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Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response.

Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han,

<h4>Context</h4>Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs). Aspirin could prevent cardiomyocyte damage by inducing heat shock response.<h4>Objective</h4>This study investigates the effect of aspirin on alleviating VSMC calcification.<h4>Materials and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):17-24]

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First, do no harm: impact of the transition to an integrated curriculum on medical knowledge acquisition of the transitional cohort.

Kirstin Nackers, Raquel Tatar, Eileen Cowan, Laura Zakowski, Katharina Stewart, Sarah Ahrens, Laura Jacques, Shobhina Chheda,

<h4>Introduction</h4>Many medical schools are moving toward integrated curricula in response to the 2010 Carnegie report. However, there is often apprehension that student performance on standard assessment metrics of medical knowledge acquisition could suffer during the transition period. Therefore, we sought to analyze the impact of curriculum redesign on the medical ... Read more >>

Med Educ Online (Medical education online)
[2022, 27(1):2007561]

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Comparative analgesic, hemodynamic, pain and duration of sensory and motor block effects of dexmedetomidine, granisetron, and nitroglycerin added to ropivacaine in intravenous anesthesia for forearm surgeries: a randomized clinical study.

Esmail Moshiri, Hesameddin Modir, Alireza Kamali, Mehran Azami, Morteza Molouk,

This trial-based paper strives to address the comparative efficacy of some ropivacaine adjuvant options, comprising dexmedetomidine, granisetron, and nitroglycerin, on pain and hemodynamic changes in intravenous anesthesia for forearm surgeries. This double-blind, placebo-controlled study enrolled four block-randomized eligible groups with patients (overall, n=128) undergoing orthopedic forearm surgeries in the dexmedetomidine, ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(3):77-82]

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Optical tissue clearing enables rapid, precise and comprehensive assessment of three-dimensional morphology in experimental nerve regeneration research.

Simeon C Daeschler, Jennifer Zhang, Tessa Gordon, Gregory H Borschel,

Morphological analyses are key outcome assessments for nerve regeneration studies but are historically limited to tissue sections. Novel optical tissue clearing techniques enabling three-dimensional imaging of entire organs at a subcellular resolution have revolutionized morphological studies of the brain. To extend their applicability to experimental nerve repair studies we adapted ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1348-1356]

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L4-to-L4 nerve root transfer for hindlimb hemiplegia after hypertensive intracerebral hemorrhage.

Teng-Da Qian, Xi-Feng Zheng, Jing Shi, Tao Ma, Wei-Yan You, Jia-Huan Wu, Bao-Sheng Huang, Yi Tao, Xi Wang, Ze-Wu Song, Li-Xin Li,

There is no effective treatment for hemiplegia after hypertensive intracerebral hemorrhage. Considering that the branches of L4 nerve roots in the lumbar plexus root control the movement of the lower extremity anterior and posterior muscles, we investigated a potential method of nerve repair using the L4 nerve roots. Rat models ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1278-1285]

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Experimental nerve transfer model in the neonatal rat.

Matthias E Sporer, Martin Aman, Konstantin D Bergmeister, Dieter Depisch, Katharina M Scheuba, Ewald Unger, Bruno K Podesser, Oskar C Aszmann,

Clinically, peripheral nerve reconstructions in neonates are most frequently applied in brachial plexus birth injuries. Most surgical concepts, however, have investigated nerve reconstructions in adult animal models. The immature neuromuscular system reacts differently to the effects of nerve lesion and surgery and is poorly investigated due to the lack of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1088-1095]

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Facial reanimation with interposition nerve graft or masseter nerve transfer: a comparative retrospective study.

Wen-Jin Wang, Wei-Dong Zhu, Mathias Tremp, Gang Chen, Zhao-Yan Wang, Hao Wu, Wei Wang,

Both interposition nerve grafts and masseter nerve transfers have been successfully used for facial reanimation after irreversible injuries to the cranial portion of the facial nerve. However, no comparative study of these two procedures has yet been reported. In this two-site, two-arm, retrospective case review study, 32 patients were included. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1125-1130]

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Repairing whole facial nerve defects with xenogeneic acellular nerve grafts in rhesus monkeys.

Guo-Chen Zhu, Da-Jiang Xiao, Bi-Wen Zhu, Yan Xiao,

Acellular nerve allografts conducted via chemical extraction have achieved satisfactory results in bridging whole facial nerve defects clinically, both in terms of branching a single trunk and in connecting multiple branches of an extratemporal segment. However, in the clinical treatment of facial nerve defects, allogeneic donors are limited. In this ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1131-1137]

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Neuroprotective effects of long noncoding RNAs involved in ischemic postconditioning after ischemic stroke.

