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Staphylococcal Meningitis

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Adult Otogenic Meningitis in the Pneumococcal Conjugated Vaccines Era.

Tal Marom, Shay Shemesh, Nadeem Habashi, Ofer Gluck, Sharon Ovnat Tamir,

Introduction   Streptococcus pneumoniae is a major pathogen of otogenic meningitis (OgM), the most commonly reported intra-cranial complication of otitis media (OM). Objectives  To study the changes in adult OgM patients in the pneumococcal conjugated vaccines (PCVs) era. Methods  Retrospective cohort of adults presenting with concurrent OM and ... Read more >>

Int Arch Otorhinolaryngol (International Archives of Otorhinolaryngology)
[2020, 24(2):e175-e181]

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Eosinophilic meningitis due to Angiostrongylus cantonensis in Europe.

Frederik Federspiel, Sofie Skovmand, Sigurdur Skarphedinsson,

OBJECTIVES:To describe and analyse the epidemiological and clinical characteristics of imported human angiostrongyliasis in Europe. METHODS:A systematic literature review of cases of human angiostrongyliasis in Europe was performed. Seven databases were searched. The epidemiological and clinical characteristics were extracted from included records and simple summary statistics were performed on extracted ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 93:28-39]

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Comparing febrile children presenting on and off antibiotics to the emergency department: a retrospective cohort study.

R D Sawaya, T El Zahran, S Mrad, C Abdul Massih, S Shaya, M Makki, H Tamim, M Majdalani,

BACKGROUND:It is not yet known how antibiotics may affect Serious Bacterial Infections (SBI). Our aim is to describe the presentation, management, and serious bacterial infections (SBI) of febrile children on or off antibiotics. METHODS:Retrospective, cohort study of febrile Emergency Department patients, 0-36 months of age, at a single institution, between 2009and ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):117]

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Travel vaccines: Update.

Louis Lamarche, Christian Taucher,

Can Pharm J (Ott) (Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC)
[2020, 153(2):72-73]

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Epidemiology and complications of late-onset sepsis: an Italian area-based study.

Alberto Berardi, Francesca Sforza, Lorenza Baroni, Caterina Spada, Simone Ambretti, Giacomo Biasucci, Serenella Bolognesi, Mariagrazia Capretti, Edoardo Carretto, Matilde Ciccia, Marcello Lanari, Maria Federica Pedna, Vittoria Rizzo, Claudia Venturelli, Crisoula Tzialla, Laura Lucaccioni, Maria Letizia Bacchi Reggiani,

BACKGROUND:Most studies regarding late-onset sepsis (LOS) address selected populations (i.e., neonates with low birth weight or extremely preterm neonates). Studying all age groups is more suitable to assess the burden of single pathogens and their clinical relevance. METHODS:This is a retrospective regional study involving paediatric departments and NICUs in Emilia-Romagna ... Read more >>

PLoS ONE (PloS one)
[2019, 14(11):e0225407]

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Comparison of 16S Ribosomal RNA Targeted Sequencing and Culture for Bacterial Identification in Normally Sterile Body Fluid Samples: Report of a 10-Year Clinical Laboratory Review.

In Young Yoo, On Kyun Kang, Myoung Keun Lee, Yae Jean Kim, Sun Young Cho, Kyungmin Huh, Cheol In Kang, Doo Ryeon Chung, Kyong Ran Peck, Hee Jae Huh, Nam Yong Lee,

As 16S ribosomal RNA (rRNA)-targeted sequencing can detect DNA from non-viable bacteria, it can be used to identify pathogens from clinical samples even in patients pretreated with antibiotics. We compared the results of 16S rRNA-targeted sequencing and culture for identifying bacterial species in normally sterile body fluid (NSBF): cerebrospinal, pericardial, ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2020, 40(1):63-67]

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Device-Associated Meningitis by Linezolid-Resistant Staphylococcus haemolyticus in a Vancomycin- Hypersensitive Patient.

