Full Text Journal Articles about
Spinal Cord Trauma and Related Diseases

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Electrical stimulation and denervated muscles after spinal cord injury.

Subhalakshmi Chandrasekaran, John Davis, Ines Bersch, Gary Goldberg, Ashraf S Gorgey,

Spinal cord injury (SCI) population with injury below T10 or injury to the cauda equina region is characterized by denervated muscles, extensive muscle atrophy, infiltration of intramuscular fat and formation of fibrous tissue. These morphological changes may put individuals with SCI at higher risk for developing other diseases such as ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1397-1407]

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Human umbilical cord mesenchymal stem cells to treat spinal cord injury in the early chronic phase: study protocol for a prospective, multicenter, randomized, placebo-controlled, single-blinded clinical trial.

Yang Yang, Mao Pang, Yu-Yong Chen, Liang-Ming Zhang, Hao Liu, Jun Tan, Bin Liu, Li-Min Rong,

Human umbilical cord mesenchymal stem cells (hUC-MSCs) support revascularization, inhibition of inflammation, regulation of apoptosis, and promotion of the release of beneficial factors. Thus, they are regarded as a promising candidate for the treatment of intractable spinal cord injury (SCI). Clinical studies on patients with early chronic SCI (from 2 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1532-1538]

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Temporal changes in the spinal cord transcriptome after peripheral nerve injury.

Jian Weng, Dong-Dong Li, Bao-Guo Jiang, Xiao-Feng Yin,

Peripheral nerve injury may trigger changes in mRNA levels in the spinal cord. Finding key mRNAs is important for improving repair after nerve injury. This study aimed to investigate changes in mRNAs in the spinal cord following sciatic nerve injury by transcriptomic analysis. The left sciatic nerve denervation model was ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1360-1367]

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Adrenomedullin: an important participant in neurological diseases.

Feng-Jiao Li, Si-Ru Zheng, Dong-Mei Wang,

Adrenomedullin, a peptide with multiple physiological functions in nervous system injury and disease, has aroused the interest of researchers. This review summarizes the role of adrenomedullin in neuropathological disorders, including pathological pain, brain injury and nerve regeneration, and their treatment. As a newly characterized pronociceptive mediator, adrenomedullin has been shown ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1199-1207]

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The N-formyl peptide receptors: contemporary roles in neuronal function and dysfunction.

Peter J G Cussell, Margarita Gomez Escalada, Nathaniel G N Milton, Andrew W J Paterson,

N-formyl peptide receptors (FPRs) were first identified upon phagocytic leukocytes, but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor family. FPRs are expressed within neuronal tissues and markedly in the central nervous system, where FPR interactions with endogenous ligands have been implicated ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1191-1198]

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Expression of long non-coding RNAs in complete transection spinal cord injury: a transcriptomic analysis.

Lu Ding, Wen-Jin Fu, Hong-Yan Di, Xiao-Min Zhang, Yu-Tian Lei, Kang-Zhen Chen, Tao Wang, Hong-Fu Wu,

Long non-coding RNAs (lncRNAs) are abundantly expressed in the central nervous system and exert a critical role in gene regulation via multiple biological processes. To uncover the functional significance and molecular mechanisms of lncRNAs in spinal cord injury (SCI), the expression signatures of lncRNAs were profiled using RNA sequencing (RNA-seq) ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1560-1567]

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Rapid progression of acute cervical syringomyelia: A case report of delayed complications following spinal cord injury.

Chenghua Yuan, Jian Guan, Fengzeng Jian,

Context: Post-traumatic syringomyelia treatment usually focuses on restoring normal cerebrospinal fluid (CSF) flow. Herein, the first-reported case of delayed post-traumatic syringomyelia associated with an L2 compression fracture 30 years prior to syringomyelia symptoms that rapidly progressed to the brainstem within 5 months, leading to respiratory and circulatory impairments, is summarized. ... Read more >>

J Spinal Cord Med (The journal of spinal cord medicine)
[2020, :1-5]

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ABC efflux transporters at blood-central nervous system barriers and their implications for treating spinal cord disorders.

Liam M Koehn,

The barriers present in the interfaces between the blood and the central nervous system form a major hurdle for the pharmacological treatment of central nervous system injuries and diseases. The family of ATP-binding cassette (ABC) transporters has been widely studied regarding efflux of medications at blood-central nervous system barriers. These ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1235-1242]

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Radiographic assessment of surgical treatment of post-traumatic syringomyelia.

Yuping D Li, Chris Therasse, Kartik Kesavabhotla, Jason B Lamano, Aruna Ganju,

Context: Symptomatic post-traumatic syringomyelia can affect the quality of life in patients whose neurologic function has already been impacted by a spinal cord injury.Objective: To investigate the radiographic and clinical outcomes following surgery for syringomyelia, we present a literature review along with a case series from a single surgeon's experience.Methods: ... Read more >>

J Spinal Cord Med (The journal of spinal cord medicine)
[2020, :1-9]

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Cervical Spine Decompression and Fusion Outcomes in Trauma Patients Actively Receiving Anticoagulation Treatment for Cerebrovascular Injury: A Retrospective Comparative Study.

