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Thromboembolism

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Direct oral anticoagulants for thromboprophylaxis in ambulatory patients with cancer.

Yiwei Wang, Maoyun Wang, Yuenan Ni, Zongan Liang,

Background: Venous thromboembolism (VTE) is a common complication in cancer patients. We aim to evaluate the effect and safety of direct oral anticoagulants (DOACs) as primary prophylaxis in ambulatory cancer patients.Methods: We conducted a literature search in PubMed, EMBASE and ClinicalTrials for studies that evaluated DOACs for thromboprophylaxis in cancer ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):63-70]

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Lamiaceae in the treatment of cardiovascular diseases.

Francesca Patrignani, Sahdeo Prasad, Miroslav Novakovic, Petar D Marin, Danka Bukvicki,

Lamiaceae (Labiatae) are an important group of medicinal plants, which have been used for treating heart disease in traditional medicine for centuries. These mainly aromatic plants are used as essential oils, extracts or isolated components (polyphenols, phenolic compounds, terpenes, iridoids etc.). Some Labiatae species (more than 30, such as cornmint, ... Read more >>

Front Biosci (Landmark Ed) (Frontiers in bioscience (Landmark edition))
[2021, 26:612-643]

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Higher Intensity Thromboprophylaxis Regimens and Pulmonary Embolism in Critically Ill Coronavirus Disease 2019 Patients.

Fabio Silvio Taccone, Pierre Alain Gevenois, Lorenzo Peluso, Zoe Pletchette, Olivier Lheureux, Alexandre Brasseur, Alessandra Garufi, Marta Talamonti, Serge Motte, Leda Nobile, David Grimaldi, Jacques Creteur, Jean-Louis Vincent,

OBJECTIVES:To assess the role of thromboprophylaxis regimens on the occurrence of pulmonary embolism in coronavirus disease 2019 patients. DESIGN:Retrospective analysis of prospectively collected data on coronavirus disease 2019 patients, included between March 10, and April 30, 2020. SETTING:ICU of an University Hospital in Belgium. PATIENTS AND INTERVENTIONS:Critically ill adult mechanically ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(11):e1087-e1090]

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Use of clinical probability scores and D-dimer in suspected pulmonary embolism. Results from a Spanish retrospective study.

Antonio Jesús Láinez-Ramos-Bossini, Sara Moreno-Suárez, María Del Carmen Pérez-García, Regina Gálvez-López, Francisco Garrido-Sanz, Mario Rivera-Izquierdo,

Eur J Emerg Med (European journal of emergency medicine : official journal of the European Society for Emergency Medicine)
[2020, 27(6):468-469]

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Venous Thromboembolism in Hip Fracture Patients: A Subanalysis of the FAITH and HEALTH Trials.

David R W MacDonald, David Neilly, Prism S Schneider, Sofia Bzovsky, Sheila Sprague, Daniel Axelrod, Rudolf W Poolman, Frede Frihagen, Mohit Bhandari, Marc Swiontkowski, Emil H Schemitsch, Iain M Stevenson, ,

BACKGROUND:The primary objective of this study was to determine the incidence of symptomatic venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), in the hip fracture population. Secondary objectives included determining timing of VTE diagnosis, VTE thromboprophylaxis given, and identifying any factors associated with VTE. METHODS:Using data ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2020, 34 Suppl 3:S70-S75]

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Pulmonary Embolism After Acute Spinal Cord Injury and COVID-19.

Thomas John Pisano, Jaclyn Joki, Beverly Hon, Sara Cuccurullo,

The coronavirus virus disease 2019 is best known for its pulmonary sequelae. Understanding of the disease process is rapidly growing, and the medical community already appreciates a hypercoagulable state associated with coronavirus virus disease 2019. Acute spinal cord injury has an inherent increased risk for venous thromboembolism. In this case ... Read more >>

Am J Phys Med Rehabil (American journal of physical medicine & rehabilitation)
[2020, 99(11):982-985]

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Venous thromboembolism and COVID-19: mind the gap between clinical epidemiology and patient management

Michela Giustozzi, Maria Cristina Vedovati, Giancarlo Agnelli,

Eur J Intern Med (European journal of internal medicine)
[2020, :]

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Thromboprophylaxis: balancing evidence and experience during the COVID-19 pandemic.

Benjamin Marchandot, Antonin Trimaille, Anais Curtiaud, Kensuke Matsushita, Laurence Jesel, Olivier Morel,

A common and potent consideration has recently entered the landscape of the novel coronavirus disease of 2019 (COVID-19): venous thromboembolism (VTE). COVID-19 has been associated to a distinctive related coagulopathy that shows unique characteristics. The research community has risen to the challenges posed by this « evolving COVID-19 coagulopathy » ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, 50(4):799-808]

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Venous Thromboembolism in COVID-19.