Wei Ma, Chun-Yan Li, Si-Jia Zhang, Cheng-Hao Zang, Jin-Wei Yang, Zhen Wu, Guo-Dong Wang, Jie Liu, Wei Liu, Kuang-Pin Liu, Yu Liang, Xing-Kui Zhang, Jun-Jun Li, Jian-Hui Guo, Li-Yan Li,

During acute reperfusion, the expression profiles of long noncoding RNAs in adult rats with focal cerebral ischemia undergo broad changes. However, whether long noncoding RNAs are involved in neuroprotective effects following focal ischemic stroke in rats remains unclear. In this study, RNA isolation and library preparation was performed for long ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1299-1309]

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Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury.

Yi-Xin Wang, Jin-Zhu Bai, Zhen Lyu, Guang-Hao Zhang, Xiao-Lin Huo,

Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. Although it has been used in spinal cord injury (SCI) therapy in basic and clinical studies, its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood. In this study, we established ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1318-1323]

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Evaluating the Efficacy of Combined P188 Treatment and Surgical Intervention in Preventing Post-Traumatic Osteoarthritis Following a Traumatic Knee Injury.

Gerardo E Narez, Gabriel Brown, Ashley Herrick, Ryan J Ek, Loic Dejardin, Feng Wei, Roger C Haut, Tammy L Haut Donahue,

Previous studies have shown that reconstructive surgery alone following injury to the anterior cruciate ligament (ACL) does not prevent the development of post-traumatic osteoarthritis (PTOA). Poloxamer 188 (P188) has been shown to prevent cell death following trauma in both articular cartilage and meniscal tissue. This study aims to test the ... Read more >>

J Biomech Eng (Journal of biomechanical engineering)
[2022, 144(4):]

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Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury.

Rui Zhao, Xue Wu, Xue-Yuan Bi, Hao Yang, Qian Zhang,

Baicalin is a natural active ingredient isolated from Scutellariae Radix that can cross the blood-brain barrier and exhibits neuroprotective effects on multiple central nervous system diseases. However, the mechanism behind the neuroprotective effects remains unclear. In this study, rat models of spinal cord injury were established using a modified Allen's ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1080-1087]

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All roads lead to Rome - a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer's disease.

Yi-Yao Liang, Li-Dan Zhang, Xi Luo, Li-Li Wu, Zhao-Wei Chen, Guang-Hao Wei, Kai-Qing Zhang, Ze-An Du, Ren-Zhi Li, Kwok-Fai So, Ang Li,

Age-related neurodegenerative disorders such as Alzheimer's disease (AD) have become a critical public health issue due to the significantly extended human lifespan, leading to considerable economic and social burdens. Traditional therapies for AD such as medicine and surgery remain ineffective, impractical, and expensive. Many studies have shown that a variety ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1210-1227]

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Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches.

Dong Han, Jiafeng Zhang, Bartley P Griffith, Zhongjun J Wu,

Shear-induced platelet activation is one of the critical outcomes when blood is exposed to elevated shear stress. Excessively activated platelets in the circulation can lead to thrombus formation and platelet consumption, resulting in serious adverse events such as thromboembolism and bleeding. While experimental observations reveal that it is related to ... Read more >>

J Biomech Eng (Journal of biomechanical engineering)
[2022, 144(4):]

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Gut-brain axis in traumatic brain injury: impact on neuroinflammation.

Marta Celorrio, Stuart H Friess,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1007-1008]

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Perioperative melatonin in COVID-19 patients: benefits beyond sedation and analgesia.

Abhijit S Nair,

Cytokine storm in coronavirus disease 2019 (COVID-19) patients leads to acute lung injury, acute respiratory distress syndrome, multiorgan dysfunction, shock, and thrombosis thus contributing to significant morbidity and mortality. Several agents like steroids, ascorbic acid, vitamins (C, D, E), glutathione, N-acetylcysteine have been used and several studies are underway to ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(2):41-43]

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Social Disparities in the Thoracic Surgery Workforce.

DuyKhanh P Ceppa,

Diversity fosters innovation, advances the work environment, and enriches patient care. Despite that, only 17%, 5%, and 3% of cardiothoracic (CT) surgeons in academia were women, Hispanic, and Black, respectively. Diversity, equity, and inclusion goals and deliberate initiatives are necessary to eradicate disparities in the CT workforce. Leading organizational changes ... Read more >>

Thorac Surg Clin (Thoracic surgery clinics)
[2022, 32(1):103-109]

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Social Disparities in Thoracic Surgery Education.

