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Temporal Lobe Epilepsy

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Long-term outcomes in temporal lobe epilepsy with glutamate decarboxylase antibodies.

Bastien Joubert, Aude Belbezier, Julie Haesebaert, Sylvain Rheims, François Ducray, Géraldine Picard, Véronique Rogemond, Dimitri Psimaras, Giulia Berzero, Virginie Desestret, Jérôme Honnorat,

OBJECTIVE:To assess the long-term outcomes of patients with temporal lobe epilepsy and CSF anti-glutamate decarboxylase antibodies (GAD65-Abs). METHODS:We retrospectively analyzed the clinical records of 35 patients with temporal lobe epilepsy and CSF GAD65-Abs, collected from January 1993 to December 2016 and assessed cognitive impairment and seizure activity at last visit. ... Read more >>

J. Neurol. (Journal of neurology)
[2020, :]

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Distributed source analysis of magnetoencephalography using a volume head model combined with statistical methods improves focus diagnosis in epilepsy surgery.

Tomotaka Ishizaki, Satoshi Maesawa, Daisuke Nakatsubo, Hiroyuki Yamamoto, Sou Takai, Masashi Shibata, Sachiko Kato, Jun Natsume, Minoru Hoshiyama, Toshihiko Wakabayashi,

Deep-seated epileptic focus estimation using magnetoencephalography is challenging because of its low signal-to-noise ratio and the ambiguity of current sources estimated by interictal epileptiform discharge (IED). We developed a distributed source (DS) analysis method using a volume head model as the source space of the forward model and standardized low-resolution ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5263]

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Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy.

Maria Elisa Serrano, Mohamed Ali Bahri, Guillaume Becker, Alain Seret, Charlotte Germonpré, Christian Lemaire, Fabrice Giacomelli, Frédéric Mievis, André Luxen, Eric Salmon, Bernard Rogister, Robrecht Raedt, Alain Plenevaux,

PURPOSE:The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES:Twenty Sprague Dawley male rats were administered with multiple systemic ... Read more >>

Mol Imaging Biol (Molecular imaging and biology)
[2020, :]

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Evaluation of brain FDG PET images in temporal lobe epilepsy for lateralization of epileptogenic focus by data mining methods.

Ümit Özgür Akdemir, Irem Çapraz, Seda Gülbahar Ateş, Kerim Şeker, Uğuray Aydos, Gökhan Kurt, Neşe Karabacak, Lütfiye Özlem Atay, Erhan Bilir,

AIM:In temporal lobe epilepsy (TLE), brain positron emission tomography (PET) performed with F-18 fluorodeoxyglucose (FDG) is commonly used for lateralization of the epileptogenic temporal lobe. In this study, we aimed to evaluate the success of quantitative analysis of brain FDG PET images using data mining methods in the lateralization of ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Focal burst suppression on intra-operative electrocorticography does not affect the surgical outcome in patients with temporal lobe epilepsy.

Cuiping Xu, Tao Yu, Xiaohua Zhang, Guojun Zhang, Ping Zhuang, Yuping Wang, Yongjie Li,

OBJECTIVE:The aim of this study was to investigate the burst suppression (BS) pattern on intra-operative electrocorticography (ECoG) in patients with temporal lobe epilepsy (TLE) and the surgical outcome. PATIENTS AND METHODS:From January 2017 to June 2017, 45 patients with TLE underwent temporal lobe resection with intra-operative ECoG at the Beijing ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2020, 193:105785]

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Pituitary apoplexy accompanying temporal lobe seizure as a complication: case report.

Katsunori Shijo, Sodai Yoshimura, Fumi Mori, Shun Yamamuro, Koichiro Sumi, Hideki Oshima, Atsuo Yoshino,

BACKGROUND:Pituitary apoplexy is an acute clinical syndrome caused by infarction and/or hemorrhage of pituitary adenoma, which typically presents with severe headache, visual deterioration, and endocrine abnormalities. However, temporal lobe seizure (and temporal lobe epilepsy) has not been viewed as a symptom of pituitary apoplexy in the literature. CASE PRESENTATION:To elucidate ... Read more >>

World Neurosurg (World neurosurgery)
[2020, :]

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[Resting state functional magnetic resonance imaging applications in the temporal lobe epilepsy surgery].

