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Full Text Journal Articles about
Use of Metered Dose Inhalers Spacers and Nebulizers

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Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial.

Seong Dae Woo, Young Min Ye, Youngsoo Lee, So Hee Lee, Yoo Seob Shin, Joo Hun Park, Hyunna Choi, Hyun Young Lee, Hyun Jung Shin, Hae Sim Park,

PURPOSE:Asthma control in older asthmatics is often less effective, which may be attributed to small airway dysfunction and poor inhalation technique. We compared the efficacy of 2 inhalers (fluticasone propionate/formoterol treatment using a pressurized metered-dose inhaler [p-MDI group] vs. fluticasone propionate/salmeterol treatment using a dry powder inhaler [DPI group]) in ... Read more >>

Allergy Asthma Immunol Res (Allergy, asthma & immunology research)
[2020, 12(3):454-466]

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Identifying patients at risk of poor asthma outcomes associated with making inhaler technique errors.

Sarah Ann Barbara, Vicky Kritikos, David B Price, Sinthia Bosnic-Anticevich,

Objectives: Correct inhaler technique is essential to optimal clinical outcomes in asthma patients. The study aim was to use real-life data from the iHARP database to determine patient factors associated with the performance of inhaler technique errors associated with poor asthma outcomes (as identified in the Critikal study) in patients ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2020, :1-12]

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Advances in pulmonary drug delivery devices for the treatment of chronic obstructive pulmonary disease.

Mario Cazzola, Francesco Cavalli, Omar S Usmani, Paola Rogliani,

Introduction: Proper device selection is crucial for the clinical results of inhalation therapy. However, none of the available devices fully conforms to the requirements for delivering drug with increased patient adherence, and we are still looking for the ideal inhaler. For this reason, there are several ongoing technical innovations to improve ... Read more >>

Expert Opin Drug Deliv (Expert opinion on drug delivery)
[2020, :1-12]

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Comparative pharmacokinetics of salbutamol inhaled from a pressurized metered dose inhaler either alone or connected to a newly enhanced spacer design.

Wesam G Ammari, Ghaleb A Oriquat, Mark Sanders,

BACKGROUND:Coordination between actuation of a pressurized metered dose inhaler (pMDI) and inhalation is a critical manoeuvre that many patients fail to perform correctly. pMDIs connected to spacers do not require hand-lung coordination. This study evaluated the relative lung and systemic bioavailability and oropharyngeal deposition of salbutamol post-inhalation from Ventolin® Evohaler® ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2020, 147:105304]

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Knowledge, practice pattern and attitude towards asthma management amongst physicians from Nepal, Malaysia, Lebanon, Myanmar and Morocco.

Ramesh Chokhani, Abdul Razak, Mirna Waked, Win Naing, Abdelaziz Bakhatar, Urvi Khorani, Vaibhav Gaur, Jaideep Gogtay,

Objective: This survey aimed to understand the physicians' practice pattern and challenges faced while treating their patients with asthma in five countries-Malaysia, Nepal, Myanmar, Morocco and Lebanon.Methods: Questionnaire-based data was gathered from internal medicine doctors (209), general practitioners (206), chest physicians (152) and pediatricians (58) from 232 locations from across ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2020, :1-23]

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The pharmacists' ability to use pressurized metered-dose inhalers with a spacer device and factors affecting it.

Erdem Topal, Mustafa Arga, Abdullah Hakan Özmen, Muhammet Arif Kurşun, Ömer Adil İlhan, Mustafa Alıcı,

Objective: The aim of this study is to evaluate the pharmacists' ability to use pMDIs with a spacer device and the factors that affect this ability.Method: Face to face interviews were conducted with the pharmacists. A nine item questionnaire was completed and the checklist for how to use pMDIs with ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2020, :1-6]

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Barriers to and competency with the use of metered dose inhaler and its impact on disease control among adult asthmatic patients in Ethiopia.