Sam Schulman, Yu Hu, Stavros Konstantinides,

The coronavirus disease 2019 (COVID-19) is our latest pandemic, preceded by the H1N1 swine flu in 2009, which lasted approximately 19 months. One of the special characteristics of COVID-19 is the propensity to cause venous thromboembolism (VTE). Thromboinflammation seems to play a prominent role in the pathogenesis. We will here ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2020, :]

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Use of apixaban and rivaroxaban in young adults with acute venous thromboembolism: a multi-center retrospective case series.

Deborah DeCamillo, Stacy Ellsworth, Scott Kaatz, Geoffrey D Barnes,

Since 2012 four direct oral anticoagulants (DOAC) have been approved by the US Food and Drug Administration (FDA) for treatment of acute venous thromboembolism (VTE). Clinical trials comparing DOACs to warfarin included more than 13,500 patients. However, included patients were all age 39 years or older. We sought to describe real-world ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, 50(4):844-848]

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Venous thromboembolism in critically ill COVID-19 patients receiving prophylactic or therapeutic anticoagulation: a systematic review and meta-analysis.

Syed Shahzad Hasan, Sam Radford, Chia Siang Kow, Syed Tabish Razi Zaidi,

Many aspects of care such as management of hypercoagulable state in COVID-19 patients, especially those admitted to intensive care units is challenging in the rapidly evolving pandemic of novel coronavirus disease 2019 (COVID-19). We seek to systematically review the available evidence regarding the anticoagulation approach to prevent venous thromboembolism (VTE) ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, 50(4):814-821]

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Venous thromboembolism prophylaxis in patients undergoing knee replacements: comparison of real-world outcomes.

Syed Shahzad Hasan, Wendy Sunter, Nadia Ahmed, Dalia Dawoud, Syed Tabish Razi Zaidi,

Background Increasing evidence for the use of the aspirin in patients undergoing an orthopaedic surgery for venous thromboembolism prophylaxis has led to a change in the national guidelines substituting anticoagulants with aspirin. Little is known about the impact of such substitution on real-world outcomes from clinical practice. Objective The study ... Read more >>

Int J Clin Pharm (International journal of clinical pharmacy)
[2020, :]

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In Response to "Coagulopathy of Coronavirus Disease 2019".

Jensen Ng, Bingwen Eugene Fan, Yew Woon Chia,

Crit Care Med (Critical care medicine)
[2020, 48(11):e1159-e1160]

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Mid-term outcomes with the use of extracorporeal membrane oxygenation for cardiopulmonary failure secondary to massive pulmonary embolism.

Federico Sertic, Dieynaba Diagne, Lexy Chavez, Thomas Richards, Ashley Berg, Michael Acker, Jay S Giri, Wilson Y Szeto, Sameer Khandhar, Jacob Gutsche, Steven Pugliese, Paul Fiorilli, Eduardo Rame, Christian Bermudez,

OBJECTIVES:There has been increasing interest in using extracorporeal membrane oxygenation (ECMO) to rescue patients with pulmonary embolism (PE) in the advanced stages of respiratory or haemodynamic decompensation. We examined mid-term outcomes and risk factors for in-hospital mortality. METHODS:We conducted a retrospective study of 36 patients who required ECMO placement (32 ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2020, 58(5):923-931]

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Prevention and treatment of venous thromboembolism in cancer patients.

Martina-Elisabeth Spehlmann, Norbert Frey, Oliver J Müller,

Deep vein thrombosis and pulmonary artery embolism are common and serious concomitant diseases in patients with cancer. The prophylaxis and therapy of such venous thromboembolic events (VTE) in oncology have so far been achieved with low-molecular-weight heparins. An increasing number of studies show evidence of the use of direct oral ... Read more >>

Herz (Herz)
[2020, 45(7):652-658]

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Thrombolysis in massive and submassive pulmonary embolism during pregnancy and the puerperium: a systematic review.

David Rodriguez, Carlos Jerjes-Sanchez, Sugely Fonseca, Rebeca Garcia-Toto, Jhon Martinez-Alvarado, Jathniel Panneflek, Claudia Ortiz-Ledesma, Francisco Nevarez,

Thrombolysis in high-risk pulmonary embolism (PE) patients is recommended worldwide; however, the evidence for thrombolysis during pregnancy and the immediate puerperium remains unclear. We conducted a systematic review from 1950 to 2019 through PubMed, Ovid/Willey, and Cochrane Library to assess the safety and effectiveness of thrombolysis during pregnancy and the ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, 50(4):929-941]

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A postdischarge venous thromboembolism risk calculator for inflammatory bowel disease surgery.

