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Toxic Neuropathy

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Ocular toxicity of intravitreal Golimumab in a rabbit model.

Ceren Durmaz Engin, Serap Cilaker Miçili, Osman Yilmaz, Hüsnü Alper Bağriyanik, Bekir Uğur Ergür, Fatoş Önen, Ali Osman Saatci,

AIM:To investigate the effect of intravitreal golimumab on rabbit retina histopathology. METHODS:Sixteen albino New Zealand rabbits were divided into three groups. The right eye of each rabbit in groups I, II, and III received a single intravitreal injection of 5 mg/0.05 ml (6 eyes), 10 mg/0.1 ml (6 eyes) or ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Treatment Outcomes after Discontinuation of Ethambutol due to Adverse Events in Mycobacterium avium Complex Lung Disease.

Yong Shik Kwon, Byoung Soo Kwon, Ock Hwa Kim, Yea Eun Park, Tae Sun Shim, Yong Pil Chong, Kyung Wook Jo,

BACKGROUND:Long-term administration of ethambutol (EMB) for Mycobacterium avium complex lung disease (MAC-LD) sometimes leads to permanent discontinuation of EMB due to various adverse events. This study aimed to investigate treatment outcomes after discontinuation of EMB. METHODS:Among patients diagnosed with MAC-LD between January 2001 and December 2014, 508 patients whose treatment ... Read more >>

J. Korean Med. Sci. (Journal of Korean medical science)
[2020, 35(9):e59]

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A systematic review of therapeutic regimens for older patients with newly diagnosed Hodgkin lymphoma.

Pamela B Allen, Amy Ayers, Madhusmita Behera, Andrew M Evens, Christopher Flowers,

Classical Hodgkin lymphoma (cHL) in older adults is associated with inferior outcomes and increased toxicity compared to younger patients. Novel therapies like brentuximab vedotin (BV) have yielded promising results, yet their optimal use in older cHL remains unclear. We performed a systematic review to assess outcomes and toxicity associated with ... Read more >>

Leuk. Lymphoma (Leukemia & lymphoma)
[2020, :1-10]

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Dose Adjustment of Oxaliplatin Based on Renal Function in Patients With Metastatic Colorectal Cancer.

Daichi Watanabe, Hironori Fujii, Nobuhisa Matsuhashi, Hirotoshi Iihara, Yunami Yamada, Takuma Ishihara, Takao Takahashi, Kazuhiro Yoshida, Akio Suzuki,

BACKGROUND/AIM:The effect of renal dysfunction on the toxicity and efficacy of oxaliplatin remains unclear. We investigated the association between creatinine clearance (Ccr), a marker of renal function, and the toxicity and efficacy of oxaliplatin in patients with metastatic colorectal cancer (mCRC). PATIENTS AND METHODS:Patients with mCRC who received oxaliplatin-based chemotherapy ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(4):2379-2386]

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Acquired long QT syndrome in chronic kidney disease patients.

Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li,

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):54-65]

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Patterns of Anthracycline-Based Chemotherapy-Induced Adverse Drug Reactions and Their Impact on Relative Dose Intensity among Women with Breast Cancer in Ethiopia: A Prospective Observational Study.

Diriba Alemayehu Gadisa, Mathewos Assefa, Gosaye Mekonen Tefera, Getnet Yimer,

Background:The breast cancer chemotherapy leads to diverse aspects of noxious or unintended adverse drug reactions (ADRs) that cause the relative dose intensity (RDI) reduced to below optimal (i.e., if the percentage of actual dose received per unit time divided by planned dose per unit time is less than 85%). Hence, ... Read more >>

J Oncol (Journal of oncology)
[2020, 2020:2636514]

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TOXICITY AND EFFICACY OF INTRAVITREAL MELPHALAN FOR RETINOBLASTOMA: 25 µg Versus 30 µg.

