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Prognostic value of circulating clonal plasma cells in newly diagnosed multiple myeloma.

Wenmin Han, Yuanyuan Jin, Min Xu, Si-Shu Zhao, Qinglin Shi, Xiaoyan Qu, Run Zhang, Jianyong Li, Yujie Wu, Lijuan Chen,

<h4>Objectives</h4>Multiple myeloma (MM) involves a clinically and biologically heterogeneous malignancy of plasma cells. It is difficult to predict the prognosis of MM. The presence of circulating clonal plasma cells (CPC) has been associated with a worse prognosis in patients with MM.<h4>Methods</h4>This study retrospectively analysed CPC in 108 newly diagnosed MM ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):510-517]

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Overexpression of EWSR1 (Ewing sarcoma breakpoint region 1/EWS RNA binding protein 1) predicts poor survival in patients with hepatocellular carcinoma.

Weijie Jiang, Tao Wu, Xuan Shi, Jiawen Xu,

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant neoplasms with high relapse and mortality rate. It is of great importance to identify novel and effective molecular markers to predict prognosis for the treatment of HCC. The Ewing sarcoma breakpoint region 1 (EWSR1) gene is well known to fuse ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):7941-7949]

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A 10-year cohort study of 175 primary gastrointestinal lymphoma cases in Thailand: clinical features and outcomes in the immunochemotherapy era.

Weerapat Owattanapanich, Theera Ruchutrakool, Tawatchai Pongpruttipan, Monthira Maneerattanaporn,

<h4>Background</h4>Primary gastrointestinal lymphoma (PGIL), an uncommon subtype of lymphoma, accounts for 1%-4% of gastrointestinal cancers. This study, therefore, aimed to investigate the current 10-year epidemiology and outcomes of PGIL.<h4>Methods</h4>This retrospective study involved a hospital-based chart review to analyze the epidemiology, clinical features, predisposing factors, and clinical outcomes of patients diagnosed ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):249-255]

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Prostate specific membrane antigen (PSMA) and Prostate Cancer Staging: is our current conventional staging obsolete?

Melissa Segura Céspedes, Jan Philipp Radtke, Xavier Cathelineau, Rafael Sanchez-Salas,

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2021, 47(6):1243-1249]

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Staging of human papilloma virus related cancers of the oropharynx.

Cristina Valero, Jatin P Shah,

For the past two decades an increasing number of oropharyngeal cancers have been found to be associated with the human papilloma virus (HPV). These tumors are a biologically distinct entity with better prognosis and excellent response to therapy. Therefore, a separate staging system has been introduced for HPV-related oropharyngeal tumors ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2021, 124(6):931-934]

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MRI Staging in an Evolving Management Paradigm for Rectal Cancer, From the AJR Special Series on Cancer Staging.

Harmeet Kaur, Helena Gabriel, Melissa Taggart, Hyunseon C Kang, Tsuyoshi Konishi, Gaiane M Rauch, Sunil Krishnan, George Chang,

The treatment of rectal cancer centers around the distinct but related goals of management of distant metastases and management of local disease. Optimal local management requires attention to the primary tumor and its anatomic relationship to surrounding pelvic structures, with the goal of minimizing local recurrence (LR). High-resolution MRI is ... Read more >>

AJR Am J Roentgenol (AJR. American journal of roentgenology)
[2021, :1-12]

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Integrating Depth of Invasion in T Classification Improves the Prognostic Performance of the American Joint Committee on Cancer Staging System for Laryngeal Squamous Cell Carcinoma: a Retrospective Multicenter Study

xueying wang, kui cao, erliang guo, xionghui mao, changming an, lunhua guo, cong zhang, xiangguang yang, ji sun, weiwei yang, xiaomei li, Susheng Miao,

<h4>Background: </h4> It has been recognized that depth of invasion (DOI) is closely associated with patient survival for all types of cancer. The purpose of this study was to determine the optimal threshold and prognostic value in laryngeal squamous carcinoma (LSCC). Most importantly, we evaluated the prognostic performance of five ... Read more >>

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Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care

Emanuele Garreffa, Ahmed Hamad, Ciara C. O’Sullivan, Antonious Z. Hazim, Joanne York, Shama Puri, Anne Turnbull, John F. Robertson, Matthew P. Goetz,

<h4>Purpose</h4> Over 1 billion doses of COVID-19 vaccines have been already administered across the US, the UK and the EU at the time of writing. Furthermore, 1.82 million of booster doses have been administered in the US since 13th August, and similar booster programmes are currently planned or under consideration ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, :]

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Incidence and relevance of clinically indeterminate nonregional lymph nodes in the treatment of oesophageal cancer.

Philip H Pucher, Annabelle White, Olivia Padfield, Andrew R Davies, Nick Maisey, Asad Qureshi, Manil Subesinghe, Cara Baker, James A Gossage,

<h4>Objectives</h4>Metastatic involvement of nonregional supraclavicular or superior mediastinal lymph nodes in distal oesophageal cancer is rare but has important implications for prognosis and management. The management of nonregional lymph nodes which appear indeterminate on CT and FDG PET-CT (subcentimeter nodes or those with preserved normal morphology, but increased FDG avidity) ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2021, 42(11):1270-1276]

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Impact of COVID-19 on presentation, staging, and treatment of head and neck mucosal squamous cell carcinoma.

