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Toxic Nutritional Optic Neuropathy

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Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory.

Tigran Makunts, Sama Alpatty, Kelly C Lee, Rabia S Atayee, Ruben Abagyan,

Proton-pump inhibitors, PPIs, are considered effective therapy for stomach acid suppression due to their irreversible inhibition of the hydrogen/potassium pump in the gastric parietal cells. They are widely prescribed and are considered safe for over-the-counter use. Recent studies have shown an association between PPI use and Alzheimer dementia, while others ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):17280]

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Adverse drug reaction prevalence and mechanisms of action of first-line anti-tubercular drugs.

Faisal Imam, Manju Sharma, Khalid Umer Khayyam, Naif O Al-Harbi, Mohd Khan Rashid, Mohammad Daud Ali, Ayaz Ahmad, Wajhul Qamar,

Purpose:Understanding the appearance of anti-tubercular drug-related adverse drug reactions (ADRs) in patients receiving tuberculosis (TB) treatment is important, and may be related to morbidity and mortality if not recognized early. Here, we aimed to characterize the mechanisms underlying adverse drug reactions due to combination anti-tuberculosis therapy of the Revised National ... Read more >>

Saudi Pharm J (Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society)
[2020, 28(3):316-324]

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Tobacco-Alcohol Toxic Optic Neuropathy.

Farah Sunnar Constantin, Monica Irina Ion, Andrei Erol Constantin,

Purpose. To present the case of a 34-year-old man with sudden bilateral decrease of visual acuity, followed by a complete and fast recovery. Material and methods. We reported a case of an apparently healthy 34-year-old patient with sudden and unpainful decrease of visual acuity, presumed of toxic etiology. The patient ... Read more >>

Rom J Ophthalmol (Romanian journal of ophthalmology)
[2019, 63(4):403-405]

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Drug-Resistant Tuberculosis and HIV Infection: Current Perspectives.

Abhijeet Singh, Rajendra Prasad, Viswesvaran Balasubramanian, Nikhil Gupta,

Drug-resistant tuberculosis (DR-TB), including multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB), is considered a potential obstacle for elimination of TB globally. HIV coinfection with M/XDR-TB further complicates the scenario, and is a potential threat with challenging management. Reports have shown poor outcomes and alarmingly high mortality rates among people ... Read more >>

HIV AIDS (Auckl) (HIV/AIDS (Auckland, N.Z.))
[2020, 12:9-31]

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Toxic-Metabolic and Hereditary Optic Neuropathies.

Cristiano Oliveira,

PURPOSE OF REVIEW:The diagnosis of visual loss from toxic-metabolic and hereditary optic neuropathies may be delayed in some cases because of a failure to elicit important information in the clinical history or to recognize typical examination findings. An understanding of the features specific to each type of toxic-metabolic and hereditary ... Read more >>

Continuum (Minneap Minn) (Continuum (Minneapolis, Minn.))
[2019, 25(5):1265-1288]

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Checklists to guide the supportive and critical care of tuberculous meningitis.

Joseph Donovan, Ursula K Rohlwink, Elizabeth W Tucker, Nguyen Thi Thu Hiep, Guy E Thwaites, Anthony A Figaji, ,

The assessment and management of tuberculous meningitis (TBM) is often complex, yet no standardised approach exists, and evidence for the clinical care of patients, including those with critical illness, is limited. The roles of proformas and checklists are increasing in medicine; proformas provide a framework for a thorough approach to ... Read more >>

Wellcome Open Res (Wellcome open research)
[2019, 4:163]

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The Role of Autophagy in Glaucomatous Optic Neuropathy.

Annagrazia Adornetto, Vincenzo Parisi, Luigi Antonio Morrone, Maria Tiziana Corasaniti, Giacinto Bagetta, Paolo Tonin, Rossella Russo,

Autophagy is a conserved lysosomal-dependent pathway responsible for the degradation of cytoplasmic macromolecules. Based on the mechanism of cargo delivery to lysosomes, mammalian cells can undergo micro, macro, and chaperone-mediated autophagy. Other than physiological turnover of proteins and organelles, autophagy regulates cellular adaptation to different metabolic states and stressful conditions ... Read more >>

Front Cell Dev Biol (Frontiers in Cell and Developmental Biology)
[2020, 8:121]

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Bilateral Optic Disc Edema in a Patient with Lead Poisoning.

Kaveh Abri Aghdam, Amin Zand, Mostafa Soltan Sanjari,

Purpose:Heavy metals, such as lead can cause optic neuropathy. Optic disc neuropathy due to lead intoxication has previously been reported. We report a rare case of lead toxicity-induced optic neuropathy presenting with bilateral hemorrhagic optic disc swelling. Case Report:The patient was a 42-year-old man with a history of chronic oral ... Read more >>

J Ophthalmic Vis Res (Journal of ophthalmic & vision research)
[2019, 14(4):513-517]

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Normal Pressure Glaucoma: The Challenge in Asia and the Scientific Contributions from Asia.

