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Spinal Cord Infarction

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Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation.

Shan-Shan Cui, Xiao-Bo Feng, Bing-Hong Zhang, Zhong-Yuan Xia, Li-Ying Zhan,

Glucagon-like peptide-1 receptor has anti-apoptotic, anti-inflammatory, and neuroprotective effects. It is now recognized that the occurrence and development of chronic pain are strongly associated with anti-inflammatory responses; however, it is not clear whether glucagon-like peptide-1 receptor regulates chronic pain via anti-inflammatory mechanisms. We explored the effects of glucagon-like peptide-1 receptor ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1333-1339]

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Fibrocartilaginous embolism as a cause of anterior spinal artery syndrome?

Ingvild Nakstad, Ivana Randjelovic, Harald Bergan, Kristin Evensen,

BACKGROUND:Fibrocartilaginous embolism (FCE) is a rare cause of spinal cord infarction. Most spinal cord infarctions are due to aortic pathologies and aortic surgeries. One theory is that material from the intervertebral discs follows a retrograde route to the anterior spinal artery. Fibrocartilaginous embolism and spinal cord infarction have also been ... Read more >>

Tidsskr. Nor. Laegeforen. (Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke)
[2020, 140(5):]

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Adrenomedullin: an important participant in neurological diseases.

Feng-Jiao Li, Si-Ru Zheng, Dong-Mei Wang,

Adrenomedullin, a peptide with multiple physiological functions in nervous system injury and disease, has aroused the interest of researchers. This review summarizes the role of adrenomedullin in neuropathological disorders, including pathological pain, brain injury and nerve regeneration, and their treatment. As a newly characterized pronociceptive mediator, adrenomedullin has been shown ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1199-1207]

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Clinical-radiological dissociation in a patient with nitrous oxide-induced subacute combined degeneration: a case report.

Jiwei Jiang, Xiuli Shang,

BACKGROUND:Several recent studies have reported subacute combined degeneration (SCD) induced by nitrous oxide (N2O) abuse. However, the association between the evolution of dynamic neuroimaging and clinical manifestations has not been reported in patients with N2O-induced SCD. CASE PRESENTATION:We described the case of a 24-year-old man who developed SCD with inverted ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):99]

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Postoperative Tetraplegia to a Child after Cerebellar Pilocytic Astrocytoma Excision at Prone Position: Case Report and Literature Review.

Dimitrios Panagopoulos, Elias Antoniades, Ploutarchos Karydakis, Dimitrios Giakoumettis, Marios Themistocleous,

BACKGROUND Various factors have been implicated in the pathogenesis of infarction after posterior fossa surgery such as venous air embolism, patient's position (seated or prone), hyperflexion of the neck, excessive spinal cord traction, cervical canal stenosis, and systemic arterial hypotension. The main aim of this case report was to elucidate ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e920213]

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Bone Infarct as an Indicator of Acute Spinal Ischaemia.

Laura López-Viñas, Kary Leonisa Quiñones-Coneo, Raquel Buenache-Espartosa, Juan Salvador Martínez-San-Millán, Gustavo Lorenzo-Sanz,

Acute spinal cord infarct in childhood is extremely rare, generally secondary to spinal/cardiovascular surgery or severe vertebral injuries. However, spontaneous spinal cord infarct cases have been described. We present a clinical case of a teenager who developed an acute weakness and paraesthesia in lower limbs after playing piggyback. Laboratory tests ... Read more >>

Case Rep Pediatr (Case reports in pediatrics)
[2020, 2020:9703625]

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Occurrence and prognostic effect of cervical spine injuries and cervical artery injuries with concomitant severe head injury.

Juho Vehviläinen, Tuomas Brinck, Matias Lindfors, Jussi Numminen, Jari Siironen, Rahul Raj,

BACKGROUND:Blunt cerebrovascular injuries (BCVIs) and cervical spinal injuries (CSIs) are not uncommon injuries in patients with severe head injury and may affect patient recovery. We aimed to assess the independent relationship between BCVI, CSI, and outcome in patients with severe head injury. METHODS:We identified patients with severe head injury from ... Read more >>

Acta Neurochir (Wien) (Acta neurochirurgica)
[2020, :]

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Vertebral artery aneurysms and the risk of cord infarction following spinal artery coverage during flow diversion.

Adam A Dmytriw, Anish Kapadia, Alejandro Enriquez-Marulanda, Carmen Parra-Fariñas, Anna Luisa Kühn, Patrick J Nicholson, Muhammad Waqas, Leonardo Renieri, Caterina Michelozzi, Paul M Foreman, Kevin Phan, I-Hsiao Yang, Vincent M Tutino, Christopher S Ogilvy, Ivan Radovanovic, Mark R Harrigan, Adnan H Siddiqui, Elad I Levy, Nicola Limbucci, Christophe Cognard, Timo Krings, Vitor Mendes Pereira, Ajith J Thomas, Thomas R Marotta, Christoph J Griessenauer,

OBJECTIVE:Coverage of the anterior spinal artery (ASA) ostia is a source of considerable consternation regarding flow diversion (FD) in vertebral artery (VA) aneurysms due to cord supply. The authors sought to assess the association between coverage of the ASA, posterior spinal artery (PSA), or lateral spinal artery (LSA) ostia when ... Read more >>

J. Neurosurg. (Journal of neurosurgery)
[2020, :1-10]

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Future challenges of spinal cord infarction treatment.

