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Spinal Metastasis

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Prospective analysis of health-related quality of life after surgery for spinal metastases.

N A Quraishi, D Pasku, J E J Koch, G Arealis, B M Boszczyk, K L Edwards,

PURPOSE:Most spinal metastases are detected late, and thus, the impact of treatment on the health-related quality of life (HRQOL) is an important consideration. This study investigated the HRQOL following surgery for spinal metastases. METHODS:A prospective study of patients operated for symptomatic spinal metastases, at a single tertiary referral spine centre ... Read more >>

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2020, :]

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Special emphasis on bone health management in prostate cancer patients: a prospective longitudinal study.

Ashish Sharma, Rahul Janak Sinha, Gaurav Garg, Samarth Agarwal, Asif Akhtar Statistician, Vishwajeet Singh,

INTRODUCTION:Use of androgen deprivation therapy (ADT) in carcinoma prostate (CaP) has deleterious effect on bone mineral density (BMD) leading to increase incidence of osteoporosis and skeletal-related events. We evaluated bone health status and impact of bone-directed therapy (BDT) and ADT on BMD in these patients from Jan 2015-Dec 2018. MATERIALS ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2020, 46(3):363-373]

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Microsurgical Resection of Lung Carcinoma Spinal Cord Metastasis: 2-Dimensional Operative Video.

Mirza Pojskić, Kenan I Arnautović,

This video demonstrates microsurgical resection of intramedullary spinal cord metastasis of lung adenocarcinoma. Lung cancer is the predominant cause of rare metastatic intramedullary involvement of the spinal cord.1-4 Because of severe disabilities, these tumors should be considered for treatment with the goal of complete removal to preserve neurological functioning.5-9  Surgical ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, 18(4):E115-E116]

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Visceral Metastasis: A Prognostic Factor of Survival in Patients with Spinal Metastases.

Deng-Xing Lun, Nai-Wang Chen, Jiang-Tao Feng, Xion-Gang Yang, Zhao-Wan Xu, Feng Li, Yong-Cheng Hu,

OBJECTIVE:To characterize the visceral metastasis as a predictive tool for the survival of patients with spinal metastases through an exploratory meta-analysis. METHODS:Two investigators independently searched PubMed and Embase databases for eligible studies from 2000-2016. The effect estimates for the hazard ratio (HR) or risk ratio (RR) and 95% confidence interval ... Read more >>

Orthop Surg (Orthopaedic surgery)
[2020, :]

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Management of Metastatic GEPNETs.

Kristen E Limbach, Rodney F Pommier,

The chief causes of death of patients with GEPNETs are liver failure from hepatic replacement by tumor in the majority and bowel obstruction in the remainder. Many patients are with liver metastases are actually eligible for hepatic cytoreductive operations, even if they have numerous bilobar metastases and extra-hepatic disease, provided ... Read more >>

Surg. Oncol. Clin. N. Am. (Surgical oncology clinics of North America)
[2020, 29(2):281-292]

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Types of pedicle signs indicating symptomatic spinal metastases and their associated clinical and radiological features.

Yasuyuki Kitagawa, Yong Kim, Ryu Tsunoda, Shinro Takai,

BACKGROUND:Cancer diagnoses are increasing rapidly due to the aging population of Japan. Pedicle sign is a valuable radiographic indicator of metastases as the pedicle is the most commonly affected part of the vertebra upon radiographic assessment. However, few detailed studies examining the morphological features of pedicle signs have been performed. ... Read more >>

J Nippon Med Sch (Journal of Nippon Medical School = Nippon Ika Daigaku zasshi)
[2020, :]

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Metastatic intradural extramedullary spinal cord tumor from ovarian cancer: A case report with a literature review.

Yuki Tajima, Masahito Takahashi, Takuya Kawai, Makoto Higashi, Hideto Sano, Shoichi Ichimura, Hiroaki Kobayashi,

Context: Metastatic intradural extramedullary spinal cord tumors are extremely rare.Findings: A 76-year-old woman presented with intractable neck pain. Three years earlier, she had been treated for ovarian cancer with bilateral salpingo-oophorectomy. A year later, she underwent resection of a brain metastasis. Magnetic resonance imaging (MRI) showed an encapsulated intradural extramedullary ... Read more >>

J Spinal Cord Med (The journal of spinal cord medicine)
[2020, :1-4]

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[Spinalcord compression secondary to metastases from a non-previous diagnosed thyroid cancer].

N Lorenzo Villalba, V Saint-Mezard, M B Ortiz Alonso, Z Sosa Cordoba, E Andrès, A A Zulfiqar,

We presented a case of a 73-year-old woman presenting to the emergency department with a spinal cord compression secondary to a T2 mass lesion and needing emergency surgery. The lesion was consistent with a papillary thyroid carcinoma. The patient had a previous history of thyroidectomy in a setting of a ... Read more >>

Rev Med Liege (Revue medicale de Liege)
[2020, 75(4):201-202]

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Rare Esophageal Leptomeningeal Metastases Detected on 18F-FDG PET/CT.

