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Velocardiofacial Syndrome

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Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF Resistant Diabetic Macular Edema.

Mitsuru Arima, Shintaro Nakao, Muneo Yamaguchi, Hao Feng, Yuya Fujii, Kensuke Shibata, Iori Wada, Yoshihiro Kaizu, Hamid Ahmadieh, Tatsuro Ishibashi, Alan Stitt, Koh-Hei Sonoda,

Approximately 40% of patients with diabetic macular edema (DME) are resistant to anti-vascular endothelial growth factor (VEGF) therapy (rDME). Here, we demonstrate that significant correlations between inflammatory cytokines and VEGF, as observed in naive DME, are lost in patients with rDME. VEGF overexpression in the mouse retina caused delayed inflammatory ... Read more >>

Diabetes (Diabetes)
[2020, :]

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Use of Preoperative Cervical Vascular Imaging in Patients With Velocardiofacial Syndrome and Velopharyngeal Dysfunction in the United Kingdom.

Nefer Fallico, Norma Timoney, Duncan Atherton,

OBJECTIVE:In patients with velocardiofacial syndrome (VCFS), medial displacement of the internal carotid arteries (ICAs) may increase the risk of vascular injury during the surgical correction of velopharyngeal dysfunction (VPD). Some surgeons advocate the use of vascular imaging studies prior to surgery. Nevertheless, the role of preoperative imaging is still controversial. ... Read more >>

Cleft Palate Craniofac. J. (The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association)
[2020, :1055665620904514]

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The Traditional Chinese Medicine Compound, GRS, Alleviates Blood-Brain Barrier Dysfunction.

Yuanyuan Zhang, Yang Hu, Min Li, Jieman Wang, Gengshuo Guo, Fang Li, Boyang Yu, Junping Kou,

Introduction:Traditional Chinese medicine (TCM) provides unique advantages for treatment of ischemic stroke, an aging-related vascular disease. Shengmai powder (GRS) is composed of three active components, specifically, ginsenoside Rb1, ruscogenin and schisandrin A, at a ratio of 6:0.75:6. The main objective of this study was to evaluate the effects of GRS ... Read more >>

Drug Des Devel Ther (Drug Design, Development and Therapy)
[2020, 14:933-947]

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Serum zonulin and claudin-5 levels in patients with bipolar disorder.

Faruk Kılıç, Ümit Işık, Arif Demirdaş, Duygu Kumbul Doğuç, Mustafa Bozkurt,

BACKGROUND:The etiology in bipolar disorder has not been fully understanding. There are limited data regarding the relationship between the permeability of intestinal and blood-brain barrier (BBB), and bipolar disorder etiology. Zonulin is regarded as a non-invasive biomarker for intestinal permeability. Claudin-5 is an important part of BBB permeability. In this ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 266:37-42]

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Serum zonulin and claudin-5 levels in children with obsessive-compulsive disorder.

Ümit Işık, Pınar Aydoğan Avşar, Evrim Aktepe, Duygu Kumbul Doğuç, Faruk Kılıç, Halil İbrahim Büyükbayram,

Background: Obsessive-compulsive disorder (OCD), a chronically debilitating neuropsychiatric disorder, is characterized by distinctive and recurrent obsessions and/or compulsions. An increasing number of evidence indicates that sophisticated interactions between different neurobiological factors play a part in OCD etiology, but the certain underlying mechanisms are still mainly unknown. The present research aimed ... Read more >>

Nord J Psychiatry (Nordic journal of psychiatry)
[2020, :1-6]

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Effect of Minoxidil on Trabecular Outflow via the Paracellular Pathway.

Hyun Gu Kang, Jae Woo Kim,

PURPOSE:To investigate the pathway and effects of minoxidil on trabecular outflow in cultured human trabecular meshwork (TM) cells. METHODS:After exposing primarily cultured TM cells to 0, 10, 50, or 100 μM minoxidil sulfate (MS), trabecular outflow was assessed by measuring TM cell monolayer permeability to carboxyfluorescein and transepithelial electrical resistance. ... Read more >>

Korean J Ophthalmol (Korean journal of ophthalmology : KJO)
[2020, 34(2):97-105]

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Herpes Simplex Virus 1-Induced Blood-Brain Barrier Damage Involves Apoptosis Associated With GM130-Mediated Golgi Stress.

