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Uremic Encephalopathy

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The dual reno- and neuro-protective effects of dimethyl fumarate against uremic encephalopathy in a renal ischemia/reperfusion model.

Diaa Ragab, Dalaal M Abdallah, Hanan S El-Abhar,

BACKGROUND:Dimethyl fumarate (DMF), a Nrf2 activator approved for multiple sclerosis (MS) in 2013, showed promising antioxidant and anti-inflammatory effects against cerebral injury. However, its mechanistic maneuver in renal ischemia/reperfusion (I/R) injury and its associated uremic encephalopathy has not been previously highlighted. METHODS:To fulfill this aim, rats were divided into 4 ... Read more >>

Pharmacol Rep (Pharmacological reports : PR)
[2020, :]

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A97 TACROLIMUS-ASSOCIATED HEMOLYTIC UREMIC SYNDROME IN A PEDIATRIC LIVER TRANSPLANT RECIPIENT.

K W Wong, S Gilmour,

AbstractBackgroundTacrolimus associated hemolytic uremic syndrome (HUS) has been reported in renal and pediatric cardiac transplantation. Furthermore, in adults receiving liver transplant, there are reports of multiorgan failure, death, and end stage renal failure secondary to tacrolimus induced HUS [J NEPHROL 2003; 16: 580–585]. Although tacrolimus is commonly used in pediatric ... Read more >>

J Can Assoc Gastroenterol (Journal of the Canadian Association of Gastroenterology)
[2020, 3(Suppl 1):113-114]

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In-hospital mortality among incident hemodialysis older patients in Peru.

Percy Herrera-Añazco, Pedro J Ortiz, Jesus E Peinado, Tania Tello, Fabiola Valero, Adrian V Hernandez, J Jaime Miranda,

BACKGROUND:Understanding the pattern of mortality linked to end stage renal disease (ESRD) is important given the increasing ageing population in low- and middle-income countries. METHODS:We analyzed older patients with ESRD with incident hemodialysis, from January 2012 to August 2017 in one large general hospital in Peru. Individual and health system-related ... Read more >>

Int Health (International health)
[2020, 12(2):142-147]

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The Impacts of a Social Networking Service-Enhanced Smart Care Model on Stage 5 Chronic Kidney Disease: Quasi-Experimental Study.

Feng-Jung Yang, Ying-Hui Hou, Ray-E Chang,

BACKGROUND:Chronic kidney disease (CKD) stage 5 presents a high risk for dialysis initiation and for complications such as uremic encephalopathy, uremic symptoms, gastrointestinal bleeding, and infection. Among the most common barriers to health care during CKD stage 5 is poor continuity of care due to unresolved communication gaps. OBJECTIVE:Our aim ... Read more >>

J. Med. Internet Res. (Journal of medical Internet research)
[2020, :]

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Pathogenic functions and diagnostic utility of cytokines/chemokines in EHEC-HUS.

Masaki Shimizu,

Hemolytic - uremic syndrome (HUS) is a severe complication of infection by Shiga toxin (STx)-producing enterohemorrhagic Escherichia coli. Hemolytic - uremic syndrome is defined clinically as a triad of non-immune microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injuries. Neurologic complications such as acute encephalopathy are also observed. In humans, endothelial cells, proximal tubular epithelial ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, 62(3):308-315]

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Therapeutic Strategies to Protect the Central Nervous System against Shiga Toxin from Enterohemorrhagic Escherichia coli.

Jorge Goldstein, Krista Nuñez-Goluboay, Alipio Pinto,

Infection with Shiga toxin-producing Escherichia coli (STEC) may cause hemorrhagic colitis, hemolytic uremic syndrome (HUS) and encephalopathy. The mortality rate derived from HUS adds up to 5% of the cases, and up to 40% when the central nervous system (CNS) is involved. In addition to the well-known deleterious effect of ... Read more >>

Curr Neuropharmacol (Current neuropharmacology)
[2020, :]

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Epidemiology of Atypical Hemolytic Uremic Syndrome: A Systematic Literature Review.

