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GPN-1/glypican and UNC-52/perlecan do not appear to function in BMP signaling to pattern the C. elegans postembryonic mesoderm.

Melisa S DeGroot, Robert Greer, Jun Liu,

Heparan sulfate proteoglycans (HSPGs) are diverse macromolecules consisting of a protein core modified with glycosaminoglycan (GAG) chains. HSPGs, including glypicans and perlecans, have been implicated in shaping the extracellular matrix (ECM) to affect growth factor signaling. Here, we tested if GPN-1/glypicanor UNC-52/perlecan plays a role in the bone morphogenetic protein ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Effects of silencing epididymal vascular endothelial growth factor (VEGF) expression on hyaluronidase (HYD) activity in arsenic poisoning rats through downregulating VEGF receptor 2 (VEGFR2).

Yan-Ping Dai, Xiao-Qin Gao,

RNA interference (RNAi) was used to investigate the role of epididymal vascular endothelial growth factor (VEGF) gene expression on sperm hyaluronidase (HYD) in a rat model of arsenic poisoning and to identify a new gene therapy target for male infertility caused by arsenic poisoning. The Rat model of chronic arsenic ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1351-1359]

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Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury.

Wei Tang, Zong-Duo Guo, Wei-Na Chai, Dong-Lin Du, Xiao-Min Yang, Lang Cao, Hong Chen, Chao Zhou, Chong-Jie Cheng, Xiao-Chuan Sun, Zhi-Jian Huang, Jian-Jun Zhong,

MicroRNA-491-5p (miR-491-5p) plays an important role in regulating cell proliferation and migration; however, the effect of miR-491-5p on neovascularization after traumatic brain injury remains poorly understood. In this study, a controlled cortical injury model in C57BL/6 mice and an oxygen-glucose deprivation model in microvascular endothelial cells derived from mouse brain ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):577-586]

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Trimetazidine ameliorates hindlimb ischaemic damage in type 2 diabetic mice.

Yan Yang, Qinqin Xu, Tao Li, Shiying Shao,

<h4>Background</h4>Ischaemia caused by lower extremity artery stenosis is the main cause of peripheral artery disease (PAD) in patients with diabetes. Trimetazidine (TMZ) has traditionally been used as an anti-ischaemic drug for coronary artery disease. The effect of TMZ on PAD in a diabetic animal model and the underlying molecular mechanisms ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1099-1107]

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Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.

Shengming Huang, Zhanguo Tan, Jirui Cai, Zhiping Wang, Yuejun Tian,

<h4>Context</h4>Cerebral ischaemia/reperfusion (I/R) injury has a high disability and fatality worldwide. Myrtenol has protective effects on myocardial I/R injury through antioxidant and anti-apoptotic effects.<h4>Objective</h4>This study investigated the effect of myrtenol on cerebral ischaemia/reperfusion (I/R) injury and the underlying mechanism.<h4>Materials and methods</h4>Cerebral I/R injury was induced in adult Sprague-Dawley rats by ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):584-593]

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Uremic serum induces prothrombotic changes in venous endothelial cells and inflammatory changes in aortic endothelial cells.

Patrycja Sosińska-Zawierucha, Andrzej Bręborowicz,

<h4>Background</h4>Uremia induces various pathologic changes in the endothelium. However, there is limited information about the differences of these effects in endothelial cells originating from different parts of the vascular tree.<h4>Methods</h4>The effect of uremic serum obtained from patients with end stage renal failure on the gene expression and secretory activity of ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):401-405]

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Imatinib-induced podocytopathies in a patient with gastrointestinal stromal tumor.

Gang Wang, Ning Zhuo, Ying Luo, Jie Li,

Ren Fail (Renal failure)
[2021, 43(1):886-889]

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Novel piperazine-chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation.

