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Vertebrobasilar Atherothrombotic Disease

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Recurrent Acute Ischemic Stroke Associated with Dolichoectatic Aneurysm of the Internal Carotid Artery.

Yusuke Morinaga, Kouhei Nii, Kimiya Sakamoto, Ritsurou Inoue, Takafumi Mitsutake, Hayatsura Hanada,

BACKGROUND:Cranial artery dolichoectasia is characterized by dilated, elongated, and tortuous cranial arteries. Dolichoectasia and dolichoectatic aneurysm-particularly of the internal carotid arteries (ICAs)-are rare but can lead to stroke. We report a case of suspected recurrent acute cerebral infarction and dolichoectatic aneurysm of the left ICA combined with right dolichoectatic aneurysm, ... Read more >>

World Neurosurg (World neurosurgery)
[2019, 126:146-150]

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Rare presentation of an isolated bilateral cerebral peduncular infarction: A case report and review of the literature.

Xiaoxue Fu, Hongyu Li, Xiaoquan Tian, Wei Wang, Hong Liu,

RATIONALE:Due to the rarity of bilateral cerebral peduncular infarction (BCPI), its symptoms and prognosis are not clear. It is necessary to collect cases of pure cerebral peduncular infarction, explore the etiology and anatomy of midbrain infarction in depth, and develop meaningful tools for explaining clinical symptoms and predicting prognosis of ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(44):e17665]

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Small obliquely oriented cortical cerebellar infarctions are associated with cardioembolic stroke.

Adrien Ter Schiphorst, Lavinia Tatu, Vincent Thijs, Christophe Demattei, Eric Thouvenot, Dimitri Renard,

BACKGROUND:A revised classification of cerebellar infarctions (CI) may uncover unrecognized associations with etiologic stroke subtypes. We hypothesized that obliquely oriented small cortical cerebellar infarction (SCCI) representing end zone infarctions on MRI would be associated with cardiac embolism. METHODS:We retrospectively analyzed consecutive stroke patients recruited between January-December 2016 in our center. ... Read more >>

BMC Neurol (BMC neurology)
[2019, 19(1):100]

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[Cerebral infarctions in vertebrobasilar artery atherosclerosis].

P L Anufriev, A N Evdokimenko, T S Gulevskaya,

AIM:to obtain more specific information on the morphology and pathogenesis of cerebral infarctions occurring in vertebrobasilar artery (VBA) atherosclerosis. MATERIAL AND METHODS:Macro- and microscopic investigations of the brain, its arterial system, and heart were conducted in 69 autopsy cases with infarctions located in the vertebrobasilar system (VBS) in atherosclerosis. RESULTS:69 ... Read more >>

Arkh. Patol. (Arkhiv patologii)
[2018, 80(1):3-10]

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Atheroma of the Innominate Artery Presenting as a Transient Ischemic Attack.

Moin Hassan, Ateeq Mubarik, Chirag Patel, Furqan Haq, Salman Muddassir,

Supra-aortic atherosclerotic lesions, including innominate artery atheromas, are an uncommon but established cause of transient ischemic attacks, stroke, upper extremity ischemia, and vertebrobasilar insufficiency. We present a patient with a transient ischemic attack admitted with right hemispheric symptoms who was found to have a severe ulcerated innominate artery atheroma. The ... Read more >>

Cureus (Cureus)
[2019, 11(1):e3961]

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Atherosclerosis Might Be Responsible for Branch Artery Disease: Evidence From White Matter Hyperintensity Burden in Acute Isolated Pontine Infarction.

Lixin Zhou, Ming Yao, Bin Peng, Yicheng Zhu, Jun Ni, Liying Cui,

Objective: To investigate an MRI-based etiological classification for acute isolated pontine infarcts and to assess differences in vascular risk factors, clinical characteristics and WMH burden among the etiological subtypes. Methods: All participants from SMART cohort with DWI-proven acute isolated pontine infarcts (AIPI) were included and categorized into 3 groups: large-artery-occlusive ... Read more >>

Front Neurol (Frontiers in neurology)
[2018, 9:840]

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[Clinical features of ischaemic stroke with cerebral venous insufficiency and its risk factors.]

L M Tibekina, D O Boricheva, A A Nikolaeva,

Current research aimed to reveal clinical and neurological features of ischaemic stroke (IS) in patients suffering from cerebral venous insufficiency (CVI) combined with arterial hypertension (AH) and to identify its risk factors. Examination data of 112 patients with IS (aged 60-93 years old; mean age 72,1±2,6 years old, males - ... Read more >>

Adv Gerontol (Advances in gerontology = Uspekhi gerontologii)
[2018, 31(2):266-272]

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Long-Term Stroke Recurrence after Transient Ischemic Attack: Implications of Etiology.

