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Status Asthmaticus

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Temporal condition pattern mining in large, sparse electronic health record data: A case study in characterizing pediatric asthma.

Elizabeth A Campbell, Ellen J Bass, Aaron J Masino,

OBJECTIVE:This study introduces a temporal condition pattern mining methodology to address the sparse nature of coded condition concept utilization in electronic health record data. As a validation study, we applied this method to reveal condition patterns surrounding an initial diagnosis of pediatric asthma. MATERIALS AND METHODS:The SPADE (Sequential PAttern Discovery ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2020, 27(4):558-566]

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Improving Influenza Vaccination in Hospitalized Children With Asthma.

Dana M Foradori, Esther M Sampayo, S Aya Fanny, Meera K Namireddy, Anjali M Kumar, Huay-Ying Lo,

OBJECTIVES:Children with asthma are at increased risk of complications from influenza; hospitalization represents an important opportunity for vaccination. We aimed to increase the influenza vaccination rate among eligible hospitalized patients with asthma on the pediatric hospital medicine (PHM) service from 13% to 80% over a 4-year period. METHODS:Serial Plan-Do-Study-Act cycles ... Read more >>

Pediatrics (Pediatrics)
[2020, 145(3):]

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Standardized Protocol Is Associated With a Decrease in Continuous Albuterol Use and Length of Stay in Critical Status Asthmaticus.

Elliot Melendez, Danielle Dwyer, Daria Donelly, Denise Currier, Daniel Nachreiner, D Marlowe Miller, Julie Hurlbut, Michael J Pepin, Michael S D Agus, Jackson Wong,

OBJECTIVES:The primary aim of this study was to reduce duration of continuous albuterol and hospital length of stay in critically ill children with severe status asthmaticus. DESIGN:Observational prospective study from September 2012 to May 2016. SETTING:Medicine ICU and intermediate care unit. PATIENTS:Children greater than 2 years old with admission diagnosis ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, :]

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Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study.

Peng Shi, Xiaobo Zhang, Lijuan Liu, Liangfeng Tang, Jing Li, Libo Wang, Albert M Li, Yang Cao, Hong Xu, Guoying Huang,

BACKGROUND:Respiratory infections are one of three leading causes of childhood mortality, and worldwide increase and recent plateau in childhood asthma has been reported. However, data on trends of respiratory diseases over long period of time is limited. This study aimed to determine the trends of respiratory disease outpatient visits (ROVs) ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):115]

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Extracorporeal carbon dioxide removal in heart-beating donor with acute severe asthma: A case report.

Silvia De Rosa, Gianlorenzo Golino, Claudio Ronco,

Status asthmaticus is a life-threatening disorder that can manifest in dangerous levels of hypercapnia and acidosis. The use of extracorporeal carbon dioxide removal (ECCO2R) has been used successfully to control pH and PaCO2 in patients with acute severe asthma. The present report describes the use of this technology in near-fatal ... Read more >>

Respir Med Case Rep (Respiratory medicine case reports)
[2020, 29:101010]

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Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus.

Nienke J Vet, Brenda C M de Winter, Muriel Koninckx, Shelley A Boeschoten, Annemie L M Boehmer, Jacintha T Verhallen, Frans B Plötz, Anja A Vaessen-Verberne, Bart C H van der Nagel, Catherijne A J Knibbe, Corinne M P Buysse, Saskia N de Wildt, Birgit C P Koch, Matthijs de Hoog,

BACKGROUND:Intravenous salbutamol is used to treat children with refractory status asthmaticus, however insufficient pharmacokinetic data are available to guide initial and subsequent dosing recommendations for its intravenous use. The pharmacologic activity of salbutamol resides predominantly in the (R)-enantiomer, with little or no activity and even concerns of adverse reactions attributed ... Read more >>

Clin Pharmacokinet (Clinical pharmacokinetics)
[2020, 59(2):257-264]

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Association of various weight-based doses of continuous albuterol on hospital length of stay.

Raymond Parlar-Chun, Kristen Arnold,

Introduction: Continuous albuterol is a mainstay in management of pediatric status asthmaticus. While the National Heart Lung and Blood Institute Asthma Guidelines suggest 0.5 mg/kg/h as the recommended dosage, there is a paucity of evidence comparing different weight-based rates on hospital outcomes.Methods: Patients requiring continuous albuterol for asthma exacerbation from January ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2020, :1-6]

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Outcome of status asthmaticus at a pediatric intensive care unit in Hong Kong.

Wing Tak Cheng, Kam Lun Hon, Renee W Y Chan, Lawrence C N Chan, William Wong, Hon Ming Cheung, Su Yun Qian,

OBJECTIVES:To characterize the clinical course and outcome of children with status asthmaticus (SA) admitted to a pediatric intensive care unit (PICU) METHODS: All patients with SA who were admitted to a PICU from January 2003 to December 2018 were reviewed. Polymerase chain reaction (PCR) studies on nasopharyngeal aspirate for respiratory ... Read more >>

Clin Respir J (The clinical respiratory journal)
[2020, :]

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Volatile anaesthetic for treatment of respiratory failure from status asthmaticus requiring extracorporeal membrane oxygenation.

