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Surgical Treatment of Pediatric Hypoplastic Left Heart Syndrome

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Effects of levosimendan on ventriculo-arterial coupling and cardiac efficiency in paediatric patients with single-ventricle physiology after surgical palliation: retrospective study.

Roberta Iacobelli, Zaccaria Ricci, Eleonora Marinari, Roberta Haiberger, Arianna Di Molfetta, Alessandra Toscano, Luca Di Chiara,

OBJECTIVES:The use of levosimendan for paediatric patients with low cardiac output after congenital heart surgery has been recently described. We sought to evaluate ventriculo-arterial coupling (VAC) and other ventricular energetic parameters before and after 72 h from levosimendan start in infants with single-ventricle physiology and cardiac failure after palliation with Norwood ... Read more >>

Interact Cardiovasc Thorac Surg (Interactive cardiovascular and thoracic surgery)
[2020, 30(4):623-629]

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Clinical Outcomes and Risk Factors for In-Hospital Mortality in Neonates with Hypoplastic Left Heart Syndrome.

Mohammed Hamzah, Hasan F Othman, Esraa Elsamny, Hemant Agarwal, Hany Aly,

The objective of this study was to identify patient and hospitalization characteristics associated with in-hospital mortality in infants with hypoplastic left heart syndrome (HLHS). We conducted a retrospective analysis of a large administrative database, the National Inpatient Sample dataset of the Healthcare Cost and Utilization Project for the years 2002-2016. Neonates ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2020, :]

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Provider perspective on the role of palliative care in hypoplastic left heart syndrome.

Sarah Lowenstein, Robert Macauley, Kathleen Perko, Christina Ronai,

OBJECTIVE:Hypoplastic left heart syndrome is a single ventricle defect. While staged surgical palliative treatments have revolutionised care, patients with hypoplastic left heart syndrome continue to have significant morbidity and mortality. In 2017, the National Pediatric Cardiology Quality Improvement Collaborative recommended all single ventricle patients to receive a prenatal palliative care ... Read more >>

Cardiol Young (Cardiology in the young)
[2020, 30(3):377-382]

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Survival, Neurocognitive, and Functional Outcomes After Completion of Staged Surgical Palliation in a Cohort of Patients With Hypoplastic Left Heart Syndrome.

Joseph Atallah, Gonzalo Garcia Guerra, Ari R Joffe, Gwen Y Bond, Sunjidatul Islam, M Florencia Ricci, Mohammed AlAklabi, Ivan M Rebeyka, Charlene M T Robertson, ,

Background Management of patients with hypoplastic left heart syndrome has benefited from advancements in medical and surgical care. Outcomes have improved, although survival and long-term functional and cognitive deficits remain a concern. Methods and Results This is a cohort study of all consecutive patients with hypoplastic left heart syndrome undergoing ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(4):e013632]

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Heart Failure in Single Right Ventricle Congenital Heart Disease: Physiologic and Molecular Considerations.

Anastacia M Garcia, Jonathan-Thomas Beatty, Stephanie Jialing Nakano,

Due to remarkable surgical and medical advances over the past several decades, there are growing numbers of infants and children living with single ventricle congenital heart disease (SV), where there is only one functional cardiac pumping chamber. Nevertheless, cardiac dysfunction and ultimately heart failure is a common complication in the ... Read more >>

Am. J. Physiol. Heart Circ. Physiol. (American journal of physiology. Heart and circulatory physiology)
[2020, :]

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Atrial septum stenting in a foetus with hypoplastic left heart syndrome and restrictive foramen ovale: an alternative to emergency atrioseptectomy in the newborn-a case report.

Andreas Tulzer, Wolfgang Arzt, Christoph Prandstetter, Gerald Tulzer,

Background:In patients with hypoplastic left heart syndrome (HLHS) premature closure or restriction of the interatrial communication causes severe cyanosis directly after birth with rapid deterioration in clinical state. An ex-utero intrapartum treatment (EXIT) procedure, extracorporal membrane oxygenation (ECMO), and emergency interventional cardiac catheterization or cardiac surgery has to be anticipated ... Read more >>

Eur Heart J Case Rep (European heart journal. Case reports)
[2020, 4(1):1-4]

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Outcomes of hypoplastic left heart syndrome: analysis of National Inpatient Sample Database 1998-2004 versus 2005-2014.

Mohammed Hamzah, Hasan F Othman, Orkun Baloglu, Hany Aly,

Neonates with hypoplastic left heart syndrome (HLHS) were identified from the National Inpatient Sample dataset for the years 1998-2014. These patients were stratified into two chronological groups, past group (1998-2005) and recent group (2006-2014). A total of 20,649 neonates with HLHS were identified. Of them, 9179 (44.5%) were born in ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2020, 179(2):309-316]

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Prevalence of Sensorineural Hearing Loss in Children with Palliated or Repaired Congenital Heart Disease.

