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Uremic Neuropathy

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Acquired long QT syndrome in chronic kidney disease patients.

Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li,

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):54-65]

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Comparison of microwave ablation treatments in patients with renal secondary and primary hyperparathyroidism.

Haoyang Ma, Chun Ouyang, Yaoyu Huang, Changying Xing, Chen Cheng, Wei Liu, Donglan Yuan, Ming Zeng, Xiangbao Yu, Haibin Ren, Yanggang Yuan, Lina Zhang, Fangyan Xu, Ying Cui, Wenkai Ren, Hui Huang, Hanyang Qian, Boqiang Fan, Ningning Wang,

Purpose: Microwave ablation (MWA) is feasible for severe renal secondary hyperparathyroidism (SHPT) and primary hyperparathyroidism (PHPT) patients ineligible for parathyroidectomy (PTX). Here we compared the clinical manifestations and characteristics of parathyroid glands in these two groups, and summarized the techniques, safety and efficacy of MWA.Methods: Baseline clinical characteristics, ablation-related techniques, ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):66-76]

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Composite Uremic Load and Physical Performance in Hemodialysis Patients: A Cross-Sectional Study.

Karsten Vanden Wyngaert, Amaryllis H Van Craenenbroeck, Els Holvoet, Patrick Calders, Wim Van Biesen, Sunny Eloot,

Impaired physical performance is common in patients on hemodialysis (HD) and is associated with poor prognosis. A patient relevant marker of adequacy of dialysis is lacking. Previous studies evaluated uremic toxicity by assessing the impact of different uremic toxins separately. However, such an approach is most likely not reflective of ... Read more >>

Toxins (Basel) (Toxins)
[2020, 12(2):]

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Factors Associated with Uremic Pruritus in Patients Undergoing Peritoneal Dialysis.

Saori Minato, Keiji Hirai, Junki Morino, Shohei Kaneko, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Mitsutoshi Shindo, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Taro Hoshino, Susumu Ookawara, Yoshiyuki Morishita,

Aim:The aim of this study was to investigate different intensities of uremic pruritus in the daytime and nighttime, as well as contributing factors, in patients undergoing peritoneal dialysis (PD). Methods:A total of 46 patients (31 males, 15 females) with a mean age of 59.4±14.7 years and mean PD vintage of ... Read more >>

Int J Nephrol Renovasc Dis (International journal of nephrology and renovascular disease)
[2020, 13:1-9]

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Bilateral proliferative retinopathy and ischemic optic neuropathy in a patient with atypical hemolytic-uremic syndrome: A case report.

I-Hung Lin, Ying-Jen Chen, Ping-Ying Chang, Po-Wei Hsiao, Tzu-Heng Weng, Yun-Hsiang Chang,

RATIONALE:To report a rare case of severe atypical hemolytic-uremic syndrome (HUS) in a patient who presented with vitreous hemorrhage and tractional retinal detachment (TRD) in both eyes. To our knowledge, this is the first reported case of atypical HUS complicated with bilateral TRD in the literature. PATIENT CONCERNS:A 20-year-old man ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(39):e17232]

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Hypercalcemic Encephalopathy as an Initial Presentation of Multiple Myeloma.

Durga Shankar Meena, Gopal Krishana Bohra, Mahendra Kumar Garg, Abhishek Purohit, Deepak Kumar, Swapnil Tripathi,

We report the case of an 84-year-old female presented to us with acute onset altered sensorium. On investigation, neurological and infectious causes were ruled out. On further evaluation, her serum calcium was found elevated (15.07 gm/dl). The diagnosis of hypercalcemic encephalopathy was made with the possibility of multiple myeloma due to ... Read more >>

Case Rep Emerg Med (Case Reports in Emergency Medicine)
[2020, 2020:4746865]

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Pain Assessment in Hemodialysis Patients.

Esmira Sadigova, Sultan Ozkurt, Ahmet Ugur Yalcin,

Background Pain is a common complaint among hemodialysis (HD) patients; however, most patients are not assessed for this aspect and are not sufficiently treated. In these patients, pain is reported to be associated with a range of parameters like increased depression and disrupted quality of life (QOL). Previously residual renal ... Read more >>

Cureus (Cureus)
[2020, 12(2):e6903]

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Acute Fulminant Uremic Neuropathy Following Coronary Angiography Mimicking Guillain Barre Syndrome.

Kumari Priti, Bhanwar Lal Ranwa,

A 55 yr old diabetic lady suffered a posterior wall STEMI. She developed Contrast induced nephropathy following coronary angiography. Acute fulminant uremic neuropathy was precipitated which initially mimicked Guillan Barre Syndrome, hence reported. ... Read more >>

J Assoc Physicians India (The Journal of the Association of Physicians of India)
[2019, 67(8):90-91]

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Reactive dicarbonyl compounds cause Calcitonin Gene-related Peptide release and synergize with inflammatory conditions in mouse skin and peritoneum.