Angel Ois, Elisa Cuadrado-Godia, Eva Giralt-Steinhauer, Jordi Jimenez-Conde, Carolina Soriano-Tarraga, Ana Rodríguez-Campello, Carla Avellaneda, Diego Cascales, Isabel Fernandez-Perez, Jaume Roquer,

Background and PURPOSE:To analyze long-term stroke recurrence (SR) characteristics after transient ischemic attack (TIA) according to initial etiological classification. METHODS:A prospective cohort of 706 TIA patients was followed up in a single tertiary stroke center. Endpoint was SR. Etiologic subgroup was determined according to the evidence-based causative classification system. Location ... Read more >>

J Stroke (Journal of stroke)
[2019, 21(2):184-189]

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Ischemic stroke due to intracranial arterial dolichoectasia coexisting with spontaneous dissection of the basilar artery: A case report.

Fang Yang, Hong Yue, Lin Wu, Xia Qin, Lili Shi, Wei Qu,

We present a rarely seen case of cerebral infarction due to intracranial dolichoectasia coexisting with spontaneous dissection of the basilar artery. A definition of dolichoectasia, its pathology, and imaging findings, as well as the clinical management and prognosis are briefly reviewed.We discuss in general terms the diagnosis of basilar artery ... Read more >>

Medicine (Baltimore) (Medicine)
[2017, 96(44):e8422]

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Relative Hypodense Vertebral Artery Sign on Computerized Tomography in Atherosclerotic Near Occlusion.

Muhammad Faraz Raghib, Slaven Pikija,

A 52-year-old white male presented with an acute onset of slurred speech along with hypoesthesia in the entire left arm. The acute computed tomography (CT) showed relative hypodensity in the intracranial segment of left vertebral artery (VA) that was not present in historical images, pointing to the possible lack of ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2016, 2016:3506161]

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Factors Associated with Intima-Media Complex Thickness of the Common Carotid Artery in Japanese Noncardioembolic Stroke Patients with Hyperlipidemia: The J-STARS Echo Study.

Shinichi Wada, Masatoshi Koga, Kazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka, Yoji Nagai, Shiro Aoki, Tomohisa Nezu, Naohisa Hosomi, Tatsuo Kagimura, Hideki Origasa, Kenji Kamiyama, Rieko Suzuki, Toshiho Ohtsuki, Hirofumi Maruyama, Kazuo Kitagawa, Shinichiro Uchiyama, Masayasu Matsumoto, ,

AIMS:There may be ethnic differences in carotid atherosclerosis and its contributing factors between Asian and other populations. The purpose of this study was to examine intima-media complex thickness (IMT) of the carotid artery and associated clinical factors in Japanese stroke patients with hyperlipidemia from a cohort of the Japan Statin ... Read more >>

J. Atheroscler. Thromb. (Journal of atherosclerosis and thrombosis)
[2018, 25(4):359-373]

Cited: 2 times

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A Mechanistic and Pathophysiological Approach for Stroke Associated with Drugs of Abuse.

Aristides Tsatsakis, Anca Oana Docea, Daniela Calina, Konstantinos Tsarouhas, Laura-Maria Zamfira, Radu Mitrut, Javad Sharifi-Rad, Leda Kovatsi, Vasileios Siokas, Efthimios Dardiotis, Nikolaos Drakoulis, George Lazopoulos, Christina Tsitsimpikou, Panayiotis Mitsias, Monica Neagu,

Drugs of abuse are associated with stroke, especially in young individuals. The major classes of drugs linked to stroke are cocaine, amphetamines, heroin, morphine, cannabis, and new synthetic cannabinoids, along with androgenic anabolic steroids (AASs). Both ischemic and hemorrhagic stroke have been reported due to drug abuse. Several common mechanisms ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(9):]

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Multimodal Therapy for Non-Superacute Vertebral Basilar Artery Occlusion.

Xiongjun He, Liang Zhang, Juan Yang, Hui Zheng, Kaifeng Li, Yajie Liu,

Objective:The aim of this study was to evaluate the feasibility and safety of multimodal therapy for patients with non-superacute vertebral basilar artery occlusion. Method:We performed a retrospective analysis of multimodal therapy for patients with vertebral basilar artery occlusion. All patients who were beyond the time window to receive intravenous thrombolysis ... Read more >>

Interv Neurol (Interventional neurology)
[2017, 6(3-4):254-262]

Cited: 1 time

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The Effectiveness of Additional Treatment Modalities after the Failure of Recanalization by Thrombectomy Alone in Acute Vertebrobasilar Arterial Occlusion.

