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Transplantation and Pregnancy

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Facial reanimation with interposition nerve graft or masseter nerve transfer: a comparative retrospective study.

Wen-Jin Wang, Wei-Dong Zhu, Mathias Tremp, Gang Chen, Zhao-Yan Wang, Hao Wu, Wei Wang,

Both interposition nerve grafts and masseter nerve transfers have been successfully used for facial reanimation after irreversible injuries to the cranial portion of the facial nerve. However, no comparative study of these two procedures has yet been reported. In this two-site, two-arm, retrospective case review study, 32 patients were included. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1125-1130]

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Uterus transplantation: the importance of uterine natural killer cells.

Aaron C K Lucander, Paige M Porrett,

<h4>Purpose of review</h4>Murine studies have established that uterine natural killer (uNK) cells are critical regulators of normal placentation and fetal development in mammals. However, the biology of uNK cells in humans remains poorly understood. This ignorance represents a costly knowledge gap, as disordered placentation is thought to underpin a variety ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):654-659]

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Cytological, Histochemical, and Ultrastructural Study of the Human Fetal Spleen of Various Gestational Age With Future Implications in Splenic Transplantation: An Anatomical Perspective

Arpan Haldar, Manisha Gaikwad, Apurba Patra, Soumya Chakraborty,

Purpose: The spleen is a fist-sized largest lymphoid organ located in the left hypochondrium. It has a unique location, embryological and histological structure that differs significantly from other lymphoid organs. The present work was undertaken to study the microscopic and ultramicroscopic histogenesis patterns of the spleen in relation to gestational ... Read more >>

Cureus (Cureus)
[0, 13(10):]

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Recurrent lupus nephritis in renal allograft triggered by pregnancy.

Takahiro Shinzato, Toshihiro Shimizu, Daiki Iwami, Noriyoshi Fukushima, Kenichi Tabata,

Herein we report the case of a 37-year-old woman with recurrence of lupus nephritis (LN) in a renal allograft during pregnancy. She had developed end-stage renal disease due to LN and was put on hemodialysis at the age of 26 years. She underwent kidney transplantation at the age 28 years. Maintenance immunosuppressants ... Read more >>

CEN Case Rep (CEN case reports)
[2021, :]

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Uterus transplantation: ethical considerations.

Briget da Graca, Liza Johannesson, Giuliano Testa, Anji Wall,

<h4>Purpose of review</h4>Uterus transplantation (Utx) offers women with absolute uterine factor infertility the opportunity to carry their own pregnancies. As Utx transitions from an experimental to standard clinical procedure, we review the status of the ethical issues applicable to the stakeholders involved.<h4>Recent findings</h4>With more than 65 Utx procedures reported to ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):664-668]

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Factors Affecting Time-Varying Clearance of Cyclosporine in Adult Renal Transplant Recipients: A Population Pharmacokinetic Perspective.

Junjun Mao, Xiaoyan Qiu, Weiwei Qin, Luyang Xu, Ming Zhang, Mingkang Zhong,

<h4>Aim</h4>The pharmacokinetic (PK) properties of cyclosporine (CsA) in renal transplant recipients are patient- and time-dependent. Knowledge of this time-related variability is necessary to maintain or achieve CsA target exposure. Here, we aimed to identify factors explaining variabilities in CsA PK properties and characterize time-varying clearance (CL/F) by performing a comprehensive ... Read more >>

Pharm Res (Pharmaceutical research)
[2021, :]

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The impact of chronic kidney disease Stages 3-5 on pregnancy outcomes.