Tadesse Melaku Abegaz, Efrata Ashuro Shegena, Natnael Fentie Gessie, Eyob Alemayehu Gebreyohanns, Mohammed Assen Seid,

BACKGROUND:Asthma is one of the chronic diseases which affects the airway, and inhalers are the preferred medications to treat this problem. Improper inhalational technique leads to decreased efficacy of the medication by reducing its deposition in the lungs. The aim of this study was to assess the barriers to and ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):48]

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Metered-dose inhaler ipratropium bromide for children with acute asthma exacerbation: A prospective, non-randomized, observational study.

Osamu Nomura, Takateru Ihara, Yoshihiko Morikawa, Hiroshi Sakakibara, Yusuke Hagiwara, Nobuaki Inoue, Akira Akasawa,

BACKGROUND:Ipratropium bromide (IB), when administered with β2-agonists, is effective in reducing hospital admissions of children presenting to the emergency department (ED) with severe asthma. While IB is commonly delivered in its nebulized form, using a metered-dose inhaler (MDI), can, reportedly, shorten patients' length of stay in the ED. However, the ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, :]

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A cautionary tale of multiple-dose drug products: Fluticasone and salmeterol combination inhaler waste.

Elissa S Y Aeng, Maninder M Dhaliwal, Aaron M Tejani,

RATIONALE:Some drugs can only be dispensed in multiple-dose containers. Multiple-dose packaging may pose a problem for hospitals in terms of drug wastage and cost. Oral inhalers, such as fluticasone propionate and salmeterol combination inhalers, are only available as multiple-dose formats in Canada. OBJECTIVES:The objectives of this study are to quantify ... Read more >>

J Eval Clin Pract (Journal of evaluation in clinical practice)
[2020, :]

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[Expert consensus on preventing nosocomial transmission during respiratory care for critically ill patients infected by 2019 novel coronavirus pneumonia].

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Definite evidence has shown that the novel coronavirus (COVID-19) could be transmitted from person to person, so far more than 1,700 bedside clinicians have been infected. A lot of respiratory treatments for critically ill patients are deemed as high-risk factors for nosocomial transmission, such as intubation, manual ventilation by resuscitator, ... Read more >>

Zhonghua Jie He He Hu Xi Za Zhi (Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases)
[2020, 17(0):E020]

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Metered-dose inhalers vs nebulization for the delivery of albuterol in pediatric asthma exacerbations: A cost-effectiveness analysis in a middle-income country.

Carlos E Rodriguez-Martinez, Monica P Sossa-Briceño, Jose A Castro-Rodriguez,

OBJECTIVES:Although the benefits of albuterol delivered via metered-dose inhalers with a spacer (MDI+S) have been increasingly recognized, the evidence regarding the cost-effectiveness of MDI+S compared to nebulization (NEB) is not sufficient, especially in less-affluent countries, where the clinical and economic burden of the disease is the greatest. The aim of ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(4):866-873]

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Influence of Gender on Inhaler Technique.

Birsen Ocakli, Ipek Ozmen, Eylem Acarturk Tuncay, Sinem Gungor, Aylin Ozalp, Yesim Yasin, Nalan Adiguzel, Gokay Gungor, Zuhal Karakurt,

BACKGROUND:This study was designed to evaluate the influence of gender on the inhaler technique of subjects on inhaler therapy and to determine the factors predicting the correct inhaler technique and a change of inhaler device. METHODS:A total of 568 adult subjects (276 male, 292 female) on inhaler therapy were included ... Read more >>

Respir Care (Respiratory care)
[2020, :]

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Air Trapping Correlates with Increased Frequency of Albuterol Use and Severity of Wheeze in Persistent Asthma.