Yang Lu, Linghua Wang, Jaffer A Ajani,

A 62-year-old man with a history of locally advanced poorly differentiated adenocarcinoma of the gastroesophageal junction had received induction chemotherapy and concurrent chemoradiation. A 6-month follow-up FDG PET/CT revealed nearly resolved primary malignancy, but new hypermetabolic mediastinal lymph node metastasis and abnormal hypermetabolism in the cerebellum region. Brain MRI and ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2020, 45(4):334-335]

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Merkel cell carcinoma spinal metastases in a immunosuppressed patient: Clinical case.

Guillermo García-Oriola, Luis Real-Peña, Félix Pastor-Escartín, Fernando Talamantes-Escribá,

Merkel cell carcinoma is a rare epidermal malignant tumor arised from neuroendocrine epidermal cells, called Merkel cells. Prognosis is poor when tumor spreads to distant locations. Among metastases sites, spinal is not frequent at all and its management remains controversial. We present the second reported case of spinal metastases from ... Read more >>

Neurocirugia (Astur) (Neurocirugia (Asturias, Spain))
[2020, :]

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Vertebral fractures following stereotactic body radiotherapy for spine metastases.

Hussein Abbouchie, Michael Chao, Mark Tacey, Daryl Lim Joon, Huong Ho, Mario Guerrieri, Michael Ng, Farshad Foroudi,

Stereotactic body radiotherapy has emerged as one of the preferred treatments for patients with spine metastases, with the potential for long-term control from lesion irradiation. Post-treatment vertebral compression fractures are a known complication of this therapy, contributing to worsening pain and reduced quality of life, sometimes requiring surgical intervention. This ... Read more >>

J Med Imaging Radiat Oncol (Journal of medical imaging and radiation oncology)
[2020, :]

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Clinical investigations of percutaneous vertebroplasty combined with intensity-modulated radiotherapy for patients with spinal metastases

Wang Feng, Xiaoqi Xie, Chen Xin, Zhang Hong, Liao Zhengying,

<title>Abstract</title> <p> <bold>Background:</bold> This study aimed to explore the use of percutaneous vertebroplasty (PVP) plus radiotherapy in patients with bone metastases. However, percutaneous vertebroplasty (PVP) combined with intensity modulated radiotherapy (IMRT) has been rarely reported in the treatment of spinal metastases.<bold>Methods: </bold>The effectiveness and feasibility of this procedure ... Read more >>

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Spinal Metastatic Disease: Survival Analysis of 146 Patients and Evaluation of 4 Different Preoperative Scoring Systems.

Alihan Derincek, Umit O Guler, Mustafa Uysal, Metin Ozalay,

STUDY DESIGN:This was a retrospective analysis. OBJECTIVE:The objective of this study was to evaluate the predictive value of the 4 different scoring systems Tomita, Bauer modified, Tokuhashi revised, and Van der Linden and some parameters that are used in these scoring systems. SUMMARY AND BACKGROUND DATA:Prediction of the survival period ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2020, 33(2):E81-E86]

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Clinical Outcomes in Patients with Renal Cell Carcinoma Metastases to the Choroid Plexus.

Celina M Crisman, Ankur R Patel, Graham Winston, Cameron W Brennan, Viviane Tabar, Nelson S Moss,

OBJECTIVE:Intraventricular metastatic brain tumors account for a small but challenging fraction of metastatic brain tumors (0.9-4.5%). Metastases from renal cell carcinoma (RCC) account for a large portion of these intraventricular tumors, and while patient outcomes are assumed to be poor, these have not been reported in a modern series with ... Read more >>

World Neurosurg (World neurosurgery)
[2020, :]

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Correction to: Outcomes of surgical treatments of spinal metastases: a prospective study.

C Bouthors, S Prost, C Court, B Blondel, Y P Charles, S Fuentes, H P Mousselard, C Mazel, C H Flouzat-Lachaniette, P Bonnevialle, F Sailhan, ,

The correct name of F. Saihlan should be F. Sailhan. ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2020, 28(5):2137]

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Bone Metastases of Gastrointestinal Stromal Tumor: A Review of Published Literature.

Jian Yang, Jijie Yan, Meihui Zeng, Wei Wan, Tielong Liu, Jian-Ru Xiao,

Background:With the occurrence and improvement of immunohistochemistry and other pathological diagnostic techniques, gastrointestinal stromal tumor (GIST) has been gradually recognized. With the prolonged survival of patients with GISTs, reports about the bone metastasis of GIST increased. However, the knowledge of GISTs is rather limited due to its very low incidence. ... Read more >>

Cancer Manag Res (Cancer Management and Research)
[2020, 12:1411-1417]

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Surgical treatment of intraspinal tumors in Southern Taiwan: The 30-year experience of a single institution.

Cheng-Yu Tsai, Tai-Hsin Tsai, Yu-Feng Su,

Our institute presented two reports of intraspinal tumors, one in 1997 and the other in 2007, which assessed 120 and 117 cases of diagnosed and surgically treated intraspinal tumors at Kaohsiung Medical University Hospital, Southern Taiwan during 1988-1995 and 1999-2004, respectively. Here, we analyze data from 247 patients with medical ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, :]

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Radium-223 as an Approved Modality for Treatment of Bone Metastases.

