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Serial evaluation of cardiac biomarker NT-proBNP with speckle tracking echocardiography in a 6-year-old Golden Retriever dog with subaortic stenosis and dilated cardiomyopathy.

Woong-Bin Ro, Min-Hee Kang, Hee-Myung Park,

Vet Q (The veterinary quarterly)
[2020, 40(1):77-82]

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Acquired long QT syndrome in chronic kidney disease patients.

Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li,

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):54-65]

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Computational translation of drug effects from animal experiments to human ventricular myocytes.

Aslak Tveito, Karoline Horgmo Jæger, Mary M Maleckar, Wayne R Giles, Samuel Wall,

Using animal cells and tissues as precise measuring devices for developing new drugs presents a long-standing challenge for the pharmaceutical industry. Despite the very significant resources that continue to be dedicated to animal testing of new compounds, only qualitative results can be obtained. This often results in both false positives ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):10537]

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Pre-excitation cardiac problems in children: recognition and treatment.

Yi Zhang, Xiao-Mei Li,

The prevalence of ventricular pre-excitation is 0.07-0.2% in the pediatric population. Kent bundle is the most common atrioventricular accessory pathway and Mahaim fiber is relatively rare. Approximately, 30-60% of children with ventricular pre-excitation have onset of atrioventricular reentrant tachycardia. Persistent atrioventricular reentrant tachycardia can lead to tachycardiomyopathy. The anterograde conduction ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2020, :]

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Supraventricular tachyarrhythmias during the intrauterine, neonatal, and infant period: A 10-year population-based study.

Marko Bjeloševič, Viera Illíková, Jaroslav Tomko, Peter Olejník, Michal Chalupka, Robert Hatala,

BACKGROUND:We aimed to evaluate the incidence, type, and management of supraventricular tachyarrhythmias (SVT) during the first year of life in a retrospective, population-based, single-center study during a 10-year period. METHODS:The analyzed patient cohort is based on data from the only specialized center managing all cases of neonatal and infant SVTs ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2020, :]

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Assessment of Sotalol and Dofetilide Dosing at a Large Academic Medical Center.

Clara Ting, Rhynn Malloy, Danielle Knowles,

BACKGROUND:Patients initiated on sotalol and dofetilide require inpatient monitoring and dose adjustments due to risks of corrected QT (QTc) prolongation and Torsades de pointes (TdP). Patients may receive higher initial doses than recommended due to close monitoring by specialized practitioners. The objective of this study was to describe prescribing practices ... Read more >>

J. Cardiovasc. Pharmacol. Ther. (Journal of cardiovascular pharmacology and therapeutics)
[2020, :1074248420921740]

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Prevalence of potential drug-drug interactions in outpatients of a general hospital in China: a retrospective investigation.

Weifang Ren, Yujuan Liu, Jun Zhang, Zhonghong Fang, Huan Fang, Yuan Gong, Xiaoqun Lv,

Background Potential drug-drug interactions are important factors resulting in adverse drug reactions or therapeutic failure. Therefore, potential drug-drug interactions need to be identified to prevent the related risk and improve drug safety. Objective This study was designed to determine the prevalence of potential drug-drug interactions and investigate the association of ... Read more >>

Int J Clin Pharm (International journal of clinical pharmacy)
[2020, :]

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Resolution of Fetal Hydrops Dependent on Sustained Fetal Supraventricular Tachycardia after Digoxin Therapy.

Aureja Maciuleviciute, Migle Semenaite, Vladas Gintautas, Regina Maciuleviciene, Aras Puodziukynas, Egle Savukyne,

We present a special case of fetal supraventricular tachycardia detected at 34 weeks gestation. Fetal hydrops was noted on ultrasound upon admission. Normal fetal heart rate was maintained for three weeks by maternal administration of digoxin. A live infant was delivered via caesarian section at 37 weeks gestation. This clinical ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(5):]

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Biomarkers of pre-existing risk of Torsade de Pointes under Sotalol treatment.