Jose Joseph Vempilly, Belayneh A Abejie, Ali Rashidian, Vipul V Jain, Nirav Bhakta,

BACKGROUND:Symptoms of asthma have been shown to correlate poorly with spirometric variables of obstruction. We hypothesized that lung volume measurements might correlate with symptoms and frequency of rescue inhaler use in asthma. METHODS:Patients with persistent asthma on treatment for ≥12 months were enrolled from university-based clinics. The association between lung ... Read more >>

Respir Care (Respiratory care)
[2020, :]

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Impact of inhaler use on dental caries in asthma pediatrics patients: A case-control study.

Víctor Chumpitaz-Cerrate, José A Bellido-Meza, Lesly Chávez-Rimache, Cecilia Rodríguez-Vargas,

INTRODUCTION:Asthma is a chronic inflammatory disease that is highly prevalent among pediatric patients. The results about the effect of asthma on the rate of dental caries are contradictory. The objective of this study was to determine the prevalence of dental caries in asthma pediatric patients using inhaled drugs. POPULATION AND ... Read more >>

Arch Argent Pediatr (Archivos argentinos de pediatria)
[2020, 118(1):38-46]

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An Efficient and Cost-Effective Nose-Only Inhalational Chamber for Rodents: Design, Optimization and Validation.

Ranjot Kaur, Anupama Kaushik, Kamalinder K Singh, O P Katare, Bhupinder Singh,

The mainstay treatment of pulmonary disorders lies around the direct drug targeting to the lungs using a nebulizer, metered-dose inhaler, or dry powder inhaler. Only few inhalers are available in the market that could be used for inhalational drug delivery in rodents. However, the available rodent inhalers invariably require high ... Read more >>

AAPS PharmSciTech (AAPS PharmSciTech)
[2020, 21(3):82]

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Impact of Single Combination Inhaler versus Multiple Inhalers to Deliver the Same Medications for Patients with Asthma or COPD: A Systematic Literature Review.

Shiyuan Zhang, Denise King, Virginia M Rosen, Afisi S Ismaila,

With increasing choice of medications and devices for asthma and chronic obstructive pulmonary disease (COPD) treatment, comparative evidence may inform treatment decisions. This systematic literature review assessed clinical and economic evidence for using a single combination inhaler versus multiple inhalers to deliver the same medication for patients with asthma or ... Read more >>

Int J Chron Obstruct Pulmon Dis (International Journal of Chronic Obstructive Pulmonary Disease)
[2020, 15:417-438]

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Treatment Adherence in Adolescents with Asthma.

Alan Kaplan, David Price,

The burden of asthma is particularly notable in adolescents, and is associated with higher rates of prevalence and mortality compared with younger children. One factor contributing to inadequate asthma control in adolescents is poor treatment adherence, with many pediatric studies reporting mean adherence rates of 50% or lower. Identifying the ... Read more >>

J Asthma Allergy (Journal of asthma and allergy)
[2020, 13:39-49]

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Checking Inhaler Technique in the Community Pharmacy: Predictors of Critical Errors.

Tatiana Makhinova, Brandie L Walker, Marlene Gukert, LeAnna Kalvi, Lisa M Guirguis,

Inhaled medications are critical in the pharmaceutical management of respiratory conditions, however, the majority of patients demonstrate at least one critical error when using an inhaler. Since community pharmacists can be instrumental in addressing this care gap, we aimed to determine the rate and type of critical inhaler errors in ... Read more >>

Pharmacy (Basel) (Pharmacy (Basel, Switzerland))
[2020, 8(1):]

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Effectiveness of Virtual vs In-Person Inhaler Education for Hospitalized Patients With Obstructive Lung Disease: A Randomized Clinical Trial.

Valerie G Press, Vineet M Arora, Colleen A Kelly, Kyle A Carey, Steve R White, Wen Wan,

Importance:Many patients who are hospitalized cannot use inhalers correctly, yet education for their use is often not provided. To address the need for an effective intervention feasible for wide-scale implementation, a virtual teach-to-goal intervention was developed to provide tailored patient-directed education using adaptive learning technology. Objective:To assess whether the virtual ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(1):e1918205]

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An innovative corticosteroid/long-acting β2-agonist breath-triggered inhaler: facilitating lung delivery of fluticasone propionate/formoterol fumarate for the treatment of asthma.

