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Tricyclic Antidepressant Toxicity in Pediatrics

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Intravenous Lipid Emulsion Rescue Therapy in a Child with Carisoprodol Overdose.

Madhuradhar Chegondi, Aditya Badheka, Swathi Chacham, Madelyn Kahana,

The use of intravenous lipid emulsion (ILE) therapy in children with carisoprodol toxicity was not described previously. We report the case of an adolescent female who presented to our pediatric intensive care unit with unresponsiveness and respiratory depression. The patient recovered immediately following ILE therapy and subsequently admitted having carisoprodol ... Read more >>

Cureus (Cureus)
[2019, 11(11):e6250]

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Rare Conduction Abnormality in a Four-year-old Child with Carbamazepine Acute Poisoning.

Cristina Iolanda Vivisenco, Coriolan Emil Ulmeanu,

Background:Cardiac conduction abnormalities are reported after ingestion of a toxic dose of carbamazepine. Case presentation:We describe the case of a four-year-old child with carbamazepine acute poisoning who developed reversible synoatrial block along with neurological toxic signs, despite a serum level of carbamazepine close to the upper limit of the therapeutic ... Read more >>

Maedica (Buchar) (Maedica)
[2019, 14(2):165-168]

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Toxicity of Bupropion Overdose Compared With Selective Serotonin Reuptake Inhibitors.

Adam Overberg, Shannon Morton, Emily Wagner, Blake Froberg,

OBJECTIVES:Adolescent depression and attempted and completed suicide are increasing in the United States. Because suicide is often impulsive, the means of self-harm are frequently items of convenience like medication. Authors of a recent study compared tricyclic antidepressant overdose to bupropion overdose. Fluoxetine and escitalopram are the only agents with Food ... Read more >>

Pediatrics (Pediatrics)
[2019, 144(2):]

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Antidepressants for Pediatric Patients.

Jennifer B Dwyer, Michael H Bloch,

Curr Psychiatr (Current psychiatry)
[2019, 18(9):26-42F]

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Accidental intoxications in toddlers: lack of cross-reactivity of vilazodone and its urinary metabolite M17 with drug of abuse screening immunoassays.

Christina D Martinez-Brokaw, Joshua B Radke, Joshua G Pierce, Alexandra Ehlers, Sean Ekins, Kelly E Wood, Jon Maakestad, Jacqueline A Rymer, Kenichi Tamama, Matthew D Krasowski,

Background:Vilazodone is an FDA approved medication used to treat major depressive disorder. The authors describe two cases of accidental vilazodone exposure in toddlers who presented with symptoms similar to amphetamine exposure and also with unexplained positive amphetamine urine immunoassay drug screens. Given a lack of published data on cross-reactivity of ... Read more >>

BMC Clin Pathol (BMC clinical pathology)
[2019, 19:2]

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Pediatric pain treatment and prevention for hospitalized children.

Stefan J Friedrichsdorf, Liesbet Goubert,

Introduction:Prevention and treatment of pain in pediatric patients compared with adults is often not only inadequate but also less often implemented the younger the children are. Children 0 to 17 years are a vulnerable population. Objectives:To address the prevention and treatment of acute and chronic pain in children, including pain ... Read more >>

Pain Rep (Pain reports)
[2020, 5(1):e804]

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Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.

Larisa H Cavallari, Sara L Van Driest, Cynthia A Prows, Jeffrey R Bishop, Nita A Limdi, Victoria M Pratt, Laura B Ramsey, D Max Smith, Sony Tuteja, Benjamin Q Duong, J Kevin Hicks, James C Lee, Aniwaa Owusu Obeng, Amber L Beitelshees, Gillian C Bell, Kathryn Blake, Daniel J Crona, Lynn Dressler, Ryan A Gregg, Lindsay J Hines, Stuart A Scott, Richard C Shelton, Kristin Wiisanen Weitzel, Julie A Johnson, Josh F Peterson, Philip E Empey, Todd C Skaar, ,

PURPOSE:A number of institutions have clinically implemented CYP2D6 genotyping to guide drug prescribing. We compared implementation strategies of early adopters of CYP2D6 testing, barriers faced by both early adopters and institutions in the process of implementing CYP2D6 testing, and approaches taken to overcome these barriers. METHODS:We surveyed eight early adopters ... Read more >>

Genet. Med. (Genetics in medicine : official journal of the American College of Medical Genetics)
[2019, 21(10):2255-2263]

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Retrospective study of irrational prescribing in French paediatric hospital: prevalence of inappropriate prescription detected by Pediatrics: Omission of Prescription and Inappropriate prescription (POPI) in the emergency unit and in the ambulatory setting.