Cary Jo R Schlick, Tarik K Yuce, Anthony D Yang, Michael F McGee, David J Bentrem, Karl Y Bilimoria, Ryan P Merkow,

BACKGROUND:Guidelines recommend extended chemoprophylaxis for venous thromboembolism in high-risk patients having operations for inflammatory bowel disease. Quantifying patients' risk of venous thromboembolism, however, remains challenging. We sought (1) to identify factors associated with postdischarge venous thromboembolism in patients undergoing colorectal resection for inflammatory bowel disease and (2) to develop a ... Read more >>

Surgery (Surgery)
[2020, :]

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Clinical outcomes of acute pulmonary embolectomy as the first-line treatment for massive and submassive pulmonary embolism: a single-centre study in China.

Wang QiMin, Chen LiangWan, Chen DaoZhong, Qiu HanFan, Huang ZhongYao, Dai XiaoFu, Huang XueShan, Lin Feng, Chen HuaBin,

BACKGROUND:Acute pulmonary embolism (PE) is one of the most critical cardiovascular diseases. PE treatment ranges from anticoagulation, and systemic thrombolysis to surgical embolectomy and catheter embolectomy. Surgical pulmonary embolectmy (SPE) indications and outcomes are still controversial. Although there have been more favourable SPE reports over the past decades, SPE has ... Read more >>

J Cardiothorac Surg (Journal of cardiothoracic surgery)
[2020, 15(1):321]

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How can we better predict pulmonary blood clots in patients hospitalised for COVID-19?

Laurent Bertoletti, Menno V Huisman,

Eur Respir J (The European respiratory journal)
[2020, 56(4):]

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A retrospective application of the pulmonary embolism rule out criteria (PERC) of the American College of Physicians would reduce the number of CTPAS by 6% without a false negative in an Irish hospital.

Advait Kothare, Muath Abahussain, Nikita Svirkov-Vainberg, Patrick O'Kelly, Galamoyo Nfila, Peadar Gilligan,

BACKGROUND:Internationally, the number of computerised tomographic pulmonary angiographies (CTPAs) being performed to rule out pulmonary embolism (PE) has caused some concern. AIM:This study was performed to assess if the application of Pulmonary Embolism Rule-out Criteria (PERC) in an Irish Emergency Department (ED) would have helped to safely reduce the number ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2020, :]

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Analysis of the quality of reporting of randomized controlled trials in anticoagulant versus antiplatelet medication for venous thromboembolism prophylaxis as governed by the CONSORT statement.

Eirini Beneki, Christos Vrysis, Elias Zintzaras, Chrysoula Doxani,

Randomized controlled trials (RCTs) are the gold standard research in evaluating healthcare interventions. The CONSORT (Consolidated Standards of Reporting Trials) statement improves the quality of RCTs in an evidence-based approach. To evaluate the reporting quality of published RCTs concerning the use of anticoagulants versus antiplatelet agents for venous thromboembolism prophylaxis ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, :]

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Global Research Highlights

Ann Emerg Med (Annals of emergency medicine)
[2020, 76(5):A23-A25]

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Splenic Artery Angioembolization is Associated with Increased Venous Thromboembolism.

M Lewis, A Piccinini, E Benjamin, D Demetriades,

BACKGROUND:Angioembolization has become an increasingly utilized adjunct for splenic preservation after trauma. Embolization of the splenic artery may produce a transient systemic hypercoagulable state. This study was designed to determine the risk of venous thromboembolism (VTE) in blunt trauma patients managed nonoperatively with splenic angioembolization, relative to those managed without. ... Read more >>

World J Surg (World journal of surgery)
[2020, :]

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Age-sex specific pulmonary embolism-related mortality in the USA and Canada, 2000-18: an analysis of the WHO Mortality Database and of the CDC Multiple Cause of Death database.

Stefano Barco, Luca Valerio, Walter Ageno, Alexander T Cohen, Samuel Z Goldhaber, Beverley J Hunt, Alfonso Iorio, David Jimenez, Frederikus A Klok, Nils Kucher, Seyed Hamidreza Mahmoudpour, Saskia Middeldorp, Thomas Münzel, Vicky Tagalakis, Aaron M Wendelboe, Stavros V Konstantinides,

BACKGROUND:Pulmonary embolism (PE)-related mortality is decreasing in Europe. However, time trends in the USA and Canada remain uncertain because the most recent analyses of PE-related mortality were published in the early 2000s. METHODS:For this retrospective epidemiological study, we accessed medically certified vital registration data from the WHO Mortality Database (USA ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, :]

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Venous thromboembolism after delayed surgery for a hip fracture: A retrospective cohort study.

Jae Youn Yoon, Shinseok Kim, Jae Suk Chang, Pil Whan Yoon, Ji Wan Kim,

AIM:The purpose of this study was to investigate the demographic characteristics and prevalence of postoperative venous thromboembolism (VTE) in delayed hip fracture patients referred to our hospital (a tertiary referral center), and further verify the effect of intensive prophylaxis protocol in preventing the occurrence of VTE. METHODS:We retrospectively evaluated 264 ... Read more >>

Geriatr Gerontol Int (Geriatrics & gerontology international)
[2020, :]

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