Priya Vijayan, Dwarakanath Srinivas, Nagarathna Siddaiah, Veena Kumari Haradara Bahubali,

Postsurgical device-related meningitis caused by multidrug-resistant coagulase-negative staphylococci often complicates the treatment options. We report a rare and, to our knowledge, the first clinical case report of drain-associated meningitis caused by methicillin- and linezolid-resistant Staphylococcus haemolyticus following linezolid therapy in a vancomycin-hypersensitive patient subsequently treated with cotrimoxazole, resulting in clinical ... Read more >>

J Neurosci Rural Pract (Journal of neurosciences in rural practice)
[2019, 10(4):718-720]

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Trimethoprim-Sulfamethoxazole-Induced Aseptic Meningitis: A Rare Presentation of Commonly Used Antibiotic.

Salem Agabawi,

Drug-induced aseptic meningitis is a rare medical condition with trimethoprim-sulfamethoxazole being one of the most common antimicrobial agents associated with it. Here, I report a case of a 56-year-old male who presented to a health care facility with shock and meningitis-like syndrome in two occasions, one year apart following an ... Read more >>

Case Rep Infect Dis (Case reports in infectious diseases)
[2019, 2019:4289502]

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Changes in incidence and etiology of early-onset neonatal infections 1997-2017 - a retrospective cohort study in western Sweden.

Margrét Johansson Gudjónsdóttir, Anders Elfvin, Elisabet Hentz, Ingegerd Adlerberth, Ingemar Tessin, Birger Trollfors,

BACKGROUND:The objective of the study was to evaluate data on early-onset neonatal invasive infections in western Sweden for the period 1997-2017. To identify changes in incidence, etiology and mortality and compare to previous studies from the same area starting from 1975. METHODS:Observational epidemiological, retrospective study on infants 0-6 days of age ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):490]

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2478. Surveillance of antibacterial resistance among clinical isolates from hospitals in Shanghai: results of 2018.

Yang Yang, Yan Guo, Demei Zhu, Fupin Hu,

AbstractBackgroundTo investigate the current state of antibacterial resistance of clinical isolates from hospitals in Shanghai, China.MethodsAntimicrobial susceptibility testing (AST) was carried out for the clinical isolates from 50 hospitals (including 30 grade A tertiary hospitals and 20 grade B tertiary hospitals/grade A secondary hospitals, and there were 3 children hospitals ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S858-S858]

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The Secretion of Toxins and Other Exoproteins of Cronobacter: Role in Virulence, Adaption, and Persistence.

Hyein Jang, Gopal R Gopinath, Athmanya Eshwar, Shabarinath Srikumar, Scott Nguyen, Jayanthi Gangiredla, Isha R Patel, Samantha B Finkelstein, Flavia Negrete, JungHa Woo, YouYoung Lee, Séamus Fanning, Roger Stephan, Ben D Tall, Angelika Lehner,

: Cronobacter species are considered an opportunistic group of foodborne pathogenic bacteria capable of causing both intestinal and systemic human disease. This review describes common virulence themes shared among the seven Cronobacter species and describes multiple exoproteins secreted by Cronobacter, many of which are bacterial toxins that may play a ... Read more >>

Microorganisms (Microorganisms)
[2020, 8(2):]

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Supratentorial Listeria monocytogenes Brain Abscess in a Patient with Liver Cirrhosis.

Romulo Omar Flores-Perez, Cesar Daniel Villarreal-Villarreal, Jesus Alberto Cardenas-de La Garza, Dionicio Angel Galarza-Delgado,

Meningitis and meningoencephalitis account for the majority of central nervous system infections by Listeria monocytogenes (Lm). Macroscopic listerial brain abscess is a rare infection. Early recognition of Listeria brain abscesses represents a major diagnostic challenge. Mortality from Listeria brain abscesses is high but can be reduced when appropriate treatment is ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2020, 23(1):107-109]

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Physiology and immunity of the invasive giant African snail, Achatina (Lissachatina) fulica, intermediate host of Angiostrongylus cantonensis.

