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Spasmodic Dysphonia

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Proposal for a Core Outcome Set of Measurement Instruments to Assess Quality of Voice in Adductor Spasmodic Dysphonia Based on a Literature Review.

Juliëtta H C Schuering, Kira S van Hof, Bas J Heijnen, Peter Paul G van Benthem, Elisabeth V Sjögren, Antonius P M Langeveld,

OBJECTIVES:Uniform evaluation of treatment effect on the quality of voice in adductor spasmodic dysphonia (AdSD) is challenging due to the broad variety of available outcome measurement instruments (OMIs). The European Laryngological Society categorized five types of measurement domains for voice quality evaluations: patient-reported outcome measures, perceptual analyses, acoustic analyses, visual ... Read more >>

J Voice (Journal of voice : official journal of the Voice Foundation)
[2020, :]

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Voice analysis in adductor spasmodic dysphonia: Objective diagnosis and response to botulinum toxin.

Antonio Suppa, Francesco Asci, Giovanni Saggio, Luca Marsili, Daniele Casali, Zakarya Zarezadeh, Giovanni Ruoppolo, Alfredo Berardelli, Giovanni Costantini,

INTRODUCTION:Adductor-type spasmodic dysphonia is a task-specific focal dystonia characterized by involuntary laryngeal muscle spasms. Due to the lack of quantitative instrumental tools, voice assessment in patients with adductor-type spasmodic dysphonia is mainly based on qualitative neurologic examination. We evaluated patients with cepstral analysis and specific machine-learning algorithms and compared the ... Read more >>

Parkinsonism Relat. Disord. (Parkinsonism & related disorders)
[2020, 73:23-30]

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Auditory Feedback Control Mechanisms Do Not Contribute to Cortical Hyperactivity Within the Voice Production Network in Adductor Spasmodic Dysphonia.

Ayoub Daliri, Elizabeth S Heller Murray, Anne J Blood, James Burns, J Pieter Noordzij, Alfonso Nieto-Castanon, Jason A Tourville, Frank H Guenther,

Purpose Adductor spasmodic dysphonia (ADSD), the most common form of spasmodic dysphonia, is a debilitating voice disorder characterized by hyperactivity and muscle spasms in the vocal folds during speech. Prior neuroimaging studies have noted excessive brain activity during speech in participants with ADSD compared to controls. Speech involves an auditory ... Read more >>

J. Speech Lang. Hear. Res. (Journal of speech, language, and hearing research : JSLHR)
[2020, 63(2):421-432]

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Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence.

Antonella Conte, Giovanni Defazio, Marcello Mascia, Daniele Belvisi, Patrizia Pantano, Alfredo Berardelli,

Focal dystonia is a movement disorder characterized by involuntary muscle contractions that determine abnormal postures. The traditional hypothesis that the pathophysiology of focal dystonia entails a single structural dysfunction (i.e. basal ganglia) has recently come under scrutiny. The proposed network disorder model implies that focal dystonias arise from aberrant communication ... Read more >>

F1000Res (F1000Research)
[2020, 9:]

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Retrospective review of dosing trends in botulinum toxin injections for the treatment of adductor spasmodic dysphonia in a long-term cohort.

Gabrielle French, J Douglas Bosch, Derrick R Randall,

BACKGROUND:Botulinum toxin A (BT) is the gold standard treatment for adductor spasmodic dysphonia (AdSD) with established use for greater than thirty years. The spasmodic dysphonia (SD) literature would benefit from additional long-term cohort data, especially in the Canadian population. The goals of this study were to evaluate whether BT dosage ... Read more >>

J Otolaryngol Head Neck Surg (Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale)
[2020, 49(1):4]

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Spasmodic Dysphonia: Standardized Spanish Tool for Ambulatory Consult Diagnosis.

Antonia E Lagos, Francisco G García-Huidobro, Phoebe H Ramos, Paulina Bustos, Norma I León, Carla A Napolitano, Pedro I Badía,

INTRODUCTION:Spasmodic dysphonia (SD) is a focal dystonia of the larynx where involuntary spasms of its intrinsic muscles are triggered by specific phonemes. The diagnosis is challenging and is performed by listening to the patient's voice, supported by nasolaryngoscopy. There is no diagnostic tool in Spanish for SD. The objective of ... Read more >>

J Voice (Journal of voice : official journal of the Voice Foundation)
[2020, :]

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An Appraisal of Printed Online Education Materials on Spasmodic Dysphonia.