Marwa F Ahmed, Eman Y Santali, Radwan El-Haggar,

New piperazine-chalcone hybrids and related pyrazoline derivatives have been designed and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. The National Cancer Institute (NCI) has selected six compounds to evaluate their antiproliferative activity <i>in vitro</i> against 60 human cancer cells lines. Preliminary screening of the examined compounds indicated promising ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):307-318]

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Multi-target mechanism of Tripteryguim wilfordii Hook for treatment of ankylosing spondylitis based on network pharmacology and molecular docking.

Jing Zhang, Yiting Zhou, Zhiyuan Ma,

<h4>Background</h4><i>Tripteryguim wilfordii</i> Hook (TWH) has significant anti-inflammatory and immunosuppressive properties and is widely used for treating autoimmune and inflammatory diseases. However, the multi-target mechanism of TWH on ankylosing spondylitis (AS) remains to be elucidated.<h4>Methods</h4>Active components and their target proteins were screened from the Traditional Chinese Medicine Systems Pharmacology Database and ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1090-1098]

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Functional identification of a rare vascular endothelial growth factor a (VEGFA) variant associating with the nonsyndromic cleft lip with/without cleft palate.

Bohui Sun, Yangjia Liu, Wenbin Huang, Qian Zhang, Jiuxiang Lin, Weiran Li, Jieni Zhang, Feng Chen,

Vascular endothelial growth factor A (VEGFA) is a crucial growth factor, which participates in multiple processes of human growth and development, such as angiogenesis and osteogenesis and is also necessary for development of palate. The purpose of this study was to investigate the effect of a rare <i>VEGFA</i> mutation (NM_001025366.2 ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1471-1483]

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Resveratrol suppresses malignant progression of oral squamous cell carcinoma cells by inducing the ZNF750/RAC1 signaling pathway.

Yue Xiao, Yanjun Duan, Yongjie Wang, Xiaojia Yin,

This study examined whether activation of zinc finger protein 750/Ras-related C3 botulinum toxin substrate 1 (ZNF750/RAC1) signaling pathway may be involved in the ability of resveratrol to inhibit malignant progression of CAL-27 oral squamous cell carcinoma cells. CAL-27 cells were treated with resveratrol and transfected with plasmids expressing a ZNF750 ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2863-2873]

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The up-regulation of miR-21 by gastrodin to promote the angiogenesis ability of human umbilical vein endothelial cells by activating the signaling pathway of PI3K/Akt.

Jianli Wang, Minghua Wu,

Studies have shown that gastrodin has a protective effect on blood vessels. The purpose of this study was to investigate the influence of gastrodin on the angiogenesis ability of human umbilical vein endothelial cells (HUVECs) and its mechanism. We found that treatment of HUVECs with 10 µM and 25 µM gastrodin, and ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5402-5410]

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Longitudinal assessment of B-RAF V595E levels in the peripheral cell-free tumor DNA of a 10-year-old spayed female Korean Jindo dog with unresectable metastatic urethral transitional cell carcinoma for monitoring the treatment response to a RAF inhibitor (sorafenib).

Jung-Hyun Kim, Dana Hyunjung Ahn, Je-Sung Moon, Hyun-Jung Han, Kieun Bae, Kyong-Ah Yoon,

Transitional cell carcinoma (TCC) is the most common malignant tumor of the canine urinary tract. In this case study, a dog with metastatic urethral TCC was treated with sorafenib. The tumor expression levels of receptor tyrosine kinase genes, including <i>VEGFR-1, VEGFR-2, PDGFR-α, PDGFR-β, ALK, EGFR, ErbB2</i>, and <i>B-RAF</i>, were analyzed. ... Read more >>

Vet Q (The veterinary quarterly)
[2021, 41(1):153-162]

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Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis.