Omar Usmani, Nicolas Roche, Jonathan Marshall, Helen Danagher, David Price,

Introduction: Incorrect inhaler technique is one reason why the efficacies of inhaled asthma treatments in clinical trials and effectiveness in the real world differ. Inhaler technique is critical for drug delivery to the lungs; incorrect technique negatively impacts asthma control and long-term outcomes. Breath-triggered inhalers (BTIs) can simplify drug administration ... Read more >>

Expert Opin Drug Deliv (Expert opinion on drug delivery)
[2019, 16(12):1367-1380]

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Budesonide/formoterol therapy: effective and appropriate use in asthma and chronic obstructive pulmonary disease.

Douglas W Mapel, Melissa H Roberts, Jill Davis,

Aim: Quality, real-world comparative effectiveness (CE) studies of asthma and chronic obstructive pulmonary disease therapy efficacy are scarce. We identified and evaluated peer-reviewed CE and appropriate-use evaluations of budesonide/formoterol combination (BFC) maintenance therapy. Materials & methods: Analyses were limited to retrospective, real-world utilization studies of BFC delivered by pressurized metered-dose ... Read more >>

J Comp Eff Res (Journal of comparative effectiveness research)
[2020, 9(4):231-251]

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[Spacer, Aerosol Therapy through Space and Time].

Thomas Voshaar, Peter Haidl, Rolf Michael Clös,

AIM OF THE LITERATURE REVIEW:Within this review, results of a literature analysis on the application of spacers with pressurized metered dose inhalers (pMDI) are described and evaluated. METHODS:Next to an extensive revision on effects of spacers, the impacts of current guidelines and the conditions for product authorisations on the use ... Read more >>

Laryngorhinootologie (Laryngo- rhino- otologie)
[2019, 98(12):845-860]

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The role of inspiratory flow in selection and use of inhaled therapy for patients with chronic obstructive pulmonary disease.

Donald A Mahler,

Inhalation therapy is the mainstay of chronic obstructive pulmonary disease management, and inhaler selection can have a profound impact on drug delivery and medication adherence, as well as on treatment outcomes. Although multiple delivery systems, such as pressurized metered-dose inhalers, dry powder inhalers, slow-mist inhalers, and nebulizers, are available, clinical ... Read more >>

Respir Med (Respiratory medicine)
[2020, 161:105857]

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The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).

Timothy E Albertson, James A Chenoweth, Skyler J Pearson, Susan Murin,

Introduction: Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) is a disease phenotype that shares T helper lymphocyte cell Th1/neutrophilic/non-Type-2 Inflammation pathways thought to be key in COPD and Th2/eosinophilic/Type-2 inflammatory pathways of asthma. The pharmacology of treating ACOS is challenging in severe circumstances.Areas covered: This review evaluates the stepwise treatment ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2020, 21(2):213-231]

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Glycopyrrolate/formoterol fumarate metered dose inhaler for maintenance-naïve patients with chronic obstructive pulmonary disease: a post-hoc analysis of the randomized PINNACLE trials.

Jinping Zheng, Jin-Fu Xu, Martin Jenkins, Pryseley Nkouibert Assam, Lijiao Wang, Brian J Lipworth,

BACKGROUND:Glycopyrrolate (GP)/formoterol fumarate (FF; GFF) metered dose inhaler is a fixed-dose combination dual bronchodilator for patients with chronic obstructive pulmonary disease (COPD); however, whether the efficacy in patients without current maintenance treatment is consistent with currently maintenance-treated patients is unclear. METHODS:Data from patients who were not maintenance-treated at screening (NMT) ... Read more >>

Respir. Res. (Respiratory research)
[2020, 21(1):69]

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