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Full Text Journal Articles about
Tuberculosis

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Drug-resistant tuberculosis: an experience from Qatar.

Maisa Ali, Faraj Howady, Waqar Munir, Hanfa Karim, Zubaida Al-Suwaidi, Muna Al-Maslamani, Abdullatif Alkhal, Nada Elmaki, Hisham Ziglam,

This study was conducted to evaluate the characteristics, treatment outcome and risk factors associated with 223 drug-resistant tuberculosis (DR-TB) cases in the State of Qatar. A descriptive records-based retrospective study was conducted on patients registered at Communicable Disease Centre (CDC), Qatar to all consecutive microbiologically confirmed tuberculosis cases for the ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2020, 15(1):1744351]

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Distinct host-immune response toward species related intracellular mycobacterial killing: A transcriptomic study.

Abhilasha Madhvi, Hridesh Mishra, Novel N Chegou, Gerard Tromp, Carel J Van Heerden, R D Pietersen, Gina Leisching, Bienyameen Baker,

The comparison of the host immune response when challenged with pathogenic and nonpathogenic species of mycobacteria can provide answers to the unresolved question of how pathogens subvert or inhibit an effective response. We infected human monocyte derived macrophages (hMDMs) with different species of mycobacteria, in increasing order of pathogenicity, i.e. ... Read more >>

Virulence (Virulence)
[2020, 11(1):170-182]

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Symposium report: emerging threats for human health - impact of socioeconomic and climate change on zooanthroponosis in the Republic of Sakha (Yakutia), Russia.

Irene Huber, Katerina Potapova, Elena Ammosova, Wolfgang Beyer, Sergey Blagodatskiy, Roman Desyatkin, Ludwig E Hoelzle, Margarita Ignateva, Ludmila Kokolova, Stefanie Lemke, Mikhail Neustroev, Ayan Nyukkanov, Galina Protodyakonova, Alexander Reshetnikov, Thomas Romig, Vyacheslav Shadrin, Izabella Samoilova, Sergey Semenov, Konstantin Stepanov, Nadezhda Tarabukina, Liliia Vinokurova, Raisa Zakharova, Konstantin Nifontov,

Population growth, socio-cultural and economic changes as well as technological progress have an immediate impact on the environment and human health in particular. Our steadily rising needs of resources increase the pressure on the environment and narrow down untainted habitats for plants and wild animals. Balance and resilience of ecosystems ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1715698]

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In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos.

Ashok Aspatwar, Milka Hammaren, Mataleena Parikka, Seppo Parkkila, Fabrizio Carta, Murat Bozdag, Daniela Vullo, Claudiu T Supuran,

We investigated a panel of 14 compounds belonging to the monothiocarbamate (MTC) and dithiocarbamate (DTC) series against the β-carbonic anhydrase 3 (β-CA3) of Mycobacterium tuberculosis (Mtb). We also evaluated all compounds for toxicity using 1-5-day post fertilisation zebrafish embryos. 11 out of the 14 investigated derivatives showed effective nanomolar or ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):65-71]

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Coverage rates of the children vaccination programme in Greenland.

Nadja Albertsen, Anna Rask Lynge, Nils Skovgaard, Jesper Søndergaard Olesen, Michael Lynge Pedersen,

In order to estimate the current coverage rate among all children in Greenland, we conducted an observational cross-sectional study identifying all children in Greenland eligible for a vaccination between 1 March 2018 and 16 June 2019. we found an overall national coverage of 85.4%. The national coverage for the vaccinations ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1721983]

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Mutation on lysX from Mycobacterium avium hominissuis impacts the host-pathogen interaction and virulence phenotype.

Greana Kirubakar, Hubert Schäfer, Volker Rickerts, Carsten Schwarz, Astrid Lewin,

The lysX gene from Mycobacterium avium hominissuis (MAH) is not only involved in cationic antimicrobial resistance but also regulates metabolic activity. An MAH lysX deficient mutant was shown to exhibit a metabolic shift at the extracellular state preadapting the bacteria to the conditions inside host-cells. It further showed stronger growth ... Read more >>

Virulence (Virulence)
[2020, 11(1):132-144]

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Sekuwe (My House): building health equity through Dene First Nations housing designs.

Linda Larcombe, Lancelot Coar, Matthew Singer, Lizette Denechezhe, Evan Yassie, Tony Powderhorn, Joe Antsanen, Kathi Avery Kinew, Pamela Orr,

The Truth and Reconciliation Commission of Canada determined that the Dene people, among other Indigenous groups, experienced cultural genocide through policies that separated them from their lands and resources, and from their families, languages, cultures, and by forcibly sending children to Indian Residential Schools. The resultant social inequity is manifested ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1717278]

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Stem-like cells of various origins showed therapeutic effect to improve the recovery of spinal cord injury.

Jian Kang, Chenglin Zhang, Zhongzheng Zhi, Yingjie Wang, Jingdong Liu, Furong Wu, Guanghui Xu,

We aimed to evaluate the therapeutic effects of exosomes, which were collected from human neuroepithelial stem cells (HNESCs) treated by miR-29b mimics, on the treatment of spinal cord injury (SCI). Computational analysis, real-time PCR, Western blot analysis and TUNEL assay, a BBB score system, the Nissl staining and IHC assay ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):627-638]

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Adult outcomes of childhood bronchiectasis.