N García-Casares, A Fernández-Cornax,

INTRODUCTION:There is a growing interest in the functional magnetic resonance imaging (fMRI) and his clinical applications in the planning of the epilepsy surgery. The conventional method of using the fMRI require the cooperation of the patient. Currently it is being studied the possibility of using this technique without the performance ... Read more >>

Rev Neurol (Revista de neurologia)
[2020, 70(7):257-263]

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Upregulation of lactate dehydrogenase A in a chronic model of temporal lobe epilepsy.

Nagisa Sada, Shogo Suto, Mana Suzuki, Shoichiro Usui, Tsuyoshi Inoue,

The ketogenic diet treatment is effective for drug-resistant epilepsy. Because its antiepileptic effect is associated with lactate dehydrogenase (LDH), drug development is possible by targeting LDH enzymes. Seizures in rodent models are suppressed by inhibiting LDH; however, it remains unclear whether LDH in the brain is changed by seizures. In ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Early-onset dementia: diagnostic challenges.

Bushra Elhusein, Omer Bakri Mahgoub, Abdalla Khairi,

A 56-year-old man was brought to our hospital by his family, seeking medical treatment for the patient's long-standing progressive word-finding difficulties, forgetfulness, agitation and social withdrawal. After multiple previous physician consultations, the patient was mistakenly diagnosed with epilepsy and prescribed multiple anticonvulsants, to which his above mentioned symptoms were unresponsive. ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(3):]

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Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy for Epilepsy: Systematic Review of Technique, Indications, and Outcomes.

Brett E Youngerman, Akshay V Save, Guy M McKhann,

BACKGROUND:For patients with focal drug-resistant epilepsy (DRE), surgical resection of the epileptogenic zone (EZ) may offer seizure freedom and benefits for quality of life. Yet, concerns remain regarding invasiveness, morbidity, and neurocognitive side effects. Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) has emerged as a less invasive option for stereotactic ... Read more >>

Neurosurgery (Neurosurgery)
[2020, 86(4):E366-E382]

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In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity.

Yulia Novitskaya, Matthias Dümpelmann, Andreas Vlachos, Peter Christoph Reinacher, Andreas Schulze-Bonhage,

The human temporal lobe is a multimodal association area which plays a key role in various aspects of cognition, particularly in memory formation and spatial navigation. Functional and anatomical connectivity of temporal structures is thus a subject of intense research, yet by far underexplored in humans due to ethical and ... Read more >>

Neuroimage (NeuroImage)
[2020, :116769]

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Lowered Paraoxonase 1 Activities May Explain the Comorbidities Between Temporal Lobe Epilepsy or Mesial Temporal Sclerosis and Comorbid Depression, Anxiety and Psychosis

Ana Paula Michelin, Mchael Maes, Thitiporn Supasitthumrong, Chusak Limotai, Andressa Keiko Matsumoto, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania Gastaldello Moreira, Buranee Kanchanatwan, Décio Sabbatini Barbosa,

Background: Temporal lobe epilepsy (TLE) is the most common focal epilepsy subtype in adults and is frequently accompanied by depression, anxiety and psychosis. Aberrations in total paraoxonase (PON)1 status may occur in TLE and those psychiatric conditions. Methods: We examined paraoxonase (PON)1 status, namely Q192R PON1 genotypes and PON1 enzymatic ... Read more >>

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Adolf Meyer: the neuroanatomist and neuropsychiatrist behind Meyer's loop and its significance in neurosurgery.

Olaf E M G Schijns, Peter J Koehler,

Brain (Brain : a journal of neurology)
[2020, 143(3):1039-1044]

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Shared hippocampal abnormalities in sporadic temporal lobe epilepsy patients and their siblings.