Albert Liao, Terry Hsieh, Jasmine H Francis, Jessica A Lavery, Audrey Mauguen, Scott E Brodie, David H Abramson,

PURPOSE:To compare retinal toxicity as measured by electroretinogram, ocular, and patient survival in retinoblastoma treated with intravitreal melphalan at two concentrations (25 vs. 30 µg). METHODS:Single-center, retrospective analysis of retinoblastoma eyes receiving 25-µg or 30-µg intravitreal melphalan from September 2012 to January 2019. Ocular toxicity was measured by electroretinogram of ... Read more >>

Retina (Philadelphia, Pa.) (Retina (Philadelphia, Pa.))
[2020, :]

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Higher proteotoxic stress rather than mitochondrial damage is involved in higher neurotoxicity of bortezomib compared to carfilzomib.

Ayse Tarbin Jannuzzi, Sema Arslan, Ayse Mine Yilmaz, Gulce Sari, Hande Beklen, Lucía Méndez, Maria Fedorova, Kazim Yalcin Arga, Betul Karademir Yilmaz, Buket Alpertunga,

Proteasome inhibitors have great success for their therapeutic potential against hematologic malignancies. First generation proteasome inhibitor bortezomib induced peripheral neuropathy is considered as a limiting factor in chemotherapy and its second-generation counterpart carfilzomib is associated with lower rates of neurotoxicity. The mitochondrial toxicity (mitotoxicity) hypothesis arises from studies with animal ... Read more >>

Redox Biol (Redox biology)
[2020, 32:101502]

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Prostate-specific Membrane Antigen Based Antibody-drug Conjugates for Metastatic Castration-resistance Prostate Cancer.

Muhammad O Niaz, Michael Sun, Marigdalia K Ramirez-Fort, Muhammad J Niaz,

Cancer cells can be selectively targeted by identifying and developing antibodies to specific antigens present on the cancer cell surface. Cytotoxic agents can be conjugated to these antibodies that bind to these cell surface antigens in order to significantly increase the therapeutic index of whichever cytotoxic agent is utilized. This ... Read more >>

Cureus (Cureus)
[2020, 12(2):]

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Enolate-forming compounds provide protection from platinum neurotoxicity.

Brian C Geohagen, Daniel A Weiser, David M Loeb, Lars U Nordstroem, Richard M LoPachin,

Cisplatin (CisPt) and other platinum (Pt)-based antineoplastic drugs (e.g., carboplatin, oxaliplatin) are highly effective and widely used in the treatment of solid tumors in both pediatric and adult patients. Although considered to be life-saving as a cancer treatment, Pt-based drugs frequently result in dose-limiting toxicities such as chemotherapy-induced peripheral neuropathies ... Read more >>

Chem. Biol. Interact. (Chemico-biological interactions)
[2020, 317:108961]

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The Safety of a Therapeutic Product Composed of a Combination of Stem Cell Released Molecules from Adipose Mesenchymal Stem Cells and Fibroblasts

Greg Maguire, Peter Friedman,

Abstract Stem cell transplants have demonstrated life-saving capabilities for some blood diseases, and the molecules and exosomes released from stem cells are currently in therapeutic development for a number of diseases and conditions, including neurodegenerative diseases, heart conditions, glaucoma, hearing loss, and skin diseases. Stem cell science is a relatively ... Read more >>

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Prediction of the Development of Severe Sepsis Among Children With Intestinal Failure and Fever Presenting to the Emergency Department.

Matthew Eisenberg, Mark Puder, Joel Hudgins,

OBJECTIVES:Children with intestinal failure (IF) and fever are frequently bacteremic, but risk factors for development of sepsis in this population are not well delineated. Our objective was to determine what clinical factors available on arrival to the emergency department (ED), including commonly used vital sign thresholds, predicted the subsequent development ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2020, :]

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Treatment Considerations for Patients with Unresectable Metastatic Melanoma Who Develop Pembrolizumab-Induced Guillain-Barré Toxicity: A Case Report.