Qiang He, Hui Liu, Chuxin Huang, Renchun Wang, Minhua Luo, Wei Lu,

Herpes simplex encephalitis (HSE) caused by herpes simplex virus 1 (HSV-1) infection can lead to a high mortality rate and severe neurological sequelae. The destruction of the blood-brain barrier (BBB) is an important pathological mechanism for the development of HSE. However, the specific mechanism underlying the BBB destruction remains unclear. ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2020, 13:2]

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Regional Differences in Tight Junction Protein Expression in the Blood-DRG Barrier and Their Alterations after Nerve Traumatic Injury in Rats.

Thomas J Lux, Xiawei Hu, Adel Ben-Kraiem, Robert Blum, Jeremy Tsung-Chieh Chen, Heike L Rittner,

The nervous system is shielded by special barriers. Nerve injury results in blood-nerve barrier breakdown with downregulation of certain tight junction proteins accompanying the painful neuropathic phenotype. The dorsal root ganglion (DRG) consists of a neuron-rich region (NRR, somata of somatosensory and nociceptive neurons) and a fibre-rich region (FRR), and ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 21(1):]

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Computational Modeling of Claudin Structure and Function.

Shadi Fuladi, Ridaka-Wal Jannat, Le Shen, Christopher R Weber, Fatemeh Khalili-Araghi,

Tight junctions form a barrier to control passive transport of ions and small molecules across epithelia and endothelia. In addition to forming a barrier, some of claudins control transport properties of tight junctions by forming charge- and size-selective ion channels. It has been suggested claudin monomers can form or incorporate ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

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Oligodendrocyte precursor cells transplantation protects blood-brain barrier in a mouse model of brain ischemia via Wnt/β-catenin signaling.

Liping Wang, Jieli Geng, Meijie Qu, Fang Yuan, Yuyang Wang, Jiaji Pan, Yongfang Li, Yuanyuan Ma, Panting Zhou, Zhijun Zhang, Guo-Yuan Yang,

Blood-brain barrier damage is a critical pathological feature of ischemic stroke. Oligodendrocyte precursor cells are involved in maintaining blood-brain barrier integrity during the development. However, whether oligodendrocyte precursor cell could sustain blood-brain barrier permeability during ischemic brain injury is unknown. Here, we investigate whether oligodendrocyte precursor cell transplantation protects blood-brain ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(1):9]

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A Case of an Adult Wilms Tumour in a Patient With Velocardiofacial Syndrome.

Elizabeth Ferreira, Mohammad Mohaghegh, Siv Venkat, Darrel Drachenberg, Susan Battistuzzi, Shuying Ji,

Adult Wilms tumors (nephroblastomas) are exceedingly rare with less than 500 cases reported in the literature. To our knowledge, ours is the first reported case of a patient with velocardiofacial syndrome (Shprintzen syndrome) acquiring an adult Wilms tumor. The case highlights the possible role of chromosome 22q aberrations toward the ... Read more >>

Urology (Urology)
[2020, 137:e8-e9]

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Pathological changes from the originating to the peripheral sites of Sinonasal Inverted Papilloma are the underlying mechanisms of preoperative MRI-tumor origin prediction.

S Ma, M Xian, B Yang, G Fang, H Lou, W Yu, X Wang, J Xian, X Song, E Fan, Y Li, L Zhang, C Wang,

BACKGROUND:Our previous study showed that convoluted cerebriform pattern (CCP)-based reverse tracing method in preoperative magnetic resonance imaging (MRI) is a reliable tool in predicting originating site of sinonasal inverted papilloma (SNIP). This study aimed to determine the underlying pathological mechanism of the preoperative MRI-CCP reverse tracing method by assessing the ... Read more >>

Rhinology (Rhinology)
[2020, 58(1):59-65]

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Immortalised hippocampal astrocytes from 3xTG-AD mice fail to support BBB integrity in vitro: Role of extracellular vesicles in glial-endothelial communication

