Full Text Journal Articles about
Urothelium

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50 week ultrasound imaging and ultrastructural abnormalities of bladder after sugar diuresis and diabetes mellitus in rats.

Kexun Yang, Qinzhang Wang,

<h4>Purpose</h4>To investigate 50 week ultrasound imaging and ultrastructure changes of bladder in diuresis and diabetes rats.<h4>Methods</h4>Forty-two healthy male Sprague-Dawley rats were randomly divided into control group, sugar-induced diuresis group and streptozotocin-induced diabetes group. The 24 h drinking and urine volume were calculated from 21 to 31 weeks. Using ultrasound to assess bladders after ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2021, :]

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Molecular pathways underlying tissue injuries in the bladder with ketamine cystitis.

Xiang Xie, Jiayu Liang, Run Huang, Chuang Luo, Jiali Yang, Hongming Xing, Le Zhou, Han Qiao, Erti Ergu, Huan Chen,

Ketamine cystitis (KC) is a chronic bladder inflammation leading to urinary urgency, frequency, and pain. The pathogenesis of KC is complicated and involves multiple tissue injuries in the bladder. Recent studies indicated that urothelium disruption, lamina propria fibrosis and inflammation, microvascular injury, neuropathological alterations, and bladder smooth muscle (BSM) abnormalities ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21703]

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The Potential of Asiatic Acid in the Reversion of Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats.

Andrzej Wróbel, Łukasz Zapała, Tomasz Kluz, Artur Rogowski, Marcin Misiek, Kajetan Juszczak, Jacek Sieńko, Daniela Gold, Klaudia Stangel-Wójcikiewicz, Ewa Poleszak, Piotr Radziszewski,

The purpose of this study was to determine if asiatic acid may act efficiently in the model of cyclophosphamide (CYP)-induced cystitis in rats. We performed experiments after administration of CYP (single dose 200 mg/kg, intraperitoneally), asiatic acid (30 mg/kg/day for 14 consecutive days, by oral gavage), or CYP plus asiatic acid, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(11):]

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Metastases of Urothelium Carcinoma: Differential Diagnosis, Resection, and Survival.

Selma Oguzhan, Stefan Sponholz, Moritz Schirren, Mesut Mese, Joachim Schirren,

<h4>Background</h4> Due to its very aggressive nature and low survival chances, the metastasized urothelium carcinoma poses a challenge in regard to therapy. The gold-standard chemotherapy is platinum based. The therapy options are considered controversial, including new systemic therapies. In this respect, surgical therapies, as already established for pulmonary metastases of other ... Read more >>

Thorac Cardiovasc Surg (The Thoracic and cardiovascular surgeon)
[2021, :]

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Novel Applications of Non-Invasive Intravesical Botulinum Toxin a Delivery in the Treatment of Functional Bladder Disorders.

Jia-Fong Jhang, Hann-Chorng Kuo,

Although intravesical botulinum toxin type A (BoNT-A) injection for functional bladder disorders is effective, the injection-related problems-such as bladder pain and urinary tract infection-make the procedure invasive and inconvenient. Several vehicles have recently been developed to deliver BoNT-A without injection, thereby making the treatment less or non-invasive. Laboratory evidence revealed ... Read more >>

Toxins (Basel) (Toxins)
[2021, 13(5):]

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Single-cell analysis reveals urothelial cell heterogeneity and regenerative cues following cyclophosphamide-induced bladder injury.

Xiaomu Cheng, Huadong Lai, Wenqin Luo, Man Zhang, Juju Miao, Weichen Song, Shunpeng Xing, Jia Wang, Wei-Qiang Gao,

Cyclophosphamide is a commonly used chemotherapeutic drug to treat cancer with side effects that trigger bladder injury and hemorrhagic cystitis. Although previous studies have demonstrated that certain cell subsets and communications are activated to drive the repair and regeneration of bladder, it is not well understood how distinct bladder cell ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(5):446]

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Species-Specific Urothelial Toxicity with an anti-HIV Non-Catalytic Site Integrase Inhibitor (NCINI) is Related to Unusual pH-Dependent Physicochemical Changes.

