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Full Text Journal Articles about
Sinonasal Manifestations of Cystic Fibrosis

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Orbital Apex Syndrome: A Review.

Akshay Badakere, Preeti Patil-Chhablani,

Orbital apex syndrome is characterized by vision loss from optic neuropathy and ophthalmoplegia due to the involvement of ocular motor nerves in the anatomical region of the orbital apex. Patients could present with signs and symptoms deriving from the involvement of structures within the orbital apex, the superior orbital fissure ... Read more >>

Eye Brain (Eye and brain)
[2019, 11:63-72]

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Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging.

Ying-Chen Claire Hou, Hung-Chun Yu, Rick Martin, Elizabeth T Cirulli, Natalie M Schenker-Ahmed, Michael Hicks, Isaac V Cohen, Thomas J Jönsson, Robyn Heister, Lori Napier, Christine Leon Swisher, Saints Dominguez, Haibao Tang, Weizhong Li, Bradley A Perkins, Jaime Barea, Christina Rybak, Emily Smith, Keegan Duchicela, Michael Doney, Pamila Brar, Nathaniel Hernandez, Ewen F Kirkness, Andrew M Kahn, J Craig Venter, David S Karow, C Thomas Caskey,

Genome sequencing has established clinical utility for rare disease diagnosis. While increasing numbers of individuals have undergone elective genome sequencing, a comprehensive study surveying genome-wide disease-associated genes in adults with deep phenotyping has not been reported. Here we report the results of a 3-y precision medicine study with a goal ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(6):3053-3062]

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A Review of Primary Vasculitis Mimickers Based on the Chapel Hill Consensus Classification.

Farah Zarka, Charles Veillette, Jean-Paul Makhzoum,

Primary systemic vasculitides are rare diseases that may manifest similarly to more commonly encountered conditions. Depending on the size of the vessel affected (large vessel, medium vessel, or small vessel), different vasculitis mimics must be considered. Establishing the right diagnosis of a vasculitis mimic will prevent unnecessary immunosuppressive therapy. ... Read more >>

Int J Rheumatol (International journal of rheumatology)
[2020, 2020:8392542]

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Evolution of sinonasal clinical features in children with cystic fibrosis.

P Suy, A Coudert, S Vrielynck, E Truy, R Hermann, S Ayari-Khalfallah,

OBJECTIVE:to assess the evolution of sinonasal manifestations in children with cystic fibrosis, since the improvement of their prognosis over the last decades. METHODS:an observational, monocentric study with a retrospective cohort. We included 173 children (from 4 to 18 years old) with cystic fibrosis followed at the pediatric cystic fibrosis center ... Read more >>

Int. J. Pediatr. Otorhinolaryngol. (International journal of pediatric otorhinolaryngology)
[2019, 124:47-53]

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Cystic Fibrosis-Associated Liver Disease in Lung Transplant Recipients.

Jorge Mallea, Candice Bolan, Cherise Cortese, Denise Harnois,

Cystic fibrosis (CF) is an autosomal recessive disease characterized by mutations in the gene that encodes for the cystic fibrosis transmembrane conductance regulator protein (CFTR). CFTR gene mutations manifest as epithelial cell dysfunction in the airways, biliary tract, pancreas, gut, sweat glands, paranasal sinuses, and genitourinary tract. The clinical manifestations ... Read more >>

Liver Transpl. (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2019, 25(8):1265-1275]

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Follow-Up and Management of Chronic Rhinosinusitis in Adults with Primary Ciliary Dyskinesia: Review and Experience of Our Reference Centers.

Emilie Bequignon, Laurence Dupuy, Virginie Escabasse, Francoise Zerah-Lancner, Laurence Bassinet, Isabelle Honoré, Marie Legendre, Marie Devars du Mayne, Bruno Crestani, Estelle Escudier, André Coste, Jean-François Papon, Bernard Maître,

Chronic rhinosinusitis is the foremost manifestation in adult patients with primary ciliary dyskinesia (PCD). We present a retrospective series of 41 adult patients with a confirmed diagnosis of PCD followed in our reference centers. As part of the diagnostic work up in our centers, sinus computed tomography scans (CTs) are ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(9):]

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Cystic fibrosis revisited.

