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Two new CRISPR-generated alleles in the C. elegans mir-1022 gene.

Connor Horn, Robert Sholl, Dustin Haskell, Shilpa Hebbar, Anna Zinovyeva,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Two Deletion Alleles in the C. elegans mir-49 gene.

Cassandra Delich, Annabelle Dillon, Noah Winans, Shilpa Hebbar, Dustin Haskell, Anna Zinovyeva,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Two novel alleles in C. elegans mir-1822 gene.

Marcy Anderson, Maddy Mash, Dustin Haskell, Shilpa Hebbar, Anna Zinovyeva,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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11C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls: a cross-sectional study.

Aline Morais de Souza, Milena Sales Pitombeira, Larissa Estessi de Souza, Fabio Luiz Navarro Marques, Carlos Alberto Buchpiguel, Caroline Cristiano Real, Daniele de Paula Faria,

<sup>11</sup>C-PK11195 is a positron emitter tracer used for Positron Emission Tomography (PET) imaging of innate immune cell activation in studies of neuroinflammatory diseases. For the image quantitative analysis, it is necessary to quantify the intact fraction of this tracer in the arterial plasma during imaging acquisition (plasma intact fraction). Due ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2494-2498]

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Application of Carbon Nanoparticle Tracers in the Lateral Neck Lymph Nodes of CN1bx Patients with Papillary Thyroid Carcinoma.

XiaoYu Qian, Jian Tang, Yongquan Chu, Liang Chen, Ziqiang Chen, Lin Li,

This study aimed to investigate the applicability of carbon nanoparticle tracers in the lateral neck lymph nodes of CN1bx patients with papillary thyroid carcinoma surgery. 73 patients with papillary thyroid carcinoma at our hospital between January 2019 to December 2019 were suspected metastasis in the lateral neck lymph node before ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(11):5408-5413]

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Positron emission tomography imaging for the assessment of mild traumatic brain injury and chronic traumatic encephalopathy: recent advances in radiotracers.

Chu-Xin Huang, Yan-Hui Li, Wei Lu, Si-Hong Huang, Meng-Jun Li, Li-Zhi Xiao, Jun Liu,

A chronic phase following repetitive mild traumatic brain injury can present as chronic traumatic encephalopathy in some cases, which requires a neuropathological examination to make a definitive diagnosis. Positron emission tomography (PET) is a molecular imaging modality that has high sensitivity for detecting even very small molecular changes, and can ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):74-81]

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Performance of Dual-tracer PET-CT for Staging Post–Liver Transplant Hepatocellular Carcinoma Recurrence

Kin-Pan Au, Wing-Chiu Dai, Albert Chi-Yan Chan, Tan-To Cheung, Chung-Mau Lo, Kenneth Siu-Ho Chok,

Background. Precise staging is essential in the management of patients with recurrent hepatocellular carcinoma (HCC) after liver transplantation. There is no current consensus on the optimal staging strategy. We conducted this study to evaluate the performance of dual-tracer positron emission tomography-computed tomography (PET-CT) for this purpose and to investigate whether ... Read more >>

Transplant Direct (Transplantation direct)
[2021, 7(10):]

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Identifying requirements for RSK2 specific inhibitors.

Eric B Wright, Shinji Fukuda, Mingzong Li, Yu Li, George A O'Doherty, Deborah A Lannigan,

Identifying isoform-specific inhibitors for closely related kinase family members remains a substantial challenge. The necessity for achieving this specificity is exemplified by the RSK family, downstream effectors of ERK1/2, which have divergent physiological effects. The natural product, SL0101, a flavonoid glycoside, binds specifically to RSK1/2 through a binding pocket generated ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1798-1809]

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Measuring Affinity of Ligands to the Oxytocin Receptor Using Radioligand Binding.

Eryn L Werry, Michael Kassiou,

Two aims of oxytocin receptor (OTR)-targeted drug discovery are development of selective OTR-binding PET tracers and development of brain-permeable selective OTR agonists. By allowing measurement of central OTR binding site occupancy after administration of intranasal oxytocin, OTR PET tracers inform an understanding of the conflicting effects on pro-social behaviors seen with administration ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2384:231-245]

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High-performance renal imaging with a radiolabeled, non-excretable chimeric fusion protein.

Dawei Jiang, Muhsin H Younis, Xiaoli Lan, Weibo Cai,

Ideal nuclear imaging tracers should exhibit high target uptake and low background signal. Traditional renal scintigraphy and SPECT scans examine kidney function <i>via</i> static or dynamic tracing of radioactive probes in the kidneys. The lack of tracer affinity to specific biological processes and high background uptake from urinary excretion have ... Read more >>

Theranostics (Theranostics)
[2021, 11(18):9177-9179]

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Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease.

