

Mathieu Nacher, Antoine Adenis, Basma Guarmit, Aude Lucarelli, Denis Blanchet, Magalie Demar, Felix Djossou, Philippe Abboud, Loïc Epelboin, Pierre Couppié,

Introduction In the past decade, new diagnostic methods and strategies have appeared, HIV testing efforts and the generalization of antiretroviral therapy may have influenced the number of opportunistic diagnoses and mortality of HIV-infected patients. To test this hypothesis we compiled data on the top opportunistic infections and causes of early ... Read more >>

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Cryptococcal meningitis and immune reconstitution inflammatory syndrome in a pediatric patient with HIV after switching to second line antiretroviral therapy: a case report.

Ssegujja Boniface Joseph Otto, Paul E George, Rebecca Mercedes, Nicolette Nabukeera-Barungi,

BACKGROUND:Cryptococcal meningitis (CCM) is a common and deadly disease among HIV-infected patients. Notable about CCM is its association with the immune reconstitution inflammatory syndrome (IRIS). Though it has been posited a switch from first to second-line antiretroviral therapy (ART) can induce CCM IRIS, a case presentation of CCM IRIS has ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):68]

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Comparison of antibiotic and acyclovir usage before and after the implementation of an on-site FilmArray meningitis/encephalitis panel in an academic tertiary pediatric hospital: a retrospective observational study.

Alexandra Hagen, Anna Eichinger, Melanie Meyer-Buehn, Tilmann Schober, Johannes Huebner,

BACKGROUND:Prompt initiation of empiric therapy is common practice in case of suspected meningitis or encephalitis. However, in children the most common pathogens are viruses that usually do not require and are not covered by the applied anti-infective treatment. Novel multiplex PCR (mPCR) panels provide rapid on-site diagnostic testing for a ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):56]

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Cytokine characteristic of cerebrospinal fluid from children with enteroviral meningitis compared to bacterial meningitis.

Jialu Xu, Jingjing Jiang, Yi Zhang, Wei Li,

BACKGROUND:Enteroviruses are the most common etiological agent for viral encephalitis, but it is uncertain whether the cytokines have the ability to differentiate enteroviral meningitis (EVM) from bacterial meningitis (BM). METHODS:A retrospective study was performed at the Children's Hospital, Zhejiang University School of Medicine from August 2016 and August 2019. CSF ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, :e23198]

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Epidemiology of Headache in Children in a Community Emergency Department: A Scoping Study.

Sharon Klim, Anne-Maree Kelly, David Krieser,

OBJECTIVE:This study aimed to describe the epidemiology of headache in children attending a community mixed adult-pediatric emergency department (ED) in Australia with a view to providing scoping data for future headache-related projects for the pediatric ED research networks. METHODS:This is a retrospective cohort study by medical record review. Participants were ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2020, :]

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Case report: meningitis as a presenting feature of anti-NMDA receptor encephalitis.

Maria Stavrou, Jing Ming Yeo, Alexander David Slater, Oliver Koch, Sarosh Irani, Peter Foley,

BACKGROUND:Meningitis is a very rare atypical presenting feature of anti-NMDA receptor encephalitis. In our case report, we describe an unusual clinical presentation of anti-NMDA receptor encephalitis with a biphasic pattern of meningitis followed by encephalitis and discuss potential mechanisms underlying this presentation. We aim to widen the differential diagnosis to ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):21]

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Understanding and managing acute encephalitis.

Rashmi Kumar,

Encephalitis is an important cause of morbidity, mortality, and permanent neurologic sequelae  globally. Causes are diverse and include viral and non-viral infections of the brain as well as autoimmune processes. In the West, the autoimmune encephalitides are now more common than any single infectious cause, but, in Asia, infectious causes ... Read more >>

F1000Res (F1000Research)
[2020, 9:]

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B Cell Compartmentalization in Blood and Cerebrospinal Fluid of HIV-Infected Ugandans with Cryptococcal Meningitis.

Samuel Okurut, David B Meya, Freddie Bwanga, Joseph Olobo, Michael A Eller, Fatim Cham-Jallow, Paul R Bohjanen, Harsh Pratap, Brent E Palmer, Katharine H Hullsiek, Yukari C Manabe, David R Boulware, Edward N Janoff,

Activated B cells modulate infection by differentiating into pathogen-specific antibody-producing effector plasmablasts/plasma cells, memory cells, and immune regulatory B cells. In this context, the B cell phenotypes that infiltrate the central nervous system during human immunodeficiency virus (HIV) and cryptococcal meningitis coinfection are ill defined. We characterized clinical parameters, mortality, ... Read more >>

Infect. Immun. (Infection and immunity)
[2020, 88(3):]

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Pathogen or bystander: clinical significance of detecting HHV-6 in pediatric CSF.

Utsav Pandey, Alexander L Greninger, Greg R Levin, Keith R Jerome, Vikram C Anand, Jennifer Dien Bard,

Detection of HHV-6 using FilmArray Meningitis/Encephalitis panel led to rapid establishment of etiology and antimicrobial optimization amongst the twenty-five patients with HHV-6 DNA detected in their CSF at our institution. Five of the 25 patients were diagnosed with HHV-6 meningitis/meningoencephalitis.Objective: Human herpesvirus 6 (HHV-6) is an important cause of meningitis ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2020, :]

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High-throughput fluorescence-based screen identifies the neuronal microRNA miR-124 as a positive regulator of alphavirus infection.