Kate Wiles, Philip Webster, Paul T Seed, Katy Bennett-Richards, Kate Bramham, Nigel Brunskill, Sue Carr, Matt Hall, Rehan Khan, Catherine Nelson-Piercy, Louise M Webster, Lucy C Chappell, Liz Lightstone,

<h4>Background</h4>Contemporaneous data are required for women with chronic kidney disease (CKD) Stages 3-5 to inform pre-pregnancy counselling and institute appropriate antenatal surveillance.<h4>Methods</h4>A retrospective cohort study in women with CKD Stages 3-5 after 20 weeks' gestation was undertaken in six UK tertiary renal centres in the UK between 2003 and 2017. Factors ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2021, 36(11):2008-2017]

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Kidney graft function before pregnancy as a predictor of graft, maternal and fetal outcomes in pregnant renal transplant recipients.

Filipe S Mira, Joana Oliveira, Filipa Sousa, Dora Antunes, Ana Carolina Figueiredo, Andreia Borges, Maria S J Pais, Ana Galvão, Paulo Moura, Rui Alves,

<h4>Objectives</h4>Maternal and fetal complications can occur in pregnant kidney transplant recipients. Since these are high-risk pregnancies, they require a multidisciplinary follow-up to prematurely detect adverse events. Identifying factors that would affect fetal, maternal and graft outcomes is essential to further stratify the risk of pregnant kidney transplant recipients.<h4>Methods</h4>All pregnancies in ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2021, :]

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Maternal, Decidual, and Neonatal Lymphocyte Composition Is Affected in Pregnant Kidney Transplant Recipients.

Dorien Feyaerts, Joshua Gillard, Bram van Cranenbroek, Lina Rigodanzo Marins, Mariam M S Baghdady, Gaia Comitini, A Titia Lely, Henk W van Hamersvelt, Olivier W H van der Heijden, Irma Joosten, Renate G van der Molen,

Pregnancy after renal transplantation is associated with an increased risk of complications. While a delicately balanced uterine immune system is essential for a successful pregnancy, little is known about the uterine immune environment of pregnant kidney transplant recipients. Moreover, children born to kidney transplant recipients are exposed in utero to ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:735564]

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Risk constellations, viral infections, and prophylaxis in uterine transplantation.

Courtney E Harris, Nicolas C Issa,

<h4>Purpose of review</h4>Uterine transplantation (UTx) is a burgeoning new category of solid organ transplantation (SOT) that is practiced at several centers worldwide (first transplantation in 2013). Although there are still relatively low numbers of transplants (<75 published in literature), they are increasing in frequency and thus we attempt to discuss ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):646-653]

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Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice

Henni Hiltunen, Hila Hanani, Raakel Luoto, Sondra Turjeman, Oren Ziv, Erika Isolauri, Seppo Salminen, Omry Koren, Samuli Rautava,

Summary Preterm birth may result in adverse health outcomes. Very preterm infants typically exhibit postnatal growth restriction, metabolic disturbances, and exaggerated inflammatory responses. We investigated the differences in the meconium microbiota composition between very preterm (<32 weeks), moderately preterm (32–37 weeks), and term (>37 weeks) human neonates by 16S rRNA gene sequencing. Human ... Read more >>

Cell Rep Med (Cell reports. Medicine)
[2021, 2(11):]

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Perinatal Outcomes After Liver Transplantation – Is There A Role For Aspirin Treatment?

Gil Zeevi, Marius Braun, Eviatar Nesher, Arnon Wiznitzer, Eran Hadar, Alyssa Hochberg,

<h4>Purpose: </h4> To describe perinatal outcomes in liver transplanted women and evaluate the effect of low-dose aspirin treatment in these women. <h4>Methods: </h4>: An observational retrospective study examining perinatal outcomes among 10 liver transplant recipients, between 2016-2020 at a single university-affiliated tertiary medical center in Israel. Demographic, obstetric and clinical ... Read more >>

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Uterus transplantation worldwide: clinical activities and outcomes.

Mats Brännström, Michael A Belfort, Jean Marc Ayoubi,

<h4>Purpose of review</h4>Women with absolute uterine factor infertility, because of uterine absence, or the presence of a nonfunctional uterus, were regarded as being untreatable until 2014 when the first birth following uterus transplantation (UTx) took place in Sweden. This proof-of-concept occurred in a woman with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHs) with congenital ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):616-626]

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Association Between Blunted Glomerular Hyperfiltration in Pregnancy and Severe Maternal Morbidity-A Research Letter.

