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A real time image-guided reposition system for the loosed bone graft in orthognathic surgery.

Xiaojun Chen, Yang Li, Lu Xu, Yi Sun, Constantinus Politis, Xiaoyi Jiang,

In traditional orthognathic surgery, the dental splint technique is typically used to assist surgeons to reposition the maxilla or mandible. However, the design and manufacturing of dental splints is time-consuming and labor-intensive, and the templates may not applicable for some complicated cases due to the anatomic intricacies in the maxillofacial ... Read more >>

Comput Assist Surg (Abingdon) (Computer assisted surgery (Abingdon, England))
[2021, 26(1):1-8]

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Inhaled nitric oxide and acute kidney injury risk: a meta-analysis of randomized controlled trials.

Junqiu Wang, Xuhui Cong, Mengrong Miao, Yitian Yang, Jiaqiang Zhang,

<h4>Purpose</h4>There are conflicting results as to the effect of inhaled nitric oxide (iNO) therapy on the risk of acute kidney injury (AKI). The aim of this study was to perform a meta-analysis to assess the updated data.<h4>Methods</h4>We systematically searched Web of Science, the Cochrane Library, Wanfang, and PubMed for relevant ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):281-290]

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The feasibility of one-stage flexible ureteroscopy lithotripsy in solitary kidney patients with 1-3 cm renal stones and risk factors of renal function changes.

Yang Pan, Han Chen, Hualin Chen, Xiaoxiang Jin, Yunxiao Zhu, Gang Chen,

<h4>Purpose</h4>To compare perioperative outcomes and long-term renal function changes between prior stenting (PS) and not prior stenting (NPS) before flexible ureteroscopy lithotripsy (f-URS) for solitary kidney patients.<h4>Methods</h4>Solitary kidney patients with 10-30 mm renal stones were enrolled in this historical control study. Perioperative parameters and complications were compared. Stone-free was defined as ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):264-272]

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Activating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/SMAD signaling pathway.

Xue-Ming Wang, Xiu-Mei Liu, Yuting Wang, Zhen-Yu Chen,

The successful treatment of keloids is a great challenge in the plastic surgery field. Activating transcription factor 3 (ATF3) is discovered as an adaptive responsive gene, which plays a critical role in fibroblast activation. This study aimed to investigate the expression and biological role of ATF3 in the pathogenesis of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):117-126]

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Patients experience of warmth and coldness in connection with surgery - a phenomenological study.

Ingrid L Gustafsson, Mikael Rask, Kristina Schildmeijer, Carina Elmqvist,

<b>Purpose</b>: The aim was to describe patients' lived experience of warmth and coldness in connection with surgery. <b>Methods</b>: A reflective lifeworld research (RLR) approach founded on phenomenology and the methodological principles of openness, flexibility, and bridling were used. The data consisted of 16 in-depth interviews with patients from four hospitals ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2021, 16(1):1858540]

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Improved procedure for Brown's Class III maxillary reconstruction with composite deep circumflex iliac artery flap using computer-assisted technique.

Wen-Bo Zhang, Hui Yuh Soh, Yao Yu, Chuan-Bin Guo, Guang-Yan Yu, Xin Peng,

Reconstruction of Brown's Class III maxillary defect can be challenging due to the complex geometry of maxilla. We aimed to introduce an improved method for maxillary reconstruction with a composite deep circumflex iliac artery (DCIA) flap aided by virtual surgical planning and intraoperative navigation. A 27-year-old woman diagnosed with left ... Read more >>

Comput Assist Surg (Abingdon) (Computer assisted surgery (Abingdon, England))
[2021, 26(1):9-14]

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Three-dimension correction of Charcot ankle deformity with a titanium implant.

Gang Wang, Junhao Lin, Hong Zhang, Yantao Pei, Lei Zhu, Qingjia Xu,

<h4>Background</h4>Charcot neuroarthropathy of the ankle is an extremely challenging clinical dilemma, and its surgical management can be highly complicated. The goal of Charcot ankle treatment is to to restore a plantigrade and stable foot, and thus to avoid ulceration with subsequent infection. This report aims to introduce a method of ... Read more >>

Comput Assist Surg (Abingdon) (Computer assisted surgery (Abingdon, England))
[2021, 26(1):15-21]

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Using standard X-ray images to create 3D digital bone models and patient-matched guides for aiding implant positioning and sizing in total knee arthroplasty.

Vincent Massé, Raju S Ghate,

X-Atlas™ is a new imaging technology intended to advance the state of the art in patient-specific instrumentation. It uses standard AP and lateral radiographs instead of CT or MRI scans to create 3D bone models, which can be used to perform pre-operative surgical planning and fabricate TKA personalized guides. The ... Read more >>

Comput Assist Surg (Abingdon) (Computer assisted surgery (Abingdon, England))
[2021, 26(1):31-40]

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Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275.