Aurore Berthe-Aucejo, Phuong Khanh Hoang Nguyen, François Angoulvant, Xavier Bellettre, Patrick Albaret, Thomas Weil, Rym Boulkedid, Olivier Bourdon, Sonia Prot-Labarthe,

BACKGROUND AND OBJECTIVE:Pediatrics: Omission of Prescription and Inappropriate prescription (POPI) is the first detection tool for potentially inappropriate medicines (PIMs) and potentially prescribing omissions (PPOs) in paediatrics. The aim of this study was to evaluate the prevalence of PIM and PPO detected by POPI regarding prescriptions in hospital and for ... Read more >>

BMJ Open (BMJ open)
[2019, 9(3):e019186]

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A case series involving young children presenting with accidental ingestion of amphetamine based stimulants.

Kelly E Wood, Patrick J McCarthy, Matthew D Krasowski,

•Attention Deficity Hyperactivity Disorder (ADHD) affects adults and children.•Stimulant prescribing for ADHD is increasing.•Overdose of amphetamine based stimulants results in a sympathomimetic toxidrome.•Lisdexamfetamine dimesylate is the first prodrug stimulant developed to treat ADHD. ... Read more >>

Toxicol Rep (Toxicology reports)
[2018, 5:1129-1133]

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Functional Somatic Symptoms.

Casper Roenneberg, Heribert Sattel, Rainer Schaefert, Peter Henningsen, Constanze Hausteiner-Wiehle,

BACKGROUND:Approximately 10% of the general population and around one third of adult patients in clinical populations suffer from functional somatic symptoms. These take many forms, are often chronic, impair everyday functioning as well as quality of life, and are cost intensive. METHODS:The guideline group (32 medical and psychological professional societies, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2019, 116(33-34):553-560]

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Prevention, Treatment, and Monitoring of Seizures in the Intensive Care Unit.

Micheal Strein, John P Holton-Burke, LaTangela R Smith, Gretchen M Brophy,

The diagnosis and management of seizures in the critically ill patient can sometimes present a unique challenge for practitioners due to lack of exposure and complex patient comorbidities. The reported incidence varies between 8% and 34% of critically ill patients, with many patients often showing no overt clinical signs of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(8):]

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Managing Chronic Pain in the Elderly: An Overview of the Recent Therapeutic Advancements.

Asad Ali, Abdul Wahab Arif, Chandur Bhan, Deepak Kumar, Muhammad Bilal Malik, Zohaib Sayyed, Khawaja Hassan Akhtar, Malik Qistas Ahmad,

A majority of the elderly suffer from chronic pain that significantly alters their daily activities and imposes an enormous burden on health care. Multiple comorbidities and the risk of polypharmacy in the elderly make it a challenge to determine the appropriate drug, dosage, and maintenance of therapy. Opioids are the ... Read more >>

Cureus (Cureus)
[2018, 10(9):e3293]

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The Society for Pediatric Anesthesia recommendations for the use of opioids in children during the perioperative period.

Joseph P Cravero, Rita Agarwal, Charles Berde, Patrick Birmingham, Charles J Coté, Jeffrey Galinkin, Lisa Isaac, Sabine Kost-Byerly, David Krodel, Lynne Maxwell, Terri Voepel-Lewis, Navil Sethna, Robert Wilder,

Opioids have long held a prominent role in the management of perioperative pain in adults and children. Published reports concerning the appropriate, and inappropriate, use of these medications in pediatric patients have appeared in various publications over the last 50 years. For this document, the Society for Pediatric Anesthesia appointed a ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(6):547-571]

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Transient endocrinologic problems in the newborn period.