Joseph E LaGrew, Kevin Robert Olsen, Amanda Frantz,

A 37-year-old male smoker with asthma presented with status asthmaticus refractory to terbutaline, intravenous magnesium, continuous bronchodilators, steroids, heliox and theophylline infusion. He was intubated on hospital day 2 and cannulated for veno-venous extracorporeal membrane oxygenation (V-V ECMO) on hospital day 3 for refractory respiratory acidosis secondary to hypercapnia and ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(1):]

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Recurrent endobronchial inflammatory myofibroblastic tumors: Novel treatment options.

Ixsy A Ramirez, Nathan S Rubalcava, George B Mychaliska, Raja Rabah, Manuel Arteta,

Endobronchial inflammatory myofibroblastic tumors (IMTs) rarely occur in children younger than 10 years of age and have intermediate malignant potential. A 7-year-old girl initially presented with pneumonia. After failing outpatient treatment, she re-presented in status asthmaticus. Computed tomography showed a left mainstem endobronchial mass which was resected bronchoscopically. Pathology was ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(3):788-790]

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Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost/Timolol Fixed-Dose Combination Therapy: The VISIONARY Study.

Francesco Oddone, Lucia Tanga, Péter Kóthy, Gábor Holló, ,

INTRODUCTION:A non-interventional, multicenter, European, prospective evaluation of the effectiveness, tolerability, and safety of a topical preservative-free tafluprost (0.0015%) and timolol (0.5%) fixed-dose combination (PF tafluprost/timolol FC) in adults with open-angle glaucoma (OAG) and ocular hypertension (OHT) demonstrating insufficient response to topical beta-receptor blockers or prostaglandin analogue (PGA) monotherapy. METHODS:Mean intraocular ... Read more >>

Adv Ther (Advances in therapy)
[2020, :]

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High flow nasal cannula oxygen therapy in patients with asthmatic crisis in the pediatric emergency department.

Rodolfo Gauto Benítez, Laura Patricia Morilla Sanabria, Viviana Pavlicich, Mirta Mesquita,

INTRODUCTION:There are few conclusive studies on the usefulness of High-Flow Nasal Cannula (HFNC) Oxygen Therapy in patients with asthmatic crises. OBJECTIVE:To determine the effectiveness of HFNC in chil dren older than 2 years of age that present severe and moderate asthmatic crises that do not respond to initial treatment. PATIENTS ... Read more >>

Rev Chil Pediatr (Revista chilena de pediatria)
[2019, 90(6):642-648]

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A winter to remember! Extracorporeal membrane oxygenation for life-threatening asthma in children: A case series and review of literature.

Shivanand S Medar, Kim R Derespina, William A Jakobleff, Michael H Ushay, Giles J Peek,

Progressive refractory near-fatal asthma requiring intubation and mechanical ventilation can lead to death. Data on outcomes in children requiring extracorporeal membrane oxygenation (ECMO) support for status asthmaticus is sparse. We describe our experience of three patients in the winter of 2018 to 2019 successfully rescued with ECMO. We also report ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(2):E1-E4]

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High frequency percussive ventilation as a rescue mode for refractory status asthmaticus - a case study.

David Albecker, T Glen Bouder, B Franklin Lewis,

Introduction: A severe asthma exacerbation is called status asthmaticus when symptoms worsen despite conventional medical treatment in the hospital. If arterial blood gas (ABG) values deteriorate and this is accompanied by respiratory muscle fatigue, the patient will require mechanical ventilation. However, mechanical ventilation of the severe asthmatic presents difficult challenges.Case ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2019, :1-4]

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Initial Modified Pulmonary Index Score Predicts Hospital Length of Stay for Asthma Subjects Admitted to the Pediatric Intensive Care Unit.

Andrew G Miller, Kaitlyn E Haynes, Rachel M Gates, Kanecia O Zimmerman, Kathleen W Bartlett, Heather S McLean, Kyle J Rehder,

BACKGROUND:Scoring systems are frequently used to assess the severity of pediatric asthma exacerbations. The modified pulmonary index score (MPIS) has been found to be highly correlated with length of stay (LOS) in the pediatric intensive care unit (PICU). We sought to evaluate the use of the MPIS to predict hospital ... Read more >>

Respir Care (Respiratory care)
[2020, :]

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Considerations in Neuromuscular Blockade in the ICU: A Case Report and Review of the Literature.

Jessica D Workum, Stephanie H V Janssen, Hugo R W Touw,

Neuromuscular blocking agents are regularly used in the intensive care unit (ICU) to facilitate mechanical ventilation in patients with acute respiratory distress syndrome and patient-ventilator dyssynchronies. However, prolonged neuromuscular blockade is associated with adverse effects like ICU-acquired weakness. Residual neuromuscular blockade is, however, not routinely monitored in the intensive care ... Read more >>

Case Rep Crit Care (Case reports in critical care)
[2020, 2020:8780979]

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Acute severe asthma (status asthmaticus).