Junpeng Feng, Jianhang Li, Peng Qie, Zhenhua Li, Yanzhao Xu, Ziqiang Tian,

It is necessary to explore new molecules for the improvement of precise diagnosis and antitumor therapies in lung cancer. LncRNAs (long non-coding RNAs) play an important role in the regulation of cancer cell malignant behavior and tumor development. In this work, we found that a newly discovered lncRNA, lncRNA PGM5P4-AS1, ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):196-207]

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Optimization of radiation settings for angiography using 3D fluoroscopy for imaging of intracranial aneurysms.

Thomas Linsenmann, Alexander März, Vera Duffner, Christian Stetter, Judith Weiland, Thomas Westermaier,

Mobile 3D fluoroscopes have become increasingly available in neurosurgical operating rooms. We recently reported its use for imaging cerebral vascular malformations and aneurysms. This study was conducted to evaluate various radiation settings for the imaging of cerebral aneurysms before and after surgical occlusion. Eighteen patients with cerebral aneurysms with the ... Read more >>

Comput Assist Surg (Abingdon) (Computer assisted surgery (Abingdon, England))
[2021, 26(1):22-30]

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Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome.

Javier Toro-Pérez, Ramón Rodrigo,

<h4>Background</h4>The extent of the damage following surgery has been subject of study for several years. Numerous surgical complications can impact postoperative quality of life of patients and even can cause mortality. Although these complications are generally due to multifactorial mechanisms, oxidative stress plays a key pathophysiological role. Moreover, oxidative stress ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):35-44]

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The intra-class heterogeneity of immunophenotyping and immune landscape in oesophageal cancer and clinical implications.

Yujie Xie, Xiaoshun Shi, Ying Chen, Bomeng Wu, Xiaolin Gong, Weicheng Lu, Wanli Lin,

<h4>Background</h4>The response rate and survival benefit of immunotherapy vary among patients, implying specific immune status of an individual could be associated with the effect of immunotherapy. However, in-depth studies of immune subtypes (ISs), immune landscape and tumour microenvironment of oesophageal cancer (ESCA) and their clinical implications are less reported.<h4>Methods</h4>We first ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):626-638]

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Three cases of retained cuff related infection after manual pull removal of peritoneal dialysis catheter.

Suojian Zhang, Xu Zhang, Haitao Li, Zhiqiang Wei, Juan Cao,

Ren Fail (Renal failure)
[2021, 43(1):58-61]

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The interaction of TEA domain transcription factor 4 (TEAD4) and Yes-associated protein 1 (YAP1) promoted the malignant process mediated by serum/glucocorticoid regulated kinase 1 (SGK1).

Songlin He, Hanlu Zhang, Zongwei Xiao, Sandeep Bhushan, Ke Gao, Wenping Wang,

TEA domain transcription factor 4 (TEAD4) has been investigated to be implicated in the progression of various cancers, and it plays a role in the esophageal squamous cell carcinoma (ESCC). The study was designed to investigate how TEAD4 affected the progression of ESCC through Hippo signaling pathway <i>in vitro</i> and ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):601-614]

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Prognostic significance of microRNA miR-24 in cancers: a meta-analysis.

Rongqiang Liu, Weihao Kong, Shiyang Zheng, Chenyu Yu, Yajie Yu, Yuling Xu, Linsen Ye, Yi Shao,

The prognostic significance of miR-24 in tumors has not been determined. Therefore, we conducted a meta-analysis to systematically assess the correlation between miR-24 and its prognostic value in cancers PubMed, EMBASE, and Web of Science databases were used to search relevant articles (up to 1 October 2020). Studies that evaluated ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):450-460]

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Selenium nanoparticles coated with pH responsive silk fibroin complex for fingolimod release and enhanced targeting in thyroid cancer.

Xiangcai Zou, Zhipeng Jiang, Liang Li, Zonghai Huang,

Cancer-targeted drug delivery systems based on nanoparticles (NPs) have been considered promising therapies. In this study, we developed a pH-responsive smart NPs drug delivery system using silk fibroin (SF), selenium nanoparticles (Se NPs), fingolimod (FTY720), and heptapeptide (T7). The prepared [email protected] NPs were spheres with an average diameter of 120 nm, ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2021, 49(1):83-95]

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Effect of galectin-3 in the pathogenesis of arteriovenous fistula stenosis formation.

Lin Ruan, Xiaoguang Yao, Wen Li, Lihong Zhang, Hongxia Yang, Jiahuan Sun, Aiying Li,

<h4>Objective</h4>This study sought to investigate the effect of local expression of galectin-3 in the development of stenotic arteriovenous fistula (AVF).<h4>Methods</h4>We collected stenotic venous tissues, adjacent nonstenotic venous tissues, and blood samples from end-stage renal disease (ESRD) patients with AVF stenosis, while normal venous tissues and blood samples were collected from ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):566-576]

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Impact of fibrin glue versus suture closure on double-headed pterygia in Asian eyes - a 7-year study in a tertiary institution.