Karolina Kriaučiūnaitė, Aida Kaušylė, Justina Pajarskienė, Virginijus Tunaitis, Dmitry Lim, Alexei Verkhratsky, Augustas Pivoriūnas,

Abstract Impairments of the blood brain barrier (BBB) and vascular dysfunction contribute to Alzheimer’s disease (AD) from the earliest stages. However, the effects of AD-affected astrocytes on the BBB remain largely unexplored. In the present study we created an in vitro BBB using human immortalised endothelial cells in combination with ... Read more >>

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Effect of MicroRNA-126a-3p on Bone Marrow Mesenchymal Stem Cells Repairing Blood-brain Barrier and Nerve Injury after Intracerebral Hemorrhage.

Chunyan Wang, Jingwei Cao, Shurong Duan, Ran Xu, Hongli Yu, Xin Huo, Yuanyuan Qian,

OBJECTIVE:Intracerebral hemorrhage (ICH) is a disease that threatens human health due to its high morbidity and mortality. On behalf of finding the better methods in the treatment of ICH, researchers pay more attention to a new technology which is finding effective genes to modify stem cells. METHODS:In this study, we ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, :104748]

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Pigment Epithelium-Derived Factor Improves Paracellular Blood-Brain Barrier Integrity in the Normal and Ischemic Mouse Brain.

Arina Riabinska, Marietta Zille, Menderes Yusuf Terzi, Ryan Cordell, Melina Nieminen-Kelhä, Jan Klohs, Ana Luisa Piña,

Pigment epithelium-derived factor (PEDF) is a neurotrophic factor with neuroprotective, antiangiogenic, and antipermeability effects. In the brain, blood-brain barrier (BBB) function is essential for homeostasis. Its impairment plays a crucial role in the pathophysiology of many neurological diseases, including ischemic stroke. We investigated (a) whether PEDF counteracted vascular endothelial growth ... Read more >>

Cell. Mol. Neurobiol. (Cellular and molecular neurobiology)
[2019, :]

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Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability.

Mónica Díaz-Coránguez, Cheng-Mao Lin, Stefan Liebner, David A Antonetti,

Vascular endothelial growth factor (VEGF) contributes to blood-retinal barrier (BRB) dysfunction in several blinding eye diseases, including diabetic retinopathy. Signaling via the secreted protein norrin through the frizzled class receptor 4 (FZD4)/LDL receptor-related protein 5-6 (LRP5-6)/tetraspanin 12 (TSPAN12) receptor complex is required for developmental vascularization and BRB formation. Here, we ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2020, :]

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Blockade of Arginine Vasopressin receptors prevents blood-brain barrier breakdown in Experimental Autoimmune Encephalomyelitis.

Verónica Viñuela-Berni, Beatriz Gómez-González, Andrés Quintanar-Stephano,

The blood-brain barrier (BBB) plays a significant pathophysiological role in multiple sclerosis (MS). Vasopressin (AVP) is released after brain injury and contributes to the inflammatory response. We propose that AVP may be modulating BBB permeability and hence affecting EAE clinical signs. Female Lewis rats were immunized s.c. with guinea-pig brain ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):467]

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Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib, prevents acute lung injury associated cognitive deficits potentially through suppression of inflammatory response.

Bijayani Sahu, Arun Narota, Amarjit S Naura,

Acute lung injury (ALI) has been reported to be associated with high mortality rate. Moreover, ALI survivors, frequently present chronic cognitive deterioration. We have previously shown that 'two hit' (hydrochloric acid + lipopolysaccharide) induced ALI resulted in cognitive dysfunction through the induction of systemic inflammation. The present study was designed to explore ... Read more >>

Eur. J. Pharmacol. (European journal of pharmacology)
[2020, :173091]

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Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats.

Yingqiu Cheng, Shipeng Li, Yi Liu, Jinghui Li, Ye Chen, Hexiang Zhao,

BACKGROUND Brain edema and neuronal apoptosis are closely associated with loss of neurological function and death in rats with subarachnoid hemorrhage (SAH). The present study investigated the effect of wogonoside on brain edema induced by SAH in rats and studied the mechanism involved. MATERIAL AND METHODS The rats were intra-gastrically ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e921250]

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Neonatal excitotoxicity modifies blood-brain barrier properties increasing its susceptibility to hypertonic shock in adulthood.