Kevin Yan, Kamal Desai, Lakshmi Gullapalli, Eric Druyts, Chakrapani Balijepalli,

Atypical hemolytic uremic syndrome (aHUS) is a rare but severe disorder that frequently has a genetic component and results from the overactivation of the alternative complement pathway. As research moves toward improved diagnosis and therapy of aHUS, it will be important to better understand its epidemiology. Our objective was to ... Read more >>

Clin Epidemiol (Clinical epidemiology)
[2020, 12:295-305]

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Hypercalcemic Encephalopathy as an Initial Presentation of Multiple Myeloma.

Durga Shankar Meena, Gopal Krishana Bohra, Mahendra Kumar Garg, Abhishek Purohit, Deepak Kumar, Swapnil Tripathi,

We report the case of an 84-year-old female presented to us with acute onset altered sensorium. On investigation, neurological and infectious causes were ruled out. On further evaluation, her serum calcium was found elevated (15.07 gm/dl). The diagnosis of hypercalcemic encephalopathy was made with the possibility of multiple myeloma due to ... Read more >>

Case Rep Emerg Med (Case Reports in Emergency Medicine)
[2020, 2020:4746865]

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Lentiform fork sign: Uremia alone or multifactorial causation?

Ajay Jaryal, Suresh Thakur, Joginder Singh Pathania, Sanjay Vikrant, Dinesh Kumar, Lokesh Verma,

Neurological complications are common in patients with acute or chronic renal failure, especially when there is marked reduction in the glomerular filtration rate (GFR). One such clinical syndrome, uremic encephalopathy (UE), occurs due to widespread dysfunction of central nervous system (CNS). It manifests with myriad clinical features and usually is ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2020, 24(1):E10-E12]

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Plasma miR-370-3p As a Biomarker of Sepsis-Associated Encephalopathy, The Transcriptomic Profiling Analysis of Microrna-Arrays From Mouse Brains.

Peerapat Visitchanakun, Pattarin Tangtanatakul, Ornjira Trithiphen, Wipasiri Soonthonchai, Jutamas Wongphoom, Sasipha Tachaboon, Nattachai Srisawat, Asada Leelahavanichkul,

The diagnosis of sepsis-associated encephalopathy (SAE), an alteration of conscious from sepsis, is difficult due to the similarity to altered states of conscious that occur from other causes. Transcriptomic analyses between mouse-brains at 24 h after cecal ligation and puncture (CLP) (SAE brain as evaluated by SHIRPA score) and at 120 h ... Read more >>

Shock (Shock (Augusta, Ga.))
[2019, :]

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Bilateral Basal Ganglia Lesions in a Dialytic Patient with Diabetes and Recurrent Hypoglycemia.

Jong Hwan Jung,

Chonnam Med J (Chonnam medical journal)
[2019, 55(3):173-174]

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Posterior Reversible Encephalopathy Syndrome: Clinical Features and Outcome.

Archana Hinduja,

Background: Posterior reversible encephalopathy syndrome (PRES) is an acute neurotoxic syndrome that is characterized by a spectrum neurological and radiological feature from various risk factors. Common neurological symptoms includes headache, impairment in level of consciousness, seizures, visual disturbances, and focal neurological deficits. Common triggering factors include blood pressure fluctuations, renal ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:71]

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Is renal replacement therapy necessary in deceased donor liver transplantation candidates with hepatorenal syndrome?: a 2-year experience at a high-volume center.

Gil-Chun Park, Shin Hwang, Dong-Hwan Jung, Gi-Won Song, Chul-Soo Ahn, Ki-Hun Kim, Deok-Bog Moon, Tae-Yong Ha, Young-In Yoon, Hui-Dong Cho, Jae-Hyun Kwon, Yong-Kyu Chung, Sang-Hyun Kang, I-Ji Jung, Jin Uk Choi, Sung-Gyu Lee,

Purpose:Hepatorenal syndrome (HRS) is a fatal complication in patients with end-stage liver disease awaiting liver transplantation (LT). HRS often develops in patients with high model for end-stage liver disease (MELD) score. This study investigated the outcomes of peritransplant management of HRS in a high-volume LT center in Korea for 2 ... Read more >>

Ann Surg Treat Res (Annals of surgical treatment and research)
[2020, 98(2):102-109]

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Uremic encephalopathy in patients undergoing assisted peritoneal dialysis: a case series and literature review.

