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Symbiont-Mediated RNA Interference (SMR): Using Symbiotic Bacteria as Vectors for Delivering RNAi to Insects.

Paul Dyson, Marcela Figueiredo, Awawing A Andongma, Miranda M A Whitten,

RNA interference (RNAi) has emerged as a widely used approach for reverse genetic analysis in eukaryotes. In insects, RNAi also has an application in the control of insect pests. Several methods have been developed for delivery of interfering RNA in insects, with varying outcomes for different species. Here we describe ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2360:295-306]

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Outcomes Associated With Hypertensive Disorders of Pregnancy in Twin Compared With Singleton Gestations.

Amir Aviram, Howard Berger, Kasim E Abdulaziz, Jon F R Barrett, Beth Murray-Davis, Sarah D McDonald, Michael Geary, Nir Melamed, ,

<h4>Objective</h4>To evaluate whether pregnancy outcomes associated with hypertensive disorders of pregnancy in twin pregnancies differ relatively from those in singleton pregnancy.<h4>Methods</h4>We conducted a retrospective, population-based cohort study of all women with a liveborn singleton or twin hospital birth in Ontario, Canada, between 2012 and 2019. Data were obtained from the ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2021, 138(3):449-458]

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Accessing Photoredox Transformations with an Iron(III) Photosensitizer and Green Light.

Akin Aydogan, Rachel E Bangle, Alejandro Cadranel, Michael D Turlington, Daniel T Conroy, Emilie Cauët, Michael L Singleton, Gerald J Meyer, Renato N Sampaio, Benjamin Elias, Ludovic Troian-Gautier,

Efficient excited-state electron transfer between an iron(III) photosensitizer and organic electron donors was realized with green light irradiation. This advance was enabled by the use of the previously reported iron photosensitizer, [Fe(phtmeimb)<sub>2</sub>]<sup>+</sup> (phtmeimb = {phenyl[tris(3-methyl-imidazolin-2-ylidene)]borate}, that exhibited long-lived and luminescent ligand-to-metal charge-transfer (LMCT) excited states. A benchmark dehalogenation reaction was ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, :]

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Sustainable food systems and nutrition in the 21st century: A report from the 22nd annual harvard nutrition obesity symposium.

Jessica Fanzo, Coral Rudie, Iman Sigman, Steven Grinspoon, Tim G Benton, Molly E Brown, Namukolo Covic, Kathleen Fitch, Christopher D Golden, Delia Grace, Marie-France Hivert, Peter Huybers, Lindsay M Jaacks, William A Masters, Nicholas Nisbett, Ruth A Richardson, Chelsea R Singleton, Patrick Webb, Walter C Willett,

Food systems are at the center of a brewing storm consisting of a rapidly changing climate, rising hunger and malnutrition and significant social inequities. At the same time, there are vast opportunities to ensure that food systems produce healthy and safe food in equitable ways that promote environmental sustainability, especially ... Read more >>

Am J Clin Nutr (The American journal of clinical nutrition)
[2021, :]

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First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies.

Olga Buerger, Tania Elger, Antonia Varthaliti, Argyro Syngelaki, Alan Wright, Kypros H Nicolaides,

We previously reported a logistic regression model for prediction of GDM from maternal characteristics and medical history in 75,161 singleton pregnancies. In this study of 1376 twin and 13,760 singleton pregnancies recruited at 11-13 weeks' gestation, we extend the model to include terms for twin pregnancies. We found the respective ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(17):]

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Impact of HLA type, age and chronic viral infection on peripheral T-cell receptor sharing between unrelated individuals.

Sarah A Johnson, Spencer L Seale, Rachel M Gittelman, Julie A Rytlewski, Harlan S Robins, Paul A Fields,

The human adaptive immune system must generate extraordinary diversity to be able to respond to all possible pathogens. The T-cell repertoire derives this high diversity through somatic recombination of the T-cell receptor (TCR) locus, a random process that results in repertoires that are largely private to each individual. However, factors ... Read more >>

PLoS One (PloS one)
[2021, 16(8):e0249484]

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Impact of fertility vs. mortality control on the demographics of Mastomys natalensis in maize fields.