Seong Mook Kim, Sung-Il Sohn, Jeong-Ho Hong, Hyuk-Won Chang, Chang-Young Lee, Chang-Hyun Kim,

Acute vertebrobasilar artery occlusion (AVBAO) is a devastating disease with a high mortality rate. One of the most important factors affecting favorable clinical outcome is early recanalization. Mechanical thrombectomy is an emerging treatment strategy for achieving a high recanalization rates. However, thrombectomy alone can be insufficient to complete recanalization, especially ... Read more >>

J Korean Neurosurg Soc (Journal of Korean Neurosurgical Society)
[2015, 58(5):419-425]

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Association between etiology and lesion site in ischemic brainstem infarcts: a retrospective observational study.

Gozde Baran, Tugce Ozdemir Gultekin, Oguz Baran, Cigdem Deniz, Salim Katar, Gulsen Babacan Yildiz, Talip Asil,

To assess the anatomical distribution of the ischemic strokes of the brainstem, the effect of anatomical distribution on clinical features and prognosis, and the association between etiology and anatomical involvement.A retrospective search of the patient database of our institution was performed for a total of 227 patients who were admitted ... Read more >>

Neuropsychiatr Dis Treat (Neuropsychiatric Disease and Treatment)
[2018, 14:757-766]

Cited: 1 time

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A review of the diagnosis and management of vertebral basilar (posterior) circulation disease.

James I Ausman, David S Liebeskind, Nestor Gonzalez, Jeffrey Saver, Neil Martin, J Pablo Villablanca, Paul Vespa, Gary Duckwiler, Reza Jahan, Tianyi Niu, Noriko Salamon, Bryan Yoo, Satoshi Tateshima, Manuel M Buitrago Blanco, Sidney Starkman,

We have reviewed the English literature published in the last 70 years on Diseases of the Vertebral Basilar Circulation, or Posterior Circulation Disease (PCD). We have found that errors have been made in the conduct and interpretation of these studies that have led to incorrect approaches to the management of ... Read more >>

Surg Neurol Int (Surgical Neurology International)
[2018, 9:106]

Cited: 2 times

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Treatment of acute vertebrobasilar occlusion using thrombectomy with stent retrievers: initial experience with 18 patients.

M Espinosa de Rueda, G Parrilla, J Zamarro, B García-Villalba, F Hernández, A Moreno,

BACKGROUND AND PURPOSE: Acute vertebrobasilar occlusion is an ominous disease with few proved effective treatments. Experience with stent retrievers is scarce and limited to combined therapies (stent retrievers associated with previous intravenous fibrinolysis, intra-arterial thrombolysis, or other mechanical devices). We present our experience with 18 patients treated with direct thrombectomy ... Read more >>

AJNR Am J Neuroradiol (AJNR. American journal of neuroradiology)
[2013, 34(5):1044-1048]

Cited: 29 times

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[Basilar artery occlusion--a diagnostic and therapeutic challenge].

Tiina Sairanen, Daniel Strbian, Perttu J Lindsberg,

Acute basilar artery occlusion is a neurological emergency that almost invariably leads to death or severe disability if not recanalized. Therapeutic recanalization is attempted using thrombolytic therapy either intravenously alone or by bridging it to on-demand, endovascular procedures. Due to often demanding differential diagnosis, angiographic evidence of basilar artery occlusion ... Read more >>

Duodecim (Duodecim; laaketieteellinen aikakauskirja)
[2013, 129(9):950-958]

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Rationale, design, and baseline features of a randomized controlled trial to assess the effects of statin for the secondary prevention of stroke: the Japan Statin Treatment Against Recurrent Stroke (J-STARS).

Yoji Nagai, Tatsuo Kohriyama, Hideki Origasa, Kazuo Minematsu, Chiaki Yokota, Shinichiro Uchiyama, Setsuro Ibayashi, Yasuo Terayama, Makoto Takagi, Kazuo Kitagawa, Eiichi Nomura, Naohisa Hosomi, Toshiho Ohtsuki, Takemori Yamawaki, Yoshihiro Matsubara, Masakazu Nakamura, Yoshimitsu Yamasaki, Etsuro Mori, Masanori Fukushima, Shotai Kobayashi, Yukito Shinohara, Takenori Yamaguchi, Masayasu Matsumoto, ,

Although statin therapy is beneficial for preventing first strokes, the benefit for recurrent stroke and its sub-types remains unknown in Asian populations. The aim of this study is to examine the role of pravastatin in the secondary prevention of stroke in Japanese patients.This is a multicenter, randomized, open-label, parallel group ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2014, 9(2):232-239]

Cited: 11 times

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Stroke Caused by Atherosclerosis of the Major Intracranial Arteries.

