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Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats.

Qiu-Shi Gao, Ya-Han Zhang, Hang Xue, Zi-Yi Wu, Chang Li, Ping Zhao,

Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains. The classical Rice-Vannucci model was used to induce hypoxic-ischemic injury, and newborn (postnatal day 7) rats were treated with 2.4% sevoflurane for 30 minutes after hypoxic-ischemic injury. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(6):1052-1061]

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Synaptic remodeling in mouse motor cortex after spinal cord injury.

Ke-Xue Zhang, Jia-Jia Zhao, Wei Chai, Ji-Ying Chen,

Spinal cord injury dramatically blocks information exchange between the central nervous system and the peripheral nervous system. The resulting fate of synapses in the motor cortex has not been well studied. To explore synaptic reorganization in the motor cortex after spinal cord injury, we established mouse models of T12 spinal ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(4):744-749]

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Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury.

Lixia Li, Yizhou Xu, Xianghai Wang, Jingmin Liu, Xiaofang Hu, Dandan Tan, Zhenlin Li, Jiasong Guo,

Wallerian degeneration occurs after peripheral nerve injury and provides a beneficial microenvironment for nerve regeneration. Our previous study demonstrated that ascorbic acid promotes peripheral nerve regeneration, possibly through promoting Schwann cell proliferation and phagocytosis and enhancing macrophage proliferation, migration, and phagocytosis. Because Schwann cells and macrophages are the main cells ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(6):1078-1085]

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Preparation of Poly(3-hydroxybutyrate-co- 3-hydroxyvalerate) Nanofiber Catheter and Its Mechanism of Nerve Injury in Patients with Cervical Spine Injury.

Xuan Chen, Haiyang Zhao, Ye Li, Lobat Tayebi, Santa Momii,

At present, surgical suture treatment can be performed for spinal patients after nerve injury, but nerve regeneration and functional recovery require comprehensive treatment including drug treatment. However, there is still a lack of adjuvant therapeutic drugs that can effectively promote nerve regeneration and functional recovery. Drug treatment after nerve injury ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1259-1265]

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Surgical intervention combined with weight-bearing walking training improves neurological recoveries in 320 patients with clinically complete spinal cord injury: a prospective self-controlled study.

Yansheng Liu, Jia-Xin Xie, Fang Niu, Zhexi Xu, Pengju Tan, Caihong Shen, Hongkun Gao, Song Liu, Zhengwen Ma, Kwok-Fai So, Wutian Wu, Chen Chen, Sujuan Gao, Xiao-Ming Xu, Hui Zhu,

Although a large number of trials in the SCI field have been conducted, few proven gains have been realized for patients. In the present study, we determined the efficacy of a novel combination treatment involving surgical intervention and long-term weight-bearing walking training in spinal cord injury (SCI) subjects clinically diagnosed ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(5):820-829]

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Radiographic and functional outcome of complex acetabular fractures: implications of open reduction in spinopelvic balance, gait and quality of life.

Vitaliano F Muzii, Giuseppe Rollo, Guido Rocca, Rocco Erasmo, Gabriele Falzarano, Francesco Liuzza, Michele Bisaccia, Giuseppe Pica, Raffaele Franzese, Luigi Meccariello,

Aim To investigate the effects of surgical reduction of complex acetabular fractures on spine balance, postural stability and quality of life. Methods Twenty-six patients with acetabular fractures surgically treated by open reduction and internal fixation were divided into two groups according to the amount of reduction. Group A consisted of ... Read more >>

Med Glas (Zenica) (Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina)
[2021, 18(1):]

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Pulmonary Implications of Pediatric Spinal Deformities.

Diane Dudas Sheehan, John Grayhack,

"Pediatric spinal deformities may be associated with pulmonary complications in a patient's lifetime. A review of the diagnosis of spinal abnormalities includes classifications of scoliosis and kyphosis, correlating physical examination findings and radiographic interpretation. The natural history of untreated spine deformities is reviewed along with the associated altered pulmonary compromise. ... Read more >>

Pediatr Clin North Am (Pediatric clinics of North America)
[2021, 68(1):239-259]

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Cathepsins in neuronal plasticity.