Anna K Becker, Andrea Auditore, Monika Pischetsrieder, Karl Messlinger, Thomas Fleming, Peter W Reeh, Susanne K Sauer,

The plasma of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene-Related Peptide ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2020, :]

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Transfusion-related acute lung injury (TRALI) after intravenous immunoglobulins: French multicentre study and literature review.

Jean Luc Baudel, Clara Vigneron, Veronique Pras-Landre, Jérémie Joffre, Frédéric Marjot, Hafid Ait-Oufella, Naike Bigé, Eric Maury, Bertrand Guidet, Olivier Fain, Arsène Mekinian,

Transfusion-related acute lung injury (TRALI), defined as the onset of acute respiratory distress after blood transfusion, is a rare complication which is a leading cause of transfusion related-mortality. In this retrospective study, we report the French nationwide experience of intravenous immunoglobulin (IVIG)-related TRALI, with a literature review and analysis of ... Read more >>

Clin. Rheumatol. (Clinical rheumatology)
[2020, 39(2):541-546]

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Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee.

Stuart G Tangye, Waleed Al-Herz, Aziz Bousfiha, Talal Chatila, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M Holland, Christoph Klein, Tomohiro Morio, Hans D Ochs, Eric Oksenhendler, Capucine Picard, Jennifer Puck, Troy R Torgerson, Jean-Laurent Casanova, Kathleen E Sullivan,

We report the updated classification of Inborn Errors of Immunity/Primary Immunodeficiencies, compiled by the International Union of Immunological Societies Expert Committee. This report documents the key clinical and laboratory features of 430 inborn errors of immunity, including 64 gene defects that have either been discovered in the past 2 years since ... Read more >>

J. Clin. Immunol. (Journal of clinical immunology)
[2020, 40(1):24-64]

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Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus.

Kyumin Shim, Rayhana Begum, Catherine Yang, Hongbin Wang,

Amplified inflammatory reaction has been observed to be involved in cardiometabolic diseases such as obesity, insulin resistance, diabetes, dyslipidemia, and atherosclerosis. The complement system was originally viewed as a supportive first line of defense against microbial invaders, and research over the past decade has come to appreciate that the functions ... Read more >>

World J Diabetes (World journal of diabetes)
[2020, 11(1):1-12]

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Renal and pulmonary thrombotic microangiopathy triggered by proteasome-inhibitor therapy in patient with smoldering myeloma: A renal biopsy and autopsy case report.

Clarissa A Cassol, Michael P A Williams, Tiffany N Caza, Sophia Rodriguez,

RATIONALE:Thrombotic microangiopathy (TMA) is a group of clinical syndromes characterized by excessive platelet activation and endothelial injury that leads to acute or chronic microvascular obliteration by intimal mucoid and fibrous thickening, with or without associated thrombi. It frequently involves the kidney but may involve any organ or system at variable ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(39):e17148]

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Atypical Hemolytic Uremic Syndrome: A Case Report.

Sohaib K Mohammed, Ateeq Mubarik, Bilal Nadeem, Khudadad Khan, Salman Muddassir,

Hemoytic uremic syndrome (HUS) is a rare type of thrombotic microangiopathies. Manifestations include thrombocytopenia, microangiopathic hemolytic anemia, and thrombi in small blood vessels. The prognosis is poor. Herein, we present a case of atypical HUS, which is very rare. ... Read more >>

Cureus (Cureus)
[2019, 11(5):e4634]

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Late Presentation of Carfilzomib Associated Thrombotic Microangiopathy.

Michael Haddadin, Mohammad Al-Sadawi, Sally Madanat, Eric Tam, Evelyn Taiwo, Carol Luhrs, Samy I Mcfarlane,

Multiple Myeloma (MM) is a plasma cell disorder characterized by abnormal proliferation of plasma cells resulting in overproduction of paraprotein. Proteasome inhibitors (PI) have been a corner stone for the treatment of MM. Thrombotic Microangiopathy (TMA) is a recent hematological adverse event that has newly been recognized in multiple PI. ... Read more >>

Am J Med Case Rep (American journal of medical case reports)
[2019, 7(10):240-243]

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Role of Dysregulated Ion Channels in Sensory Neurons in Chronic Kidney Disease-Associated Pruritus.

Akishi Momose, Micihihiro Yabe, Shigetoshi Chiba, Kenjirou Kumakawa, Yasuo Shiraiwa, Hiroki Mizukami,

Background: We investigated ion channels at the skin, including peripheral nerve endings, which serve as output machines and molecular integrators of many pruritic inputs mainly received by multiple G protein-coupled receptors (GPCRs). Methods: Based on the level of chronic kidney disease-associated pruritus (CKD-aP), subjects were divided into two groups: non-CKD-aP ... Read more >>

Medicines (Basel) (Medicines (Basel, Switzerland))
[2019, 6(4):]

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Uremic leontiasis ossea due to secondary hyperparathyroidism complicated by vitamin C deficiency in a non-adherent chronic hemodialysis patient: A case report.