H Kulkarni, S Kansra, S Karande,

J Postgrad Med (Journal of postgraduate medicine)
[2019, 65(4):193-196]

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Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis.

Zheng Liu, Jianjun Chen, Lei Cheng, Huabin Li, Shixi Liu, Hongfei Lou, Jianbo Shi, Ying Sun, Dehui Wang, Chengshuo Wang, Xiangdong Wang, Yongxiang Wei, Weiping Wen, Pingchang Yang, Qintai Yang, Gehua Zhang, Yuan Zhang, Changqing Zhao, Dongdong Zhu, Li Zhu, Fenghong Chen, Yi Dong, Qingling Fu, Jingyun Li, Yanqing Li, Chengyao Liu, Feng Liu, Meiping Lu, Yifan Meng, Jichao Sha, Wenyu She, Lili Shi, Kuiji Wang, Jinmei Xue, Luoying Yang, Min Yin, Lichuan Zhang, Ming Zheng, Bing Zhou, Luo Zhang,

The current document is based on a consensus reached by a panel of experts from the Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck Surgery, Rhinology Group. Chronic rhinosinusitis (CRS) affects approximately 8% of Chinese adults. The inflammatory and remodeling mechanisms of CRS in the Chinese ... Read more >>

Allergy Asthma Immunol Res (Allergy, asthma & immunology research)
[2020, 12(2):176-237]

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Overexpression of Inducible Nitric Oxide Synthase in Allergic and Nonallergic Nasal Polyp.

Ahmed Adel Sadek, Soha Abdelwahab, Safaa Yehia Eid, Riyad A Almaimani, Mohammad A Althubiti, Mahmoud Zaki El-Readi,

Sinonasal polyps are very common benign lesions of the nasal mucosa. Most of nasal polyps (NP) are idiopathic, and the pathophysiology of this disease is still incompletely understood. Nitric oxide (NO) is a reactive molecule generated by nitric oxide synthase (NOS). NO has been identified as an important mediator in ... Read more >>

Oxid Med Cell Longev (Oxidative Medicine and Cellular Longevity)
[2019, 2019:7506103]

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Review of Systemic Antibiotic Treatments in Children with Rhinosinusitis.

Sara Torretta, Lorenzo Drago, Paola Marchisio, Lorenzo Gaini, Claudio Guastella, Antonio Moffa, Vittorio Rinaldi, Manuel Casale, Lorenzo Pignataro,

Antibiotic treatment in paediatric rhinosinusitis is still a matter of debate, as the current guidelines have been drafted mainly based on clinical studies published before 2013. Recent modifications in the epidemiological basis of the disease might mean that current treatments are not completely adequate considering the evolving microbiological profile of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(8):]

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Critical Evaluation of Sinonasal Disease in 64 Adults with Primary Ciliary Dyskinesia.

Emilie Bequignon, Laurence Dupuy, Francoise Zerah-Lancner, Laurence Bassinet, Isabelle Honoré, Marie Legendre, Marie Devars du Mayne, Virginie Escabasse, Bruno Crestani, Bernard Maître, Estelle Escudier, André Coste, Jean-François Papon,

To date, no study precisely described ear, nose and throat (ENT) disease in adults with primary ciliary dyskinesia (PCD) and its relationship with ciliary function/ultrastructure. A retrospective study of standardized ENT data (exam, audiogram, sinus Computed tomography (CT), and bacteriology) was conducted in 64 adults with confirmed PCD who were ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(5):]

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Anatomical Factors in Children with Orbital Complications Due to Acute Rhinosinusitis.

Mustafa Çelik, Kamil-Hakan Kaya, Yakup Yegin, Burak Olgun, Fatma-Tülin Kayhan,

Introduction:The role of the anatomical variations and severity of acute rhinosinusitis (ARS) in the development of ARS complications is still an unknown issue. Regarding this, the present study evaluated the relationship between the severity of ARS and anatomical nasal variations in pediatric patients with ARS-related orbital complications. Materials and Methods:This ... Read more >>

Iran J Otorhinolaryngol (Iranian journal of otorhinolaryngology)
[2019, 31(106):289-295]

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Clinical predictors of cystic fibrosis chronic rhinosinusitis severity.