Akane Yanai, Kiyotaka Uchiyama, Yoshitaka Ishibashi,

We sometimes hesitate to switch renal replacement therapy from peritoneal dialysis (PD) particularly in elderly patients due to their physical tolerance levels and lifestyles. Here, we describe the cases of three patients treated with PD alone despite an anuric status who subsequently developed uremic encephalopathy, which was successfully treated with ... Read more >>

CEN Case Rep (CEN case reports)
[2019, 8(4):271-279]

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Consensus regarding diagnosis and management of atypical hemolytic uremic syndrome.

Hajeong Lee, Eunjeong Kang, Hee Gyung Kang, Young Hoon Kim, Jin Seok Kim, Hee-Jin Kim, Kyung Chul Moon, Tae Hyun Ban, Se Won Oh, Sang Kyung Jo, Heeyeon Cho, Bum Soon Choi, Junshik Hong, Hae Il Cheong, Doyeun Oh,

Thrombotic microangiopathy (TMA) is defined by specific clinical characteristics, including microangiopathic hemolytic anemia, thrombocytopenia, and pathologic evidence of endothelial cell damage, as well as the resulting ischemic end-organ injuries. A variety of clinical scenarios have features of TMA, including infection, pregnancy, malignancy, autoimmune disease, and medications. These overlapping manifestations hamper ... Read more >>

Korean J. Intern. Med. (The Korean journal of internal medicine)
[2020, 35(1):25-40]

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Complete Genome Sequence of an Enterohemorrhagic Escherichia coli O111:H8 Strain Recovered from a Large Outbreak in Japan Associated with Consumption of Raw Beef.

Tsuyoshi Sekizuka, Kenichi Lee, Keiko Kimata, Junko Isobe, Makoto Kuroda, Sunao Iyoda, Makoto Ohnishi, Tetsutaro Sata, Masanori Watahiki,

We present the complete genome sequence of an enterohemorrhagic Escherichia coli O111:H8 strain. This strain was isolated from a hemolytic-uremic syndrome patient and was responsible for a large outbreak associated with the consumption of raw beef in 2011. ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2019, 8(40):]

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Nosocomial Myiasis Caused by Lucilia sericata (Diptera: Calliphoridae) in a Pediatric Patient in Mexico.

Hugo Martínez-Rojano, Herón Huerta, Luis M Hernández-Triana, Eduardo Francisco Ruiz Pérez, Reyna Sámano,

Prevention of nosocomial myiasis, or hospital-acquired larvae infestation, should be an essential part of all hospital infection control programs. However, little is known about nosocomial myiasis, despite the extensive medical and psychological effects it has on patients and their families and the negative effects it has on hospitals' reputation and ... Read more >>

Case Rep Infect Dis (Case reports in infectious diseases)
[2020, 2020:1285459]

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Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats.

Fatemeh Sharifi, Parham Reisi, Maryam Malek,

BACKGROUND:Neurological complications may occur in patients with acute or chronic renal failure; however, in cases of acute renal failure, the signs and symptoms are usually more pronounced, and progressed rapidly. Oxidative stress and nitric oxide in the hippocampus, following kidney injury may be involved in cognitive impairment in patients with ... Read more >>

BMC Neurosci (BMC neuroscience)
[2019, 20(1):52]

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Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee.

Stuart G Tangye, Waleed Al-Herz, Aziz Bousfiha, Talal Chatila, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M Holland, Christoph Klein, Tomohiro Morio, Hans D Ochs, Eric Oksenhendler, Capucine Picard, Jennifer Puck, Troy R Torgerson, Jean-Laurent Casanova, Kathleen E Sullivan,

We report the updated classification of Inborn Errors of Immunity/Primary Immunodeficiencies, compiled by the International Union of Immunological Societies Expert Committee. This report documents the key clinical and laboratory features of 430 inborn errors of immunity, including 64 gene defects that have either been discovered in the past 2 years since ... Read more >>

J. Clin. Immunol. (Journal of clinical immunology)
[2020, 40(1):24-64]

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The Effect of Serum Calcium Levels on Uremic Encephalopathy in Patients with Acute Kidney Injury in the Emergency Department.