Dennis S C Lam, Clement C Y Tham, Robert Ritch,

Asia Pac J Ophthalmol (Phila) (Asia-Pacific journal of ophthalmology (Philadelphia, Pa.))
[2019, 8(6):419-421]

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Illicit drugs: Effects on eye.

Deepika Dhingra, Savleen Kaur, Jagat Ram,

There is a myriad of changes that can be produced in the eye by toxic drugs ranging from mild/no symptoms to severe loss of vision from endophthalmitis. The routes of administration include oral ingestion, smoking, nasal inhalation, intravenous injection, topical application or application to other mucosal surfaces. It is important ... Read more >>

Indian J. Med. Res. (The Indian journal of medical research)
[2019, 150(3):228-238]

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Long segment 3D double inversion recovery (DIR) hypersignal on MRI in glaucomatous optic neuropathy.

Thomas Sartoretti, Jörg Stürmer, Elisabeth Sartoretti, Arash Najafi, Árpád Schwenk, Michael Wyss, Christoph Binkert, Sabine Sartoretti-Schefer,

BACKGROUND:In this retrospective study the relationship between intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness and pathologic hypersignal in optic nerve segments on 3D double inversion recovery (DIR) MR sequence in 21 patients with proven glaucoma of different origin was evaluated. METHODS:All patients were examined on a 3 T MR ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2019, 19(1):258]

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Thiamine (vitamin B1) in septic shock: a targeted therapy.

Ari Moskowitz, Michael W Donnino,

Thiamine (vitamin B1) is a water-soluble vitamin essential for human health. Thiamine deficiency is causal and/or contributory in a number of debilitating diseases including beri-beri, the Wernicke-Korsakoff syndrome, optic neuropathy, and others. While thiamine deficiency is relatively rare in developed nations as a result of dietary supplementation, thiamine deficiency is ... Read more >>

J Thorac Dis (Journal of thoracic disease)
[2020, 12(Suppl 1):S78-S83]

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Tacrolimus-Induced Optic Neuropathy After Multivisceral Transplantation.

Emilio Canovai, Catherine Cassiman, Laurens J Ceulemans, Philippe Demaerel, Mauricio Sainz-Barriga, Ina Jochmans, Diethard Monbaliu, Jacques Pirenne, Tim Vanuytsel,

Transplant Direct (Transplantation Direct)
[2020, 6(1):e516]

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Stage IV Small Lymphocytic Lymphoma Presenting with Unilateral Vision Loss.

Christopher Le, Adam Jacob, Devarajan Iyengar, John Dedousis, Antonios Tsompanidis,

Small lymphocytic lymphoma (SLL) is a manifestation of chronic lymphocytic leukemia (CLL) in which malignant B-cell lymphocytes accumulate in the lymph nodes or bone marrow. In this report, we describe the medical course of a patient diagnosed with stage IV small cell lymphocytic lymphoma, who presented to the emergency room ... Read more >>

Case Rep Oncol Med (Case reports in oncological medicine)
[2020, 2020:3752409]

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Therapeutic Strategies for Attenuation of Retinal Ganglion Cell Injury in Optic Neuropathies: Concepts in Translational Research and Therapeutic Implications.

Lin Fu, Sum Sum Kwok, Yau Kei Chan, Jimmy Shiu Ming Lai, Weihua Pan, Li Nie, Kendrick Co Shih,

Retinal ganglion cell (RGC) death is the central and irreversible endpoint of optic neuropathies. Current management of optic neuropathies and glaucoma focuses on intraocular pressure-lowering treatment which is insufficient. As such, patients are effectively condemned to irreversible visual impairment. This review summarizes experimental treatments targeting RGCs over the last decade. ... Read more >>

Biomed Res Int (BioMed research international)
[2019, 2019:8397521]

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Extracting Clinical Features From Dictated Ambulatory Consult Notes Using a Commercially Available Natural Language Processing Tool: Pilot, Retrospective, Cross-Sectional Validation Study.

Jeremy Petch, Jane Batt, Joshua Murray, Muhammad Mamdani,

BACKGROUND:The increasing adoption of electronic health records (EHRs) in clinical practice holds the promise of improving care and advancing research by serving as a rich source of data, but most EHRs allow clinicians to enter data in a text format without much structure. Natural language processing (NLP) may reduce reliance ... Read more >>

JMIR Med Inform (JMIR medical informatics)
[2019, 7(4):e12575]

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Pattern Visually Evoked Potentials in Japanese Girl With Optic Neuritis and Seropositive to Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibody.

Shunichiro Takano, Aya Hanabusa, Yuji Yoshikawa, Kaori Sassa, Airi Shimura, Takuhei Shoji, Hisao Ohde, Kei Shinoda, Hideo Yamanouchi,

Purpose: To describe a Japanese girl with unilateral optic neuritis who was seropositive for the anti-myelin-oligodendrocyte glycoprotein (MOG). Serial recordings of the pattern visual evoked potentials (pVEPs) were made to follow the dynamic changes of the disease activity. Observations: A 5-year-old girl developed a sudden reduction of vision and deep ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:1339]

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Caecocentral Scotoma: A Rare Presentation of Optic Perineuritis.