Mohammad Reza Farahpour, Sara Sheikh, Elham Kafshdooz, Ali Sonboli,

<h4>Context</h4><i>Zataria multiflora</i> Boiss (Lamiaceae) essential oil (ZME) is believed to be a bactericide herbal medicine and might alleviate negative effects of infection.<h4>Objective</h4>This study evaluates the effects of an ointment prepared from ZME (ZMEO) on infected wounds.<h4>Materials and methods</h4>A full-thickness excisional skin wound was surgically created in each mouse and inoculated ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1-10]

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Assessment of the synergic effect of Avastin and VEGF siRNA on inhibition of cell proliferation and angiogenic factor expression of human breast cancer cells

Abdolkhalegh Deezagi, Bahar Ghorbani,

Angiogenesis is an important process in tumor growth and metastasis and vascular endothelial growth factor (VEGF) plays an important role in this process. Several VEGF inhibitors have been developed as anticancer agents including humanized monoclonal antibodies, and various small molecules. The aim of this work was to investigate the effect ... Read more >>

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Bioadhesive hydrogel comprising bilirubin/β-cyclodextrin inclusion complexes promote diabetic wound healing.

Qing Yao, Yannan Shi, Xing Xia, Yingying Tang, Xue Jiang, Ya-Wen Zheng, Hailin Zhang, Ruijie Chen, Longfa Kou,

<h4>Context</h4>Chronic non-healing diabetic wound therapy is an important clinical challenge. Manipulating the release of bioactive factors from an adhesive hydrogel is an effective approach to repair chronic wounds. As an endogenous antioxidant, bilirubin (BR) has been shown to promote wound healing. Nonetheless, its application is limited by its low water ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1139-1149]

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The protective effects of naproxen against interleukin-1β (IL-1β)- induced damage in human umbilical vein endothelial cells (HUVECs).

Yuliang Wu, Ruina Hao, Beidi Lan, Yiping Mu, Fuping Dang, Ruitao Wang,

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used medications in the world. Naproxen is an NSAID with relatively low selectivity for cyclooxygenase-2 (COX-2), thereby having decreased risk for cardiovascular (CV) events. However, it is unclear whether naproxen might provide protection against atherosclerosis, an underlying cause of numerous ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5361-5372]

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Intravitreal Dexamethasone Implant in Patients Who Did Not Complete Anti-VEGF Loading Dose During the COVID-19 Pandemic: a Retrospective Observational Study.

Vincenzo Scorcia, Giuseppe Giannaccare, Valentina Gatti, Sabrina Vaccaro, Gabriele Piccoli, Annarita Villì, Mario Damiano Toro, Angeli Christy Yu, Claudio Iovino, Francesca Simonelli, Adriano Carnevali,

<h4>Introduction</h4>To compare the functional and anatomic outcomes between eyes in patients with diabetic macular edema (DME) who underwent a complete anti-vascular endothelial growth factor (VEGF) loading dose with aflibercept and those who were switched to dexamethasone intravitreal (DEX) implant after an incomplete anti-VEGF treatment regimen during the coronavirus disease 2019 ... Read more >>

Ophthalmol Ther (Ophthalmology and therapy)
[2021, :]

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Association of specific single nucleotide variants (SNVs) in the promoter and 3'-Untranslated region of Vascular Endothelial growth factor (VEGF) gene with risk and higher tumour grade of head and neck cancers.

Sadia Ajaz, Rabbia Muneer, Aisha Siddiqa, Muhammad Ali Memon, Sadaf Firasat, Aiysha Abid, Shagufta Khaliq,

<h4>Background</h4>Head and Neck Cancers (HNCs)comprise one of the most frequent cancers in South-Asian region. Vascular Endothelial Growth Factor (VEGF) has a potent role in tumorigenesis and metastasis. Certain common single nucleotide variants (SNVs) in the highly polymorphic VEGF gene are correlated with variations in VEGF functions. The data for these ... Read more >>

Oral Oncol (Oral oncology)
[2021, 122:105519]

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Non-immediate drug hypersensitivity reactions secondary to intravitreal anti-vascular endothelial growth factors.