Neha T Agnihotri, Carol Saltoun,

Acute severe asthma, formerly known as status asthmaticus, is defined as severe asthma unresponsive to repeated courses of beta-agonist therapy. It is a medical emergency that requires immediate recognition and treatment. Albuterol in combination with ipratropium bromide in the emergency department (ED) has been shown to decrease the time spent ... Read more >>

Allergy Asthma Proc (Allergy and asthma proceedings)
[2019, 40(6):406-409]

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Pediatric asthma severity scores distinguish suitable inpatient level of care for children admitted for status asthmaticus.

Kelsey S Ryan, Sorany Son, Meghan Roddy, Shaila Siraj, Scott D McKinley, Thomas A Nakagawa, Anthony A Sochet,

Objective: To determine if the Pediatric Asthma Severity Score (PASS) can distinguish "late-rescues" (transfer to the pediatric intensive care unit [PICU] within 24-hours of general pediatric floor admission), "PICU readmissions" (readmission within 24-h after transfer to a lower inpatient level of care), and unplanned 30-day hospital readmission in children admitted ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2019, :1-9]

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Refractory Status Asthmaticus: Treatment With Sevoflurane.

Lynn M Keenan, Terri L Hoffman,

A patient with life-threatening asthma and status asthmaticus was treated with sevoflurane general anesthesia. ... Read more >>

Fed Pract (Federal practitioner : for the health care professionals of the VA, DoD, and PHS)
[2019, 36(10):476-479]

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Procalcitonin Levels in Critically Ill Children With Status Asthmaticus.

Ravi S Samraj, Eric J Crotty, Derek S Wheeler,

BACKGROUND:Children with status asthmaticus (SA) often present with fever and are evaluated with chest radiographs (CXRs). In the absence of a confirmatory test for bacterial infection, antibiotics are started whenever there are radiological infiltrates or if there is a suspicion of pneumonia. We undertook this study to determine if serum ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2019, 35(10):671-674]

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Tonsillectomy does not reduce asthma in children: A longitudinal follow-up study using a national sample cohort.

So Young Kim, Dong Jun Oh, Hyo Geun Choi,

This study aimed to investigate the occurrence of tonsillectomy in asthmatic children using a control group with a comparable frequency of a preoperative history of asthma. Asthmatic children ≤15 years old were collected from the Korean Health Insurance Review and Assessment Service - National Sample Cohort (HIRA-NSC) from 2002 through ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):13382]

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Safety of prolonged magnesium sulfate infusions during treatment for severe pediatric status asthmaticus.

Danielle M Graff, Michelle D Stevenson, John W Berkenbosch,

OBJECTIVE:Magnesium sulfate (Mg) is one of several "second-tier" therapies for treating severe status asthmaticus. Pediatric reports primarily describe bolus use with limited data regarding prolonged infusions. We sought to describe the safety of prolonged Mg infusions during therapy of status asthmaticus in critically ill children. DESIGN:Single center, retrospective study. SETTING:Thirty-four-bed ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2019, 54(12):1941-1947]

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Adrenaline before Unconventional Therapy for Status Asthamaticus.

Jayendra R Gohil,

How to cite this article: Gohil JR. Adrenaline before Unconventional Therapy for Status Asthamaticus. Indian J Crit Care Med 2019; 23(10):492. ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2019, 23(10):492]

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Continuous Albuterol in Pediatric Acute Care: Study Demonstrates Safety Outside the Intensive Care Unit.

Amanda F Messer, Esther M Sampayo, Brent Mothner, Elizabeth A Camp, Jennifer Jones, Terri Brown, Joyee Vachani,

There are little data to support the use of continuous aerosolized albuterol (CAA) in the non-intensive care unit (ICU) or non-emergency department (ED) setting for pediatric asthma patients. A 2014 study demonstrated low rates of adverse outcomes associated with administration of CAA on the acute care unit; however, the authors ... Read more >>

Pediatr Qual Saf (Pediatric quality & safety)
[2019, 4(6):e225]

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Admissions for ambulatory care sensitive conditions on rural islands and their association with patient experience: a multicentred prospective cohort study.

Makoto Kaneko, Takuya Aoki, Masafumi Funato, Keita Yamashiro, Kaku Kuroda, Moe Kuroda, Yusuke Saishoji, Tatsuya Sakai, Syo Yonaha, Kazuhisa Motomura, Machiko Inoue,

OBJECTIVES:The rate of admissions for ambulatory care sensitive conditions (ACSCs) is a key outcome indicator for primary care, and patient experience (PX) is a crucial process indicator. Studies have reported higher rates of admission for ACSCs in rural areas than in urban areas. Whether there is an association between admissions ... Read more >>

BMJ Open (BMJ open)
[2019, 9(12):e030101]

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