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Anti-oxidant MitoQ rescue of AWB chemosensory neuron impairment in a C. elegans model of X-linked Adrenoleukodystrophy.

Sanjib Guha, Aurora Pujol, Esther Dalfo,

X-linked Adrenoleukodystrophy (X-ALD) is a neurometabolic disorder caused by a defective peroxisomal ABCD1 transporter of very long-chain fatty acids (VLCFAs). We have characterized a nematode model of X-ALD with loss of the <i>pmp-4</i> gene, the worm orthologue of <i>ABCD1</i>. These mutants recapitulated the key hallmarks of X-ALD and importantly mitochondria ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos.

Fan-Suo Geng, Elisa de la Calle-Mustienes, José Luis Gómez-Skarmeta, Ryan Lister, Ozren Bogdanovic,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Spatiotemporal control of genome recombination through combined FLP-Frt and GAL4-UAS technologies.

Cristina Ayuso, Peter Askjaer,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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Efficient FLP-mediated germ-line recombination in C. elegans.

Javier Macías-León, Peter Askjaer,

MicroPubl Biol (microPublication biology)
[2018, 2018:]

Cited: 2 times

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Neuron-specific enolase in cerebrospinal fluid as a biomarker of brain damage in infants with hypoxic-ischemic encephalopathy.

Alfredo Garcia-Alix, Juan Arnaez,

Neural Regen Res (Neural regeneration research)
[2022, 17(2):318-319]

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Celeboxib-mediated neuroprotection in focal cerebral ischemia: an interplay between unfolded protein response and inflammation.

María Santos-Galdiano, Diego Pérez-Rodríguez, Arsenio Fernández-López,

Neural Regen Res (Neural regeneration research)
[2022, 17(2):302-303]

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Central nervous system stimulation therapies in phantom limb pain: a systematic review of clinical trials.

M Ángeles Garcia-Pallero, Diana Cardona, Lola Rueda-Ruzafa, Miguel Rodriguez-Arrastia, Pablo Roman,

Phantom limb pain is a chronic pain syndrome that is difficult to cope with. Despite neurostimulation treatment is indicated for refractory neuropathic pain, there is scant evidence from randomized controlled trials to recommend it as the treatment choice. Thus, a systematic review was performed to analyze the efficacy of central ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):59-64]

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Drug interactions detected by a computer-assisted prescription system in primary care patients in Spain: MULTIPAP study.

Eloísa Rogero-Blanco, Isabel Del-Cura-González, Mercedes Aza-Pascual-Salcedo, Francisca García de Blas González, Carmen Terrón-Rodas, Sergio Chimeno-Sánchez, Eva García-Domingo, Juan A López-Rodríguez, ,

<h4>Background</h4>Drug interactions increase the risk of treatment failure, intoxication, hospital admissions, consultations and mortality. Computer-assisted prescription systems can help to detect interactions.<h4>Objectives</h4>To describe the drug-drug interaction (DDI) and drug-disease interaction (DdI) prevalence identified by a computer-assisted prescription system in patients with multimorbidity and polypharmacy. Factors associated with clinically relevant interactions ... Read more >>

Eur J Gen Pract (The European journal of general practice)
[2021, 27(1):90-96]

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Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster.

Marco Brustolin, Jordi Rodon, María Luisa Rodríguez de la Concepción, Carlos Ávila-Nieto, Guillermo Cantero, Mónica Pérez, Nigeer Te, Marc Noguera-Julián, Víctor Guallar, Alfonso Valencia, Núria Roca, Nuria Izquierdo-Useros, Julià Blanco, Bonaventura Clotet, Albert Bensaid, Jorge Carrillo, Júlia Vergara-Alert, Joaquim Segalés,

Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question of immunity generated by a single infection is sufficient to provide sterilizing/protective immunity to a subsequent SARS-CoV-2 re-exposure. The Golden Syrian ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):797-809]

Cited: 2 times

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Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry.

Francisco Javier Carrasco-Sánchez, Mª Dolores López-Carmona, Francisco Javier Martínez-Marcos, Luis M Pérez-Belmonte, Alicia Hidalgo-Jiménez, Verónica Buonaiuto, Carmen Suárez Fernández, Santiago Jesús Freire Castro, Davide Luordo, Paula Maria Pesqueira Fontan, Julio César Blázquez Encinar, Jeffrey Oskar Magallanes Gamboa, Andrés de la Peña Fernández, José David Torres Peña, Joaquim Fernández Solà, Jose Javier Napal Lecumberri, Francisco Amorós Martínez, María Esther Guisado Espartero, Carlos Jorge Ripper, Raquel Gómez Méndez, Natalia Vicente López, Berta Román Bernal, María Gloria Rojano Rivero, José Manuel Ramos Rincón, Ricardo Gómez Huelgas, ,

<h4>Background</h4>Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19.<h4>Methods</h4>This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):103-116]

Cited: 17 times

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Human prion disease surveillance in Spain, 1993-2018: an overview.