Ruth A Roberts, Richard A Campbell, Phumzile Sikakana, Claire Sadler, Mark Osier, Yili Xu, Joy Y Feng, Michael Mitchell, Roman Sakowicz, Anne Chester, Eric Paoli, Jianhong Wang, Leigh Ann Burns-Naas,

GS-9695 and GS-9822 are next generation Non-Catalytic Site Integrase Inhibitors (NCINIs) with significantly improved potency against HIV compared with previous drugs such as BI-224436. Development stopped due to vacuolation of the bladder urothelium seen in cynomolgus monkey but not in rat; this lesion was absent in equivalent preclinical studies with ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2021, :]

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Donor kidney lithiasis and back-table endoscopy: a successful combination.

Michaël M E L Henderickx, Joyce Baard, Pauline C Wesselman van Helmond, Ilaria Jansen, Guido M Kamphuis,

<h4>Introduction</h4>Urolithiasis in renal allografts is relatively rare with an incidence of 0.17-4.40%. It is nonetheless an important issue, as there is a risk of obstruction, sepsis and even loss of the renal allograft. The management of stones in renal allografts remains challenging because of the anatomy, the renal denervation and ... Read more >>

Acta Chir Belg (Acta chirurgica Belgica)
[2021, :1-4]

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Pparg drives luminal differentiation and luminal tumor formation in the urothelium

Tiffany Tate, Tina Xiang, Mi Zhou, William Kim, Xiao Chen, Hyunwoo Kim, Ekatherina Batourina, Chyuan-Sheng Lin, Chao Lu, Sara Wobker, James Mckiernan, Cathy Lee Mendelsohn,

Pparg , a nuclear receptor, is downregulated in basal subtype bladder cancers that tend to be muscle invasive and amplified in luminal subtype bladder cancers that tend to be non-muscle invasive. Bladder cancers derive from the urothelium, one of the most quiescent epithelia in the body which is composed of ... Read more >>

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Decreased urothelial cytoskeleton and cell proliferation protein expression suggest interstitial cystitis/bladder pain syndrome patients with Hunner's lesion and grade 3 glomerulation might be different from other types of patients.

Jia-Fong Jhang, Yuan-Hong Jiang, Yung-Hsiang Hsu, Han-Chen Ho, Hann-Chorng Kuo,

<h4>Objectives</h4>To explore the expression of cytoskeletal and cell proliferation proteins in urothelial cells of patients diagnosed with various clinical subtypes of interstitial cystitis/bladder pain syndrome.<h4>Methods</h4>Biopsy specimens from 85 interstitial cystitis/bladder pain syndrome patients were classified according to findings on cystoscopy. Cytokeratins and cell proliferation proteins detected in the specimens were ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, :]

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Tubularized urethral reconstruction using everted saphenous vein graft in a beagle model.

Dan Li, Zhou Shen, Yujie Xu,

<h4>Background</h4>A long segment stricture in the anterior urethra is a challenge in urology. We conducted a study to investigate the efficacy of anterior urethral reconstruction using an everted saphenous vein graft (SVG) in a tubular fashion.<h4>Methods</h4>Twelve male beagles were randomly divided into three groups: experimental group (n = 5), control group (n = 5) ... Read more >>

BMC Urol (BMC urology)
[2021, 21(1):63]

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Receptor Activator of NF Kappa B (RANK) Expression Indicates Favorable Prognosis in Patients with Muscle-invasive Bladder Cancer.

Moritz Maas, Steffen Rausch, Teresa Guttenberg, Roland Seiler, Jörg Hennenlotter, Htoo Zarni Oo, Ladan Fazli, Ursula Kühs, Georgios Gakis, Arnulf Stenzl, Christian Schwentner, Peter C Black, Tilman Todenhöfer,

<h4>Background</h4>Receptor activator of NF kappa B (RANK) and its ligand have an essential role in T-cell regulation and the development of bone metastases. The role of RANK expression in muscle-invasive bladder cancer (MIBC) is unknown.<h4>Objective</h4>To assess the relevance of RANK expression in patients with MIBC.<h4>Design, setting, and participants</h4>Expression of RANK ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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The role of the bladder urothelium as a chemical-neural transducer via purinergic signalling in the rapid defence against bacterial infection.