Lili Long, Marian Galovic, Yayu Chen, Tjardo Postma, Sjoerd B Vos, Fenglai Xiao, Wenyue Wu, Yanmin Song, Sha Huang, Matthias Koepp, Bo Xiao,

OBJECTIVE:To examine the shared familial contribution to hippocampal and extrahippocampal morphological abnormalities in patients with sporadic temporal lobe epilepsy (TLE) and their unaffected siblings. METHODS:We collected clinical, electrophysiological, and T1-weighted magnetic resonance imaging (MRI) data of 18 sporadic patients with TLE without lesions other than hippocampal sclerosis (12 right, 6 ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Procedure-Related Temporal Infarct After Retractorless Transsylvian Selective Amygdalohippocampectomy and Impact on 2-Year Epilepsy Outcome.

Chih-Hsiang Liao, Shao-Ching Chen, Hsiang-Yu Yu, Chun-Fu Lin, Chien-Chen Chou, Cheng-Chia Lee, Chung-Jung Lin, Sanford P C Hsu, Yang-Hsin Shih,

BACKGROUND:Selective amygdalohippocampectomy (SAH) is designed to treat patients with mesial temporal lobe epilepsy (MTLE). OBJECTIVE:To determine the volume and impact of temporal lobe infarction after retractorless transsylvian SAH (en bloc resection of the hippocampus) that have not been reported. METHODS:A retrospective analysis of patients treated with retractorless transsylvian SAH. Infarctions ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, 18(4):430-437]

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Reduced hippocampal recruitment during response conflict resolution in mesial temporal lobe epilepsy.

Markus Ramm, Benedikt Sundermann, Carlos Assuncao Dias Gomes, Gabriel Möddel, Lisa Langenbruch, Nina Nagelmann, Mahboobeh Dehghan Nayyeri, Peter Young, Bettina Pfleiderer, Nikolai Axmacher,

Recent evidence suggests that the human hippocampus (HC) is not only involved in the processing of motivationally relevant approach-avoidance conflicts but is also engaged in the resolution of more general response conflicts as measured in the Stroop paradigm. Here we investigated whether neural activity in the HC is necessary for ... Read more >>

Neuroimage (NeuroImage)
[2020, :116723]

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Alterations in intra- and internetwork functional connectivity associated with levetiracetam treatment in temporal lobe epilepsy.

Xiao-Min Pang, Xiu-Lin Liang, Xia Zhou, Jin-Ping Liu, Zhao Zhang, Jin-Ou Zheng,

OBJECTIVE:Levetiracetam (LEV) is an antiepileptic drug with a novel pharmacological mechanism. Advances in functional magnetic resonance imaging (fMRI) enable researchers to explore the cognitive effects of antiepileptic drugs on the living brain. This study aimed to explore how the functional connectivity patterns of the cognitive networks changed in association with ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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Effects of hippocampus-sparing resections in the temporal lobe: Hippocampal atrophy is associated with a decline in memory performance.

Kathrin Wagner, Karin Gau, Birgitta Metternich, Maximilian J Geiger, Anne-Sophie Wendling, Navah E Kadish, Gitta Reuner, Hans Mayer, Irina Mader, Jürgen Beck, Josef Zentner, Horst Urbach, Andreas Schulze-Bonhage, Christoph P Kaller, Niels A Foit,

OBJECTIVE:In patients with temporal lobe epilepsy (TLE) with a nonlesional and nonepileptogenic hippocampus (HC), in order to preserve functionally intact brain tissue, the HC is not resected. However, some patients experience postoperative memory decline, possibly due to disruption of the extrahippocampal memory network and secondary hippocampal volume (HV) loss. The ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Hippocampal Sclerosis Detection with NeuroQuant Compared with Neuroradiologists.

S Louis, M Morita-Sherman, S Jones, D Vegh, W Bingaman, I Blumcke, N Obuchowski, F Cendes, L Jehi,

BACKGROUND AND PURPOSE:NeuroQuant is an FDA-approved software that performs automated MR imaging quantitative volumetric analysis. This study aimed to compare the accuracy of NeuroQuant analysis with visual MR imaging analysis by neuroradiologists with expertise in epilepsy in identifying hippocampal sclerosis. MATERIALS AND METHODS:We reviewed 144 adult patients who underwent presurgical ... Read more >>

AJNR Am J Neuroradiol (AJNR. American journal of neuroradiology)
[2020, :]

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Epileptogenic zone localization using a new automatic quantitative analysis based on normal brain glucose metabolism database.