Jesús De Pedro-Cuesta, Javier Almazán-Isla, Laura Tejedor-Romero, María Ruiz-Tovar, Fuencisla Avellanal, Alberto Rábano, Miguel Calero, Fernando J García López, ,

In Spain, human transmissible spongiform encephalopathies (TSEs) have been undergoing continuous surveillance for over 25 years. In 1995, the system was launched as an EU Concerted Action, with EU surveillance network procedures being incorporated from 2002 onwards. The aim of this report was to describe performance and outcomes of this surveillance ... Read more >>

Prion (Prion)
[2021, 15(1):94-106]

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Current and future therapeutic strategies for the treatment of retinal neurodegenerative diseases.

Victoria Maneu, Pedro Lax, Nicolás Cuenca,

Neural Regen Res (Neural regeneration research)
[2022, 17(1):103-104]

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Oligonucleotide-capped nanoporous anodic alumina biosensor as diagnostic tool for rapid and accurate detection of Candida auris in clinical samples.

Luis Pla, Sara Santiago-Felipe, María Ángeles Tormo-Mas, Alba Ruiz-Gaitán, Javier Pemán, Eulogio Valentín, Félix Sancenón, Elena Aznar, Ramón Martínez-Máñez,

<i>Candida auris</i> has arisen as an important multidrug-resistant fungus because of several nosocomial outbreaks and elevated rates of mortality. Accurate and rapid diagnosis of <i>C. auris</i> is highly desired; nevertheless, current methods often present severe limitations and produce misidentification. Herein a sensitive, selective, and time-competitive biosensor based on oligonucleotide-gated nanomaterials ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):407-415]

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Quality of life in patients with nonvalvular atrial fibrillation treated with oral anticoagulants.

Miren Gabilondo, Jesús Loza, Angel Pereda, Ohiane Caballero, Nerea Zamora, Ania Gorostiza, Javier Mar,

<h4>Objectives</h4>Health-related quality of life (HRQL) is a key factor in making anticoagulant treatment decisions. The objective of this study was to assess the HRQL of patients with nonvalvular atrial fibrillation by treatment type: direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs).<h4>Methods</h4>We carried out a cross-sectional observational study with clinical ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):277-283]

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Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers.

Javier Martínez-Sanz, Daniel Jiménez, Laura Martínez-Campelo, Raquel Cruz, Pilar Vizcarra, Matilde Sánchez-Conde, Raquel Ron, Mario Rodríguez, Sabina Herrera, Santiago Moreno, María Rosa López-Huertas, Sergio Serrano-Villar,

We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):493-496]

Cited: 1 time

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Rain in the desert; A precipitation reconstruction of the last 156 years inferred from Aleppo Pine in the Bardenas Natural Park, Spain

Ernesto Tejedor, Roberto Serrano-Notivoli, Miguel Ángel Saz, Luis Alberto Longares, Klemen Novak, José M Cuadrat, Martín de Luis,

Understanding the regional hydroclimatic variability beyond the instrumental period is essential to contextualize the current climatic period within a longer record. Dendrochronology has been used as a powerful tool for estimating the temperature and precipitation variability of the last centuries on an annual and even seasonal scale. However, most of ... Read more >>

(Dendrochronologia.)
[2021, 64:Not Available]

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The combined vaccination protocol of DNA/MVA expressing Zika virus structural proteins as efficient inducer of T and B cell immune responses.

Patricia Pérez, Miguel A Martín-Acebes, Teresa Poderoso, Adrián Lázaro-Frías, Juan-Carlos Saiz, Carlos Óscar S Sorzano, Mariano Esteban, Juan García-Arriaza,

Zika virus (ZIKV) is a mosquito-borne pathogen with public health importance due to the high risk of its mosquito vector dissemination and the severe neurological and teratogenic sequelae associated with infection. Vaccines with broad immune specificity and control against this re-emerging virus are needed. Here, we described that mice immunized ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1441-1456]

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Variability of blood eosinophil count and prognosis of COPD exacerbations.