Shahidatul-Adha Mohamad, Embong Zunaina, Wan-Hazabbah Wan Hitam,

Optic perineuritis (OPN) is a subtype of optic neuritis (ON) in which the inflammatory process involves meningeal sheath surrounding the optic nerve. Clinically, OPN simulates ON. However, in contrast to ON, patient with OPN shows sparing of central vision, improves dramatically with high-dose corticosteroid, are more likely to experience recurrence after ... Read more >>

Cureus (Cureus)
[2019, 11(11):e6101]

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Bilateral primary optic neuropathy as the presenting manifestation of tuberculosis in an immunocompetent patient.

Santhosh Narayanan, Divya Prakash, Gomathy Subramaniam,

Vision impairment is one of the devastating complications of central nervous system tuberculosis (CNS TB). Optic atrophy is a sequelae of various forms of CNS TB which, ultimately, is responsible for vision impairment. It is usually the secondary optic atrophy which occurs in CNS TB. In this case report, we ... Read more >>

IDCases (IDCases)
[2019, 18:e00579]

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Leber's Hereditary Optic Neuropathy as a Promising Disease for Gene Therapy Development.

Cuneyt Karaarslan,

Leber's hereditary optic neuropathy (LHON) is a relatively common, rapidly progressing inherited optic neuropathy wherein LHON-affected eyes undergo optic nerve atrophy due to retinal ganglion cell (RGC) loss. It is a maternally inherited (or sporadic) mitochondrial disorder caused primarily by mutations in genes that encode components of respiratory complex (RC)1 ... Read more >>

Adv Ther (Advances in therapy)
[2019, 36(12):3299-3307]

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Optic Neuropathy, Secondary to Ethmoiditis, and Onodi Cell Inflammation during Childhood: A Case Report and Review of the Literature.

Marina Mazzurco, Piero Pavone, Milena Di Luca, Pierluigi Smilari, Elena Pustorino, Agata Fiumara, Paola Di Mauro, Filippo Greco, Salvatore Cocuzza,

Optic neuropathy consists of several etiological events. The primary etiologies of its acute form include optic neuritis, ischemic optic neuropathy, inflammatory (nondemyelinating) disorders, and trauma. Its subacute and chronic forms are most often linked to compressive, toxic, nutritional, or hereditary-genetic causes. Visual loss, dyschromatopsia, and visual field defects are the ... Read more >>

Neuropediatrics (Neuropediatrics)
[2019, 50(6):341-345]

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Species Differences in the Nutrition of Retinal Ganglion Cells among Mammals Frequently Used as Animal Models.

Christian Albrecht May,

The diffusion rate for proper nutrition of the inner retina depends mainly on four factors which are discussed in this review: 1. The diffusion distance between blood and retinal ganglion cells shows morphological variants in different mammalian species, namely a choroidal nutrition type, a retinal nutrition type, and a mixture ... Read more >>

Cells (Cells)
[2019, 8(10):]

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Neuroprotein Targets of γ-Diketone Metabolites of Aliphatic and Aromatic Solvents That Induce Central-Peripheral Axonopathy.

Peter S Spencer,

Peripheral neuropathy associated with chronic occupational and deliberate overexposure to neurotoxic organic solvents results from axonal degeneration in the central and peripheral nervous system. Human and experimental studies show that axonopathy is triggered by the action of neuroprotein-reactive γ-diketone metabolites formed from exposure to certain aliphatic solvents (n-hexane, 2-hexanone) and ... Read more >>

Toxicol Pathol (Toxicologic pathology)
[2020, 48(3):411-421]

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Treatment and Outcomes in Nutritional Optic Neuropathy.

Joanna M Jefferis, Simon J Hickman,

PURPOSE OF REVIEW:Nutritional optic neuropathy is a potential cause of severe visual loss; however, appropriate and timely management can result in excellent visual outcomes. The purpose of this review is to outline our current understanding of the treatment and outcomes for nutritional optic neuropathy. RECENT FINDINGS:Current understanding of nutritional optic ... Read more >>

Curr Treat Options Neurol (Current treatment options in neurology)
[2019, 21(1):5]

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Incidence of blindness in a population of rheumatic patients treated with hydroxychloroquine.

Dilpreet K Singh, Leila Muhieddine, Douglas Einstadter, Stanley Ballou,

Objective:Long-term HCQ use for the treatment of rheumatic diseases has been associated with retinopathy in a daily and cumulative dose-dependent manner by weight. We examined the incidence of ocular toxicity in a large population of patients treated with HCQ for inflammatory arthritis and SLE and followed long term in a ... Read more >>

Rheumatol Adv Pract (Rheumatology advances in practice)
[2019, 3(1):rkz009]

Cited: 2 times

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