Christopher I Imakando, G Mandela FERNáNDEZ-Grandon, Grant R Singleton, Steven R Belmain,

The multimammate mouse, Mastomys natalensis, is the most common rodent pest species in sub-Saharan Africa. Currently, rodenticides are the preferred method used to reduce the population of rodent pests, but this method poses direct and indirect risks to humans and other non-target species. Fertility control is a promising alternative that ... Read more >>

Integr Zool (Integrative zoology)
[2021, :]

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National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged 13-17 Years - United States, 2020.

Cassandra Pingali, David Yankey, Laurie D Elam-Evans, Lauri E Markowitz, Charnetta L Williams, Benjamin Fredua, Lucy A McNamara, Shannon Stokley, James A Singleton,

The Advisory Committee on Immunization Practices (ACIP) recommends that adolescents aged 11-12 years routinely receive tetanus, diphtheria, and acellular pertussis (Tdap); meningococcal conjugate (MenACWY); and human papillomavirus (HPV) vaccines. Catch-up vaccination is recommended for hepatitis B (HepB); hepatitis A (HepA); measles, mumps, and rubella (MMR); and varicella (VAR) vaccines for ... Read more >>

MMWR Morb Mortal Wkly Rep (MMWR. Morbidity and mortality weekly report)
[2021, 70(35):1183-1190]

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Emergency cervical cerclage in twin and singleton pregnancies with 0-mm cervical length or prolapsed membranes.

Georgina D Freegard, Vera Donadono, Lawrence W M Impey,

<h4>Introduction</h4>Cervical cerclage is controversial in twin pregnancies, although recent data from the USA supports its use where "physical examination-indicated". Limited data exist, however, in the extreme situation of 0-mm ultrasound-measured cervical length or even prolapsed membranes. This research compares the success of emergency cervical cerclage in multiple and singleton pregnancies.<h4>Material ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2021, :]

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Evaluating Housing Characteristics Associated With Childhood Lead Exposure in Providence, Rhode Island.

Taylor-Marie Vasil, Michelle L Rogers, Cindy Singleton, Patrick M Vivier,

<h4>Objective</h4>This research aims to take an in-depth look into the child, housing, and neighborhood characteristics associated with Providence children's likelihood of having elevated blood lead levels (BLLs).<h4>Design and setting</h4>The 2019 Providence, Rhode Island, Property Tax Assessor's database, containing each property owner's address, was geocoded and spatially joined with the 2017-2019 ... Read more >>

J Public Health Manag Pract (Journal of public health management and practice : JPHMP)
[2021, :]

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Clinical outcomes in higher-order multiples reduced to dichorionic diamniotic (DCDA) twins compared with primary twins and singletons: A prospective observational study.

Chanchal Singh, Seema Thakur, Gazala Shahnaz, Savita Dagar, Aditi Shastri, Deeksha Khurana,

<h4>Objective</h4>To compare outcomes in higher-order multiple pregnancies reduced to dichorionic diamniotic (DCDA) twins with primary DCDA twins and singleton pregnancies.<h4>Methods</h4>This prospective observational study included all higher-order multiple pregnancies that underwent ultrasound-guided transabdominal fetal reduction at 11-13 weeks of gestation from January 2018 to June 2020. Outcomes were compared with 100 primary ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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Neonatal adverse outcome in twin pregnancies complicated by small-for-gestational age: twin vs singleton reference chart.

C Briffa, C Di Fabrizio, E Kalafat, V Giorgione, R Bhate, C Huddy, J Richards, S Shetty, A Khalil,

<h4>Objective</h4>The use of twin-specific versus singleton charts in the assessment of twin pregnancies has been controversial. The aim of the study was to assess whether a diagnosis of small for gestational age (SGA) made using twin specific estimated fetal weight (EFW) and birthweight (BW) charts is more strongly associated with ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2021, :]

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Lower respiratory tract infection hospitalizations among American Indian/Alaska Native adults, Indian Health Service and Alaska Region, 1998-2014.

