Full Text Journal Articles about
Sudden Unexpected Death in Epilepsy

Advertisement

Find full text journal articles






Prevention of sudden unexpected death in epilepsy: current status and future perspectives.

Max Christian Pensel, Robert Daniel Nass, Erik Taubøll, Dag Aurlien, Rainer Surges,

INTRODUCTION:Sudden unexpected death in epilepsy (SUDEP) affects about 1 in 1000 people with epilepsy, and even more in medically refractory epilepsy. As most people are between 20 and 40 years when dying suddenly, SUDEP leads to a considerable loss of potential life years. The most important risk factors are nocturnal ... Read more >>

Expert Rev Neurother (Expert review of neurotherapeutics)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP).

Melissa J Maguire, Cerian F Jackson, Anthony G Marson, Sarah J Nevitt,

BACKGROUND:This is an updated version of the original Cochrane Review, published in 2016, Issue 7. Sudden Unexpected Death in Epilepsy (SUDEP) is defined as sudden, unexpected, witnessed or unwitnessed, non-traumatic or non-drowning death of people with epilepsy, with or without evidence of a seizure, excluding documented status epilepticus and in ... Read more >>

Cochrane Database Syst Rev (The Cochrane Database of Systematic Reviews)
[2020, 4:CD011792]

Cited: 0 times

View full text PDF listing >>



Advertisement

Genetic generalized and focal epilepsy prevalence in the North American SUDEP Registry.

Chloe Verducci, Daniel Friedman, Elizabeth Donner, Orrin Devinsky,

OBJECTIVE:To assess relative rates and clinical features of patients with genetic generalized epilepsy (GGE), focal epilepsy (FE), and developmental encephalopathic epilepsy (DEE) in the North American SUDEP Registry (NASR). METHODS:We identified all adjudicated definite, definite plus, and probable sudden unexpected death in epilepsy (SUDEP) cases (n = 262) and determined ... Read more >>

Neurology (Neurology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP.

Smriti Patodia, Beatrice Paradiso, Maria Garcia, Matthew Ellis, Beate Diehl, Maria Thom, Orrin Devinsky,

OBJECTIVE:The "adenosine hypothesis of SUDEP" (sudden unexpected death in epilepsy) predicts that a seizure-induced adenosine surge combined with impaired metabolic clearance can foster lethal apnea or cardiac arrest. Changes in adenosine receptor density and adenosine kinase (ADK) occur in surgical epilepsy patients. Our aim was to correlate the distribution of ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Sudden death in a patient with long QT syndrome presenting with an epileptic phenotype.

Esseim Sharma, Stephen Gannon, Brian McCauley, Antony F Chu,

Patients with epilepsy suffer from a higher mortality rate than the general population, a portion of which is not due to epilepsy itself or comorbid conditions. Sudden unexpected death in epilepsy (SUDEP) is a common but poorly understood cause of death in patients with intractable epilepsy and often afflicts younger ... Read more >>

Ann Noninvasive Electrocardiol (Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc)
[2020, :e12753]

Cited: 0 times

View full text PDF listing >>



Incorporating Ethically Relevant Empirical Data From Systematic Review of Reasons: A Case Study of Sudden Unexpected Death in Epilepsy.

Robert Torrance, Chang-Ho Yoon, Andrew B Torrance, Robert C Tasker,

In this report we use a case study of risk of sudden unexpected death in epilepsy (SUDEP) to illustrate the contribution of systematic literature reviews of disease-specific ethical issues (DSEI). In particular, we show how ethically-relevant empirical data from such reviews can be used in the examination of the reasons ... Read more >>

AJOB Empir Bioeth (AJOB empirical bioethics)
[2020, :1-13]

Cited: 0 times

View full text PDF listing >>



A human amygdala site that inhibits respiration and elicits apnea in pediatric epilepsy.