Madelyn N Stevens, Ankita Patro, Bushra Rahman, Yue Gao, Dandan Liu, Anthony Cmelak, Jamie Wiggleton, Young J Kim, Alexander Langerman, Kyle Mannion, Robert J Sinard, James L Netterville, Sarah L Rohde, Michael C Topf,

<h4>Objectives</h4>During the COVID-19 pandemic, maintenance of safe and timely oncologic care has been challenging. The goal of this study is to compare presenting symptoms, staging, and treatment of head and neck mucosal squamous cell carcinoma during the pandemic with an analogous timeframe one year prior.<h4>Materials and methods</h4>Retrospective cohort study at ... Read more >>

Am J Otolaryngol (American journal of otolaryngology)
[2021, 43(1):103263]

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FIGO staging for carcinoma of the vulva: 2021 revision.

Alexander B Olawaiye, Joseph Cotler, Mauricio A Cuello, Neerja Bhatla, Aikou Okamoto, Sarikapan Wilailak, Chittaranjan N Purandare, Gerhard Lindeque, Jonathan S Berek, Sean Kehoe,

To revise the FIGO staging for carcinoma of the vulva using a new approach that involves analyses of prospectively collected data. The FIGO Committee for Gynecologic Oncology reviewed the recent literature to gain an insight into the impact of the 2009 vulvar cancer staging revision. The Committee resolved to revise ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):43-47]

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Volumetric staging in radiotherapy for oropharyngeal cancers.

Marcin Miszczyk, Emilia Staniewska, Iwona Jabłońska, Aleksandra Lipka-Rajwa, Konrad Stawiski, Rafał Tarnawski,

<h4>Introduction</h4>Despite routine use of 3D radiotherapy planning in radical radio(chemo)therapy for oropharyngeal cancers, volumetric data have not been implemented in initial staging. We analyzed 228 oropharyngeal cancer cases treated at one institution between 2004 and 2014 to compare the predictive value of volumetric staging and tumor nodal metastasis staging system ... Read more >>

Tumori (Tumori)
[2021, :3008916211050959]

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A proposal for uniformity in classification of lymph node stations in esophageal cancer.

N Schuring, S Matsuda, E R C Hagens, J Sano, S Mayanagi, H Kawakubo, M I van Berge Henegouwen, Y Kitagawa, S S Gisbertz,

The 11th edition of the "Japanese Classification of Esophageal Cancer" by the Japan Esophageal Society (JES) and the 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) "Cancer Staging Manual" are two separate classification systems both widely used for the clinical and pathological staging ... Read more >>

Dis Esophagus (Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus)
[2021, 34(10):]

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A 33-Year-Old Woman in the Third Trimester of Pregnancy Diagnosed with Advanced-Staged Squamous Cell Cervical Carcinoma by Magnetic Resonance Imaging and Biopsy.

Courtney R Fox, Shayna Burdeaux, Keith T Downing,

BACKGROUND Cervical cancer is the most common gynecologic malignancy diagnosed in pregnancy. When cervical cancer is diagnosed late in pregnancy, pelvic lymphadenectomy is avoided. Advanced imaging adds an alternative way to assess nodal involvement. The aim of this case report is to demonstrate how magnetic resonance imaging (MRI) can contribute ... Read more >>

Am J Case Rep (The American journal of case reports)
[2021, 22:e933639]

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Adrenal Findings in FDG-PET– Analysis of a Cohort of 1021 Patients From a Cancer Center

Joana Maciel, Daniela Cavaco, Davide Fraga, Sara Donato, Helder Simões, Rita Sousa, Joana Simões-Pereira,

<h4>Purpose: </h4> The use of FDG-PET/TC for cancer staging has been leading to the increasing diagnosis of adrenal lesions, which usually represent a clinical challenge. Our aim was to characterize the adrenal lesions found in FDG-PET of patients followed in a cancer center. <h4>Methods: </h4>: Retrospective analysis of all FDG-PET ... Read more >>

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High quality palliative alternative for patients with advanced locoregional (CN3 Stage) penile cancer.

Stenio de C Zequi,

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2021, 47(6):1176-1177]

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Comparison of the sixth, seventh, and eighth editions of the American Joint Committee on Cancer Tumor-Node-Metastasis staging system for gastric cancer: A single institution experience.