Pablo Daniel Cruces, Drago Torkar, Pedro David Arini,

INTRODUCTION:Antiarrhythmic drugs therapies are currently going through a turning point. The high risk that exists during the treatments has led to an ongoing search for new non-invasive toxicity risk biomarkers. METHODS:We propose the use of spatial biomarkers obtained through the quaternion algebra, evaluating the dynamics of the cardiac electrical vector ... Read more >>

J Electrocardiol (Journal of electrocardiology)
[2020, 60:177-183]

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Reduced-dose Antiarrhythmic Drugs: Valuable or Valueless?

James A Reiffel,

J Innov Card Rhythm Manag (The Journal of innovations in cardiac rhythm management)
[2020, 11(4):4063-4067]

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Ventricular Arrhythmia Risk Based on Ethnicity in COVID-19 Patients on Hydroxychloroquine and Azithromycin Combination: Viewpoint.

Sayak Roy, MainakMukhopadhyay,

There are many reports available now, which are mostly observational or registry trial outcomes having varied results on coronavirus 2019 (COVID-19) patients put on hydroxychloroquine and azithromycin combination. Some are showing increased in-hospital mortality and ventricular arrhythmia increase, while some are showing overall benefit with significant viral RNA load reduction. ... Read more >>

SN Compr Clin Med (Sn Comprehensive Clinical Medicine)
[0, :1-6]

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A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial.

Irene García García, Miguel Rodriguez-Rubio, Amelia Rodríguez Mariblanca, Lucía Martínez de Soto, Lucía Díaz García, Jaime Monserrat Villatoro, Javier Queiruga Parada, Enrique Seco Meseguer, María J Rosales, Juan González, José R Arribas, Antonio J Carcas, Pedro de la Oliva, Alberto M Borobia,

OBJECTIVES:Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. Secondary objectives: To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin ... Read more >>

Trials (Trials)
[2020, 21(1):466]

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Electrical Restitution and Its Modifications by Antiarrhythmic Drugs in Undiseased Human Ventricular Muscle.

Tamás Árpádffy-Lovas, István Baczkó, Beáta Baláti, Miklós Bitay, Norbert Jost, Csaba Lengyel, Norbert Nagy, János Takács, András Varró, László Virág,

Introduction:Re-entry is a basic mechanism of ventricular fibrillation, which can be elicited by extrasystolic activity, but the timing of an extrasystole can be critical. The action potential duration (APD) of an extrasystole depends on the proximity of the preceding beat, and the relation between its timing and its APD is ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:479]

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An Exciting New Tool in the Electrophysiologist's Toolbox, Intravenous Sotalol: Faster, Safer, Better?

Susan P Etheridge, Sarah Yukiko Asaki,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2020, 6(4):433-435]

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Atrial fibrillation - QT interval and catheter ablation.

Linda Mann, Paul Salmon, Deep Chandh Raja,

Aust Prescr (Australian prescriber)
[2020, 43(2):65]

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Adult Double-Chambered Right Ventricle Associated With Ventricular Tachycardia and New-Onset Heart Failure.

Saikrishna Patibandla, Siddhant Trehan, Htoo Kyaw, Kevin Tsai, Sarath Reddy,

A double-chambered right ventricle is an uncommon form of congenital heart disease that is characterized by the division of the right ventricle into a proximal high-pressure chamber and a distal low-pressure chamber. A 70-year-old male presented to the emergency room from his outpatient doctor's office with unstable wide complex ventricular ... Read more >>

Cureus (Cureus)
[2020, 12(5):e8122]

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Transesophageal and intracardiac ultrasound in arrhythmogenic right ventricular dysplasia/cardiomyopathy: Two case reports.

Gabriel Cismaru, Alin Grosu, Sabina Istratoaie, Laura Mada, Maria Ilea, Gabriel Gusetu, Dumitru Zdrenghea, Dana Pop, Radu Rosu,

RATIONALE:Two-dimensional echocardiography (2D echo) is a major tool for the diagnosis of Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). However 2D echo can skip regional localized anomalies of the right ventricular wall. We aimed to determine whether transesophageal and intracardiac ultrasound can provide additional information, on the right ventricular abnormalities compared to ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(15):e19817]

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Intravenous Sotalol in the Young: Safe and Effective Treatment With Standardized Protocols.