Sivraj Muralikrishnan, Lara K Ronan, Shodeinde Coker, Paula K Rauschkolb, Keisuke Shirai,

Immunotherapy has improved outcomes in many malignancies, most notably in melanoma, lung cancer, and bladder cancer. Understanding the side effects associated with these medications is an important part of managing our patients. Although fatigue, rash, and diarrhea are commonly reported side effects, it is important to be cognizant of rarer ... Read more >>

Case Rep Oncol (Case reports in oncology)
[2020, 13(1):43-48]

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Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.

Francesca Conradie, Andreas H Diacon, Nosipho Ngubane, Pauline Howell, Daniel Everitt, Angela M Crook, Carl M Mendel, Erica Egizi, Joanna Moreira, Juliano Timm, Timothy D McHugh, Genevieve H Wills, Anna Bateson, Robert Hunt, Christo Van Niekerk, Mengchun Li, Morounfolu Olugbosi, Melvin Spigelman, ,

BACKGROUND:Patients with highly drug-resistant forms of tuberculosis have limited treatment options and historically have had poor outcomes. METHODS:In an open-label, single-group study in which follow-up is ongoing at three South African sites, we investigated treatment with three oral drugs - bedaquiline, pretomanid, and linezolid - that have bactericidal activity against ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2020, 382(10):893-902]

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Left ventricular ejection fraction decrease related to BRAF and/or MEK inhibitors in metastatic melanoma patients: A retrospective analysis.

Mathilde Berger, Mona Amini-Adlé, Delphine Maucort-Boulch, Philip Robinson, Luc Thomas, Stéphane Dalle, Pierre-Yves Courand,

BRAF and MEKis have revolutionized the management of BRAFV600 -mutated melanoma patients. Left ventricular ejection fraction decrease (LVEF-D) related to these treatments has not been thoroughly evaluated to date. The main objective of this study was to describe characteristics of LVEF-D in melanoma patients treated with BRAF and/or MEKis. Metastatic ... Read more >>

Cancer Med (Cancer medicine)
[2020, :]

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Intravitreal Steroid Treatment for Uveitis Associated with Dabrafenib and Trametinib for Metastatic Cutaneous Melanoma.

Nora Woltsche, Michael Andreas Kruger, Martin Weger, Ingrid Hildegard Wolf, Gerald Seidel,

Purpose: To report a case of bilateral retinal inflammation under long-term therapy with dabrafenib/trametinib for metastatic cutaneous melanoma.Methods: Retrospective chart review.Results: A 59-year-old patient with metastatic cutaneous melanoma diagnosed in 2004 under treatment with dabrafenib/trametinib since 2014 presented to our department with intraretinal hemorrhage and extrafoveal macula edema on the ... Read more >>

Ocul. Immunol. Inflamm. (Ocular immunology and inflammation)
[2020, :1-3]

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The "wing-heeled" traveler.

Taylor Kain, Jordan Weinstein, Aaron Thompson, Andrea K Boggild,

Intoxication syndromes may be travel acquired, and are related to intentional or accidental inhalational or percutaneous exposures or ingestions. Due to their myriad clinical presentations, initial differential diagnosis of such intoxications in returned travelers is broad, and typically requires detailed history and laboratory investigations to disentangle. We herein use a ... Read more >>

Trop Dis Travel Med Vaccines (Tropical diseases, travel medicine and vaccines)
[2020, 6:2]

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Toxic Optic Neuropathy From Quinine Overdose.

Paul R Freund, Tom Wright, Edward A Margolin,

A 45-year-old man presented with longstanding poor vision in both eyes. His medical history was significant for a remote overdose of quinine. After the ingestion, he fell into a coma and on awakening was not able to see light out of both eyes. Several days later, his central vision began ... Read more >>

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2019, :]

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Consolidation with carfilzomib, lenalidomide, and dexamethasone (KRd) following ASCT results in high rates of minimal residual disease negativity and improves bone metabolism, in the absence of bisphosphonates, among newly diagnosed patients with multiple myeloma.