Ziv Harel, Alison L Park, Joel G Ray,

<h4>Background</h4>Glomerular hyperfiltration is one physiological adaptation to pregnancy, marked by a decline in serum creatinine (SCr) concentration by 16 weeks' gestation. It is not known whether blunted glomerular hyperfiltration leads to adverse maternal outcomes, including severe maternal morbidity (SMM).<h4>Objective</h4>To evaluate the association between blunted glomerular hyperfiltration and subsequent SMM or ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2021, 8:20543581211035221]

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Uterus Transplantation and the redefinition of core bioethics precepts.

Federica Umani Ronchi, Gabriele Napoletano,

To the Editor, The first uterus transplantation (UTx) to be successfully carried out in Italy occurred at the Transplant Center of the Policlinico di Catania, on 21st August 2020. The patient, a 30-year-old woman with absolute uterine factor infertility (AUFI) due to Rokitansky syndrome, is now set to undergo a ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2021, 92(5):e2021435]

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Unilateral Anophthalmic Socket Reconstruction With Dermis Fat Graft

Saba Alkhairy, Mahad M Baig, Usman A Pasha,

A 15-year-old girl presented with the complaint of a cosmetically disfigured right eye since birth. The initial assessment was carried out by way of a history and physical examination. The patient’s history revealed no significant findings. Physical examination revealed that the right ophthalmic socket was seemingly devoid of an identifiable globe ... Read more >>

Cureus (Cureus)
[0, 13(10):]

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Stem cell-based therapy for ameliorating intrauterine adhesion and endometrium injury.

Yu-Ting Song, Peng-Cheng Liu, Jie Tan, Chen-Yu Zou, Qian-Jin Li, Jesse Li-Ling, Hui-Qi Xie,

Intrauterine adhesion refers to endometrial repair disorders which are usually caused by uterine injury and may lead to a series of complications such as abnormal menstrual bleeding, recurrent abortion and secondary infertility. At present, therapeutic approaches to intrauterine adhesion are limited due to the lack of effective methods to promote ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2021, 12(1):556]

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Pregnancy in Chronic Liver Disease: Before and After Transplantation.

Amr Dokmak, Hirsh D Trivedi, Alan Bonder, Jacqueline Wolf,

Chronic liver disease poses various challenges for women of reproductive age. Cirrhosis, particularly if decompensated, and liver transplantation may impact gestation and perinatal outcomes. Tailored management of underlying liver disease is critical to optimize maternal and fetal wellbeing. Early education, timely intervention, close monitoring, and a multidisciplinary approach are key ... Read more >>

Ann Hepatol (Annals of hepatology)
[2021, :100557]

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Successful pregnancy and follow-up after in vitro fertilization of a kidney transplant patient with systemic lupus erythematosus, primary biliary cholangitis, and hypothyroidism.

Teresa Gastañaga-Holguera, Marta Calvo, Laura Gómez-Irwin, Isabel Campo Gesto, Virginia González-González, Marta Vidaurreta,

This report describes the case of a female kidney transplant patient with systemic lupus erythematosus, primary biliary cholangitis, and postsurgical hypothyroidism due to Grave's disease who had a healthy newborn after in vitro fertilization (IVF). Cases of successful pregnancy involving women who underwent IVF after kidney transplantation have been reported. ... Read more >>

JBRA Assist Reprod (JBRA assisted reproduction)
[2021, 25(4):657-660]

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MicroRNA-21-containing microvesicles from tubular epithelial cells promote cardiomyocyte hypertrophy.