Selim Kurtoğlu, Gül Direk, Zeynep Uzan Tatlı, Nihal Hatipoğlu,

Many transient endocrinologic disorders are frequently seen in newborn period. Early diagnosis and treatment is important for babies. In this article, transient endocrinopathy of newborn and relevant literature were reviewed. Blood sugar problems, especially adrenal insufficiency due to adrenal problems, thyroid problems such as transient hypotirotropinemia, are frequently encountered by ... Read more >>

Turk Pediatri Ars (Turk pediatri arsivi)
[2019, 54(1):3-12]

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Role of chronic cannabis use: Cyclic vomiting syndrome vs cannabinoid hyperemesis syndrome.

Thangam Venkatesan, David J Levinthal, B U K Li, Sally E Tarbell, Kathleen A Adams, Robert M Issenman, Irene Sarosiek, Safwan S Jaradeh, Ravi N Sharaf, Shahnaz Sultan, Christopher D Stave, Andrew A Monte, William L Hasler,

Cannabis is commonly used in cyclic vomiting syndrome (CVS) due to its antiemetic and anxiolytic properties. Paradoxically, chronic cannabis use in the context of cyclic vomiting has led to the recognition of a putative new disorder called cannabinoid hyperemesis syndrome (CHS). Since its first description in 2004, numerous case series ... Read more >>

Neurogastroenterol. Motil. (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2019, 31 Suppl 2:e13606]

Cited: 1 time

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Acute intoxications among Turkish children.

Baran S Kizilyildiz, Kamuran Karaman, Selvi Özen, Abdurrahman Üner,

The aim of this study was to investigate characteristics, outcomes and clinical features of acute intoxications among children in Van region of Turkey.All cases with a diagnosis of acute intoxication admitted to the Pediatric Emergency Department of the Yüzüncü Yıl University of Van from June 1, 2010 to November 30, ... Read more >>

Minerva Pediatr. (Minerva pediatrica)
[2018, 70(1):46-50]

Cited: 1 time

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Pain Management in Pediatric Chronic Kidney Disease.

Amanda Reis, Caitlyn Luecke, Thomas Keefe Davis, Aadil Kakajiwala,

Pain is a common problem in children with chronic kidney disease (CKD); however, limited data exist regarding its management. Although most pain is managed pharmacologically, in some instances non-pharmacologic management can aid in safely ameliorating discomfort. Because of the accumulation of toxic metabolites, many common pain medications have adverse effects ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2018, 23(3):192-202]

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Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Yoshihiro Inamoto, Igor Petriček, Linda Burns, Saurabh Chhabra, Zack DeFilipp, Peiman Hematti, Alicia Rovó, Raquel Schears, Ami Shah, Vaibhav Agrawal, Aisha Al-Khinji, Ibrahim Ahmed, Asim Ali, Mahmoud Aljurf, Hassan Alkhateeb, Amer Beitinjaneh, Neel Bhatt, Dave Buchbinder, Michael Byrne, Natalie Callander, Kristina Fahnehjelm, Nosha Farhadfar, Robert Peter Gale, Siddhartha Ganguly, Gerhard C Hildebrandt, Erich Horn, Ann Jakubowski, Rammurti T Kamble, Jason Law, Catherine Lee, Sunita Nathan, Olaf Penack, Ravi Pingali, Pinki Prasad, Drazen Pulanic, Seth Rotz, Aditya Shreenivas, Amir Steinberg, Khalid Tabbara, André Tichelli, Baldeep Wirk, Jean Yared, Grzegorz W Basak, Minoo Battiwalla, Rafael Duarte, Bipin N Savani, Mary E D Flowers, Bronwen E Shaw, Nuria Valdés-Sanz,

Non-graft-vs.-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and ... Read more >>

Bone Marrow Transplant. (Bone marrow transplantation)
[2019, 54(5):648-661]

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The Toxicology Investigators Consortium Case Registry-the 2017 Annual Report.