Ariane E Rhone, Christopher K Kovach, Gail Is Harmata, Alyssa W Sullivan, Daniel Tranel, Michael A Ciliberto, Matthew A Howard, George B Richerson, Mitchell Steinschneider, John A Wemmie, Brian J Dlouhy,

BACKGROUNDSeizure-induced inhibition of respiration plays a critical role in sudden unexpected death in epilepsy (SUDEP). However, the mechanisms underlying seizure-induced central apnea in pediatric epilepsy are unknown.METHODSWe studied 8 pediatric patients with intractable epilepsy undergoing intracranial electroencephalography. We recorded respiration during seizures and during electrical stimulation mapping of 174 forebrain ... Read more >>

JCI Insight (JCI insight)
[2020, 5(6):]

Cited: 0 times

View full text PDF listing >>



Mortality in infantile spasms: A hospital-based study.

Chellamani Harini, Elanagan Nagarajan, Ann M Bergin, Phillip Pearl, Tobias Loddenkemper, Masanori Takeoka, Peter F Morrison, David Coulter, Gita Harappanahally, Candice Marti, Kanwaljit Singh, Christopher Yuskaitis, Annapurna Poduri, Mark H Libenson,

OBJECTIVE:To determine risk factors and causes for mortality during childhood in patients with infantile spasms (IS). We describe the overall goals of care for those who died. METHODS:This is a retrospective chart review of IS patients born between 2000 and 2011. We examined potential risk factors for mortality, including etiology, ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy.

Alba González, Cecilie Gjessing Nome, Bård Andre Bendiksen, Ivar Sjaastad, Lili Zhang, Mona Aleksandersen, Erik Taubøll, Dag Aurlien, Kjell Heuser,

Sudden unexpected death in epilepsy (SUDEP) is a significant cause of premature seizure-related death. An association between SUDEP and cardiac remodeling has been suggested. However, whether SUDEP is a direct consequence of acute or recurrent seizures is unsettled. The purpose of this study was to evaluate the impact of status ... Read more >>

Epilepsy Res. (Epilepsy research)
[2020, 161:106300]

Cited: 0 times

View full text PDF listing >>



The Epileptic Heart: Concept and clinical evidence.

Richard L Verrier, Trudy D Pang, Bruce D Nearing, Steven C Schachter,

Sudden unexpected death in epilepsy (SUDEP) is generally considered to result from a seizure, typically convulsive and usually but not always occurring during sleep, followed by a sequence of events in the postictal period starting with respiratory distress and progressing to eventual cardiac asystole and death. Yet, recent community-based studies ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 105:106946]

Cited: 0 times

View full text PDF listing >>



Cardiac arrhythmias in Dravet syndrome: an observational multicenter study.

Sharon Shmuely, Rainer Surges, Robert M Helling, W Boudewijn Gunning, Eva H Brilstra, Judith S Verhoeven, J Helen Cross, Sanjay M Sisodiya, Hanno L Tan, Josemir W Sander, Roland D Thijs,

OBJECTIVES:We ascertained the prevalence of ictal arrhythmias to explain the high rate of sudden unexpected death in epilepsy (SUDEP) in Dravet syndrome (DS). METHODS:We selected cases with clinical DS, ≥6 years, SCN1A mutation, and ≥1 seizure/week. Home-based ECG recordings were performed for 20 days continuously. Cases were matched for age and sex to ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



SUDEP among young adults in the San Diego County Medical Examiner Office.

Esma Karlovich, Orrin Devinsky, Michael Brandsoy, Daniel Friedman,

Excess mortality due to epilepsy is greatest among young adults. However, the relative proportions of sudden unexpected death in epilepsy (SUDEP) and other epilepsy-related causes of death are not well defined. We prospectively adjudicated cause of death in all 18- to 45-year-olds with a history of seizure/epilepsy who underwent medicolegal ... Read more >>

Epilepsia (Epilepsia)
[2020, 61(3):e17-e22]

Cited: 0 times

View full text PDF listing >>



Review on post-mortem diagnosis in suspected SUDEP: Currently still a difficult task for Forensic Pathologists.