Steven Y Yap, Barbara Frias, Melissa C Wren, Michael Schöll, Nick C Fox, Erik Årstad, Tammaryn Lashley, Kerstin Sander,

A next generation of tau PET tracers for the imaging of Alzheimer's disease and other dementias has recently been developed. Whilst the new compounds have now entered clinical studies, there is limited information available to assess their suitability for clinical applications. Head-to-head comparisons are urgently needed to understand differences in ... Read more >>

Brain (Brain : a journal of neurology)
[2021, 144(8):2284-2290]

Cited: 2 times

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Dissecting the Binding Profile of PET Tracers to Corticobasal Degeneration Tau Fibrils.

Yang Zhou, Junhao Li, Agneta Nordberg, Hans Ågren,

Alzheimer's disease and primary tauopathies are characterized by the presence of tau pathology in brain. Several tau positron emission tomography (PET) tracers have been developed and studied in Alzheimer's disease (AD), but there is still a lack of 4R-tau specific tracers for non-AD tauopathies. We here present the first computational ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2021, 12(18):3487-3496]

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Targeted design of a recombinant tracer for SPECT renal imaging.

Pan Liu, Steven E Johnson, Xinfang Xie, Li Gao, Chad R Haney, Ming Zhao, Jing Jin,

<b>Rationale:</b> A robust radiopharmaceutical has high uptake in the target and low retention in non-target tissues. However, traditional tracers for renal imaging that chemically chelate <sup>99m</sup>Tc are excreted through the renal route with transient resident time in the kidney. Following a rational design approach, we constructed a protein-based radiotracer, designated ... Read more >>

Theranostics (Theranostics)
[2021, 11(18):9118-9132]

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Synthesis and characterization of tracers and development of a fluorescence polarization immunoassay for amantadine with high sensitivity in chicken.

Liuchuan Guo, Meixuan Liu, Qiang Li, Baolei Dong, Hongfang Li, Ghulam Mujtaba Mari, Rui Liu, Wenbo Yu, Xuezhi Yu, Zhanhui Wang, Suxia Zhang, Jianzhong Shen, Kai Wen,

Fluorescence polarization immunoassay (FPIA) is a homogeneous and rapid analytical method that is suitable for high-throughput screening of large numbers of samples. However, FPIA typically suffers from lower sensitivity than the well-established enzyme-linked immunosorbent assay (ELISA), limiting its wide application as an analytical tool that can be run with trace ... Read more >>

J Food Sci (Journal of food science)
[2021, :]

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Prophage Tracer: precisely tracing prophages in prokaryotic genomes using overlapping split-read alignment.

Kaihao Tang, Weiquan Wang, Yamin Sun, Yiqing Zhou, Pengxia Wang, Yunxue Guo, Xiaoxue Wang,

The life cycle of temperate phages includes a lysogenic cycle stage when the phage integrates into the host genome and becomes a prophage. However, the identification of prophages that are highly divergent from known phages remains challenging. In this study, by taking advantage of the lysis-lysogeny switch of temperate phages, ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2021, :]

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The role of spatial embedding in mouse brain networks constructed from diffusion tractography and tracer injections.

Scott Trinkle, Sean Foxley, Gregg Wildenberg, Narayanan Kasthuri, Patrick La Rivière,

Diffusion MRI tractography is the only noninvasive method to measure the structural connectome in humans. However, recent validation studies have revealed limitations of modern tractography approaches, which lead to significant mistracking caused in part by local uncertainties in fiber orientations that accumulate to produce larger errors for longer streamlines. Characterizing ... Read more >>

Neuroimage (NeuroImage)
[2021, 244:118576]

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Molecular Imaging and the PD-L1 Pathway: From Bench to Clinic.

David Leung, Samuel Bonacorsi, Ralph Adam Smith, Wolfgang Weber, Wendy Hayes,

Programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors target the important molecular interplay between PD-1 and PD-L1, a key pathway contributing to immune evasion in the tumor microenvironment (TME). Long-term clinical benefit has been observed in patients receiving PD-(L)1 inhibitors, alone and in combination with other treatments, across ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:698425]

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Machine learning-based noninvasive quantification of single-imaging session dual-tracer 18F-FDG and 68Ga-DOTATATE dynamic PET-CT in oncology.