E Moret, A Ambresin, C Gianniou, J Bijon, C Besse-Hayat, S Bogiatzi, D Hohl, F Spertini, I Mantel,

<h4>Purpose</h4>To describe a series of non-immediate drug hypersensitivity reactions after intravitreal anti-vascular endothelial growth factors (anti-VEGFs).<h4>Patients and methods</h4>Retrospective report of 6 patients with cutaneous non-immediate drug hypersensitivity reactions following intravitreal anti-VEGF injections, 4 after ranibizumab, 1 after bevacizumab and 1 after aflibercept.<h4>Results</h4>Clinical manifestations ranged from mild maculopapular rash, purpura to ... Read more >>

Graefes Arch Clin Exp Ophthalmol (Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie)
[2021, :]

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A bivalent cyclic RGD-siRNA conjugate enhances the antitumor effect of apatinib via co-inhibiting VEGFR2 in non-small cell lung cancer xenografts.

Lumin Liao, Bohong Cen, Guoxian Li, Yuanyi Wei, Zhen Wang, Wen Huang, Shuai He, Yawei Yuan, Aimin Ji,

The vascular endothelial growth factor receptor 2 (VEGFR2) is considered to be a pivotal target for anti-tumor therapy against angiogenesis of non-small cell lung cancer (NSCLC). However, effective and low-toxicity targeted therapies to inhibit VEGFR2 are still lacking. Here, biRGD-siVEGFR2 conjugate comprising murine VEGFR2 siRNA and [cyclo(Arg-Gly-Asp-D-Phe-Lys)-Ahx]<sub>2</sub>-Glu-PEG-MAL (biRGD) peptide which ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):1432-1442]

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Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability.

Li Wang, Matteo Astone, Sk Kayum Alam, Zhu Zhu, Wuhong Pei, David A Frank, Shawn M Burgess, Luke H Hoeppner,

Vascular permeability triggered by inflammation or ischemia promotes edema, exacerbates disease progression, and impairs tissue recovery. Vascular endothelial growth factor (VEGF) is a potent inducer of vascular permeability. VEGF plays an integral role in regulating vascular barrier function physiologically and in pathologies, including cancer, stroke, cardiovascular disease, retinal conditions, and ... Read more >>

Dis Model Mech (Disease models & mechanisms)
[2021, :]

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Thalidomide Suppresses Angiogenesis Through the Signal Transducer and Activator of Transcription 3/SP4 Signaling Pathway in the Peritoneal Membrane.

Nan Zhu, Ling Wang, Huimin Guo, Jieshuang Jia, Lijie Gu, Xuan Wang, Man Yang, Haochen Guan, Weijie Yuan,

Peritoneal angiogenesis is the key pathophysiological factor that limits peritoneal ultrafiltration during peritoneal dialysis (PD) in uremic patients. Thalidomide has been confirmed to inhibit angiogenesis by inhibiting the secretion of vascular endothelial growth factor (VEGF), but the exact mechanism by which thalidomide inhibits vascular proliferation during PD is still unclear. ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:712147]

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Multiple genetic variants predict the progression-free survival of bevacizumab plus chemotherapy in advanced ovarian cancer: A retrospective study.

Jie Gao, Fang Li, Zihao Liu, Mengli Huang, Huoming Chen, Guoqing Liao, Jichang Meng, Qing Wang, Hui Zhao, Chenxi Li, Jing Ji, Shangli Cai, Nan Du,

<h4>Abstract</h4>Bevacizumab (BV) plus chemotherapy is broadly used in advanced ovarian cancer (OC). However, the efficacy of BV-based regimens for advanced OC patients is not satisfactory. Therefore, it is urgent to explore the predictive genetic biomarkers for BV.Tumor tissues from advanced OC patients receiving BV-based regimens were analyzed with a 150-gene ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(35):e27130]

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Vascular endothelial growth factor response with propranolol therapy in patients with infantile hemangioma.

S M Makkeyah, M E Elseedawy, H M Abdel-Kader, G M Mokhtar, I A Ragab,

Vascular endothelial growth factor-A (VEGF-A) is a master regulator of angiogenesis, with higher levels in infantile hemangioma (IH). The effects of propranolol on IH are not fully understood and may involve vasoconstriction, angiogenesis inhibition, and apoptosis induction. Therefore, we examined the effects of propranolol therapy on levels of VEGF-A in ... Read more >>

Pediatr Hematol Oncol (Pediatric hematology and oncology)
[2021, :1-10]

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