Rosario Barranco, Fiorella Caputo, Andrea Molinelli, Francesco Ventura,

Sudden and unexpected death in epilepsy (SUDEP) represents the predominant cause of premature deaths in young adults with epilepsy and is more common with patients with poorly controlled and generalized convulsive seizures. It is reported that there are 1,16 cases for every 1000 subjects affected with epilepsy. This review takes ... Read more >>

J Forensic Leg Med (Journal of forensic and legal medicine)
[2020, 70:101920]

Cited: 0 times

View full text PDF listing >>



Detection of Postictal Generalized Electroencephalogram Suppression: Random Forest Approach.

Xiaojin Li, Shiqiang Tao, Shirin Jamal-Omidi, Yan Huang, Samden D Lhatoo, Guo-Qiang Zhang, Licong Cui,

BACKGROUND:Sudden unexpected death in epilepsy (SUDEP) is second only to stroke in neurological events resulting in years of potential life lost. Postictal generalized electroencephalogram (EEG) suppression (PGES) is a period of suppressed brain activity often occurring after generalized tonic-clonic seizure, a most significant risk factor for SUDEP. Therefore, PGES has ... Read more >>

JMIR Med Inform (JMIR medical informatics)
[2020, 8(2):e17061]

Cited: 0 times

View full text PDF listing >>



EPO And EPO-Receptor System As Potential Actionable Mechanism To Protection of Brain And Heart In Refractory Epilepsy And SUDEP.

Jerónimo Auzmendi, María Bernardita Puchulu, Julio Cesar Garcia Rodriguez, Ana María Balaszczuk, Alberto Lazarowski, Amalia Merelli,

The most important activity of erythropoietin (EPO) is the regulation of erythrocyte production by activation of the erythropoietin receptor (EPO-R), which triggers the activation of antiapoptotic and proliferative responses of erythroid progenitor cells. Additionally, to erythropoietic EPO activity, an antiapoptotic effect has been described in a wide spectrum of tissues. ... Read more >>

Curr. Pharm. Des. (Current pharmaceutical design)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Progressive cardiorespiratory dysfunction in Kv1.1 knockout mice may provide temporal biomarkers of pending sudden unexpected death in epilepsy (SUDEP): The contribution of orexin.

Shruthi H Iyer, Ankita Aggarwal, Ted J Warren, Jodi Hallgren, Peter W Abel, Timothy A Simeone, Kristina A Simeone,

OBJECTIVE:Immediately preceding sudden unexpected death in epilepsy (SUDEP), patients experienced a final generalized tonic-clonic seizure (GTCS), rapid ventilation, apnea, bradycardia, terminal apnea, and asystole. Whether a progressive pathophysiology develops and increases risk of SUDEP remains unknown. Here, we determined (a) heart rate, respiratory rate, and blood oxygen saturation (SaO2 ) ... Read more >>

Epilepsia (Epilepsia)
[2020, 61(3):572-588]

Cited: 0 times

View full text PDF listing >>



Sudden unexpected death in epilepsy (SUDEP) in New Zealand; a retrospective review.

Mary Brennan, Shona Scott, Peter Bergin,

AIM:Sudden unexpected death in epilepsy (SUDEP) is well recognised and widely reported but remains poorly understood. SUDEP in young adults is 27 times more common than sudden death in control populations. The incidence of SUDEP in New Zealand is not known but up to 40 people with epilepsy may die ... Read more >>

N. Z. Med. J. (The New Zealand medical journal)
[2020, 133(1508):65-71]

Cited: 0 times

View full text PDF listing >>



Prone, lateral, or supine positioning at seizure onset determines the postictal body position: A multicenter video-EEG monitoring cohort study.

Katharina Mahr, Marc-Philipp Bergmann, Lara Kay, Leona Möller, Philipp S Reif, Laurent M Willems, Katja Menzler, Susanne Schubert-Bast, Karl Martin Klein, Susanne Knake, Felix Rosenow, Johann Philipp Zöllner, Adam Strzelczyk,

PURPOSE:Most patients who die from sudden unexpected death in epilepsy (SUDEP) are found in the prone position. We evaluated whether changes in body position occur during generalized convulsive seizures (GCSs). METHOD:GCSs in patients undergoing video-EEG-monitoring between 2007 and 2017 at epilepsy centers in Frankfurt and Marburg were analyzed in relation ... Read more >>

Seizure (Seizure)
[2020, 76:173-178]

Cited: 0 times

View full text PDF listing >>



Neuropeptide depletion in the amygdala in sudden unexpected death in epilepsy: A postmortem study.