Mohamedkazim M Alwani, Khaled A Campa, Thomas J Svenstrup, Elhaam H Bandali, Benjamin P Anthony,

OBJECTIVE:The use of the Internet for seeking health-related information has increased exponentially. We aimed to comprehensively appraise the readability, understandability, actionability, and quality of printed online education materials (POEMs) pertaining to Spasmodic Dysphonia (SD). STUDY DESIGN:Descriptive, correlational study. METHODS:POEMs were identified using the Google search engine with the phrase "spasmodic ... Read more >>

J Voice (Journal of voice : official journal of the Voice Foundation)
[2019, :]

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Unilateral versus bilateral botulinum toxin injections in adductor spasmodic dysphonia in a large cohort.

Ishaan Dharia, Steven Bielamowicz,

OBJECTIVES/HYPOTHESIS:The primary treatment of adductor spasmodic dysphonia is repeated injections of botulinum toxin type A (Botox) into the thyroarytenoid muscles. Dosing can be performed into either one or both thyroarytenoid muscles. The objective of this study was to evaluate the treatment effect and side effect profile across a large number ... Read more >>

Laryngoscope (The Laryngoscope)
[2019, :]

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Laryngeal vibration as a non-invasive neuromodulation therapy for spasmodic dysphonia.

Sanaz Khosravani, Arash Mahnan, I-Ling Yeh, Joshua E Aman, Peter J Watson, Yang Zhang, George Goding, Jürgen Konczak,

Spasmodic dysphonia (SD) is an incurable focal dystonia of the larynx that impairs speech and communication. Vibro-tactile stimulation (VTS) alters afferent proprioceptive input to sensorimotor cortex that controls speech. This proof-of-concept study examined the effect of laryngeal VTS on speech quality and cortical activity in 13 SD participants who vocalized the ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):17955]

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Isolated Voice Tremor: A Clinical Variant of Essential Tremor or a Distinct Clinical Phenotype?

Julie M Barkmeier-Kraemer,

Background:The consensus statement by the Task Force on Tremor of the International Parkinson and Movement Disorder Society excludes individuals with "isolated voice tremor" as a clinical variant of essential tremor (ET). This clinical viewpoint presents a rationale for reconsideration of "isolated voice tremor" as a clinical variant of ET. Methods:Evidence ... Read more >>

Tremor Other Hyperkinet Mov (N Y) (Tremor and other hyperkinetic movements (New York, N.Y.))
[2020, 10:]

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[Application status and prospect of botulinum toxin A in otorhinolaryngological treatment].

Y L Xu, J H Chen,

Botulinum toxin A is a kind of neurotoxin produced by clostridium botulinum, and has been applied for nearly thirty years in China.The target of BTX-A is to selectively cleave the synaptosome-associated protein of 25 KD molecular mass, commonly abbreviated SNAP-25, thereby inhibiting neurotransmitter release and causing chemodenervation. The potential application ... Read more >>

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery)
[2020, 34(1):88-91]

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Quality of Life After Botulinum Toxin Injection in Patients With Adductor Spasmodic Dysphonia; a Systematic Review and Meta-analysis.

Maryam Faham, Akram Ahmadi, Erin Silverman, Gholamreza Ghaedamini Harouni, Payman Dabirmoghaddam,

INTRODUCTION:Adductor spasmodic dysphonia is an extremely disabling voice disorder that negatively impacts a patient's quality of life (QOL). We performed a systematic review to determine if Botulinum Toxin (BT) injections improved voice related QOL in patients with this disorder. METHODS:PubMed, EMBASE, Web of Science, Cochrane Library, ProQuest, and Scopus from ... Read more >>

J Voice (Journal of voice : official journal of the Voice Foundation)
[2019, :]

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Impact of an Upper Respiratory Tract Infection on Botulinum Toxin Efficacy in Spasmodic Dysphonia Patients.