Blanca Fabiola Fajardo-Fregoso, Jose Luis Castañeda-Cabral, Carlos Beas-Zárate, Mónica E Ureña-Guerrero,

Early responses to a neurological excitotoxic process include blood-brain barrier (BBB) impairment and overexpression of vascular endothelial growth factor (VEGF), but the long-term effects of excitotoxicity on the BBB properties remain unknown. To assess this, we induced an excitotoxic process on male rats by neonatal monosodium glutamate (MSG) treatment. At ... Read more >>

Int. J. Dev. Neurosci. (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience)
[2020, :]

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Evaluation of long-term rt-PA effects on bEnd.3 endothelial cells under ischemic conditions; changes in ZO-1 expression and glycosylation of the bradykinin B2 receptor.

Carme Gubern, Pau Comajoan, Gemma Huguet, Juan Manuel Sánchez, Joaquín Serena, Elisabet Kádár, Mar Castellanos,

Recombinant tissue plasminogen activator (rt-PA) has proven effective in the treatment of acute ischemic stroke, despite the increased risk of hemorrhagic transformation (HT), its major associated complication. Although it is known that HT is related to blood brain barrier (BBB) disruption, the underlying mechanisms are not well established. We assessed ... Read more >>

Thromb. Res. (Thrombosis research)
[2020, 187:1-8]

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Idiopathic pulmonary fibrosis is associated with tight junction protein alterations.

Jinjing Zou, Ye Li, Jimian Yu, Li Dong, Aliya N Husain, Le Shen, Christopher R Weber,

Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by an abnormal healing response to injury of the alveolar epithelium. Tight junctions provide a physical barrier at the apical intercellular space between epithelial cells and regulate paracellular flux. While tight junction alterations are known to contribute to barrier dysfunction in ... Read more >>

Biochim Biophys Acta Biomembr (Biochimica et biophysica acta. Biomembranes)
[2020, 1862(5):183205]

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Effect of monoacylglycerol lipase inhibition on intestinal permeability in chronic stress model.

Jing Wang, Xiaohua Zhang, Chongmei Yang, Shulei Zhao,

The endocannabinoid 2-arachidonoylglycerol (2-AG) is an anti-nociceptive lipid, which is inactivated through cellular uptake and subsequent catabolism by monoacylglycerol lipase (MAGL). The present study aimed to explore the effects of inhibition of MAGL on intestinal permeability. We first tested it in differentiated CaCO2 cells after 21 days' culture. The rat ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, :]

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Sevoflurane anesthesia during pregnancy in mice induces cognitive impairment in the offspring by causing iron deficiency and inhibiting myelinogenesis.

Yong Zuo, Bowen Li, Jinhong Xie, Zhao Ma, Anand Thirupathi, Peng Yu, Guofen Gao, Jinjuan Zhou, Changhao Zhou, Hongmeng Xu, Yanzhong Chang, Zhenhua Shi,

Maternal anesthetic exposure during pregnancy is associated with an increased risk of cognitive impairment in offspring. The balance of cerebral iron metabolism is essential for the development of brain tissue. Iron deficiency affects the myelinogenesis and nerve tissue development, especially in fetus or infant, which has a key role in ... Read more >>

Neurochem. Int. (Neurochemistry international)
[2020, 135:104693]

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Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability

Romain Marignier, Alvaro Calvo, Alvaro Cobo-Calvo, Anne Ruiz, Chloé Richard, Sandrine Blondel, Sylvie Cavagna, Nathalie Strazielle, Jean-François Ghersi-Egea, Pascal Giraudon,

<title>Abstract</title> <p> <bold>Background</bold>: Blood-brain barrier (BBB) breakdown is considered one of the key steps for the development and lesion formation of neuromyelitis optica spectrum disorder (NMOSD). However, little is known about the molecular mechanisms involved. The aim of the study was to evaluate the effect of human immunoglobulins ... Read more >>

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