Anna C Zemke, Seyed Mehdi Nouraie, John Moore, Jordan R Gaston, Nicholas R Rowan, Joseph M Pilewski, Jennifer M Bomberger, Stella E Lee,

BACKGROUND:Chronic rhinosinusitis (CRS) is a significant manifestation of cystic fibrosis (CF) with wide-ranging symptom and disease severity. The goal of the study was to determine clinical variables that correlate with outcome measures of disease severity. METHODS:A prospective, longitudinal, observational study of 33 adults with symptomatic CRS treated in a CF-focused ... Read more >>

Int Forum Allergy Rhinol (International forum of allergy & rhinology)
[2019, 9(7):759-765]

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Differentiating Rhinitis in the Paediatric Population by Giving Focus on Medical History and Clinical Examination.

Maria Doulaptsi, Noriaki Aoi, Hideyuki Kawauchi, Athanasia Milioni, Alexander Karatzanis, Emmanuel Prokopakis,

Chronic rhinitis is defined as an inflammation of the nasal epithelium, and is characterized by the presence of two or more specific nasal symptoms including obstruction, rhinorrhea, sneezing, and/or itching for at least 12 weeks. In childhood, this clinical entity is very common and carries a significant socioeconomic burden. The ... Read more >>

Med Sci (Basel) (Medical sciences (Basel, Switzerland))
[2019, 7(3):]

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Primary immunodeficiency-related bronchiectasis in adults: comparison with bronchiectasis of other etiologies in a French reference center.

Hélène Goussault, Hélène Salvator, Emilie Catherinot, Marie-Laure Chabi, Colas Tcherakian, Alexandre Chabrol, Morgane Didier, Elisabeth Rivaud, Alain Fischer, Felipe Suarez, Olivier Hermine, Fanny Lanternier, Olivier Lortholary, Nizar Mahlaoui, Philippe Devillier, Louis-Jean Couderc,

BACKGROUND:Bronchiectasis is a heterogeneous disease depending on etiology. It represents the most frequent non-infectious pulmonary complication of primary immunodeficiencies (PID). We investigated whether bronchiectasis associated with PID had a distinct course in comparison to bronchiectasis of other causes. METHODS:Retrospective single-center study of adult patients diagnosed with non-cystic fibrosis bronchiectasis with ... Read more >>

Respir. Res. (Respiratory research)
[2019, 20(1):275]

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Spectrum of imaging findings in pulmonary infections. Part 2: Fungal, mycobacterial, and parasitic.

Mandeep Garg, Nidhi Prabhakar, Ajay Gulati, Ritesh Agarwal, Sahajal Dhooria,

Chest radiography is generally the first imaging modality used for the evaluation of pneumonia. It can establish the presence of pneumonia, determine its extent and location, and assess the response to treatment. Computed tomography is not used for the initial evaluation of pneumonia, but it may be used when the ... Read more >>

Pol J Radiol (Polish journal of radiology)
[2019, 84:e214-e223]

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Short review on the diagnosis and treatment of bronchiectasis.

Andrei Lesan, Alicia Elisabeth Lamle,

Bronchiectasis refers to the permanent dilation of the bronchi. It is often a sequel of insufficiently treated lung disease that develops into a pathological pattern of dilated bronchi, which heightens susceptibility to further lung infections. Modernization of diagnostic procedures (computed tomography scan) and definition of a clinical picture (repeated lung ... Read more >>

Med Pharm Rep (Medicine and pharmacy reports)
[2019, 92(2):111-116]

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A putative enoyl-CoA hydratase contributes to biofilm formation and the antibiotic tolerance of Achromobacter xylosoxidans.

Lydia C Cameron, Benjamin Bonis, Chi Q Phan, Leslie A Kent, Alysha K Lee, Ryan C Hunter,

Achromobacter xylosoxidans has attracted increasing attention as an emerging pathogen in patients with cystic fibrosis. Intrinsic resistance to several classes of antimicrobials and the ability to form robust biofilms in vivo contribute to the clinical manifestations of persistent A. xylosoxidans infection. Still, much of A. xylosoxidans biofilm formation remains uncharacterized ... Read more >>

NPJ Biofilms Microbiomes (NPJ biofilms and microbiomes)
[2019, 5:20]

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Primary myelofibrosis: spectrum of imaging features and disease-related complications.