Canan Akman, Dilek Ülker Çakır, Serkan Bakırdöğen, Serdal Balcı,

BACKGROUND AND OBJECTIVES:Uremic encephalopathy is the most important complication of renal failure and urgent dialysis treatment is required. Parathormone (PTH) contributes to the etiopathogenesis of uremic encephalopathy. PTH is a hormone that acts in the calcium balance in the organism. The aim of our study was to investigate the effect ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(5):]

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Uremic leontiasis ossea due to secondary hyperparathyroidism complicated by vitamin C deficiency in a non-adherent chronic hemodialysis patient: A case report.

David Massicotte-Azarniouch, Laurie McLean, Pierre Antoine Brown,

Non-adherence to medical therapy in patients with end-stage kidney disease (ESKD) can lead to severe metabolic derangements rarely seen in the current medical era. Such complications may take the form of secondary hyperparathyroidism (HPT) leading to rare manifestations of bone mineral disease, and profound vitamin C deficiency from poor nutrition ... Read more >>

Clin Nephrol Case Stud (Clinical nephrology. Case studies)
[2019, 7:54-59]

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Delaying Renal Replacement Therapy Could Be Harmful in Patients with Acute Brain Injury.

Benjamin G Chousterman, Matthieu Jamme, Nahid Tabibzadeh, Samuel Gaugain, Charles Damoisel, Romain Barthélémy,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 200(5):645-646]

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Dilated cardiomyopathy: A rare and late complication of the hemolytic-uremic syndrome.

Oumaima Naour, Abdenasser Drighil, Kaoutar Idouz, Sellama Nadifi, Fatima Ezzahra Rochdi, Kenza Bouayed, Nabiha Mikou,

Hemolytic uremic syndrome (HUS) is a non-exceptional, progressive complication of acute gastroenteritis in children, especially secondary to Escherichia coli infection. It is responsible for significant morbidity and significant mortality (10% of deaths) because of acute renal failure which often complicates it. Dilated cardiomyopathy is a rare but critical extra renal ... Read more >>

J Cardiol Cases (Journal of cardiology cases)
[2019, 20(4):125-128]

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Metastatic Multiple Myeloma to the Skin.

Alex C Holliday, Mohammed I Khan, Sean E Mazloom, Rahul N Chavan, Douglas J Grider,

Cutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with relapsed lambda light chain MM who developed abrupt asymptomatic skin metastases. Biopsy revealed a dermis replete of ... Read more >>

Case Rep Dermatol Med (Case reports in dermatological medicine)
[2019, 2019:7930123]

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Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice.

Ryo Ozuru, Shohei Wakao, Takahiro Tsuji, Naoya Ohara, Takashi Matsuba, Muhammad Y Amuran, Junko Isobe, Morio Iino, Naoki Nishida, Sari Matsumoto, Kimiharu Iwadate, Noriko Konishi, Kaori Yasuda, Kosuke Tashiro, Misato Hida, Arisato Yadoiwa, Shinsuke Kato, Eijiro Yamashita, Sohkichi Matsumoto, Yoichi Kurozawa, Mari Dezawa, Jun Fujii,

Shiga toxin-producing Escherichia coli (STEC) causes hemorrhagic colitis, hemolytic uremic syndrome, and acute encephalopathies that may lead to sudden death or severe neurologic sequelae. Current treatments, including immunoglobulin G (IgG) immunoadsorption, plasma exchange, steroid pulse therapy, and the monoclonal antibody eculizumab, have limited effects against the severe neurologic sequelae. Multilineage-differentiating ... Read more >>

Mol. Ther. (Molecular therapy : the journal of the American Society of Gene Therapy)
[2020, 28(1):100-118]

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