Maria Gavriatopoulou, Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Panagiotis Malandrakis, Evangelos Eleutherakis-Papaiakovou, Athanasios Papatheodorou, Nikolaos Kanellias, Magdalini Migkou, Despina Fotiou, Ioanna Dialoupi, Maria Roussou, Nikoletta-Aikaterini Kokkali, Efstathios Kastritis, Meletios A Dimopoulos,

Blood Cancer J (Blood cancer journal)
[2020, 10(3):25]

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Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy.

Shinji Kobuchi, Risa Shimizu, And Yukako Ito,

Oxaliplatin (L-OHP) is widely prescribed for treating gastroenterological cancer. L-OHP-induced peripheral neuropathy is a critical toxic effect that limits the dosage of L-OHP. An ideal chemotherapeutic strategy that does not result in severe peripheral neuropathy but confers high anticancer efficacy has not been established. To establish an optimal evidence-based dosing ... Read more >>

Pharmaceutics (Pharmaceutics)
[2020, 12(2):]

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[Diagnostics of polyneuropathies].

D Heuß,

The diagnosis of polyneuropathy (PNP) is based on the anamnesis and description of complaints of the patient and clinical findings. The type of distribution as well as known diseases and drug toxic factors can provide indications. Electromyography and electroneurography can be used to differentiate between axonal and demyelinating PNP. The ... Read more >>

Internist (Berl) (Der Internist)
[2020, 61(3):235-242]

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Ocular Hypotonia and Transient Decrease of Vision as a Consequence of Exposure to a Common Toad Poison.

Renato Pejic, Marija Simic Prskalo, Josip Simic,

The common toad produces venom (bufotoxin) that is produced in the parotid gland of the toad as well as in the skin. This toxic compound is a potent inhibitor of Na+/K+-ATPase activity. Physiological effects of bufotoxin are similar to those of digitalis and cause increased heart rate and muscle contractions. ... Read more >>

Case Rep Ophthalmol Med (Case reports in ophthalmological medicine)
[2020, 2020:2983947]

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Management of immune checkpoint inhibitor-related adverse events: A review of case reports.

Xiaoyan Si, Peng Song, Jun Ni, Mingyi Di, Chunxia He, Li Zhang, Xiaowei Liu, Yue Li, Hanping Wang, Xiaoxiao Guo, Jiaxin Zhou, Lian Duan, Xu Yang, Mengzhao Wang, Li Zhang,

Immune checkpoint inhibitors represent a major breakthrough in cancer therapy. Immune-related adverse events (irAEs) may occur during treatment due to their unique mechanism of action. Management of irAEs is based on clinical experience because it is not easy to conduct prospective trials to evaluate the best treatment strategy. Using a ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, 11(3):498-504]

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Medical management of acute loss of vision in tuberculous meningitis: A case report.

Maryam Amour, Sarah Shali Matuja, Jerome H Chin,

Blindness and vision impairment are unpredictable complications of tuberculous meningitis (TBM) that are often unrecognized in the acute stages of illness due to inability to assess vision in patients with depressed levels of consciousness or confusion. We present a patient with definite TBM confirmed by positive Xpert MTB/RIF assay of ... Read more >>

J Clin Tuberc Other Mycobact Dis (Journal of clinical tuberculosis and other mycobacterial diseases)
[2020, 19:100145]

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Adverse drug reaction prevalence and mechanisms of action of first-line anti-tubercular drugs.

Faisal Imam, Manju Sharma, Khalid Umer Khayyam, Naif O Al-Harbi, Mohd Khan Rashid, Mohammad Daud Ali, Ayaz Ahmad, Wajhul Qamar,

Purpose:Understanding the appearance of anti-tubercular drug-related adverse drug reactions (ADRs) in patients receiving tuberculosis (TB) treatment is important, and may be related to morbidity and mortality if not recognized early. Here, we aimed to characterize the mechanisms underlying adverse drug reactions due to combination anti-tuberculosis therapy of the Revised National ... Read more >>

Saudi Pharm J (Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society)
[2020, 28(3):316-324]

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