Amanda Phuong Tran, Jerry Silver,

Proteases comprise a variety of enzymes defined by their ability to catalytically hydrolyze the peptide bonds of other proteins, resulting in protein lysis. Cathepsins, specifically, encompass a class of at least twenty proteases with potent endopeptidase activity. They are located subcellularly in lysosomes, organelles responsible for the cell's degradative and ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(1):26-35]

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Opioid Modulation of Neuronal Iron and Potential Contributions to NeuroHIV.

Bradley Nash, Elena Irollo, Renato Brandimarti, Olimpia Meucci,

Opioid use has substantially increased over recent years and remains a major driver of new HIV infections worldwide. Clinical studies indicate that opioids may exacerbate the symptoms of HIV-associated neurocognitive disorders (HAND), but the mechanisms underlying opioid-induced cognitive decline remain obscure. We recently reported that the μ-opioid agonist morphine increased ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2201:139-162]

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New Beginnings.

Jeffrey C Wang, Jens R Chapman, Karsten Wiechert,

Global Spine J (Global spine journal)
[2020, 10(8):957]

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Evaluation and Treatment of Foot Drop Using Nerve Transfer Techniques.

Arshad A Khan, Edgardo R Rodriguez-Collazo, Erwin Lo, Asim Raja, Sujin Yu, Hamid A Khan,

Foot drop represents a complex pathologic condition, requiring a multidisciplinary approach for appropriate evaluation and treatment. Multiple etiologic factors require recognition before considering invasive/operative intervention. When considering surgical management for the treatment of foot drop, it is first and foremost imperative to establish the cause of the condition. Not all ... Read more >>

Clin Podiatr Med Surg (Clinics in podiatric medicine and surgery)
[2021, 38(1):83-98]

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Improving the Quality of Systematic Reviews in Spinal Surgery Requires Community-Wide Engagement and Pragmatism.

Ben Grodzinski, Oliver Mowforth, Lindsay A Tetreault, Benjamin M Davies,

Global Spine J (Global spine journal)
[2020, 10(8):1078-1079]

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Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.

Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, Ryu Takeya,

Changes in the shape and size of the dendritic spines are critical for synaptic transmission. These morphological changes depend on dynamic assembly of the actin cytoskeleton and occur differently in various types of neurons. However, how the actin dynamics are regulated in a neuronal cell type-specific manner remains largely unknown. ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, :]

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Regarding "Telemedicine for the Spine Surgeon in the Age of COVID-19: Multicenter Experiences of Feasibility and Implementation Strategies" by Franco et al.

Vikaesh Moorthy,

Global Spine J (Global spine journal)
[2020, 10(8):1082-1083]

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KLHL17/Actinfilin, a brain-specific gene associated with infantile spasms and autism, regulates dendritic spine enlargement.

Hsiao-Tang Hu, Tzyy-Nan Huang, Yi-Ping Hsueh,

BACKGROUND:Dendritic spines, the actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain. Many actin-regulating molecules modulate dendritic spine morphology. Since dendritic spines are neuron-specific structures, it is reasonable to speculate that neuron-specific or -predominant factors are involved in dendritic spine formation. KLHL17 (Kelch-like ... Read more >>

J Biomed Sci (Journal of biomedical science)
[2020, 27(1):103]

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Letter to the editor regarding: "degenerate-disc infection study with contaminant control (DISC): a multi-center prospective case-control trial".

Dilip Chand Raja Soundararajan, Rajasekaran Shanmuganathan,

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, 20(12):2044-2045]

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The 2019 Cervical Spine Research Society (CSRS) Asia Pacific Traveling Fellowship.

Ilyas Aleem, Lee Tan, Aju Bosco, Rui Reinas, Paula V Ter Wengel, Hwee Weng Dennis Hey,

The Cervical Spine Research Society (CSRS) is dedicated to advancing the care of patients with cervical spine pathology. The authors present here highlights of the 2019 CSRS-Asia Pacific Traveling Fellowship. ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2020, 33(10):393-399]

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Reply to "Comments on 'Critically Low Confidence in the Results Produced by Spine Surgery Systematic Reviews: An AMSTAR-2 Evaluation From 4 Spine Journals' by Dettori et al".