Kun Guo, Menghui Yuan, Longxiao Wei, Jie Lu,

Objectives: To assess the clinical value of voxel-based automatic quantitative analysis using a normal brain glucose metabolism database in the preoperative localization of focal intractable temporal lobe epilepsy patients.Methods: Patients with refractory temporal lobe epilepsy who underwent 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging were retrospectively enrolled from January to ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-7]

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Multidimensional associations between cognition and connectome organization in temporal lobe epilepsy.

Raúl Rodríguez-Cruces, Boris C Bernhardt, Luis Concha,

OBJECTIVE:Temporal lobe epilepsy (TLE) is known to affect large-scale structural networks and cognitive function in multiple domains. The study of complex relations between structural network organization and cognition requires comprehensive analytical methods and a shift towards multivariate techniques. Here, we sought to identify multidimensional associations between cognitive performance and structural ... Read more >>

Neuroimage (NeuroImage)
[2020, 213:116706]

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Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy.

Osmi Hamamoto, Daniela Pretti da Cunha Tirapelli, Fermino Sanches Lizarte Neto, Priscila Freitas-Lima, Fabiano Pinto Saggioro, Mucio Luiz de Assis Cirino, João Alberto Assirati, Luciano Neder Serafini, Tonicarlo Rodrigues Velasco, Américo Ceiki Sakamoto, Carlos Gilberto Carlotti,

Mesial temporal lobe epilepsy with hippocampal sclerosis is the most frequent form of focal epilepsy in adults, and it is often refractory to drug treatment. Regardless of the efforts on developing new antiepileptic drugs for refractory cases, studies suggest a need for better understanding the molecular bases of epilepsy. The ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, :]

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Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy.

Alba González, Cecilie Gjessing Nome, Bård Andre Bendiksen, Ivar Sjaastad, Lili Zhang, Mona Aleksandersen, Erik Taubøll, Dag Aurlien, Kjell Heuser,

Sudden unexpected death in epilepsy (SUDEP) is a significant cause of premature seizure-related death. An association between SUDEP and cardiac remodeling has been suggested. However, whether SUDEP is a direct consequence of acute or recurrent seizures is unsettled. The purpose of this study was to evaluate the impact of status ... Read more >>

Epilepsy Res. (Epilepsy research)
[2020, 161:106300]

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Microstructural imaging in temporal lobe epilepsy: Diffusion imaging changes relate to reduced neurite density.

Gavin P Winston, Sjoerd B Vos, Benoit Caldairou, Seok-Jun Hong, Monika Czech, Tobias C Wood, Stephen J Wastling, Gareth J Barker, Boris C Bernhardt, Neda Bernasconi, John S Duncan, Andrea Bernasconi,

PURPOSE:Previous imaging studies in patients with refractory temporal lobe epilepsy (TLE) have examined the spatial distribution of changes in imaging parameters such as diffusion tensor imaging (DTI) metrics and cortical thickness. Multi-compartment models offer greater specificity with parameters more directly related to known changes in TLE such as altered neuronal ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 26:102231]

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Mean apparent propagator-MRI: A new diffusion model which improves temporal lobe epilepsy lateralization.

Keran Ma, Xiaonan Zhang, Huiting Zhang, Xu Yan, Ankang Gao, Chengru Song, Shaoyu Wang, Yajun Lian, Jingliang Cheng,

PURPOSE:To compare MRI volume measurements, FLAIR image intensity, Diffusion tensor imaging (DTI) and mean apparent propagator (MAP)-MRI measurements in hippocampus ipsilateral and contralateral to the epileptogenic focus for non-invasive lateralization of temporal lobe epilepsy (TLE) and also compare these DTI and MAP-MRI measurements to cognitive function. METHOD:A cohort of patients ... Read more >>

Eur J Radiol (European journal of radiology)
[2020, 126:108914]

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