Dawn Sibanda, Rosalyn Singleton, John Clark, Christine Desnoyers, Ellen Hodges, Gretchen Day, Gregory Redding,

Recent literature has highlighted the importance of transition from paediatric to adult care for children with chronic conditions. Non-cystic fibrosis bronchiectasis is an important cause of respiratory morbidity in low-income countries and in indigenous children from affluent countries; however, there is little information about adult outcomes of childhood bronchiectasis. We ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1731059]

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Clinical risk factors and outcomes of massive ascites accumulation after discontinuation of peritoneal dialysis.

Ming-Shan Chang, Nai-Ching Chen, Chih-Yang Hsu, Chien-Wei Huang, Po-Tsang Lee, Kang-Ju Chou, Hua-Chang Fang, Chien-Liang Chen,

Background: Encapsulating peritoneal sclerosis (EPS) is a serious complication of peritoneal dialysis (PD), with high morbidity and mortality that requires an early diagnosis for effective treatment. PD withdrawal and bacterial peritonitis are important triggers for the onset of EPS. However, few studies have focused on cases of PD withdrawal without ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):1-9]

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Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents.

Fengyi Zhao, Xu Sun, Wen Lu, Li Xu, Jiuzhou Shi, Shilong Yang, Mengyi Zhou, Fan Su, Feng Lin, Fuliang Cao,

Several dehydroabietylamine derivatives containing heterocyclic moieties such as thiophene and pyrazine ring were successfully synthesized. The antiproliferative activities of these thiophene-based Schiff-bases, thiophene amides, and pyrazine amides were investigated in vitro against Hela (cervix), MCF-7 (breast), A549 (lung), HepG2 (liver), and HUVEC (umbilical vein) cells by MTT assay. The toxicity of ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):216-227]

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Rifampicin quinone pretreatment improves neuronal survival by modulating microglia inflammation induced by α-synuclein.

Leonardo Acuna, Natalia S Corbalán, Rita Raisman-Vozari,

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1473-1474]

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Human global and population-specific genetic susceptibility to Mycobacterium tuberculosis infection and disease.

Marlo Möller, Craig J Kinnear,

PURPOSE OF REVIEW:Multiple lines of evidence support a role of the host genetic component in Mycobacterium tuberculosis infection and disease progression. However, genomic studies of tuberculosis susceptibility have been disappointing compared with that of other complex disorders. Recently the field has explored alternative strategies to facilitate locus discovery. Results emanating ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):302-310]

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Beyond antibiotics for pulmonary nontuberculous mycobacterial disease.

Grant Waterer,

PURPOSE OF REVIEW:Pulmonary nontuberculous mycobacterial disease (NTM) remains a significant clinical challenge with suboptimal therapy. This review focuses on recent understandings around the pathogenesis of NTM disease and nonantibiotic therapeutic approaches that are being pursued. RECENT FINDINGS:The absence of animal models that truly replicate human disease remains a major problem ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):260-266]

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Advances in the diagnosis and treatment of latent tuberculosis infection.

Ye Eun Grace Jung, Neil W Schluger,

PURPOSE OF REVIEW:This review describes the major developments in the rationale for treating latent tuberculosis infection; new approaches to identifying persons with latent infection who are most likely to progress to active disease; and the development of novel short-course regimens for treatment of latent tuberculosis. RECENT FINDINGS:As many as one-third ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):166-172]

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Guidelines for the Treatment of Latent Tuberculosis Infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020.

Timothy R Sterling, Gibril Njie, Dominik Zenner, David L Cohn, Randall Reves, Amina Ahmed, Dick Menzies, C Robert Horsburgh, Charles M Crane, Marcos Burgos, Philip LoBue, Carla A Winston, Robert Belknap,

Comprehensive guidelines for treatment of latent tuberculosis infection (LTBI) among persons living in the United States were last published in 2000 (American Thoracic Society. Am J Respir Crit Care Med 161:S221-S247, 2000). Since then, several new regimens have been evaluated in clinical trials. To update previous guidelines, the National Tuberculosis ... Read more >>

Am. J. Transplant. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2020, 20(4):1196-1206]

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Capsular glycan recognition provides antibody-mediated immunity against tuberculosis.

Tingting Chen, Caroline Blanc, Yanyan Liu, Elise Ishida, Sarah Singer, Jiayong Xu, Maju Joe, Elizabeth R Jenny-Avital, John Chan, Todd L Lowary, Jacqueline M Achkar,

A better understanding of all immune components involved in protecting against Mycobacterium tuberculosis infection is urgently needed to inform strategies for novel immunotherapy and tuberculosis (TB) vaccine development. Although cell-mediated immunity is critical, increasing evidence supports that antibodies also have a protective role against TB. Yet knowledge of protective antigens ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2020, 130(4):1808-1822]

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Leukocyte telomere length as a diagnostic biomarker for anti-tuberculosis drug-induced liver injury.

