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Symptomatic Generalized Epilepsy

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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National Institutes of Health Stroke Scale (NIHSS) on admission predicts acute symptomatic seizure risk in ischemic stroke: a population-based study involving 135,117 cases.

Johann Philipp Zöllner, Björn Misselwitz, Manfred Kaps, Marco Stein, Jürgen Konczalla, Christian Roth, Karsten Krakow, Helmuth Steinmetz, Felix Rosenow, Adam Strzelczyk,

The National Institutes of Health Stroke Scale (NIHSS) score is the most frequently used score worldwide for assessing the clinical severity of a stroke. Prior research suggested an association between acute symptomatic seizures after stroke and poorer outcome. We determined the frequency of acute seizures after ischemic stroke in a ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3779]

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Status Epilepticus Manifested as Continuous Epileptic Spasms.

Jianxiang Liao, Tieshuan Huang, Myriam Srour, Yuhan Xiao, Yan Chen, Sufang Lin, Li Chen, Yan Hu, Lina Men, Jialun Wen, Bing Li, Feiqiu Wen, Lan Xiong,

Objective: The etiology and outcome of status epilepticus with continuous epileptic spasms have not been fully understood; and only rare cases have been reported in the literature. Here, we described 11 children, who manifested continuous epileptic spasms with various etiologies and different outcomes. Methods: This is a case series study ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:65]

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The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study.

Tang Xinghua, Li Lin, Fan Qinyi, Wei Yarong, Pu Zheng, Liu Zhenguo,

BACKGROUD:This study aimed to explore the clinical value of long - term electroencephalogram (LTM EEG) in seizure-free individuals taking antiepileptic drugs (AEDs) for more than 2 years. We try to look for clinical factors associated with epileptiform activity on LTM EEG in seizure free patients. We hope that the detection of ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):88]

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A girl with protein-losing enteropathy during a ketogenic diet: a case report.

Juan Wang, Li Jiang, Min Cheng,

BACKGROUND:A ketogenic diet (KD) is an effective treatment for intractable epilepsy in children. Protein-losing enteropathy (PLE) is a rarely reported but serious complication of KDs. CASE PRESENTATION:A 3-month-old female patient presented with PLE while following a KD as treatment for intractable epilepsy. She also had genovariation of the STXBP1 gene. ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):102]

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Acute symptomatic seizures in intracerebral and subarachnoid hemorrhage: A population study of 19,331 patients.

Johann Philipp Zöllner, Jürgen Konczalla, Marco Stein, Christian Roth, Karsten Krakow, Manfred Kaps, Helmuth Steinmetz, Felix Rosenow, Björn Misselwitz, Adam Strzelczyk,

BACKGROUND:Risk factors for acute symptomatic seizures after stroke demonstrated in retrospective analyses should be confirmed in large population studies. While seizures following ischemic stroke have been studied intensively, less is known about seizure predictors in hemorrhagic stroke. This study sought to identify risk factors of acute symptomatic seizures and to ... Read more >>

Epilepsy Res. (Epilepsy research)
[2020, 161:106286]

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Electroencephalography in Neonatal Epilepsies.

Akihisa Okumura,

Neonatal epilepsies, neonatal seizures caused by remote symptomatic etiologies, are infrequent compared with those caused by acute symptomatic etiologies. The etiologies of neonatal epilepsies are classified into structural, genetic, and metabolic. EEG and amplitude-integrated EEG (aEEG) are essential for the diagnosis and monitoring of neonatal epilepsies. EEG/aEEG findings may differ ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, :]

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Neonatal Seizures: Diagnosis, Etiologies, and Management.

Julie Ziobro, Renée A Shellhaas,

Neonates are exquisitely susceptible to seizures due to several physiologic factors and combination of risks that are uniquely associated with gestation, delivery, and the immediate postnatal period. Neonatal seizures can be challenging to identify; therefore, it is imperative that clinicians have a high degree of suspicion for seizures based on ... Read more >>

Semin Neurol (Seminars in neurology)
[2020, :]

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Clinical Profile and Short-term Outcome of Pediatric Status Epilepticus at a Tertiary-care Center in Northern India.

Chinmay Chetan, Suvasini Sharma, Surendra B Mathur, Puneet Jain, Satinder Aneja,

OBJECTIVE:To assess clinical profile and short term treatment outcomes of pediatric status epilepticus (SE) at a tertiary-care center in northern India. METHODS:Prospective cohort study enrolled children aged 1 month to 18 years presenting with SE to the emergency department. Enrolled children (109) were treated as per hospital protocols. Clinical features ... Read more >>

Indian Pediatr (Indian pediatrics)
[2020, 57(3):213-217]

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EEG Monitoring of the Epileptic Newborn.