Sheng Fei Oon, Dalveer Singh, Teng Han Tan, Allan Lee, Geertje Noe, Kate Burbury, Joseph Paiva,

Primary myelofibrosis is a chronic clonal stem cell disorder that results in a build-up of marrow fibrosis and dysfunction, hypermetabolic states, and myeloid metaplasia. The clinical and radiological consequences can be quite diverse and range from the manifestations of osteosclerosis and extramedullary haematopoiesis to thrombohaemorrhagic complications from haemostatic dysfunction. In ... Read more >>

Insights Imaging (Insights into imaging)
[2019, 10(1):71]

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Subcutaneous calcification as a supportive radiologic finding for diagnosis of rhinofacial entomophthoromycosis.

Navarat Vatcharayothin, Pornthep Kasemsiri, Cattleya Thongrong, Chanticha Laohakittikul, Surapol Suetrong, Piti Ungarreevittaya, Nipon Chaisuriya,

Rhinofacial entomophthoromycosis is an uncommon chronic fungal infection of the head and neck. The diagnosis is usually based on clinical manifestations; however, diagnosis of this infection based on early manifestations is difficult and occasionally rhinofacial entomophthoromycosis is mistaken for other diseases. Therefore, computed tomography is introduced to support the diagnosis. ... Read more >>

Clin Pract (Clinics and practice)
[2019, 9(2):1125]

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Salivary Secretor Status of Blood Group Antigens in Patients with Head and Neck Cancer.

Sedighe Bakhtiari, Soheila Mani Far, Zahra Alibakhshi, Mohammad Shirkhoda, Fahimeh Anbari,

BACKGROUND:Head and neck cancers include malignancies of the scalp and neck skin, nasal cavity, paranasal sinuses, oral cavity, salivary glands, pharynx and larynx. The term ABO secretor refers to people who secrete blood group antigens in their body fluids such as saliva, sweat, tears, semen, and serum. Non-secretors refer to ... Read more >>

Open Access Maced J Med Sci (Open access Macedonian journal of medical sciences)
[2019, 7(3):373-377]

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IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway.

Xiaoping Lai, Xia Li, Lihong Chang, Xiaohong Chen, Zizhen Huang, Hongwei Bao, Jiancong Huang, Luoying Yang, Xifu Wu, Zhiyuan Wang, Joseph A Bellanti, Song Guo Zheng, Gehua Zhang,

The mucin gene, MUC5AC, is highly expressed both in chronic respiratory inflammatory diseases and inflammatory bowel disease where mucin secretion is regulated by members of the interleukin IL-20 subfamily. This study was conducted to determine the roles and mechanisms of IL-19, a member of the IL-20 subfamily, in regulating MUC5AC ... Read more >>

Front Immunol (Frontiers in Immunology)
[2019, 10:1682]

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Abstracts from the 24th Congress of the Italian Society of Cystic Fibrosis and the 14th National Congress of Cystic Fibrosis Italian Society: Salerno, Italy. 8 -10 November 2018.

Ital J Pediatr (Italian journal of pediatrics)
[2019, 45(Suppl 1):]

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Predictive and Diagnostic Value of Fractional Exhaled Nitric Oxide in Patients with Chronic Rhinosinusitis.

Junyi Zhang, Yanan Sun, Ming Liu, Chuanhui Sun, Linli Tian,

BACKGROUND Fractional exhaled nitric oxide (FeNO) participates in the local defense of the upper respiratory tract. Abnormal FeNO level is directly related to the occurrence of nasal diseases. However, the clinical value of FeNO in the upper airway is limited, which greatly impedes the diagnosis and treatment of nasal diseases. ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2019, 25:150-156]

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Allergic Fungal Otomastoiditis in a Patient without Allergic Fungal Rhinosinusitis: A Case Report.

Marzouqi Abdulaziz Salamah, Mansour Al-Shamani,

BACKGROUND Allergic fungal rhinosinusitis is an inflammatory condition involving the paranasal sinuses and linings of the nasal passages that lasts 12 weeks or longer. In 2013 Chen et al. reported the first case of middle ear allergic otomastoiditis in a patient who tested negative for allergic sinus-nasal disease. To the ... Read more >>

Am J Case Rep (The American journal of case reports)
[2019, 20:877-881]

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