Paula López, Erika Girardi, Bryan C Mounce, Amélie Weiss, Béatrice Chane-Woon-Ming, Mélanie Messmer, Pasi Kaukinen, Arnaud Kopp, Diane Bortolamiol-Becet, Ali Fendri, Marco Vignuzzi, Laurent Brino, Sébastien Pfeffer,

Micro (mi)RNAs are small regulatory RNAs, which act by modulating the expression of target genes. In addition to their role in maintaining essential physiological functions in the cell, miRNAs can also regulate viral infections. They can do so directly by targeting RNAs of viral origin or indirectly by targeting host ... Read more >>

J. Virol. (Journal of virology)
[2020, :]

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Chemical meningitis in children as a risk factor following craniopharyngioma resection - a case report.

Magdalena Chrościńska-Krawczyk, Ewa Zienkiewicz, Arkadiusz Podkowiński, Maria Klatka,

BACKGROUND:Craniopharyngiomas are defined by the WHO as "benign" tumours, but their location and surgical treatment may be associated with major complications, one being chemical meningitis. Although rare, especially in children, it should be taken into account when worrying symptoms appear after surgery. CASE PRESENTATION:The aim of this study is to ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):56]

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Coxsackievirus B3 Infection of Human Neural Progenitor Cells Results in Distinct Expression Patterns of Innate Immune Genes.

Soo-Jin Oh, Jeong-An Gim, Jae Kyung Lee, Hosun Park, Ok Sarah Shin,

Coxsackievirus B3 (CVB3), a member of Picornaviridae family, is an important human pathogen that causes a wide range of diseases, including myocarditis, pancreatitis, and meningitis. Although CVB3 has been well demonstrated to target murine neural progenitor cells (NPCs), gene expression profiles of CVB3-infected human NPCs (hNPCs) has not been fully ... Read more >>

Viruses (Viruses)
[2020, 12(3):]

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Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis.

Leonardo Silva de Araujo, Kevin Pessler, Kurt-Wolfram Sühs, Natalia Novoselova, Frank Klawonn, Maike Kuhn, Volkhard Kaever, Kirsten Müller-Vahl, Corinna Trebst, Thomas Skripuletz, Martin Stangel, Frank Pessler,

BACKGROUND:The timely diagnosis of bacterial meningitis is of utmost importance due to the need to institute antibiotic treatment as early as possible. Moreover, the differentiation from other causes of meningitis/encephalitis is critical because of differences in management such as the need for antiviral or immunosuppressive treatments. Considering our previously reported ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):9]

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HIV-Associated Histoplasmosis: Current Perspectives.

Thein Myint, Nicole Leedy, Evelyn Villacorta Cari, L Joseph Wheat,

AbstractHistoplasmosis is an endemic mycosis caused by Histoplasma capsulatum. Infection develops by inhalation of microconidia from environmental sites inhabited by birds and bats. Disseminated disease is the usual presentation due to impaired cellular immunity. Common clinical manifestations include fever, fatigue, malaise, anorexia, weight loss, and respiratory symptoms. Histoplasma antigen detection ... Read more >>

HIV AIDS (Auckl) (HIV/AIDS (Auckland, N.Z.))
[2020, 12:113-125]

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Virology: syndromic diagnosis of meningitis and encephalitis.

Marta Domínguez-Gil, Arturo Artero, José Antonio Oteo, José María Eiros,

Viral infections of the nervous system represent a major health problem. It is estimated that the incidence of viral meningitis in the general population ranges from 5-17 cases per 100,000 inhabitants per year in developed countries. This heading encompasses highly varied clinical pictures, ranging from meningitis to encephalitis. This article ... Read more >>

Enferm. Infecc. Microbiol. Clin. (Enfermedades infecciosas y microbiologia clinica)
[2020, 38 Suppl 1:19-23]

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Neisseria meningitidis as a Cause of Septic Arthritis: An Unusual Case of Periprosthetic Joint Infection.

A. Mc Carthy, J. M. Broderick, A. P. Molloy,

One of the most feared complications after arthroplasty is infection due to its significant impact on patient morbidity. Infection may transfer to the joint at the time of surgery or be seeded, haematologically, to the prosthetic joint from another infection source. In this case, a 72-year-old female presented with symptoms ... Read more >>

(Case Reports in Infectious Diseases)
[2020, 2020:]

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Median Cleft Lip with Nasal Dermoid: A Rare Occurrence.

Lalit Agrawal, Arshad Afeez Khan, Naveen Khubchandani, Sarfaraz Sheikh Ali,

Median cleft lip with nasal dermoid is a very rare occurrence. Midline nasal dermoid results from the abnormal fusion of embryological processes. They can present as asymptomatic midline nasal swelling, infection, or meningitis due to intracranial extension. Median cleft lip also results from failure of fusion of embryological processes and ... Read more >>

J Indian Assoc Pediatr Surg (Journal of Indian Association of Pediatric Surgeons)
[2020, 25(2):110-111]

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