Chirantan Banerjee, Marc I Chimowitz,

Our goal in this review is to discuss the pathophysiology, diagnosis, and treatment of stroke caused by atherosclerosis of the major intracranial arteries. References for the review were identified by searching PubMed for related studies published from 1955 to June 2016 using search terms intracranial stenosis and intracranial atherosclerosis. Reference ... Read more >>

Circ. Res. (Circulation research)
[2017, 120(3):502-513]

Cited: 27 times

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The utility of middle cerebral artery clot density and burden assessment by noncontrast computed tomography in acute ischemic stroke patients treated with thrombolysis.

Mehmet A Topcuoglu, E Murat Arsava, Oguzhan Kursun, Erhan Akpinar, Bulent Erbil,

BACKGROUND: Quantitative and qualitative evaluation of middle cerebral artery (MCA) density, together with extent of thrombi, was assessed on plain computerized tomography (CT) to delineate better the prognostic value of the hyperdense MCA sign (HMCAS) in a cohort of patients who underwent intravenous or intra-arterial thrombolysis. METHODS: Density of MCA ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2014, 23(2):e85-91]

Cited: 8 times

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Minor trauma causing stroke in a young athlete.

Vineet Gupta, Naveen Dhawan, Jaya Bahl,

A 17-year-old Caucasian male presented with sudden dizziness, ataxia, vertigo, and clumsiness lasting for a couple of hours. He had a subtle trauma during a wrestling match 2 days prior to the presentation. A CT Angiogram (CTA) and MRI showed left vertebral artery dissection (VAD). The patient was treated with ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2015, 2015:182875]

Cited: 2 times

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Complementary examinations other than neuroimaging and neurosonology in acute stroke.

Adrià Arboix, Víctor Obach, Maria José Sánchez, Joan Massons,

The etiologic diagnosis of cerebrovascular diseases requires non-routine complementary examinations to be performed. Thus, in specific cases, after neuroimaging (computed tomography/magnetic resonance imaging cerebral scan sequences) and neurosonology (Doppler test of the supra-aortic trunks, transcranial echography and echocardiography), which academically allow us to classify the patients according to their etiologic ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2017, 5(6):191-202]

Cited: 1 time

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Intravenous alteplase at 0.6 mg/kg for acute stroke patients with basilar artery occlusion: the stroke acute management with urgent risk factor assessment and improvement (SAMURAI) Recombinant tissue plasminogen activator registry.

Tetsuya Miyagi, Masatoshi Koga, Yoshiaki Shiokawa, Jyoji Nakagawara, Yasuhiro Hasegawa, Eisuke Furui, Kazumi Kimura, Kazuomi Kario, Satoshi Okuda, Hiroshi Yamagami, Yasushi Okada, Tomohisa Nezu, Koichiro Maeda, Kaoru Endo, Kazuo Minematsu, Kazunori Toyoda,

BACKGROUND: The therapeutic efficacy of low-dose intravenous alteplase (0.6 mg/kg) for basilar artery occlusion (BAO) remains unknown. METHODS: BAO patients enrolled from the Japanese multicenter registry involving 600 stroke patients treated with the low-dose intravenous alteplase were studied. RESULTS: Twenty-five patients had BAO (8 women ranging from 32-92 years of ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2013, 22(7):1098-1106]

Cited: 5 times

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One-year follow-up in patients with brainstem infarction due to large-artery atherothrombosis.

Mehmet Kolukısa, Tugce Ozdemir Gültekin, Gozde Eryigit Baran, Ayse Aralasmak, Gülsen Kocaman, Azize Esra Gürsoy, Talip Asil,

BACKGROUND: Posterior circulation infarction accounts for approximately 25% of the ischemic strokes. A number of different conditions may be associated with the development of brainstem infarction. Prognosis and recurrence rate of brainstem infarction due to large-artery atherothrombosis is still controversial. METHODS: A total of 826 patients with ischemic stroke were ... Read more >>

Neuropsychiatr Dis Treat (Neuropsychiatric Disease and Treatment)
[2015, 11:379-384]

Cited: 1 time

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