Basu Chakrabarty,

Purinergic Signal (Purinergic signalling)
[2021, :]

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Expression patterns of the immune checkpoint ligand CD276 in urothelial carcinoma.

Wilhelm K Aicher, M Korn, L Reitnauer, F B Maurer, J Hennenlotter, P C Black, T Todenhofer, J Bedke, A Stenzl,

<h4>Background</h4>CD276 is an immune checkpoint molecule. Elevated CD276 expression by urothelial carcinoma is associated with poor prognosis, but little is known about its expression across different tumor stages. We therefore investigated CD276 expression in bladder cancer (BC) cells and in tissue samples of BC stages from pT2 to pT4.<h4>Methods</h4>CD276 expression ... Read more >>

BMC Urol (BMC urology)
[2021, 21(1):60]

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Interstitial Cystitis: Diagnosis and Treatment in a Pregnant Patient.

Sofía Argüelles Rojas, José G Oviedo Ortega, Roberto Velasco Sordo,

Interstitial cystitis or painful bladder syndrome is a chronic condition characterized by severe and acyclic pelvic pain lasting for a period of at least six weeks. Although this condition is not accompanied by urinary infection, the patient's daily activities are impeded. The most common symptoms are urinary frequency, dysuria, suprapubic ... Read more >>

Cureus (Cureus)
[2021, 13(4):e14549]

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Correlation Between Nitric Oxide and Urodynamics in Men With Bladder Outlet Obstruction.

Kang Jun Cho, Jun Sung Koh, Jin Bong Choi, Sang Hi Park, Weon Sun Lee, Joon Chul Kim,

<h4>Purpose</h4>To investigate the correlation between nitric oxide (NO) and urodynamics in men with bladder outlet obstruction (BOO) by analyzing nitric oxide synthase (NOS) in the urothelium.<h4>Methods</h4>We prospectively enrolled 25 men who planned to undergo surgical treatment for benign prostatic obstruction and identified as BOO in the preoperative urodynamics. Bladder tissue ... Read more >>

Int Neurourol J (International neurourology journal)
[2021, :]

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Segmentation of the Urothelium in Optical Coherence Tomography Images with Dynamic Contrast

Zhuo Xu, Hui Zhu, Hui Wang,

<h4>Significance</h4> Speckle variations induced by intracellular motion (IM) in the urothelium was observed in optical coherence tomography (OCT) images. It is feasible to use the IM as a dynamic contrast to segment the urothelium with only two sequential OCT images. This new method opens the possibility of tracking the distribution ... Read more >>

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Molecular pathology of urothelial carcinoma.

Antonio Lopez-Beltran, Alessia Cimadamore, Rodolfo Montironi, Liang Cheng,

The current personalized oncology era has witnessed significant efforts to integrate clinical, pathological, and molecular classifications. The growing need for molecular biomarkers to feed personalized oncology, together with the unprecedented wealth of knowledge on the molecular basis of bladder cancer, has led to a novel approach to this disease, incorporating ... Read more >>

Hum Pathol (Human pathology)
[2021, 113:67-83]

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Primary signet-ring cell carcinoma of the urinary bladder.

Nirmalya Benerjee, Kalpesh Parmar, Kim Vaiphei,

Primary signet-ring cell carcinoma of the urinary bladder is a rare tumor. The overall incidence is approximately 0.12-0.6% of all urinary bladder malignancies. The majority of the patients present in an advanced stage with a uniformly grim prognosis. As signet-ring cell carcinomas are more common in the gastrointestinal tract, a ... Read more >>

Autops Case Rep (Autopsy & case reports)
[2021, 11:e2021264]

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Biofabrication of a Tubular Model of Human Urothelial Mucosa Using Human Wharton Jelly Mesenchymal Stromal Cells.