Jia Di, Min Yang, Hua Zhou, Min Li, Jiabi Zhao,

<h4>Background</h4>Cardiomyocyte hypertrophy has been reported as one of the important mechanisms for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). MiroRNA-21(miR-21) was determined to play an important role in myocardial hypertrophy. However, the role of microvesicles (MVs) containing miR-21 in CKD-related cardiomyocyte hypertrophy remains largely unexplored.<h4>Methods</h4>Renal tubular epithelial ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):391-400]

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Mode of Obstetric Delivery in Kidney and Liver Transplant Recipients and Associated Maternal, Neonatal, and Graft Morbidity During 5 Decades of Clinical Practice.

Ophelia Yin, Aneesh Kallapur, Lisa Coscia, Lorna Kwan, Megha Tandel, Serb An Constantinescu, Michael J Moritz, Yalda Afshar,

<h4>Importance</h4>Rates of cesarean delivery (CD) are increased among transplant recipients. There is a need to define the indications for CD and associated outcomes among transplant recipients to determine the safest mode of obstetric delivery.<h4>Objective</h4>To evaluate the association of mode of obstetrical delivery with maternal and neonatal morbidity among pregnant women ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(10):e2127378]

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Use of bile acids as potential markers of liver dysfunction in humans : A systematic review

Samy A. Azer, Rana Hasanato,

Abstract <h4>Objective:</h4> This study aimed to determine the effectiveness of using total, individual serum, or urinary bile acids (BA) as potential markers of liver dysfunction. <h4>Methods:</h4> We searched the PubMed and Web of Science databases using the following keywords- “serum bile acids,” “liver dysfunction,” “liver injury,” “liver disease,” “traditional liver ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(41):]

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Pregnancy and pregnancy outcomes after hematopoietic stem cell transplantation in childhood: a cross-sectional survey of the EBMT Pediatric Diseases Working Party.

T Diesch-Furlanetto, A Rovó, J E Galimard, G Szinnai, A Dalissier, P Sedlacek, I Bodova, V K Roussou, B E Gibson, X Poiré, F Fagioli, H Pichler, M Faraci, F G Gumy-Pause, J H Dalle, A Balduzzi, P Bader, S Corbacioglu,

<h4>Study question</h4>What are the characteristics of patients with conceptions transplanted in childhood and adolescence?<h4>Summary answer</h4>Insemination and conception after hematopoietic stem cell transplantation (HCT) in childhood or adolescence was possible, even after myeloablative conditioning regimes, although some patients required reproductive medicine support.<h4>What is known already</h4>Preparative regimens of HCT are highly gonadotoxic, ... Read more >>

Hum Reprod (Human reproduction (Oxford, England))
[2021, 36(11):2871-2882]

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Assessment of Donor Liver Pathology Predicts Survival After Liver Transplantation: A Retrospective Cohort Study.

Yaruo Zhang, Shaojun Ye, Dongjing Liu, Weiyang He, Zibiao Zhong, Qifa Ye, Yan Xiong,

<h4>Background</h4>The aims of this study were to investigate the pathologic manifestation of pretransplant biopsy and to provide an accurate assessment method for liver graft of China Donation after Citizen's Death (CDCD).<h4>Methods</h4>A retrospective analysis was performed based on clinical and biopsy data of 96 CDCD liver transplantations completed between January 2012 ... Read more >>

Transplant Proc (Transplantation proceedings)
[2021, :]

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Human adipose-derived stromal cells transplantation prolongs reproductive lifespan on mouse models of mild and severe premature ovarian insufficiency.

Giulia Salvatore, Massimo De Felici, Susanna Dolci, Cosimo Tudisco, Rosella Cicconi, Luisa Campagnolo, Antonella Camaioni, Francesca Gioia Klinger,

<h4>Background</h4>Although recent studies have investigated the ability of Mesenchymal Stromal Cells (MSCs) to alleviate short-term ovarian damage in animal models of chemotherapy-induced Premature Ovarian Insufficiency (POI), no data are available on reproductive lifespan recovery, especially in a severe POI condition. For this reason, we investigated the potential of MSCs isolated ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2021, 12(1):537]

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