Joseph R Dettori, Andrea C Skelly, Erika D Brodt,

Global Spine J (Global spine journal)
[2020, 10(8):1080]

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Health Care Lobbying, Political Action Committees, and Spine Surgery.

Richard Menger, Thomas Shaw, Jaclyn Bunch, James Barry, Gerard Marciano, Austin Menger, Anthony Martino, Lawrence Lenke, Michael G Vitale,

STUDY DESIGN:Retrospective review. OBJECTIVE:The aim of this study was to analyze the political contributions and strategies of the Political Action Committee (PACs) lobbying for the political interests of spine surgeons. SUMMARY OF BACKGROUND DATA:In 2016, a presidential election year, $514,224,628 was spent on health care lobbying. Only 16% ($85,061,148) was ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2020, 45(24):1736-1742]

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Response to "Comments on 'How Fragile Are the Results of a Trial? The Fragility Index' by Dettori and Norvell".

Joseph R Dettori, Daniel C Norvell,

Global Spine J (Global spine journal)
[2020, 10(8):1081]

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3D-printed Patient-specific Spine Implants: A Systematic Review.

Nicholas Wallace, Nathaniel E Schaffer, Ilyas S Aleem, Rakesh Patel,

STUDY DESIGN:Systematic review. OBJECTIVE:To review the current clinical use of 3-dimensional printed (3DP) patient-specific implants in the spine. SUMMARY OF BACKGROUND DATA:Additive manufacturing is a transformative manufacturing method now being applied to spinal implants. Recent innovations in technology have allowed the production of medical-grade implants with unprecedented structure and customization, ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2020, 33(10):400-407]

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Letter to the Editor: Cervical Spine Balance of Multilevel Total Disc Replacement, Hybrid Surgery, and Anterior Cervical Discectomy and Fusion With a Long-term Follow-up.

Chengyi Huang, Tingkui Wu, Beiyu Wang, Hao Liu,

Spine (Phila Pa 1976) (Spine)
[2020, 45(23):E1634-E1635]

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Industry Payments to Orthopedic Spine Surgeons Reported by the Open Payments Database: 2014-2017.

Neil Pathak, Michael R Mercier, Anoop R Galivanche, Elbert J Mets, Patawut Bovonratwet, Paul S Bagi, Arya G Varthi, Jonathan N Grauer,

STUDY DESIGN:This was a retrospective study of publicly available data. OBJECTIVE:The objective of this study was to characterize and assess trends in Open Payments Database (OPD) industry payments reported to orthopedic spine surgeons from 2014 to 2017. SUMMARY OF BACKGROUND DATA:There have been a lack of studies characterizing OPD industry ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2020, 33(10):E572-E578]

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Cirbp-PSD95 Axis Protects Against Hypobaric Hypoxia-Induced Aberrant Morphology of Hippocampal Dendritic Spines and Cognitive Deficits

Yang Zhou, Huanyu Lu, Ying Liu, Zaihua Zhao, Qian Zhang, Chong Xue, Yuankang Zou, Zipeng Cao, Wenjing Luo,

Abstract Hypobaric hypoxia (HH) is a typical characteristic of high altitude environment and causes a spectrum of pathophysiological effects, including headaches, gliovascular dysfunction and cognitive slowing. Here, we sought to understand the mechanisms underlying cognitive deficits under HH exposure. Our results showed that HH exposure impaired cognitive function and suppressed ... Read more >>

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Therapeutic Facet Joint Interventions in the Lumbar Spine: An Economic Value Perspective.

Aditya Mazmudar, Rusheel Nayak, Alpesh A Patel,

OBJECTIVE:In this narrative review, the current literature on therapeutic interventions for low back pain of facet joint etiology is assessed from an economic value perspective. SUMMARY OF BACKGROUND DATA:The efficacy and economics of facet joint interventions in the treatment of lumbar back pain is a controversial topic. Trends show that ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2020, 33(10):411-417]

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