Mariana G Lima, Ronaldo de C Augusto, Jairo Pinheiro, Silvana C Thiengo,

As one of the most successful invasive land snail species, Achatina (Lissachatina) fulica Bowdich, 1822 has achieved wide global distribution, particularly in (sub)tropical regions, with further dispersal likely due to climate change. This species of giant African snails (up to 17 cm shell length) is a pest that has extensive negative ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 105:103579]

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Methicillin-resistant Staphylococcus aureus (MRSA) sepsis complicated by warm autoimmune haemolytic anaemia secondary to antimicrobial therapy.

Jorge Verdecia, Jarelys Hernandez, Christopher Izzo, Elisa Sottile, Carmen Isache,

A 61-year-old Caucasian woman presented to the emergency room complaining of left-sided chest pain and altered mentation for 3 days. Her medical history included liver cirrhosis and coronary artery disease. On admission, she was found to have methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia. Due to a decline in mental status, a lumbar ... Read more >>

BMJ Case Rep (BMJ case reports)
[2019, 12(8):]

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Assisted Reproductive Technology as a Transcutaneous Route for Bacterial Contamination of Ovarian Endometrioma with Coagulase-Negative Staphylococcus: Case Report and Review of the Literature.

Shimon Edelstein, Inbar Ben Shachar, Hila Ben-Amram, Seema Biswas, Naama Marcus,

Tubo-ovarian abscess may develop in women with endometrioma following assisted reproductive technology (ART). The infection, though rare, is typically late in onset and may present several months after the procedure, and in pregnancy-with the risks of abortion and premature labor. It is thought that transcutaneous oocyte retrieval during ART is ... Read more >>

Infect Dis Obstet Gynecol (Infectious diseases in obstetrics and gynecology)
[2019, 2019:4149587]

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Incidence, Bacterial Profiles, And Antimicrobial Resistance Of Culture-Proven Neonatal Sepsis In South China.

Kankan Gao, Jie Fu, Xiaoshan Guan, Sufei Zhu, Lanlan Zeng, Xiaoming Xu, Chien-Yi Chang, Haiying Liu,

Background:Neonatal sepsis (NS) is one of the leading causes of infant morbidity and mortality, but little is known about pathogen incidence and distribution in China. Methods:In this retrospective study (January 2012 to December 2016), culture-proven cases aged less than 28 days with diagnosed NS in the Guangzhou Women and Children's ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2019, 12:3797-3805]

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Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens.

Zahra Akbarian-Rad, Seyed Mohammad Riahi, Ali Abdollahi, Parisa Sabbagh, Soheil Ebrahimpour, Mostafa Javanian, VeneelaKrishnaRekha Vasigala, Ali Rostami,

BACKGROUND:Neonatal sepsis is accounted for 30-50% of annual neonatal deaths in developing countries. We performed a systematic review and meta-analysis study to evaluate the national prevalence and identification of the etiological pathogens of neonatal sepsis in Iran. METHODS:A comprehensive literature search was done on the national and international databases for ... Read more >>

PLoS ONE (PloS one)
[2020, 15(1):e0227570]

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Neisseria meningitidis as a Cause of Septic Arthritis: An Unusual Case of Periprosthetic Joint Infection.

A Mc Carthy, J M Broderick, A P Molloy,

One of the most feared complications after arthroplasty is infection due to its significant impact on patient morbidity. Infection may transfer to the joint at the time of surgery or be seeded, haematologically, to the prosthetic joint from another infection source. In this case, a 72-year-old female presented with symptoms ... Read more >>

Case Rep Infect Dis (Case reports in infectious diseases)
[2020, 2020:8431019]

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Linezolid for the treatment of postneurosurgical infection caused by methicillin-resistant Staphylococcus.