Ingrid Garzón, Boris Damián Jaimes-Parra, Manrique Pascual-Geler, José Manuel Cózar, María Del Carmen Sánchez-Quevedo, María Auxiliadora Mosquera-Pacheco, Indalecio Sánchez-Montesinos, Ricardo Fernández-Valadés, Fernando Campos, Miguel Alaminos,

Several models of bioartificial human urothelial mucosa (UM) have been described recently. In this study, we generated novel tubularized UM substitutes using alternative sources of cells. Nanostructured fibrin-agarose biomaterials containing fibroblasts isolated from the human ureter were used as stroma substitutes. Then, human Wharton jelly mesenchymal stromal cells (HWJSC) were ... Read more >>

Polymers (Basel) (Polymers)
[2021, 13(10):]

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Effect of irradiation on the expression of E-cadherin and β-catenin in early and late radiation sequelae of the urinary bladder and its modulation by NF-κB inhibitor thalidomide.

Alexander Krischak, Jakob Kowaliuk, Sina Sarsarshahi, Wolfgang Dörr, Miriam Kleiter,

<h4>Purpose</h4>In a previous study we have shown in a mouse model that administration of nuclear factor-kappa B (NF-κB) inhibitor thalidomide has promising therapeutic effects on early radiation cystitis (ERC) and late radiation sequelae (LRS) of the urinary bladder. The aim of this study was to evaluate in the same mice the effect of ... Read more >>

Strahlenther Onkol (Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al])
[2021, 197(6):537-546]

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Expression of Low Affinity Nerve Growth Factor Receptor p75 in Classic Bladder Exstrophy.

Martin Promm, Wolfgang Otto, Florian Weber, Stefanie Götz, Maximilian Burger, Karolina Müller, Peter Rubenwolf, Winfried Neuhuber, Wolfgang H Roesch,

Successful primary closure of classic bladder exstrophy (BE) is crucial for development of bladder capacity and voided continence. It is universally agreed that an intensive pain management including the use of caudal epidural anesthesia is an essential cornerstone for the outcome of this complex surgery. Whether and to what extent ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:634343]

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Urothelium-Specific Deletion of Connexin43 in the Mouse Urinary Bladder Alters Distension-Induced ATP Release and Voiding Behavior.

Jin Kono, Masakatsu Ueda, Atsushi Sengiku, Sylvia O Suadicani, Osamu Ogawa, Hiromitsu Negoro,

Connexin43 (Cx43), the main gap junction and hemichannel forming protein in the urinary bladder, participates in the regulation of bladder motor and sensory functions and has been reported as an important modulator of day-night variations in functional bladder capacity. However, because Cx43 is expressed throughout the bladder, the actual role ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(4):]

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Single-cell transcriptomes of mouse bladder urothelium uncover novel cell type markers and urothelial differentiation characteristics.

Yan Li, Yaxiao Liu, Zhengdong Gao, Lekai Zhang, Lipeng Chen, Zonglong Wu, Qinggang Liu, Shuai Wang, Nan Zhou, Toby C Chai, Benkang Shi,

<h4>Objectives</h4>Much of the information to date in terms of subtypes and function of bladder urothelial cells were derived from anatomical location or by the expression of a small number of marker genes. To have a comprehensive map of the cellular anatomy of bladder urothelial cells, we performed single-cell RNA sequencing ... Read more >>

Cell Prolif (Cell proliferation)
[2021, 54(4):e13007]

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PD-L2 Is Constitutively Expressed in Normal and Malignant Urothelium.

Alexander C Dowell, Haydn Munford, Anshita Goel, Naheema S Gordon, Nicholas D James, K K Cheng, Maurice P Zeegers, Douglas G Ward, Richard T Bryan,

The use of immune checkpoint blockade, in particular PD-1 and PD-L1 inhibitors, is now commonplace in many clinical settings including the treatment of muscle-invasive bladder cancer (MIBC). Notwithstanding, little information exists regarding the expression of the alternative PD-1 ligand, PD-L2 in urothelial bladder cancer (UBC). We therefore set out to ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:626748]

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