Sandra Martínez-Gestoso, María-Teresa García-Sanz, Uxío Calvo-Álvarez, Liliana Doval-Oubiña, Sandra Camba-Matos, Francisco-Javier Salgado, Xavier Muñoz, Purificación Perez-Lopez-Corona, Francisco-Javier González-Barcala,

<h4>Background</h4>Eosinophils in peripheral blood are one of the emerging biomarkers in chronic obstructive pulmonary disease (COPD) patients. However, when analysing the relationship between peripheral eosinophilia and COPD prognosis, highly variable results are obtained. The aim of our study is to describe the serum eosinophilia levels in COPD patients and to ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1152-1158]

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Boosting proteolytic pathways as a treatment against glycation-derived damage in the brain?

Allen Taylor, Eloy Bejarano,

Neural Regen Res (Neural regeneration research)
[2022, 17(2):320-322]

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Association between measurements of arterial stiffness and target organ damage in a general Spanish population.

Rosario Alonso-Domínguez, Natalia Sánchez-Aguadero, María C Patino-Alonso, Cristina Agudo-Conde, Ángela de Cabo-Laso, Marta Gómez-Sánchez, Leticia Gómez-Sánchez, Emiliano Rodríguez-Sánchez, Luis García-Ortiz, Manuel A Gómez-Marcos, ,

<h4>Introduction</h4>Little is known about the relationship between arterial stiffness and cardiovascular target organ damage (TOD) in the general population. The aim was to analyse the relationship between different measurements of arterial stiffness and TOD, in a general Spanish population without a history of cardiovascular event.<h4>Materials and methods</h4>Transversal descriptive study. Through ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):345-356]

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A long story for a short peptide: therapeutic efficacy of a cleavage-specific tau antibody.

Giuseppina Amadoro, Valentina Latina, Pietro Calissano,

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2417-2419]

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Development and multimodal characterization of an elastase-induced emphysema mouse disease model for the COPD frequent bacterial exacerbator phenotype.

Irene Rodríguez-Arce, Xabier Morales, Mikel Ariz, Begoña Euba, Nahikari López-López, Maider Esparza, Derek W Hood, José Leiva, Carlos Ortíz-de-Solórzano, Junkal Garmendia,

Chronic obstructive pulmonary disease (COPD) patients undergo infectious exacerbations whose frequency identifies a clinically meaningful phenotype. Mouse models have been mostly used to separately study both COPD and the infectious processes, but a reliable model of the COPD frequent exacerbator phenotype is still lacking. Accordingly, we first established a model ... Read more >>

Virulence (Virulence)
[2021, 12(1):1672-1688]

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Extracellular water/total body water ratio as predictor of mortality in hemodialysis patients.

Rosa Pérez-Morales, Javier Donate-Correa, Ernesto Martín-Núñez, Nayra Pérez-Delgado, Carla Ferri, Aurora López-Montes, Alejandro Jiménez-Sosa, Juan Francisco Navarro-González,

<h4>Background</h4>Overhydration is a predictor of mortality in hemodialysis (HD) patients. Bioimpedance spectroscopy (BIS) is used to determine the body composition. Extracellular Water/Total Body Water (ECW/TBW) ratio has been proposed to predict mortality.<h4>Methods</h4>Multicenter, prospective, observational, proof-of-concept study to estimate the impact of ECW/TBW in global and cardiovascular mortality and the relationship ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):821-829]

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Adaptation of the emerging pathogenic yeast Candida auris to high caspofungin concentrations correlates with cell wall changes.

Violeta Lara-Aguilar, Cristina Rueda, Irene García-Barbazán, Sarai Varona, Sara Monzón, Pilar Jiménez, Isabel Cuesta, Ángel Zaballos, Óscar Zaragoza,

<i>Candida auris</i> has emerged as a fungal pathogen that causes nosocomial outbreaks worldwide. Diseases caused by this fungus are of concern, due to its reduced susceptibility to several antifungals. <i>C. auris</i> exhibits paradoxical growth (PG; defined as growth at high, but not intermediate antifungal concentrations) in the presence of caspofungin ... Read more >>

Virulence (Virulence)
[2021, 12(1):1400-1417]

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Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment.

María E Cárdaba-García, Encarnación Abad-Lecha, Miguel Á Calleja-Hernández,

<b>Background/Aims.</b> Despite the high efficacy and safety of direct-acting antivirals against hepatitis C virus shown in clinical trials, treatment failures continue to occur. Our aim was to establish the effectiveness of these drugs in routine clinical practice, as well as to determine factors that could influence the response to the ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2021, 16(1):1949797]

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