Lalitha Gopineti, Mane Paulpillai, Andrea Rosenquist, Andrew H Van Bergen,

Background Children with congenital heart disease (CHD) are at increased risk of neurodevelopmental deficits, and the presence of sensorineural hearing loss (SNHL) may further lead to poor language skills acquisition and speech delays. Prevalence of SNHL in the general pediatric population is estimated to be 0.2% at birth to 0.35% ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6566]

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Use of Sodium Bicarbonate During Pediatric Cardiac Admissions with Cardiac Arrest: Who Gets It and What Does It Do?

Rohit S Loomba, Mubbasheer Ahmed, Mubeena Abdulkarim, Enrique G Villarreal, Saul Flores,

The objectives of this study were to characterize the use of sodium bicarbonate in pediatric cardiac admissions that experience cardiac arrest, to determine sodium bicarbonate use over the years, and to determine the impact of sodium bicarbonate on length of admissions, billed charges, and inpatient mortality. A cross-sectional study was ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2019, 6(12):]

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Venoarterial extracorporeal membrane oxygenation in heart surgery post-operative pediatric patients: A retrospective study at Christus Muguerza Hospital, Monterrey, Mexico.

Gerardo Vargas-Camacho, Verónica Contreras-Cepeda, Rene Gómez-Gutierrez, Guillermo Quezada-Valenzuela, Adriana Nieto-Sanjuanero, Jesús Santos-Guzmán, Francisco González-Salazar,

Objectives:Extracorporeal membrane oxygenation is a life support procedure developed to offer cardiorespiratory support when conventional therapies have failed. The purpose of this study is to describe the findings during the first years using venoarterial extracorporeal membrane oxygenation in pediatric patients after cardiovascular surgery at Christus Muguerza High Specialty Hospital in ... Read more >>

SAGE Open Med (SAGE Open Medicine)
[2020, 8:2050312120910353]

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Congenital Cardiothoracic Surgeons and Palliative Care: A National Survey Study.

Emily Morell, Jess Thompson, Satish Rajagopal, Elizabeth D Blume, Rachna May,

BACKGROUND:The majority of children with advanced heart disease in the inpatient setting die in an intensive care unit under 1 year of age following multiple interventions. While pediatric cardiology and palliative care provider attitudes have been described, little is known about pediatric cardiothoracic surgeon attitudes toward palliative care in children ... Read more >>

J Palliat Care (Journal of palliative care)
[2019, :825859719874765]

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Stage 1 hybrid palliation of hypoplastic left heart syndrome: an initial experience in pulmonary trunk approach, procedural modifications, and complication management

Emrah Akay, Onur Işık, Ayşen Yaprak Engin, Volkan Çakır,

Background/aim:Hypoplastic left heart syndrome (HLHS) is a rare pathology with a very high mortality rate. The present study aimed to share our initial experience with the ductus arteriosus stenting procedure using the pulmonary trunk approach in the treatment of HLHS, as well as provide some technical suggestions and discuss complications ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2019, 49(5):1374-1380]

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Leveraging big data to advance knowledge in pediatric heart failure and heart transplantation.

Justin Godown, Michael Gaies, James D Wilkinson,

Transl Pediatr (Translational pediatrics)
[2019, 8(4):342-348]

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Diagnosis and Management of Hip Dislocation in Patients with Kabuki Syndrome.

Chaemoon Lim, Sung-Taek Jung, Chang Ho Shin, Moon Seok Park, Won Joon Yoo, Chin Youb Chung, In Ho Choi, Jung Min Ko, Tae-Joon Cho,

Background:Kabuki syndrome is a rare genetic disorder characterized by distinct dysmorphic facial features, growth deficiency, intellectual disabilities, unusual dermatoglyphic patterns, and skeletal abnormalities. The incidence of hip dislocation in Kabuki syndrome ranges from 18% to 62%. We reviewed the outcomes of management of hip dislocations in patients with Kabuki syndrome ... Read more >>

Clin Orthop Surg (Clinics in orthopedic surgery)
[2019, 11(4):474-481]

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3D bioprinting and its potential impact on cardiac failure treatment: An industry perspective.

Ravi K Birla, Stuart K Williams,

3D printing technologies are emerging as a disruptive innovation for the treatment of patients in cardiac failure. The ability to create custom devices, at the point of care, will affect both the diagnosis and treatment of cardiac diseases. The introduction of bioinks containing cells and biomaterials and the development of ... Read more >>

APL Bioeng (APL bioengineering)
[2020, 4(1):010903]

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An evolving anesthetic protocol fosters fast tracking in pediatric cardiac surgery: A comparison of two anesthetic techniques.

Vipul K Sharma, Gaurav Kumar, Saajan Joshi, Nikhil Tiwari, Vivek Kumar, H Ravi Ramamurthy,

Background:The past two decades have seen rapid development of new surgical techniques for repair as well as palliation of complex congenital heart diseases. For a better patient outcome, minimal postoperative ventilation remains one of the most important endpoints of an effectual perioperative management. Aims and Objectives:The aim of this randomized ... Read more >>

Ann Pediatr Cardiol (Annals of pediatric cardiology)
[2020, 13(1):31-37]

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Fontan Circulation of the Next Generation: Why It's Necessary, What it Might Look Like.