Alejandro A Borquez, Othman A Aljohani, Matthew R Williams, James C Perry,

OBJECTIVES:This study assessed the safety and efficacy of novel and standardized protocols for the use of intravenous (IV) sotalol in pediatric patients. BACKGROUND:Acute arrhythmia treatments in children remain limited. IV sotalol is a new option but pediatric experience is limited. There is no standardized protocol for rapid infusion during acute ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2020, 6(4):425-432]

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Massive gallstone in an asymptomatic Indigenous Canadian male: Case report and literature review.

Angela W. Chan, Rathi M. Sabaratnam, Yagan Pillay,

IntroductionGallstones are present in 10–15% of North Americans, but only 20% become symptomatic. This case report describes a patient with a 7.5 cm gallstone detected incidentally while being investigated for cardiac pathology. This is the first report in the English literature of a stone this size that has remained clinically ... Read more >>

Int J Surg Case Rep (International Journal of Surgery Case Reports)
[2020, 72:429-432]

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The successful use of therapeutic plasma exchange for severe COVID-19 acute respiratory distress syndrome with multiple organ failure.

Philip Keith, Matthew Day, Carol Choe, Linda Perkins, Lou Moyer, Erin Hays, Marshall French, Kristi Hewitt, Gretchen Gravel, Amanda Guffey, L Keith Scott,

The COVID-19 pandemic has brought about an urgent need for effective treatment, while conserving vital resources such as intensive care unit beds and ventilators. Antivirals, convalescent plasma, and biologics have been used with mixed results. The profound "cytokine storm" induced endotheliopathy and microthrombotic disease in patients with COVID-19 may lead ... Read more >>

SAGE Open Med Case Rep (SAGE Open Medical Case Reports)
[2020, 8:2050313X20933473]

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[Combined Approach for Management of the Chronic Heart Failure with Preserved Left Ventricular Ejection Fraction and Permanent Atrial Fibrillation: a Case Report].

A V Ardashev, E G Zhelyakov, A A Kocharian,

The article described a clinical case of a patient with chronic heart failure (CHF) with preserved ejection fraction (CHF-PEF) and permanent normosystolic atrial fibrillation (AF). A 73 year-old man (body mass index, 26.4 kg /m2) with permanent normosystolic AF (duration, 10 years) was hospitalized for augmenting of CHF symptoms. The patient had ... Read more >>

Kardiologiia (Kardiologiia)
[2020, 60(4):157-160]

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Persistent atrial fibrillation: When the pulmonary veins are no longer the answer.

Matthew C Hyman, Francis E Marchlinski,

J. Cardiovasc. Electrophysiol. (Journal of cardiovascular electrophysiology)
[2020, 31(7):1861-1863]

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Drug-specific risk of severe QT prolongation following acute drug overdose.

Sharan L Campleman, Jeffery Brent, Anthony F Pizon, Joshua Shulman, Paul Wax, Alex F Manini, ,

Background: Severe QT prolongation (SQTP) has been identified as a strong predictor of adverse cardiovascular events in acute drug overdose, but drug-specific causes of SQTP in the setting of acute drug overdose remain unclear. We aimed to perform the most definitive study to date describing drug-specific risk of SQTP following ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2020, :1-9]

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Protocolo de manejo hospitalario de alteraciones electrocardiográficas en pacientes con COVID-19 con un sistema portátil vinculado a smartphone.

Luis Ruiz Guerrero, Aritz Gil Ongay, Ángela Canteli Álvarez, Gonzalo Martín Gorría, Víctor Expósito García, José M. de la Torre-Hernández,

(Rec. Cardioclinics)
[0, :]

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Treatment for beta-blocker poisoning: a systematic review.

Joe-Anthony Rotella, Shaun L Greene, Zeff Koutsogiannis, Andis Graudins, Yit Hung Leang, Kelvin Kuan, Helen Baxter, Elyssia Bourke, Anselm Wong,

Introduction: Beta-adrenoreceptor antagonist (beta-blocker) poisoning is a common overdose which can lead to significant morbidity and mortality.Objective: To evaluate the effects of treatments for beta-adrenoreceptor antagonist poisoning.Methods: Searches were conducted across MEDLINE (1946-26 November 2019, Ovid); Embase (1974-26 November 2019, Ovid); and the Cochrane Central Register of Controlled Trials (CENTRAL, ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2020, :1-41]

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