David Massicotte-Azarniouch, Laurie McLean, Pierre Antoine Brown,

Non-adherence to medical therapy in patients with end-stage kidney disease (ESKD) can lead to severe metabolic derangements rarely seen in the current medical era. Such complications may take the form of secondary hyperparathyroidism (HPT) leading to rare manifestations of bone mineral disease, and profound vitamin C deficiency from poor nutrition ... Read more >>

Clin Nephrol Case Stud (Clinical nephrology. Case studies)
[2019, 7:54-59]

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Status Epilepticus as a Consequence of Hemophagocytic Lymphohistiocytosis in a Previously Healthy Infant.

Saeed M Nassar, Muath A AlBattah, Ahmad A Bukhari, Aryaf Alslimah, Assalh A Nahass,

Hemophagocytic lymphohistiocytosis (HLH) is a rare and fatal entity with an incidence rate of 1.2 cases per million people per year. HLH is explained as a highly destructive inflammatory consequence of rampant hypercytokinemia due to excessive lymphocyte-mediated activation of macrophages and histiocytes. Primary HLH is a product of genetic dysfunction ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6824]

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Management of Itch in the Elderly: A Review.

Kayla M Fourzali, Gil Yosipovitch,

Chronic itch is common in the elderly patient and may be caused by a variety of known dermatologic and non-dermatologic conditions and can have a significant effect on quality of life. Age-related changes in barrier function, immunosenescence, and neuronal changes and neuropathies are common predisposing factors to chronic itch in ... Read more >>

Dermatol Ther (Heidelb) (Dermatology and therapy)
[2019, 9(4):639-653]

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Uremic neuropathy: an overview of the current literature.

Celeste Rodovalho Soares de Camargo, Jean Henri Maselli Schoueri, Beatriz da Costa Aguiar Alves, Glaucia R L da Veiga, Fernando L A Fonseca, Marcelo R Bacci,

INTRODUCTION:Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy (UN) is attributed to the accumulation of organic waste, evident in patients with ... Read more >>

Rev Assoc Med Bras (1992) (Revista da Associacao Medica Brasileira (1992))
[2019, 65(3):469-474]

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Epicardial adipose tissue deposition in patients with diabetes and renal impairment: Analysis of the literature.

Zoi Kleinaki, Aris P Agouridis, Maria Zafeiri, Theodoros Xanthos, Constantinos Tsioutis,

Diabetes mellitus (DM) is defined as a chronic disease of disordered metabolism with an ongoing increase in prevalence and incidence rates. Renal disease in patients with diabetes is associated with increased morbidity and premature mortality, particularly attributed to their very high cardiovascular risk. Since this group of patients frequently lacks ... Read more >>

World J Diabetes (World journal of diabetes)
[2020, 11(2):33-41]

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Uremic neuropathy: an overview of the current literature.

Celeste R de Camargo, Jean H M Schoueri, Beatriz da Costa Aguiar Alves, Glaucia R L da Veiga, Fernando L A Fonseca, Marcelo R Bacci,

INTRODUCTION:Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy is attributed to the accumulation of organic waste, evident in patients with reduced ... Read more >>

Rev Assoc Med Bras (1992) (Revista da Associacao Medica Brasileira (1992))
[2019, 65(2):281-286]

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Case-management protocol for bloody diarrhea as a model to reduce the clinical impact of Shiga toxin-producing Escherichia coli infections. Experience from Southern Italy.

Daniela Loconsole, Mario Giordano, Nicola Laforgia, Diletta Torres, Luisa Santangelo, Vincenza Carbone, Antonio Parisi, Michele Quarto, Gaia Scavia, Maria Chironna, ,

To describe an operating protocol for bloody diarrhea (BD) in a pediatric population as a rapid response to a public health threat represented by an excess of pediatric HUS cases in the Apulia region (Southern Italy) starting from 2013. The protocol was set up with the goal of correct clinical ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2020, 39(3):539-547]

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Relative contributions of diabetes and chronic kidney disease to neuropathy development in diabetic nephropathy patients.

Tushar Issar, Ria Arnold, Natalie C G Kwai, Susan Walker, Aimy Yan, Adeniyi A Borire, Ann M Poynten, Bruce A Pussell, Zoltan H Endre, Matthew C Kiernan, Arun V Krishnan,

OBJECTIVE:Chronic kidney disease (CKD) caused by diabetes is known as diabetic kidney disease (DKD). The present study aimed to examine the underlying mechanisms of axonal dysfunction and features of neuropathy in DKD compared to CKD and type 2 diabetes (T2DM) alone. METHODS:Patients with DKD (n = 30), CKD (n = 28) or T2DM (n = 40) ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2019, 130(11):2088-2095]

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Hyperkalemia: pathophysiology, risk factors and consequences.

Robert W Hunter, Matthew A Bailey,

There have been significant recent advances in our understanding of the mechanisms that maintain potassium homoeostasis and the clinical consequences of hyperkalemia. In this article we discuss these advances within a concise review of the pathophysiology, risk factors and consequences of hyperkalemia. We highlight aspects that are of particular relevance ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2019, 34(Suppl 3):iii2-iii11]

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