Wei Wei Dayna Yong, Liang Shen, Ray Manotosh, Wee Tien Anna Marie Tan, Hui Chen Charmaine Chai,

<h4>Background</h4>To compare the recurrence rate and outcomes of double-headed pterygia using fibrin glue versus suture closure of conjunctival autograft.<h4>Methods</h4>All patients with double-headed pterygia who underwent pterygia excision with conjunctival autograft from January 2012 to January 2019 in the National University Hospital of Singapore were included. Patients were divided into 2 ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):448-455]

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Autologous decellularized extracellular matrix promotes adipogenic differentiation of adipose derived stem cells in low serum culture system by regulating the ERK1/2-PPARγ pathway.

Yao Qian, Hao Chen, Tianyun Pan, Tian Li, Zikai Zhang, Xuling Lv, Jingping Wang, Ziwan Ji, Yucang He, Liqun Li, Ming Lin,

High viability and further adipogenic differentiation of adipose-derived stem cells (ADSCs) are fundamental for engraftment and growth of the transplanted adipose tissue. It has been demonstrated that extracellular matrix (ECM) regulates cell proliferation and differentiation by interacting with ERK1/2 signalling pathway. In this study, we prepared autologous decellularized extracellular matrix ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):174-188]

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Biomolecular assembly on interdigitated electrode nanosensor for selective detection of insulin-like growth factor-1.

Yan Gu, Lijie Liu, Jian Guo, Shun Xiao, Fang Fang, Xiaoyun Yu, Subash C B Gopinath, Jianlie Wu, Xunqiang Liu,

This research is focussed to quantify IGF1 by electroanalytical analysis on InterDigitated electrode surface and characterized by the microscopic observations. For the detection, antibody and aptamer were used to analyze the level of IGF1. The sandwich pattern (aptamer-IGF1-antibody) was designed on the chemically modified IDE surface and reached the limit ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2021, 49(1):30-37]

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Ten minutes to midnight: a narrative inquiry of people living with dying with advanced copd and their family members.

Anita E Molzahn, Laurene Sheilds, Marcy Antonio, Anne Bruce, Kara Schick-Makaroff, Robyn Wiebe,

<b>Purpose</b>: To explore how people with end stage chronic obstructive pulmonary disease and their family members describe living in the face of impending death.<b>Methods</b>: A narrative inquiry was undertaken using a social constructionist perspective. Data were collected in 2017-18 in two in-depth interviews, lasting 90 to 120 minutes approximately 3-4 months apart, ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2021, 16(1):1893146]

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Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression.

Chuan-Cui Zhang, Yuhua Li, Xian-Zhen Feng, Dian-Bo Li,

As a type of non-coding RNA, circular RNA (circRNA) figures prominently in human cancer progression. Nonetheless, the expression, function, and regulatory mechanism of circ_0001287 in non-small cell lung cancer (NSCLC) remain obscure. In this work, quantitative real-time polymerase chain reaction (qRT-PCR) was implemented to quantify circ_0001287 and miR-21 expressions in ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):414-425]

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Clinical profile of a Polish cohort of children and young adults with cystinuria.

Marcin Tkaczyk, Katarzyna Gadomska-Prokop, Iga Załuska-Leśniewska, Kinga Musiał, Jan Zawadzki, Katarzyna Jobs, Tadeusz Porowski, Anna Rogowska-Kalisz, Anna Jander, Meritrafat Kirolos, Adam Haliński, Aleksandra Krzemień, Agnieszka Sobieszczańska-Droździel, Katarzyna Zachwieja, Bodo B Beck, Przemysław Sikora, Marcin Zaniew,

<h4>Background</h4>Cystinuria is an inherited disorder that results in increased excretion of cystine in the urine. It accounts for about 1-2% of pediatric kidney stones. In this study, we sought to identify the clinical characteristics of patients with cystinuria in a national cohort.<h4>Methods</h4>This was a retrospective study involving 30 patients from ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):62-70]

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Long intergenic noncoding RNA00265 promotes proliferation of gastric cancer via the microRNA-144-3p/Chromobox 4 axis.

Zengxi Yang, Xi OuYang, Liang Zheng, Lizhen Dai, Wenjuan Luo,

The expression and biological function of long intergenic noncoding RNA00265 (LINC00265) in gastric cancer (GC) have not yet been explored. This study aimed to detect LINC00265 expression in GC tissues and cell lines, investigate its roles in the proliferation of GC cells in vitro, and elucidate the regulatory mechanisms of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1012-1025]

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Alpha lipoic acid attenuates evoked and spontaneous pain following surgical skin incision in rats.

Sonja Lj Joksimovic, Nathan Lamborn, Vesna Jevtovic-Todorovic, Slobodan M Todorovic,

Our previous studies have implicated Ca<sub>V</sub>3.2 isoform of T-type Ca2+ channels (T-channels) in the development of postsurgical pain. We have also previously established that different T-channel antagonists can alleviate in vivo postsurgical pain. Here we investigated the analgesic potential of another T-channel blocker and endogenous antioxidant molecule, α-lipoic acid (ALA), in ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):398-407]

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