Diana N Kirke, Rachel Kaye, Andrew Blitzer,

OBJECTIVE:To determine whether the presence of a concomitant upper respiratory tract infection (URI) impacts upon Botulinum toxin (BoNT) efficacy in spasmodic dysphonia (SD) patients. STUDY DESIGN:Case series and literature review. METHODS:All SD patients with a concurrent URI, presenting for BoNT therapy at a clinical research center from November 2016 to ... Read more >>

Laryngoscope (The Laryngoscope)
[2019, :]

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Risk of spread in adult-onset isolated focal dystonia: a prospective international cohort study.

Brian D Berman, Christopher L Groth, Stefan H Sillau, Sarah Pirio Richardson, Scott A Norris, Johanna Junker, Norbert Brüggemann, Pinky Agarwal, Richard L Barbano, Alberto J Espay, Joaquin A Vizcarra, Christine Klein, Tobias Bäumer, Sebastian Loens, Stephen G Reich, Marie Vidailhet, Cecilia Bonnet, Emmanuel Roze, Hyder A Jinnah, Joel S Perlmutter,

OBJECTIVE:Isolated focal dystonia can spread to muscles beyond the initially affected body region, but risk of spread has not been evaluated in a prospective manner. Furthermore, body regions at risk for spread and the clinical factors associated with spread risk are not well characterised. We sought here to prospectively characterise ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(3):314-320]

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Laboratory Evaluation of Spasmodic Dysphonia.

Sammy Othman, Srihari Daggumati, Rohan Patel, Justin Ross, Robert T Sataloff,

OBJECTIVES:To evaluate the utility of comprehensive laboratory evaluation in patients with spasmodic dysphonia (SD). STUDY DESIGN:Retrospective chart review. METHODS:A review of the medical records of 40 patients diagnosed with spasmodic dysphonia from 2009-2018 was preformed to evaluate abnormal test results that were significant when compared with abnormal results of the ... Read more >>

J Voice (Journal of voice : official journal of the Voice Foundation)
[2019, :]

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Oro-Pharyngeal Dysphagia in Parkinson's Disease and Related Movement Disorders.

Miseon Kwon, Jae-Hong Lee,

Oro-pharyngeal dysphagia is a common symptom in patients with Parkinson's disease (PD) and related disorders, even in their early stage of diseases. Dysphagia in these patients has been underdiagnosed, probably due to poor the self-awareness of the conditions and the underuse of validated tools and objective instruments for assessment. The ... Read more >>

J Mov Disord (Journal of movement disorders)
[2019, 12(3):152-160]

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Multimodal Quantitative MRI Reveals No Evidence for Tissue Pathology in Idiopathic Cervical Dystonia.

René-Maxime Gracien, Franca Petrov, Pavel Hok, Alexandra van Wijnen, Michelle Maiworm, Alexander Seiler, Ralf Deichmann, Simon Baudrexel,

Background: While in symptomatic forms of dystonia cerebral pathology is by definition present, it is unclear so far whether disease is associated with microstructural cerebral changes in idiopathic dystonia. Previous quantitative MRI (qMRI) studies assessing cerebral tissue composition in idiopathic dystonia revealed conflicting results. Objective: Using multimodal qMRI, the presented ... Read more >>

Front Neurol (Frontiers in Neurology)
[2019, 10:914]

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Spasmodic dysphonia as a presenting symptom of spinocerebellar ataxia type 12.

Jessica Rossi, Francesco Cavallieri, Giada Giovannini, Carla Budriesi, Annalisa Gessani, Miryam Carecchio, Daniela Di Bella, Elisa Sarto, Jessica Mandrioli, Sara Contardi, Stefano Meletti,

Autosomal dominant spinocerebellar ataxia (SCA) type 12 is a rare SCA characterized by a heterogeneous phenotype. Action tremor of the upper limbs is the most common presenting sign and cerebellar signs can appear subsequently. In many cases, minor signs, like dystonia, can be predominant even at onset. Laryngeal dystonia (spasmodic ... Read more >>

Neurogenetics (Neurogenetics)
[2019, 20(3):161-164]

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Involuntary Thumb Flexion on Neurological Examination: An Unusual Form of Upper Limb Dystonia in the Faroe Islands.