Francesco Pisani, Carlotta Spagnoli, Carlo Fusco,

PURPOSE OF REVIEW:Although differentiating neonatal-onset epilepsies from acute symptomatic neonatal seizures has been increasingly recognized as crucial, existing guidelines, and recommendations on EEG monitoring are mainly based on acute symptomatic seizures, especially secondary to hypoxic-ischemic encephalopathy. We aimed to narratively review current knowledge on neonatal-onset epilepsies of genetic, metabolic, and ... Read more >>

Curr Neurol Neurosci Rep (Current neurology and neuroscience reports)
[2020, 20(4):6]

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Novel CDKL5 mutations were found in patients in China: retrospective investigation in cases of CDKL5-related disorders.

Yumei Yan, Dake He, Jing Wu, Ruolin Hou, Kun Sun, Ling Li,

OBJECTIVE:CDKL5-related disorders (CDD) is an epileptic encephalopathy resulted of gene mutations of CDKL5. This study aimed to explore the development process of CDD and to expand its mutation spectrum. METHODS:Clinic datawas collected about three infantile epileptic encephalopathy cases diagnosed at Xinhua Hospital Affiliated to Shanghai Jiaotong University, School of Medicine. ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):27]

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Postencephalitic epilepsy in dogs with meningoencephalitis of unknown origin: Clinical features, risk factors, and long-term outcome.

Adriana Kaczmarska, Roberto José-López, Michał Czopowicz, Kali Lazzerini, Guillaume Leblond, Catherine Stalin, Rodrigo Gutierrez-Quintana,

BACKGROUND:Although the presence of seizures in dogs with meningoencephalitis of unknown origin (MUO) has been associated with shorter survival times, data regarding the prevalence and risk factors for postencephalitic epilepsy (PEE) is lacking. OBJECTIVES:To describe the clinical features, prevalence, risk factors, and long-term outcome of PEE in dogs with MUO. ... Read more >>

J. Vet. Intern. Med. (Journal of veterinary internal medicine)
[2020, 34(2):808-820]

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Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome.

Stéphane Auvin, Blandine Dozières-Puyravel, Andreja Avbersek, David Sciberras, Jo Collier, Karine Leclercq, Pavel Mares, Rafal M Kaminski, Pierandrea Muglia,

OBJECTIVE:Infantile spasm syndrome (ISS) is an epileptic encephalopathy without established treatment after the failure to standard of care based on steroids and vigabatrin. Converging lines of evidence indicating a role of NR2B subunits of the N-methyl-D-aspartate (NMDA) receptor on the onset of spams in ISS patients, prompted us to test ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(3):343-352]

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Neuro-Developmental and Epilepsy Outcomes of Children with West Syndrome: A Cross-Sectional Study from North India.

Juhi Gupta, Suvasini Sharma, Sharmila B Mukherjee, Puneet Jain, Satinder Aneja,

Objectives:To assess the neurodevelopmental outcome of West syndrome (WS) in Indian children, who differ in their clinical profile from the western population. Materials and Methods:This cross-sectional study enrolled children aged 2--5 years with prior diagnosis of WS between November 2013 and March 2015. They were assessed for epilepsy outcome and ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2020, 23(2):177-181]

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Comparison of pseudocontinuous arterial spin labeling perfusion MR images and time-of-flight MR angiography in the detection of periictal hyperperfusion.

Noritoshi Shirozu, Takato Morioka, So Tokunaga, Takafumi Shimogawa, Daisuke Inoue, Shoji Arihiro, Ayumi Sakata, Nobutaka Mukae, Sei Haga, Koji Iihara,

Background:Magnetic resonance imaging (MRI), including perfusion MRI with three-dimensional pseudocontinuous arterial spin labeling (ASL) and diffusion-weighted imaging (DWI), are applied in the periictal (including ictal and postictal) detection of circulatory and metabolic consequences associated with epilepsy. Our previous report revealed that periictal hyperperfusion can firstly be detected on ASL, and ... Read more >>

eNeurologicalSci (eNeurologicalSci)
[2020, 19:100233]

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Vaccination management in an asymptomatic child with a novel SCN1A variant and family history of status epilepticus following vaccination: A case report on a potential new direction in personalised medicine.

Lucy Deng, Alan Ma, Nicholas Wood, Simone Ardern-Holmes,

PURPOSE:SCN1A variants cause a spectrum of epilepsy syndromes from Dravet Syndrome, a severe epileptic encephalopathy of early infancy to the milder disorder of genetic epilepsy with febrile seizures plus (GEFS+). These genetic epilepsies are associated with increased risk of poor outcome including complications of status epilepticus and early mortality. Individualised ... Read more >>

Seizure (Seizure)
[2020, 78:49-52]

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Analyzing clinical and genetic characteristics of a cohort with multiple congenital anomalies-hypotonia-seizures syndrome (MCAHS).

Xianru Jiao, Jiao Xue, Pan Gong, Xinhua Bao, Ye Wu, Yuehua Zhang, Yuwu Jiang, Zhixian Yang,

OBJECTIVE:To summarize and extend the phenotypic characterization of Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome, and to discuss genotype-phenotype correlations. METHODS:Collecting clinical information of 17 patients with pathogenic variants in PIGN, PIGA, and PIGT. Genetic studies were performed on all patients. RESULTS:There were 7 patients with 15 PIGN mutations (one patient carrying 3 ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):78]

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Genetic variations associated with pharmacoresistant epilepsy.