Wanvisa Udomsinprasert, Noppadol Chanhom, Supharat Suvichapanich, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol, Wasun Chantratita, Jiraphun Jittikoon,

Despite being relatively rare, anti-tuberculosis drug-induced liver injury (ATDILI) is a leading cause of acute liver failure and a major reason for treatment discontinuation, because of no specific and selective markers for ATDILI. Herein, this study aimed to investigate whether telomere length, a biological indicator of age-related diseases, is associated ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5628]

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Point-of-Care Ultrasound Predictors for the Diagnosis of Tuberculosis in HIV-Positive Patients Presenting to an Emergency Center.

Daniël Jacobus Van Hoving, Andre P Kenge, Gary Maartens, Graeme Meintjes,

BACKGROUND:The performance of point-of-care ultrasound (PoCUS) to diagnose HIV-associated tuberculosis has not been evaluated in large prospective studies. We determined the diagnostic accuracy of individual PoCUS features, performed an external validation of the focused assessment with sonography for HIV/TB (FASH) protocol, and determined independent PoCUS predictors of HIV-associated tuberculosis appropriate ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2020, 83(4):415-423]

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Machine learning reveals that Mycobacterium tuberculosis genotypes and anatomic disease site impacts drug resistance and disease transmission among patients with proven extra-pulmonary tuberculosis

Jotam Pasipanodya, Doctor Sibandze, Beki Magazi, Lesibana Malinga, Nontuthuko Maningi, Bong Shey, Nontombi Mbelle,

<title>Abstract</title> <p> Background There is a general dearth of information on extrapulmonary tuberculosis (EPTB). We investigated Mycobacterium tuberculosis (Mtb) drug resistance and transmission patterns in EPTB patients treated in the Tshwane metropolitan area, South Africa. Methods Consecutive Mtb culture-positive non-pulmonary samples from unique EPTB patients underwent mycobacterial genotyping ... Read more >>

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Temporal Factors and Missed Doses of Tuberculosis Treatment. A Causal Associations Approach to Analyses of Digital Adherence Data.

Helen R Stagg, James J Lewis, Xiaoqiu Liu, Shitong Huan, Shiwen Jiang, Daniel P Chin, Katherine L Fielding,

Rationale: Tuberculosis treatment lasts for 6 months or more. Treatment adherence is critical; regimen length, among other factors, makes this challenging. Globally, analyses mapping common types of nonadherence are lacking. For example, is there a greater challenge resulting from early treatment cessation (discontinuation) or intermittent missed doses (suboptimal dosing implementation)? ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(4):438-449]

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HLA-E-restricted CD8+ T Lymphocytes Efficiently Control Mycobacterium tuberculosis and HIV-1 Coinfection.

Marco Pio La Manna, Valentina Orlando, Teresa Prezzemolo, Paola Di Carlo, Antonio Cascio, Giovanni Delogu, Guido Poli, Lucy C Sullivan, Andrew G Brooks, Francesco Dieli, Nadia Caccamo,

We investigated the contribution of human leukocyte antigen A2 (HLA-A2) and HLA-E-restricted CD8+ T cells in patients with Mycobacterium tuberculosis and human immunodeficiency virus 1 (HIV-1) coinfection. HIV-1 downregulates HLA-A, -B, and -C molecules in infected cells, thus influencing recognition by HLA class I-restricted CD8+ T cells but not by ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, 62(4):430-439]

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Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters.

Jansy P Sarathy, Véronique Dartois,

SUMMARYCaseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open cavities connecting with an airway. Several commonly accepted characteristics of caseum were established during the preantibiotic era, when autopsies of deceased tuberculosis (TB) patients were common ... Read more >>

Clin. Microbiol. Rev. (Clinical microbiology reviews)
[2020, 33(3):]

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High Incidence of Active Tuberculosis in Asylum Seekers from Eritrea and Somalia in the First 5 Years after Arrival in the Netherlands.

Jossy van den Boogaard, Erika Slump, Henrieke J Schimmel, Wim van der Hoek, Susan van den Hof, Gerard de Vries,

Three quarters of tuberculosis (TB) patients in the Netherlands are foreign-born; 26% are from Eritrea or Somalia. We analyzed TB incidence rates in asylum seekers from Eritrea and Somalia in the first 5 years after arrival in the Netherlands (2013-2017) and performed survival analysis with Cox proportional hazards regression to ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(4):675-681]

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EXPRESSION OF Mycobacterium tuberculosis RpsA IN Mycobacterium smegmatis INCREASES SUSCEPTIBILITY TO PYRAZINAMIDE

Ricardo Antiparra, Marco Santos, Angie Toledo, Robert Gilman, Daniela Kirwan, Patricia Sheen, Mirko Zimic,

Pyrazinamide (PZA) is one of the most important drugs used in combined anti-tuberculous therapy. After the drug enters Mycobacterium tuberculosis it is hydrolyzed by pyrazinamidase (PZAse) to the bactericidal molecule pyrazinoic acid (POA). Ribosomal protein S1 (RpsA) was recently identified as a possible target of PZA based on its binding ... Read more >>

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