Francis X Camillo, Sean M Mitchell,

Background:Cervical spine blunt trauma patients with the presence of a cerebrovascular injury may be given initiation of heparin anticoagulation treatment prior to necessary surgical stabilization. Literature regarding the safety and efficacy of these procedures while a patient is on active anticoagulation is limited, requiring further investigation. The primary research question ... Read more >>

Int J Spine Surg (International Journal of Spine Surgery)
[2020, 14(1):66-71]

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Biomaterials and neural regeneration.

Yi Liu, Shan-Hui Hsu,

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1243-1244]

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Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation.

Ya Zheng, Ye-Ran Mao, Ti-Fei Yuan, Dong-Sheng Xu, Li-Ming Cheng,

Spinal cord injury is linked to the interruption of neural pathways, which results in irreversible neural dysfunction. Neural repair and neuroregeneration are critical goals and issues for rehabilitation in spinal cord injury, which require neural stem cell repair and multimodal neuromodulation techniques involving personalized rehabilitation strategies. Besides the involvement of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1437-1450]

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Spinal epidural hematoma without significant trauma in children: two case reports and review of the literature.

Audrey Carlhan-Ledermann, Bernard Laubscher, Maja Steinlin, Christian T Ulrich, Rajeev Kumar Verma, Mattia Rizzi, Rodolfo Maduri, Sebastian Grunt,

BACKGROUND:Spinal epidural hematoma without significant trauma is a rare condition with potentially severe outcome. This case report and systematic review of the literature illustrates the clinical presentation, risk factors, evaluation, treatment and outcomes of spinal epidural hematoma without significant trauma in children. CASE PRESENTATION:We report one case of a 7-year-old ... Read more >>

BMC Pediatr (BMC Pediatrics)
[2020, 20(1):77]

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Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation.

Shan-Shan Cui, Xiao-Bo Feng, Bing-Hong Zhang, Zhong-Yuan Xia, Li-Ying Zhan,

Glucagon-like peptide-1 receptor has anti-apoptotic, anti-inflammatory, and neuroprotective effects. It is now recognized that the occurrence and development of chronic pain are strongly associated with anti-inflammatory responses; however, it is not clear whether glucagon-like peptide-1 receptor regulates chronic pain via anti-inflammatory mechanisms. We explored the effects of glucagon-like peptide-1 receptor ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1333-1339]

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Circulating PAMM, a novel antioxidant and anti-inflammatory protein, is elevated in acute SCI.

Leslie R Morse, Nguyen Nguyen, Yan Xu, Prakash Jha, Ricardo A Battaglino,

BACKGROUND:Peroxiredoxin activated in M-CSF stimulated monocytes (PAMM) is a novel protein produced by adipocytes with putative redox regulatory and anti-inflammatory properties. Because acute spinal cord injury (SCI) is associated with oxidative stress and neuroinflammation and because PAMM can be detected in systemic circulation, we hypothesized that acute neuro-trauma might induce ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):135]

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Pneumorrhachis and hyponatremia after a neck hack-A case report.

Tommy Supit, Ajid Risdianto, Dody Priambada, Muhamad Thohar Arifin, Happy Kurnia Brotoarianto,

INTRODUCTION:Penetrating cervical spinal cord injury (SCI) is a rare clinical entity that requires a multitude of health care specialists for proper management. The unpredictable nature of penetrating SCI and complex systemic sequela contribute to the high mortality rates of penetrating SCI. PRESENTATION OF CASE:An 18-year-old-male patient was admitted to the ... Read more >>

Int J Surg Case Rep (International journal of surgery case reports)
[2020, 68:174-177]

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Dihydrotanshinone I Alleviates Spinal Cord Injury via Suppressing Inflammatory Response, Oxidative Stress and Apoptosis in Rats.

Liuqian Yu, Jinfeng Qian,

BACKGROUND Spinal cord injury (SCI) is a serious nervous system injury, causing extremely low quality of life and immensurable economic losses. However, there is few therapies that can effectively cure the injury. The goal of the present study was to explore the potential therapeutic effects of dihydrotanshinone I (DI) for ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e920738]

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Neuroimaging in Neuro-Urology.

Ulrich Mehnert, Stéphanie van der Lely, Maryam Seif, Lorenz Leitner, Martina D Liechti, Lars Michels,

Neuroimaging allows in vivo visualization of neuronal structures/processes to assess their involvement in bodily functions. This is particularly valuable for the assessment of complex, multilevel neuronal controlled functions, such as urine storage and micturition. Using positron emission tomography or functional magnetic resonance imaging, significant alterations of supraspinal lower urinary tract ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

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Identification of biological pathways and genes associated with neurogenic heterotopic ossification by text mining.