Dominika Jakubowicz-Lachowska, Joanna Tarasiuk, Katarzyna Kapica-Topczewska, Anna Mirończuk, Jan Kochanowicz, Alina Kułakowska,

Neurol. Neurochir. Pol. (Neurologia i neurochirurgia polska)
[2020, :]

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"Chronic" State in Neural Diseases as the Target of Cellular Therapy with Mesenchymal Stem Cells.

Masanori Sasaki, Shinichi Oka, Yuko Kataoka-Sasaki, Jeffery D Kocsis, Osamu Honmou,

World Neurosurg (World neurosurgery)
[2020, 135:375-376]

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Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity.

Richard Ang, Nephtali Marina,

Sudden cardiac death caused by ventricular arrhythmias is among the leading causes of mortality, with approximately half of all deaths attributed to heart disease worldwide. Periodic repolarization dynamics (PRD) is a novel marker of repolarization instability and strong predictor of death in patients post-myocardial infarction that is believed to occur ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

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The Apelin/APJ System in Psychosis and Neuropathy.

Shuang-Yu Lv, Wei-Dong Chen, Yan-Dong Wang,

Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in diverse physiological and pathological processes. The ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2020, 11:]

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Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function.

Yongxing Lai, Peiqiang Lin, Manli Chen, Yixian Zhang, Jianhao Chen, Mouwei Zheng, Ji Liu, Houwei Du, Ronghua Chen, Xiaodong Pan, Nan Liu, Hongbin Chen,

BACKGROUND:Ischemic stroke can induce changes in mitochondrial morphology and function. As a regulatory gene in mitochondria, optic atrophy 1 (OPA1) plays a pivotal role in the regulation of mitochondrial dynamics and other related functions. However, its roles in cerebral ischemia-related conditions are barely understood. METHODS:Cultured rat primary cortical neurons were ... Read more >>

Redox Biol (Redox biology)
[2020, :101503]

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Spinal cord hemodynamic infarction after vertebral artery endovascular trapping despite preserved flow in the anterior spinal artery.

Jordi Sarto, Aurora Semerano, Javier Luis Moreno, Gerard Mayà-Casalprim, Jordi Blasco, Xabier Urra,

Context: Spinal cord infarction is a rare condition that develops as a result of insufficient vascular perfusion, sometimes related to procedures involving the aorta and vertebral arteries.Findings: We present the case of a 66-year-old woman who developed weakness on all four extremities and thermalgesic sensory deficit following an elective endovascular ... Read more >>

J Spinal Cord Med (The journal of spinal cord medicine)
[2020, :1-4]

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Fabry Disease With Concomitant Lewy Body Disease.

Kelly Del Tredici, Albert C Ludolph, Simone Feldengut, Christian Jacob, Heinz Reichmann, Jürgen R Bohl, Heiko Braak,

Although Gaucher disease can be accompanied by Lewy pathology (LP) and extrapyramidal symptoms, it is unknown if LP exists in Fabry disease (FD), another progressive multisystem lysosomal storage disorder. We aimed to elucidate the distribution patterns of FD-related inclusions and LP in the brain of a 58-year-old cognitively unimpaired male ... Read more >>

J. Neuropathol. Exp. Neurol. (Journal of neuropathology and experimental neurology)
[2020, 79(4):378-392]

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Surgical treatment of adolescent idiopathic scoliosis: Complications.

Omar A Al-Mohrej, Sahar S Aldakhil, Mohammed A Al-Rabiah, Anwar M Al-Rabiah,

Despite the fact that spinal surgeries for adolescent idiopathic scoliosis (AIS) result in good outcomes for most patients, they are not without complications either medically or surgically. Neurologic injury represents the most severe complication and is, as such, the most feared. Further complications include dural tears, peripheral neuropathy, surgical-site infections, ... Read more >>

Ann Med Surg (Lond) (Annals of medicine and surgery (2012))
[2020, 52:19-23]

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Palliative Care of Malignant Fibrous Histiocytoma of Spine with Cord Compression and Multiple Bone Metastases Treated by Multidisciplinary Therapy: Case Report.

Ivan Sekiguchi, Naoki Takeda, Naoki Ishida,

Malignant fibrous histiocytoma (MFH) of the spine is rare, with only a few dozen cases reported in the literature. A 60-year-old male was referred to us with symptoms of thoracic myelopathy. A solid tumor in the Th8 right costovertebral junction invading the spinal canal and compressing the spinal cord, and ... Read more >>

Case Rep Oncol (Case reports in oncology)
[2020, 13(1):12-16]

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The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload.