Wenxiang Ding, Jiangyuan Yu, Chaojie Zheng, Peng Fu, Qiu Huang, David Dagan Feng, Zhi Yang, Richard L Wahl, Yun Zhou,

68Ga-DOTATATE PET-CT is routinely used for imaging neuroendocrine tumor (NET) somatostatin receptor subtype 2 (SSTR2) density in patients, and is complementary to FDG PET-CT for improving the accuracy of NET detection, characterization, grading, staging, and predicting/monitoring NET responses to treatment. Performing sequential 18F-FDG and 68Ga-DOTATATE PET scans would require 2 ... Read more >>

IEEE Trans Med Imaging (IEEE transactions on medical imaging)
[2021, PP:]

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The Use of Water To Reduce Physiological Infra-Cardiac Tracer Uptake in Stress Myocardial Perfusion Imaging Using Single Photon Emission Computed Tomography: First Experience in Indonesia

Nora Anggun Prasetyo, Erwin Affandi Soeriadi, Hendra Budiawan, Achmad Hussein Sundawa Kartamihardja,

<h4>Background: </h4> Coronary artery disease (CAD) remains an important cause of morbidity and the main global cause of death. Myocardial perfusion imaging (MPI) used in diagnosing and evaluating in myocardial ischemia has been shown to be more cost effective and sensitive than other modalities. Milk is usually used to reduce ... Read more >>

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Intravitreal fluorogold tracing as a method to label retinal neurons and the retinal pigment epithelium.

Francisco Javier Valiente-Soriano, Fernando Lucas-Ruiz, Juan A Miralles de Imperial-Ollero, Manuel Vidal-Sanz, Marta Agudo-Barriuso,

Neural Regen Res (Neural regeneration research)
[2021, 16(10):2000-2001]

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Heat tracing in a fractured aquifer with injection of hot and cold water.

Richard Hoffmann, Jean-Christophe Maréchal, Adrien Selles, Alain Dassargues, Pascal Goderniaux,

Heat as a tracer in fractured porous aquifers is more sensitive to fracture-matrix processes than a solute tracer. Temperature evolution as a function of time can be used to differentiate fracture and matrix characteristics. Experimental hot (50 °C) and cold (10 °C) water injections were performed in a weathered and ... Read more >>

Ground Water (Ground water)
[2021, :]

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EANM recommendations based on systematic analysis of small animal radionuclide imaging in inflammatory musculoskeletal diseases.

Erik H J G Aarntzen, Edel Noriega-Álvarez, Vera Artiko, André H Dias, Olivier Gheysens, Andor W J M Glaudemans, Chiara Lauri, Giorgio Treglia, Tim van den Wyngaert, Fijs W B van Leeuwen, Samantha Y A Terry,

Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and adaptive immune responses. Understanding the pathogenesis of inflammatory musculoskeletal diseases is, to a large extent, derived from preclinical and basic research experiments. ... Read more >>

EJNMMI Res (EJNMMI research)
[2021, 11(1):85]

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Development of Discordant Hypermetabolic Prostate Cancer Lesions in the Course of [177Lu]PSMA Radioligand Therapy and Their Possible Influence on Patient Outcome.

Philipp E Hartrampf, Constantin Lapa, Sebastian E Serfling, Andreas K Buck, Anna Katharina Seitz, Philipp T Meyer, Juri Ruf, Kerstin Michalski,

<h4>Introduction</h4>Positron emission tomography/computer tomography (PET/CT) targeting the prostate-specific membrane antigen (PSMA) is crucial for the assessment of adequate PSMA expression in patients with metastatic castration-resistant prostate cancer (mCRPC) prior to PSMA radioligand therapy (PSMA RLT). Moreover, initial dual tracer staging using combined PSMA and [<sup>18</sup>F]fluorodeoxyglucose (FDG) PET/CT provides relevant information, ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(17):]

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Equivalent servings of free-range reindeer promote greater net protein balance compared to commercial beef.

Melynda S Coker, Scott E Schutzler, Sanghee Park, Rick H Williams, Arny A Ferrando, Nicolaas E P Deutz, Robert R Wolfe, Robert H Coker,

Wild game consumption has been associated with health benefits but the acute influence on human protein metabolism remains unknown. We compared feeding-induced responses of equivalent amounts of free-range reindeer (FR) and commercial beef (CB) on protein kinetics using stable isotope methodology. Seven participants (age: 40 ± 14 years; body mass index: 24 ± 3 kg/m<sup>2</sup>) ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1897222]

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A Direct Comparison of Afferents to the Rat Anterior Thalamic Nuclei and Nucleus Reuniens: Overlapping But Different.

Mathias L Mathiasen, Andrew J D Nelson, Eman Amin, Shane M O'Mara, John P Aggleton,

Both nucleus reuniens and the anterior thalamic nuclei are densely interconnected with medial cortical and hippocampal areas, connections that reflect their respective contributions to learning and memory. To better appreciate their comparative roles, pairs of different retrograde tracers were placed in these two thalamic sites in adult rats. Both thalamic ... Read more >>

eNeuro (eNeuro)
[2021, 8(5):]

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