Noemí Cárdenas-Rodríguez, Liliana Carmona-Aparicio, Diana L. Pérez-Lozano, Daniel Ortega-Cuellar, Saúl Gómez-Manzo, Iván Ignacio-Mejía,

Epilepsy is a common, serious neurological disorder worldwide. Although this disease can be successfully treated in most cases, not all patients respond favorably to medical treatments, which can lead to pharmacoresistant epilepsy. Drug-resistant epilepsy can be caused by a number of mechanisms that may involve environmental and genetic factors, as ... Read more >>

Mol Med Rep (Molecular Medicine Reports)
[2020, 21(4):1685-1701]

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Infantile Spasms: An Update on Pre-Clinical Models and EEG Mechanisms.

Remi Janicot, Li-Rong Shao, Carl E Stafstrom,

Infantile spasms (IS) is an epileptic encephalopathy with unique clinical and electrographic features, which affects children in the middle of the first year of life. The pathophysiology of IS remains incompletely understood, despite the heterogeneity of IS etiologies, more than 200 of which are known. In particular, the neurobiological basis ... Read more >>

Children (Basel) (Children)
[2020, 7(1):]

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Nonconvulsive status epilepticus in the elderly.

S Dupont, K Kinugawa,

There is a higher incidence of status epilepticus in the older adult population that commonly presents as nonconvulsive status epilepticus (NCSE). NCSE most often corresponds to prolonged focal seizures with impaired consciousness with three main clinical presentations: i) an unexplained acute confusional state, ii) subtle eye, motor or behavioral signs ... Read more >>

Rev. Neurol. (Paris) (Revue neurologique)
[2020, :]

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Clinical conundrum: status epilepticus culminating into acute dystonia myoclonus.

Madhuri Laxman Khilari, Praveen Kumar Sharma,

A 7-year-old child who suffered from symptomatic focal epilepsy as a sequel to perinatal hypoxia used to have frequent seizures. This time she developed prolonged status epilepticus lasting for over 5 hours. She received a treatment in the form of intravenous midazolam and reinitiation of sodium valproate and clobazam that were ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(2):]

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Gamma Knife radiosurgery for cerebral cavernous malformation.

Cheng-Chia Lee, Wei-Hsin Wang, Huai-Che Yang, Chung-Jung Lin, Hsiu-Mei Wu, Yen-Yu Lin, Yong-Sin Hu, Ching-Jen Chen, Yu-Wei Chen, Chien-Chen Chou, Yo-Tsen Liu, Wen-Yuh Chung, Cheng-Ying Shiau, Wan-Yuo Guo, David Hung-Chi Pan, Sanford P C Hsu,

This is a retrospective study examining the efficacy and safety of Gamma Knife radiosurgery (GKS) in treating patients with cerebral cavernous malformations (CCMs). Between 1993 and 2018, 261 patients with 331 symptomatic CCMs were treated by GKS. The median age was 39.9 years and females were predominant (54%). The median ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):19743]

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Mood variations and personality traits in patients with epilepsy over the course of their menstrual cycle.

María Raquel Huerta-Franco, Alicia Ulloa-Aguirre, Aguayo-Leytte Gerónimo, Kathleen Capaccione, Juan Manuel Marquez-Romero,

INTRODUCTION:The incidence of mood disorders and psychopathology is more frequent in patients with epilepsy (PWE) than in the general population. Also, it has been reported that PWE suffer more seizures during certain phases of their menstrual cycle (MC). Still, limited information exists regarding the relationship between the physical and emotional ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 105:106990]

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Consensus of the Hellenic Headache Society on the diagnosis and treatment of migraine.

Evangelos Kouremenos, Chrysa Arvaniti, Theodoros S Constantinidis, Ermioni Giannouli, Nikolaos Fakas, Themistoklis Kalamatas, Evangelia Kararizou, Dimitrios Naoumis, Dimos D Mitsikostas, ,

More than 0.6 million people suffer from disabling migraines in Greece causing a dramatic work loss, but only a small proportion of migraineurs attend headache centres, most of them being treated by non-experts. On behalf of the Hellenic Headache Society, we report here a consensus on the diagnosis and treatment ... Read more >>

J Headache Pain (The journal of headache and pain)
[2019, 20(1):113]

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Elevated Serum Matrix Metalloproteinase-9, Interleukin-6, Hypersensitive C-Reactive Protein, and Homocysteine Levels in Patients with Epilepsy.

Huai Tao, Yuji Gong, Qi Yu, Hongfei Zhou, Yong Liu,

Neuroinflammation contributes to the occurrence and development of epilepsy. However, several inflammatory factors that are important for facilitating the diagnosis to reduce or prevent seizures need to be further studied. This study is aimed to explore serum levels of matrix metalloproteinase-9 (MMP-9), interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), and homocysteine ... Read more >>

J. Interferon Cytokine Res. (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research)
[2020, 40(3):152-158]

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