Mei-Wen Chen, Hsu-Heng Yen,

<h4>Abstract</h4>In 2018, the eighth edition of the American Joint Committee on Cancer Tumor-Node-Metastasis classification and staging system was implemented. Few reports were made comparing the performance of different editions of the American Joint Committee on Cancer (AJCC) system. Therefore, this study aimed to examine the prognostic predictability from the sixth ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(39):e27358]

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Initial Experience in Staging Primary Oesophageal/Gastroesophageal Cancer with 18F-FDG PET/MRI

Amy Sharkey, Bert-Ram Sah, Samuel Withey, Shaheel Bhuva, Radhouene Neji, Sami Jejeli, Adrian Green, Gary JR C, Vicky Goh,

<h4>Background: </h4> 18 F-Fluorodesoxyglucose Positron-emission tomography magnetic resonance imaging (18F-FDG PET/MRI) may improve cancer staging by combining sensitive cancer detection with high contrast resolution and detail. We compared the diagnostic performance of 18F-FDG PET/MRI to 18 F-Fluorodesoxyglucose Positron-emission tomography computed tomography (18F-FDG PET/CT )for staging oesophageal/gastroesophageal cancer.Following ethical approval and ... Read more >>

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Structured reporting in radiology: a systematic review to explore its potential.

J Martijn Nobel, Koos van Geel, Simon G F Robben,

<h4>Objectives</h4>Structured reporting (SR) in radiology reporting is suggested to be a promising tool in clinical practice. In order to implement such an emerging innovation, it is necessary to verify that radiology reporting can benefit from SR. Therefore, the purpose of this systematic review is to explore the level of evidence ... Read more >>

Eur Radiol (European radiology)
[2021, :]

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Staging and Classification of Primary Musculoskeletal Bone and Soft-Tissue Tumors According to the 2020 WHO Update, From the AJR Special Series on Cancer Staging.

Mark Douglas Murphey, Mark Jay Kransdorf,

Staging of primary musculoskeletal bone and soft-tissue tumors is most commonly performed using the AJCC and the Enneking or Musculoskeletal Tumor Society (MSTS) staging systems. Radiologic imaging is integral in achieving adequate musculoskeletal neoplastic staging by defining lesion extent and identifying regional lymph node involvement and distant metastatic disease. Additional ... Read more >>

AJR Am J Roentgenol (AJR. American journal of roentgenology)
[2021, :1-15]

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Combined biomechanical and tomographic keratoconus staging: Adding a biomechanical parameter to the ABCD keratoconus staging system.

Elias Flockerzi, Riccardo Vinciguerra, Michael Wellington Belin, Paolo Vinciguerra, Renato Ambrósio, Berthold Seitz,

<h4>Purpose</h4>This retrospective cross-sectional study evaluated the potential of an additional biomechanical parameter 'E' as an addition to the tomographic ABCD ectasia/keratoconus (KC) staging.<h4>Methods</h4>The Corvis Biomechanical Factor (CBiF) represents the modified linear term of the Corvis Biomechanical Index (CBI) developed based on 448 KC corneas from the Homburg Keratoconus Center (HKC). ... Read more >>

Acta Ophthalmol (Acta ophthalmologica)
[2021, :]

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FDG PET/CT - not PSMA trendy, but available, comfortable, and complementary.

Robert J Hamilton,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, 15(10):308-309]

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Impact of the COVID-19 lockdown in France on the diagnosis and staging of breast cancers in a tertiary cancer centre.

Pierre-Antoine Linck, Cassandre Garnier, Marie-Pierre Depetiteville, Gaëtan MacGrogan, Simone Mathoulin-Pélissier, Nathalie Quénel-Tueux, Hélène Charitansky, Martine Boisserie-Lacroix, Foucauld Chamming's,

<h4>Objectives</h4>Due to COVID-19, a lockdown took place between March 17 and May 1, 2020, in France. This study evaluates the impact of the lockdown on the diagnosis and staging of breast cancers in a tertiary cancer centre.<h4>Methods</h4>Our database was searched for all consecutive invasive breast cancers diagnosed in our institution ... Read more >>

Eur Radiol (European radiology)
[2021, :]

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A novel pN3 gastric cancer staging system with superior prognostic utility based upon the examination of over 31 lymph nodes: a propensity score-matching analysis.

Qiantao Hu, Siwei Pan, Zijun Guo,

<h4>Background</h4>Individuals with pN3 gastric cancer (GC) account for a large proportion of pN + GC, and exhibit poor survival outcomes. The pN3 stage is defined based upon the number of metastatic lymph nodes (mLNs), but the subclassification of pN3 patients based upon the number of examined LNs (eLNs) is rarely performed.<h4>Methods</h4>In total, ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2021, 21(1):352]

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Clinical Characteristics of Resected Acinar Cell Carcinoma of the Pancreas: A Korean Multi-Institutional Study

Sang Hyun Shin, Ho Kyoung Hwang, Jin-Young Jang, Hongbeom Kim, Sang Jae Park, Sung-Sik Han, In Woong Han, Dae Wook Hwang, Jin Seok Heo,

<h4>Simple Summary</h4> Pancreatic acinar cell carcinoma accounts for less than 1% of primary pancreatic neoplasms. Because of its rarity, its characteristics and clinical outcomes remain unclear. Treatment strategies for pancreatic acinar cell carcinoma have relied on those of pancreatic ductal adenocarcinoma. In previous studies, it has been difficult to identify ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(20):]

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