Christine Y Kim, Maria Skaalum Petersen, Eina H Eliasen, Giovanni Defazio, Paul Greene, Hyder A Jinnah, Marina A J Tijssen, Elan D Louis,

Background:The prevalence of dystonia varies worldwide. A prior report suggested a high prevalence of focal dystonia in the Faroese population, possibly reflecting a founder effect. During standardized neurological examination as part of an ongoing neuroepidemiologic study in the Faroe Islands, we noted an unusual phenomenon of thumb flexion during repetitive ... Read more >>

Tremor Other Hyperkinet Mov (N Y) (Tremor and other hyperkinetic movements (New York, N.Y.))
[2019, 9:]

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Monitoring the Outcome of Phonosurgery and Vocal Exercises with Established and New Diagnostic Tools.

Matthias Seipelt, Andreas Möller, Tadeus Nawka, Ute Gonnermann, Felix Caffier, Philipp P Caffier,

Instrument-assisted measuring procedures expand the options within phoniatric diagnostics by quantifying the condition of the voice. The aim of this study was to examine objective treatment-associated changes of the recently developed vocal extent measure (VEM) and the established dysphonia severity index (DSI) in relation to subjective tools, i.e., self-evaluation via ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:4208189]

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Adductor spasmodic dysphonia: Botulinum toxin a injections or laser thyroarytenoid myoneurectomy? A comparison from the patient perspective.

Juliëtta H C Schuering, Bas J Heijnen, Elisabeth V Sjögren, Antonius P M Langeveld,

OBJECTIVES/HYPOTHESIS:The current gold standard of therapy for adductor spasmodic dysphonia (AdSD) is injection of botulinum toxin A (BTX) in the adductor musculature. A surgical procedure could potentially offer more stable and long-lasting voice quality. In this study, we report the long-term results of endoscopic laser thyroarytenoid (TA) myoneurectomy versus BTX ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, 130(3):741-746]

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Use of botulinum toxin for movement disorders.

Carlos Henrique Ferreira Camargo, Hélio Afonso Ghizoni Teive,

The term movement disorders encompasses all disorders hypokinetic and hyperkinetic, which were previously known as extrapyramidal syndromes. With the definition of movement disorders and their diagnostic criteria and classifications, new studies for therapeutics could be performed. New drugs were launched, functional neurosurgery was developed, and the introduction of botulinum toxin ... Read more >>

Drugs Context (Drugs in context)
[2019, 8:212586]

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The Influence of Linguistic Demand on Symptom Expression in Adductor Spasmodic Dysphonia.

Laura L O Froeschke,

INTRODUCTION:Adductor Spasmodic Dysphonia (ADSD), a form of focal dystonia, has been defined as a neurogenic, task-specific disorder characterized by abrupt spasms of intrinsic laryngeal muscles that result in phonatory breaks. Voice breaks are typically isolated to propositional speech, and reported to increase in severity as speaking demand or complexity increases. ... Read more >>

J Voice (Journal of voice : official journal of the Voice Foundation)
[2019, :]

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The extrinsic risk and its association with neural alterations in spasmodic dysphonia.

Laura de Lima Xavier, Kristina Simonyan,

INTRODUCTION:Spasmodic dysphonia (SD) is an isolated focal dystonia characterized by laryngeal spasms during voluntary voice production. Environmental factors have been assumed to play a role in SD pathophysiology; however, the exact extrinsic risk factors and their association with neural alterations remain unknown. METHODS:A total of 186 SD patients and 85 ... Read more >>

Parkinsonism Relat. Disord. (Parkinsonism & related disorders)
[2019, 65:117-123]

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Movement Disorders and Voice.

Grace Snow, Elizabeth Guardiani,

The primary movement disorders affecting the voice are laryngeal dystonia (including spasmodic dysphonia), essential voice tremor, and Parkinson disease. Diagnosis of these conditions is clinical and based on a detailed history, voice evaluation, and physical and laryngoscopic examination. Laryngeal dystonia and essential voice tremor are hyperfunctional disorders and are treated ... Read more >>

Otolaryngol. Clin. North Am. (Otolaryngologic clinics of North America)
[2019, 52(4):759-767]

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