Ana Emília Brito, Elba Etchebehere,

Radium-223 dichloride (223Ra) is an α-emitter radionuclide approved for treatment of osteoblastic metastases in castrate-resistant prostate cancer (mCRPC) patients. 223Ra increases overall survival, improves bone pain, increases the median time to the first skeletal-related event, reduces the use of external beam radiation therapy for bone pain palliation, reduces the rates ... Read more >>

Semin Nucl Med (Seminars in nuclear medicine)
[2020, 50(2):177-192]

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Factors Affecting the Discharge Destination of Patients With Spinal Bone Metastases.

Yoshiteru Akezaki, Eiji Nakata, Masato Kikuuchi, Shinsuke Sugihara,

OBJECTIVE:To investigate the factors affecting the discharge destination of patients with spinal bone metastases. METHODS:We reviewed the medical records of patients admitted to our institute with a diagnosis of skeletalrelated events secondary to malignant disease. Exclusion criteria comprised decreased cognitive function and hypercalcemia, brain metastasis, peritoneal dissemination, and pleural dissemination. ... Read more >>

Ann Rehabil Med (Annals of rehabilitation medicine)
[2020, 44(1):69-76]

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Stereotactic Body Radiotherapy for Non-Spine Bone Metastases: A Synthesis of International Practice Patterns to Guide Treatment Planning.

Timothy K Nguyen, Arjun Sahgal, Roi Dagan, Wietse Eppinga, Matthias Guckenberger, Jin Ho Kim, Simon S Lo, Kristin J Redmond, Shankar Siva, Bradley J Stish, Chia-Lin Tseng,

PURPOSE:Stereotactic body radiotherapy (SBRT) is increasingly used for non-spine bone metastases (NSBM); however, there are limited data informing treatment planning. We surveyed international experts to better understand worldwide practice patterns in delivering non-spine bone (NSBM)-SBRT. METHODS:Nine international radiation oncologists were invited to participate based on demonstrated expertise with NSBM-SBRT. Experts ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2020, :]

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Role of mTOR and VEGFR Inhibition in Prevention of Metastatic Tumor Growth in the Spine.

Tobias Kratzsch, Andras Piffko, Thomas Broggini, Marcus Czabanka, Peter Vajkoczy,

Objective: Spinal metastatic disease remains a major problem of oncological diseases. Patients affected may suffer pain, spinal instability, and severe neurological deficits. Today, palliative surgery and radiotherapy are the mainstays of therapy. In contrast, preventive treatment strategies or treatment concepts for an early stage are lacking. Here, we have used ... Read more >>

Front Oncol (Frontiers in Oncology)
[2020, 10:174]

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Retrospective evaluation of prognostic factors in metastatic spine disease: serum albumin and primary tumour type are key.

William H Cook, Joseph F Baker,

BACKGROUND:Treatment decisions for metastatic spine disease are complex and depend on prognosis. Four prognostic systems in use are the Oswestry Risk Index, modified Bauer score (MBS), van der Linden score and New England Spinal Metastasis Score (NESMS). We aimed to determine the performance of these scoring systems in a New ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2020, :]

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Perspectives on Spinal Precautions in Patients Who Have Cancer and Spinal Metastasis.

Ying Guo, An Thuy Ngo-Huang, Jack B Fu,

Bones are the third most common site for cancer metastases, and the axial skeleton is the most frequent skeletal location. In a postmortem study, bone metastases were reported in 70% of breast and prostate cancer patients. Bone metastases from breast, lung, prostate, thyroid, and kidney cancers account for 80% of ... Read more >>

Phys Ther (Physical therapy)
[2020, 100(3):554-563]

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Vertebral Fractures Following Stereotactic Body Radiotherapy for Spine Oligometastases: A Multi-institutional Analysis of Patient Outcomes.

H Abbouchie, M Chao, M Tacey, D L Joon, H Ho, M Guerrieri, M Ng, F Foroudi,

AIMS:Stereotactic body radiotherapy (SBRT) is a locally ablative therapy used for the treatment of patients with spine metastases. However, it is associated with higher rates of vertebral compression fractures (VCF) than conventionally fractionated palliative radiotherapy. The purpose of this study was to determine the rate of VCF following spine SBRT ... Read more >>

Clin Oncol (R Coll Radiol) (Clinical oncology (Royal College of Radiologists (Great Britain)))
[2020, :]

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Prognostic factors for overall survival in patients with spinal metastasis secondary to prostate cancer: a systematic review and meta-analysis

Wen-xue Jiang, Zhong-yu Gao, Tao Zhang, Hui Zhang, Cheng-gang Pang,

<title>Abstract</title> <p> Background: To guide the selection of treatments for spinal metastases, the expected survival time is one of the most important determinants. Few scoring systems are fully applicable for spinal metastasis secondary to prostate cancer (PCa). This study aimed to identify the independent factors to predict the ... Read more >>

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