Luis A Godoy, Elise Hill, David T Cooke,

Despite an ever-diversifying US population, women, and underrepresented minorities lack proportionate membership in the CT surgery workforce. CT surgery is the surgical specialty practiced by the oldest surgeons as a group. This highlights a deficit within our specialty and foreshadows a shrinking of the CT surgery workforce that will be ... Read more >>

Thorac Surg Clin (Thoracic surgery clinics)
[2022, 32(1):91-102]

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Social Disparities in Thoracic Surgery: Actionable Items.

Virginia R Litle,

Thorac Surg Clin (Thoracic surgery clinics)
[2022, 32(1):xi]

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Soft Tissue Injuries Including Auricular Hematoma Management.

Zachary A Zimmerman, Douglas M Sidle,

Facial trauma accounts of 7% to 10% of emergency department visits in the United States every year. The management of facial soft tissue trauma is an essential skill for the facial plastic surgeon. Understanding preoperative evaluation, repair/management of concomitant injuries, postoperative care, and scar treatment help the facial plastic surgeon ... Read more >>

Facial Plast Surg Clin North Am (Facial plastic surgery clinics of North America)
[2022, 30(1):15-22]

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Challenges in the Methodology for Health Disparities Research in Thoracic Surgery.

Sakib M Adnan, Michael Poulson, Virginia R Litle, Cherie P Erkmen,

Research on health disparities in thoracic surgery is based on large population-based studies, which is associated with certain biases. Several methodological challenges are associated with these biases and warrant review and attention. The lack of standardized definitions in health disparities research requires clarification for study design strategy. Further inconsistencies remain ... Read more >>

Thorac Surg Clin (Thoracic surgery clinics)
[2022, 32(1):67-74]

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Social Disparities in Thoracic Surgery Database Research: Implications and Impact.

Kyle G Mitchell, Ian C Bostock, Mara B Antonoff,

A complex relationship exists between health care disparities and large databases among the thoracic surgical patient population. Using the example of thoracic malignancies, the ability of investigations leveraging large databases and novel analytical approaches to highlight disparate access to care and discordant outcomes following treatment is illustrated. Large, widely used ... Read more >>

Thorac Surg Clin (Thoracic surgery clinics)
[2022, 32(1):83-90]

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Surgical Management of Chronic Thromboembolic Pulmonary Hypertension.

Andrew M Vekstein, Joseph R Nellis, Sharon L McCartney, John C Haney,

Chronic thromboembolic pulmonary hypertension is a progressive disease, which may lead to severe right ventricular dysfunction and debilitating symptoms. Pulmonary thromboendarterectomy (PTE) provides the best opportunity for complete resolution of obstructing thromboembolic disease and functional improvement in appropriately selected patients. In this article, the authors review preoperative workup, patient selection, ... Read more >>

Cardiol Clin (Cardiology clinics)
[2022, 40(1):89-101]

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Effect of Temperature and Freezing on Human Adipose Tissue Material Properties Characterized by High-Rate Indentation: Puncture Testing.

Zhaonan Sun, Bronislaw D Gepner, Sang-Hyun Lee, Michelle L Oyen, Joshua Rigby, Patrick S Cottler, Jason J Hallman, Jason R Kerrigan,

The characterization of human subcutaneous adipose tissue (SAT) under high-rate loading is valuable for development of biofidelic finite element human body models (FE-HBMs) to predict seat belt-pelvis interaction and injury risk in vehicle crash simulations. While material characterization of SAT has been performed at 25 °C or 37 °C, the effect of ... Read more >>

J Biomech Eng (Journal of biomechanical engineering)
[2022, 144(3):]

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Current Concepts in Prophylactic Antibiotics in Oral and Maxillofacial Surgery.

Chad Dammling, Shelly Abramowicz, Brian Kinard,

Antibiotic prophylaxis is the use of antibiotics in the perioperative period to prevent surgical site infections from local flora. Specific guidelines and criteria exist to prevent these infections while also practicing antimicrobial stewardship. Most dentoalveolar procedures do not require antibiotic prophylaxis. For nondentoalveolar procedures, the decision to provide antibiotic prophylaxis ... Read more >>

Oral Maxillofac Surg Clin North Am (Oral and maxillofacial surgery clinics of North America)
[2022, 34(1):157-167]

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