Alyma Somani, Charlotte Perry, Smriti Patodia, Zuzanna Michalak, Matthew Ellis, Sanjay M Sisodiya, Maria Thom,

OBJECTIVE:Sudden unexpected death in epilepsy (SUDEP) is typically unwitnessed but can be preceded by seizures in the period prior to death. Peri-ictal respiratory dysfunction is a likely mechanism for some SUDEP, and central apnea has been shown following amygdala stimulation. The amygdala is enriched in neuropeptides that modulate neuronal activity ... Read more >>

Epilepsia (Epilepsia)
[2020, 61(2):310-318]

Cited: 0 times

View full text PDF listing >>



Editorial: Ketogenic Diet in Epilepsy and Associated Comorbidities: Clinical Efficacy and Mechanisms.

Tianfu Li, Jiong Qin, Xiang-Ping Chu,

Front Neurol (Frontiers in neurology)
[2020, 11:66]

Cited: 0 times

View full text PDF listing >>



Neuron-specific Kv1.1 deficiency is sufficient to cause epilepsy, premature death, and cardiorespiratory dysregulation.

Krystle Trosclair, Hemangini A Dhaibar, Nicole M Gautier, Vikas Mishra, Edward Glasscock,

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but the precise cellular substrates involved remain elusive. Epilepsy-associated ion channel genes with co-expression in brain and heart have been proposed as SUDEP candidate genes since they provide a singular unifying link between seizures and lethal cardiac ... Read more >>

Neurobiol. Dis. (Neurobiology of disease)
[2020, 137:104759]

Cited: 0 times

View full text PDF listing >>



Patients with generalized epilepsy are also at risk for SUDEP.

Milena Pavlova, Elizabeth E Gerard, Gregory D Cascino,

Neurology (Neurology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Audiogenic seizure as a model of sudden death in epilepsy: A comparative study between four inbred mouse strains from early life to adulthood.

Benoît Martin, Gabriel Dieuset, Jodi L Pawluski, Nathalie Costet, Arnaud Biraben,

OBJECTIVE:Mouse models of sudden unexpected death in epileptic patients (SUDEP) using audiogenic seizures (AGS) are valuable because death can occur following a sound-induced seizure in the absence of any pharmacologic or electric component. However, only a few strains of mice are AGS prone, and the vast majority of studies involve ... Read more >>

Epilepsia (Epilepsia)
[2020, 61(2):342-349]

Cited: 0 times

View full text PDF listing >>



Knowledge and attitudes about sudden death in epilepsy among people living with epilepsy and their healthcare providers in Mulago Hospital, Uganda: A cross-sectional study.

Mark Kaddumukasa, Emmanuel Mwesiga, Nelson Sewankambo, Carol Blixen, Samden Lhatoo, Martha Sajatovic, Elly Katabira,

Objective:The objective of the study was to assess level of knowledge and attitudes of SUDEP among people living with epilepsy (PLWE) and healthcare workers providing epilepsy care in Uganda. Methods:This cross-sectional study of 48 PLWE and 19 epilepsy care providers used a tailored questionnaire to evaluate epilepsy and SUDEP knowledge, ... Read more >>

Epilepsia Open (Epilepsia open)
[2020, 5(1):80-85]

Cited: 0 times

View full text PDF listing >>



Systematic Review of the Genetics of Sudden Unexpected Death in Epilepsy: Potential Overlap With Sudden Cardiac Death and Arrhythmia-Related Genes.

C Anwar A Chahal, Mohammad N Salloum, Fares Alahdab, Joseph A Gottwald, David J Tester, Lucman A Anwer, Elson L So, Mohammad Hassan Murad, Erik K St Louis, Michael J Ackerman, Virend K Somers,

Background Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related death. SUDEP shares many features with sudden cardiac death and sudden unexplained death in the young and may have a similar genetic contribution. We aim to systematically review the literature on the genetics of SUDEP. Methods and ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(1):e012264]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.1136 s