Michael G Bruce, Sara S Bressler, Andria Apostolou, Rosalyn J Singleton,

<h4>Objectives</h4>In this study, we describe changes in LRTI rates from 1998-2014 among hospitalized AI/AN adults residing in Alaska and other Indian Health Service (IHS) regions.<h4>Methods</h4>We calculated age-adjusted hospital discharge rates and rate ratios from the IHS Direct and Contract Health Services Inpatient Dataset, IHS National Patient Information Reporting System for ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, :]

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Developmental outcomes in small for gestational age twins using a singleton versus twin birthweight reference in Upstate KIDS.

Jessica L Gleason, Edwina Yeung, Rajeshwari Sundaram, Pauline Mendola, Erin M Bell, Yassaman Vafai, Sonia L Robinson, Diane L Putnick, Katherine L Grantz,

<h4>Background</h4>Little is known about potential developmental delays in appropriately-grown twins, though they may be at higher risk for developmental delay than singletons. Small-for-gestational age (SGA) is a risk factor for developmental delay and typically based on singleton birthweight references, which may misclassify SGA in a subset of appropriately-grown twins.<h4>Objective</h4>To evaluate ... Read more >>

Am J Obstet Gynecol MFM (American journal of obstetrics & gynecology MFM)
[2021, :100465]

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Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight.

Jeffrey J Beck, René Pool, Margot van de Weijer, Xu Chen, Eva Krapohl, Scott D Gordon, Marianne Nygaard, Birgit Debrabant, Teemu Palviainen, Matthijs D van der Zee, Bart Baselmans, Casey T Finnicum, Lu Yi, Sebastian Lundström, Toos van Beijsterveldt, Lene Christiansen, Kauko Heikkilä, Julie Kittelsrud, Anu Loukola, Miina Ollikainen, Kaare Christensen, Nicholas G Martin, Robert Plomin, Michel Nivard, Meike Bartels, Conor Dolan, Gonneke Willemsen, Eco de Geus, Catarina Almqvist, Patrik K E Magnusson, Hamdi Mbarek, Erik A Ehli, Dorret I Boomsma, Jouke-Jan Hottenga,

Birth weight (BW) is an important predictor of newborn survival and health and has associations with many adult health outcomes, including cardiometabolic disorders, autoimmune diseases and mental health. On average, twins have a lower BW than singletons as a result of a different pattern of fetal growth and shorter gestational ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2021, 30(19):1894-1905]

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Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects

Lynne Krohn, Karl Heilbron, Cornelis Blauwendraat, Regina Reynolds, Eric Yu, Konstantin Senkevich, Uladzislau Rudakou, Mehrdad Estiar, Emil Gustavsson, Kajsa Brolin, Jennifer Ruskey, Kathryn Freeman, Farnaz Asayesh, Ruth Chia, Isabelle Arnulf, Michele T.M. Hu, Jacques Montplaisir, Jean-François Gagnon, Alex Desautels, Yves Dauvilliers, Gian Luigi Gigli, Mariarosaria Valente, Francesco Janes, Andrea Bernardini, Birgit Högl, Ambra Stefani, Abubaker Ibrahim, Karel Sonka, David Kemlink, Wolfgang Oertel, Annette Janzen, Giuseppe Plazzi, Francesco Biscarini, Elena Antelmi, Michela Figorilli, Monica Puligheddu, Brit Mollenhauer, Claudia Trenkwalder, Friederike Sixel-Döring, Valérie Cochen De Cock, Christelle Charley Monaca, Anna Heidbreder, Luigi Ferini-Strambi, Femke Dijkstra, Mineke Viaene, Beatriz Abril, Bradley Boeve, Sonja Scholz, Mina Ryten, Sara Bandres-Ciga, Alastair Noyce, Paul Cannon, Lasse Pihlstrøm, Mike Nalls, Andrew Singleton, Guy Rouleau, Ronald Postuma, Ziv Gan-Or, ,

<h4>ABSTRACT</h4> Rapid eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom of alpha-synucleinopathies. RBD also defines more severe forms of alpha-synucleinopathies. The genetic background of RBD and its underlying mechanisms are not well understood. Here, we performed the first genome-wide association ... Read more >>

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Incidence and Risk Factors of Postpartum Hemorrhage in China: A Multicenter Retrospective Study.