Lynn A Farrugia, Sean H Rhyee, Sharan L Campleman, Bryan Judge, Louise Kao, Anthony Pizon, Lauren Porter, Anne M Riederer, Timothy Wiegand, Diane Calello, Paul M Wax, Jeffrey Brent, ,

The Toxicology Investigators Consortium (ToxIC) Case Registry was established by the American College of Medical Toxicology in 2010. The Registry collects data from participating sites with the agreement that all bedside medical toxicology consultations will be entered. The objective of this eighth annual report is to summarize the Registry's 2017 ... Read more >>

J Med Toxicol (Journal of medical toxicology : official journal of the American College of Medical Toxicology)
[2018, 14(3):182-211]

Cited: 3 times

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Bidirectional relations among common psychiatric and neurologic comorbidities and epilepsy: Do they have an impact on the course of the seizure disorder?

Andres M Kanner, Ramses Ribot, Andrey Mazarati,

The treatment of epilepsy is not limited to the achievement of a seizure-free state. It must also incorporate the management of common psychiatric and neurologic comorbidities, affecting on average between 30 and 50% of patients with epilepsy, which have a significant impact on their lives at various levels, including quality ... Read more >>

Epilepsia Open (Epilepsia open)
[2018, 3(Suppl Suppl 2):210-219]

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ACMT 2020 Annual Scientific Meeting Abstracts – New York, NY.

J Med Toxicol (Journal of Medical Toxicology)
[0, :1-53]

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Population Pharmacokinetics of Clozapine and Norclozapine and Switchability Assessment between Brands in Uruguayan Patients with Schizophrenia.

Ismael Olmos, Manuel Ibarra, Marta Vázquez, Cecilia Maldonado, Pietro Fagiolino, Gustavo Giachetto,

Clozapine (CZP) is an atypical antipsychotic agent commonly used in the treatment of schizophrenia. It is metabolized primarily by CYP1A2 enzyme, yielding a pharmacologically active metabolite, norclozapine (NCZP). Significant intra- and interindividual pharmacokinetic (PK) variability for CZP and NCZP has been observed in routine therapeutic drug monitoring. So the goal ... Read more >>

Biomed Res Int (BioMed research international)
[2019, 2019:3163502]

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Peripheral neuropathy in children and adolescents treated for cancer.

Kari L Bjornard, Laura S Gilchrist, Hiroto Inaba, Barthelemy Diouf, Marilyn J Hockenberry, Nina S Kadan-Lottick, Daniel C Bowers, M Eileen Dolan, Nicole J Ullrich, William E Evans, Kirsten K Ness,

Peripheral neuropathy is a well recognised treatment-related toxicity in children with cancer, associated with exposure to neurotoxic chemotherapy agents. Acute damage can occur in sensory, motor, or autonomic neurons, with symptoms that are rarely life threatening, but often severe enough to interfere with function during therapy and after treatment ends. ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2018, 2(10):744-754]

Cited: 1 time

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Managing cyclic vomiting syndrome in children: beyond the guidelines.

B U K Li,

Cyclic vomiting syndrome (CVS) in children is characterized by frequent hospitalizations, multiple comorbidities, and poor quality of life. In the absence of robust data, the treatment of CVS remains largely empiric starting with the 2008 NASPGHAN Consensus Statement recommendations of cyproheptadine for children < 5 years of age and amitriptyline for those ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2018, 177(10):1435-1442]

Cited: 1 time

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Frequencies of poor metabolizer alleles of 12 pharmacogenomic actionable genes in Punjabi Sikhs of Indian Origin.

Dharambir K Sanghera, Cynthia Bejar, Bishwa Sapkota, Gurpreet S Wander, Sarju Ralhan,

Diversity in drug response is attributed to both genetic and non-genetic factors. However, there is paucity of pharmacogenetics information across ethnically and genetically diverse populations of India. Here, we have analyzed 21 SNPs from 12 pharmacogenomics genes in Punjabi Sikhs of Indian origin (N = 1,616), as part of the Sikh Diabetes ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):15742]

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