Lotfi Rebai, Nizar Fitouhi, Mohamed Aziz Daghmouri, Kamel Bahri,

Background:Postneurosurgical infection (PNSI) is a major problem. Linezolid is a bacteriostatic oxazolidinone antibiotic with a highly activity against Gram-positive cocci resistant to methicillin and a good cerebrospinal fluid penetration. The purpose of this study is to evaluate the efficacy of linezolid in the treatment of PNSI caused by methicillin-resistant Staphylococcus ... Read more >>

Surg Neurol Int (Surgical Neurology International)
[2019, 10:215]

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[A case of clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) associated with infectious endocarditis caused by Staphylococcus aureus].

Ryoko Anada, Takamasa Nukui, Tomohiro Hayashi, Hirofumi Konishi, Nobuhiro Dougu, Yuji Nakatsuji,

A 17-year-old woman was admitted to our hospital because of a high fever, consciousness disturbance, and delirious behavior. Methicillin susceptible Staphylococcus aureus (MSSA) infection was confirmed by blood culture. Transthoracic echocardiogram showed no abnormality at first. Diffusion-weighted brain MRI showed a high intensity lesion in the middle portion of the ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2019, 59(10):666-668]

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The Effect of Frequent Exposure to P. falciparum, HIV-Infection and Other Co-Morbidities on Development of Severe Malaria in Malawian Adults.

Alinane U Munyenyembe, Kamunkhwala Gausi, Jasmin Hiestand, Jane Mallewa, Wilson Mandala,

Aim:Plasmodium falciparum malaria predominantly affects children residing in endemic areas. However, recently a significant number of Malawian adults, who otherwise should have attained some malaria-specific immunity, have been observed to succumb to either uncomplicated malaria (UM) or severe malaria (SM). In addition, it is still unknown whether HIV is a ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2020, 13:63-68]

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Bacteriological pattern and their correlation with complications in culture positive cases of acute bacterial conjunctivitis in a tertiary care hospital of upper Assam: A cross sectional study.

Anusuya Bhattacharyya, Phulen Sarma, Bhaswati Sarma, Subodh Kumar, Tapan Gogoi, Hardeep Kaur, Manish Prajapat,

Acute conjunctivitis is inflammation of conjunctiva of less than 3 to 4 weeks duration, characterized by cellular infiltration and exudation. It may also result into corneal, lid or orbital involvement which may lead to various complications.A hospital based prospective study was conducted in Assam Medical College and Hospital with 110 ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(7):e18570]

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Cerebrospinal Fluid Characterization in Cynomolgus Monkeys, Beagle Dogs, and Göttingen Minipigs.

Cristina Ballesteros, Mylène Pouliot, Rémi Froment, Mohamed Said Maghezzi, Camille St-Jean, Christian Li, Dominique Paquette, Simon Authier,

Intrathecal administration is an important route for drug delivery, and in pharmacology and toxicology studies, cerebrospinal fluid (CSF) collection and analysis is required for evaluating blood-brain barrier penetration and central nervous system exposure. The characteristics of CSF in commonly used nonrodent models are lacking. The purpose of this study is ... Read more >>

Int. J. Toxicol. (International journal of toxicology)
[2020, 39(2):124-130]

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul T Heath, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

BACKGROUND:The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, recruited in single centres or countries, evaluated antibiotics not in clinical use anymore ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229380]

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Staphylococcus Toxin-Mediated Motor Polyneuropathy.

Abdullah M Pervaiz, Raheel Akhtar, Melissa Mercado,

Staphylococcus aureus infection is known to cause a variety of neurologic complications, most involving the CNS, however, rarely have cases of S. aureus affecting the peripheral nervous system been reported in literature. We report a case of S. aureus toxin-mediated motor polyneuropathy in a patient presenting with acute flaccid quadriplegia. ... Read more >>

Crit Care Explor (Critical Care Explorations)
[2019, 1(9):e0041]

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