Xiaopu Wang, Junyu Pei, Xinqun Hu,

Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of acute heart failure syndrome triggered by intense psychological or physiological stress. TTS typically manifests as acute chest pain, dyspnea or syncope that mimics an acute myocardial infarction but does not involve coronary artery obstruction. The current understanding of ... Read more >>

Cardiol Res Pract (Cardiology research and practice)
[2020, 2020:4150291]

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The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury.

Kazumichi Yagura, Hirokazu Ohtaki, Tomomi Tsumuraya, Atsushi Sato, Kazuyuki Miyamoto, Naoto Kawada, Keisuke Suzuki, Motoyasu Nakamura, Koji Kanzaki, Kenji Dohi, Masahiko Izumizaki, Yutaka Hiraizumi, Kazuho Honda,

Human bone marrow-derived mesenchymal stem/stromal cells (hMSCs) have shown potential in facilitating recovery from spinal cord injury (SCI) through communicating with microglia/macrophages (MG/MΦ). We here focused on chemokines as a candidate for the communication. Selected MG/MΦ-related chemokines were determined gene expression after SCI and further focused CCL2/CCR2 and CCL5/CCR5 to ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230080]

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Application of a new blood flow regulator in aortic endovascular therapy.

Chang Liu, Yun-Xing Xue, Dong-Jin Wang, Qing Zhou,

BACKGROUND:Endovascular repair involving branches of the aorta is still difficult in clinical treatment. A new type of blood flow regulator has been used in thoracic endovascular aortic repair/endovascular aortic repair in our centre, and the effects were followed and analysed. METHODS:From March 2014 to January 2015, 14 patients with Stanford ... Read more >>

J Cardiothorac Surg (Journal of cardiothoracic surgery)
[2020, 15(1):47]

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The role of cofilin in age-related neuroinflammation.

Amsha S Alsegiani, Zahoor A Shah,

Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active "pro-inflammatory" state, causing chronic low-grade neuroinflammation. Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years, the underlying causes remain unclear. The identification of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1451-1459]

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The application of the single branch-first combined with the mid-arch clamping technique and the embedded anastomosis technique for DeBakey type II aortic dissection.

Quan Li, Hong Qu, Tianqi Liu, Min Li, Shanliang Chen, Peijie Li, Li Xu, Hengbao Wang,

BACKGROUND:Patients with DeBakey type II aortic dissection or ascending aortic aneurysms involving the right innominate artery require hemiarch replacement and placement of a right innominate artery graft. Traditional aortic hemiarch replacement surgery must be performed under right axillary artery cannulation perfusion and moderate or deep hypothermia circulatory arrest. However, the ... Read more >>

J Cardiothorac Surg (Journal of cardiothoracic surgery)
[2020, 15(1):38]

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Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy.

Aishika Datta, Deepaneeta Sarmah, Leela Mounica, Harpreet Kaur, Radhika Kesharwani, Geetesh Verma, Pabbala Veeresh, Vignesh Kotian, Kiran Kalia, Anupom Borah, Xin Wang, Kunjan R Dave, Dileep R Yavagal, Pallab Bhattacharya,

Ischemic stroke is one of the significant causes of morbidity and mortality, affecting millions of people across the globe. Cell injury in the infarct region is an inevitable consequence of focal cerebral ischemia. Subsequent reperfusion exacerbates the harmful effect and increases the infarct volume. These cellular injuries follow either a ... Read more >>

Transl Stroke Res (Translational stroke research)
[2020, :]

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Angiotensin-(1–7) Receptor Mas Deficiency Does Not Exacerbate Cardiac Atrophy Following High-Level Spinal Cord Injury in Mice.

Anne Järve, Fatimunnisa Qadri, Mihail Todiras, Shirley Schmolke, Natalia Alenina, Michael Bader,

Experimental spinal cord injury (SCI) causes a morphological and functional deterioration of the heart, in which the renin–angiotensin system (RAS) might play a role. The recently discovered non-canonical axis of RAS with angiotensin-(1–7) and its receptor Mas, which is associated with cardioprotection could be essential to prevent damage to the ... Read more >>

Front Physiol (Frontiers in Physiology)
[2020, 11:]

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Comorbid SUNCT Syndrome and Opalski Syndrome Caused by Dorsolateral Medullary Infarction.

Qi Lei, Jianmeng Lv, Bei Kang, Hena Guo, Yulang Fei, Ruili Chen, Hui Guo, Qian Yang,

Opalski syndrome is a rare variation of lateral medullary syndrome (LMS) accompanied by ipsilateral hemiparesis. Short-lasting unilateral neuralgiform headaches with conjunctival injection and tearing (SUNCT) is a rare headache syndrome which belongs to the trigeminal autonomic cephalalgias. SUNCT syndrome has been previously described in association with LMS. We here describe ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:52]

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