Yichong Zhang, Yuanbo Zhan, Yuhui Kou, Xiaofeng Yin, Yanhua Wang, Dianying Zhang,

Background:Neurogenic heterotopic ossification is a disorder of aberrant bone formation affecting one in five patients sustaining a spinal cord injury or traumatic brain injury (SCI-TBI-HO). However, the underlying mechanisms of SCI-TBI-HO have proven difficult to elucidate. The aim of the present study is to identify the most promising candidate genes ... Read more >>

PeerJ (PeerJ)
[2020, 8:e8276]

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Bone Infarct as an Indicator of Acute Spinal Ischaemia.

Laura López-Viñas, Kary Leonisa Quiñones-Coneo, Raquel Buenache-Espartosa, Juan Salvador Martínez-San-Millán, Gustavo Lorenzo-Sanz,

Acute spinal cord infarct in childhood is extremely rare, generally secondary to spinal/cardiovascular surgery or severe vertebral injuries. However, spontaneous spinal cord infarct cases have been described. We present a clinical case of a teenager who developed an acute weakness and paraesthesia in lower limbs after playing piggyback. Laboratory tests ... Read more >>

Case Rep Pediatr (Case reports in pediatrics)
[2020, 2020:9703625]

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Clinical decision-making on spinal cord injury-associated pneumonia: a nationwide survey in Germany.

Claudia Druschel, Ramin R Ossami Saidy, Ulrike Grittner, Claus P Nowak, Andreas Meisel, Klaus-Dieter Schaser, Andreas Niedeggen, Thomas Liebscher, Marcel A Kopp, Jan M Schwab,

STUDY DESIGN:Survey study. OBJECTIVES:Spinal cord injury (SCI)-associated pneumonia (SCI-AP) is associated with poor functional recovery and a major cause of death after SCI. Better tackling SCI-AP requires a common understanding on how SCI-AP is defined. This survey examines clinical algorithms relevant for diagnosis and treatment of SCI-AP. SETTING:All departments for ... Read more >>

Spinal Cord (Spinal cord)
[2020, :]

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Abnormalities in spinal cord ultrastructure in a rat model of post-traumatic syringomyelia.

Joel Berliner, Sarah Hemley, Elmira Najafi, Lynne Bilston, Marcus Stoodley, Magdalena Lam,

BACKGROUND:Syringomyelia is a serious complication of spinal cord trauma, occurring in approximately 28% of spinal cord injuries. Treatment options are limited and often produce unsatisfactory results. Post-traumatic syringomyelia (PTS) is presumably related to abnormalities of cerebrospinal fluid (CSF) and interstitial fluid hydrodynamics, but the exact mechanisms are unknown. METHODS:Transmission electron ... Read more >>

Fluids Barriers CNS (Fluids and barriers of the CNS)
[2020, 17(1):11]

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Refining rodent models of spinal cord injury.

Elliot Lilley, Melissa R Andrews, Elizabeth J Bradbury, Heather Elliott, Penny Hawkins, Ronaldo M Ichiyama, Jo Keeley, Adina T Michael-Titus, Lawrence D F Moon, Stefano Pluchino, John Riddell, Kathy Ryder, Ping K Yip,

This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an ... Read more >>

Exp. Neurol. (Experimental neurology)
[2020, 328:113273]

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Prolonged inflammation leads to ongoing damage after spinal cord injury.

Jacek M Kwiecien, Wojciech Dabrowski, Beata Dąbrowska-Bouta, Grzegorz Sulkowski, Wendy Oakden, Christian J Kwiecien-Delaney, Jordan R Yaron, Liqiang Zhang, Lauren Schutz, Barbara Marzec-Kotarska, Greg J Stanisz, John P Karis, Lidia Struzynska, Alexandra R Lucas,

The pathogenesis of spinal cord injury (SCI) remains poorly understood and treatment remains limited. Emerging evidence indicates that post-SCI inflammation is severe but the role of reactive astrogliosis not well understood given its implication in ongoing inflammation as damaging or neuroprotective. We have completed an extensive systematic study with MRI, ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0226584]

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Fast-tracking regenerative medicine for traumatic brain injury.

Brooke Bonsack, Matt Heyck, Chase Kingsbury, Blaise Cozene, Nadia Sadanandan, Jea-Young Lee, Cesar V Borlongan,

Traumatic brain injury remains a global health crisis that spans all demographics, yet there exist limited treatment options that may effectively curtail its lingering symptoms. Traumatic brain injury pathology entails a progression from primary injury to inflammation-mediated secondary cell death. Sequestering this inflammation as a means of ameliorating the greater ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1179-1190]

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