Shelby Kutty, Marshall L Jacobs, W Reid Thompson, David A Danford,

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(1):e013691]

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Update on stem cell technologies in congenital heart disease.

Matthew A Brown, Siva Rajamarthandan, Berline Francis, Meghan K O'Leary-Kelly, Pranava Sinha,

BACKGROUND:Congenital heart disease (CHD) continues to be among the most common birth defects, affecting an estimated 40 000 births annually in the United States. The most common complication of CHD is heart failure. With improved medical management and surgical outcomes, survival for complex congenital heart defects has dramatically improved, but consequentially ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2020, 35(1):174-179]

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Parachute mitral valve: Morphology and surgical management.

Shi-Min Yuan,

Background:This review aims to discuss morphology and surgical management of parachute mitral valve. Methods:A total of 62 articles in the English language with 330 parachute mitral valve patients were retrieved from the PubMed, HighWire Press, and Cochrane Library databases using specific MeSH terms and keywords between January 2000 and December ... Read more >>

Turk Gogus Kalp Damar Cerrahisi Derg (Turk gogus kalp damar cerrahisi dergisi)
[2020, 28(1):219-226]

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Early Neurodevelopmental Outcomes in Children with Hypoplastic Left Heart Syndrome and Related Anomalies After Hybrid Procedure.

O M Khalid, T M Harrison,

The hybrid strategy is one approach to single ventricle palliation. In this study, we reported neurodevelopment at 12 months for two cohorts of children managed with the hybrid and clinical factors associated with neurodevelopment in the entire sample. We performed a retrospective study of children with single ventricle who had undergone ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2019, 40(8):1591-1598]

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Transplantation of the failing Fontan.

Amanda D McCormick, Kurt R Schumacher,

Half a century has passed since the original Fontan palliation. In the interim, surgical and medical advancements have allowed more single ventricle patients to reach Fontan and long-term survival for Fontan patients to improve significantly. However, the risk for Fontan failure and need for heart transplantation remains. In this article ... Read more >>

Transl Pediatr (Translational pediatrics)
[2019, 8(4):290-301]

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A Novel Case of Marfan Syndrome in an Infant With Hypoplastic Left Heart Syndrome.

Aravinth Karunanandaa, Kari Crawford Plant, James René Herlong, Berrin Monteleone, Paul M Kirshbom, Matthew C Schwartz,

This report describes a case of hypoplastic left heart syndrome (HLHS) and Marfan syndrome presenting in conjunction, and highlights how a connective tissue disorder may alter medical and surgical management of newborns with HLHS. ... Read more >>

World J Pediatr Congenit Heart Surg (World journal for pediatric & congenital heart surgery)
[2019, 10(5):641-642]

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Temporary bronchial stenting for airway compression in the interstage palliation of functional single ventricle.

Jason Hawes Barnes, Richard Paul Boesch, Karthik Balakrishnan, Sameh M Said, Charlotte S Van Dorn,

The Norwood procedure is the first of three palliative surgical procedures offered for hypoplastic left heart syndrome (HLHS). Due to the small size of the thorax and proximity of airway and vascular structures, compression of the airway is possible following the Norwood procedure. We describe the management of an infant ... Read more >>

Ann Pediatr Cardiol (Annals of pediatric cardiology)
[2019, 12(3):308-311]

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Airway anomalies in cases of anomalous pulmonary venous connection - A single-center experience.

Anuradha Kamath, Pankaj Punetha, Aditya N Doddamane, Kolli S Chalam, C S Hiremath,

Background:Patients with congenital heart defects may present with concomitant defects involving other organ systems. Roughly 4 percent of this nature are airway anomalies. Presence of anomalous airways summon major challenge before the anesthesiologist, surgeon, and intensivist in the perioperative management of such patients. There is paucity of literature in the ... Read more >>

Ann Card Anaesth (Annals of cardiac anaesthesia)
[2020, 23(1):14-19]

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Pediatric Intensive Care: Immunomodulation With Activated Protein C ex vivo.

Hassan O Eliwan, William R G Watson, Irene Regan, Brian Philbin, Fiona M O'Hare, Tammy Strickland, Amanda O'Neill, Michelle O'Rourke, Alfonso Blanco, Martina Healy, Beatrice Nolan, Owen Smith, Eleanor J Molloy,

Objective: Sepsis is major cause of morbidity and mortality in the Pediatric Intensive Care Unit (PICU). PICU patients may develop transient immune deficiency during sepsis. Activated Protein C (APC) has significant anti-inflammatory and cytoprotective effects. Clinical trials of APC in adult sepsis initially showed improved outcome but recent trials showed ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2019, 7:386]

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