Sijian Li, Jinsong Gao, Juntao Liu, Jing Hu, Xiaoxu Chen, Jing He, Yabing Tang, Xinghui Liu, Yinli Cao, Xiaowei Liu, Xietong Wang,

<b>Background:</b> Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide but the incidence and its risk factors in China is limited. The objective of this study is to investigate the incidence and the risk factors of PPH in Chinese women. <b>Methods:</b> A multi-center retrospective study of ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:673500]

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Provisional research criteria for the behavioral variant of Alzheimer’s disease A systematic review and meta-analysis

Ossenkoppele, E.H. Singleton, Groot, Anke Dijkstra, Willem Eikelboom, William Seeley, Bruce Miller, Laforce, Scheltens, J.M. Papma, G.D. Rabinovici, Y.A.L. Pijnenburg,

<h4>ABSTRACT</h4> <h4>Importance</h4> The behavioral variant of Alzheimer’s disease (bvAD) is characterized by early and predominant behavioral deficits caused by AD pathology. This AD phenotype is insufficiently understood and lacks standardized clinical criteria, limiting reliability and reproducibility of diagnosis and scientific reporting. <h4>Objective</h4> To perform a systematic review and meta-analysis of ... Read more >>

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A novel pathogenic variant p.Asp797Val in IFIH1 in a Japanese boy with overlapping Singleton-Merten syndrome and Aicardi-Goutières syndrome.

Kosei Hasegawa, Hiroyuki Tanaka, Natsuko Futagawa, Hiroyuki Miyahara, Yousuke Higuchi, Hirokazu Tsukahara,

Pathogenic-activating variants of interferon induced with Helicase C domain 1 (IFIH1) cause Singleton-Merten (S-M) syndrome, which accompanies acro-osteolysis, loss of permanent teeth, and aortic calcification, as well as causing Aicardi-Goutières (A-G) syndrome, which shows progressive encephalopathy, spastic paraplegia, and calcification of basal ganglia. Recently, patients with overlapping syndromes presenting with ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2021, :]

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Characteristics of young people accessing recently implemented Community Forensic Child and Adolescent Mental Health Services (F:CAMHS) in England: insights from national service activity data.

Rebecca Lane, Sophie D'Souza, Rosie Singleton, Nick Hindley, Dickon Bevington, Oliver White, Jenna Jacob, James Wheeler, Julian Edbrooke-Childs,

Children and young people in contact with forensic child and adolescent mental health services present with more complex needs than young people in the general population. Recent policy in child and adolescent mental health has led to the implementation of new workstreams and programmes to improve service provision. This research ... Read more >>

Eur Child Adolesc Psychiatry (European child & adolescent psychiatry)
[2021, :]

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Classic Visual Search Effects in an Additional Singleton Task: An Open Dataset.

Kirsten C S Adam, Titiksha Patel, Nicole Rangan, John T Serences,

Visual search refers to our ability to find what we are looking for among many competing visual inputs. Here, we report the availability of a rich dataset that replicates key visual search effects and shows that these effects are robust to several changes to the experimental design. Experiment 1 replicates ... Read more >>

J Cogn (Journal of cognition)
[2021, 4(1):34]

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Open late: neuronal membrane disruption late in traumatic brain injury.

Martina L Hernandez, MiJin Cho, Audrey D Lafrenaye,

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2409-2410]

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Neuropsychiatric and Cognitive Symptoms Across the Alzheimer Disease Clinical Spectrum: Cross-sectional and Longitudinal Associations.

Willem S Eikelboom, Esther van den Berg, Ellen H Singleton, Sara J Baart, Michiel Coesmans, Annebet E Leeuwis, Charlotte E Teunissen, Bart N M van Berckel, Yolande A L Pijnenburg, Philip Scheltens, Wiesje M van der Flier, Rik Ossenkoppele, Janne M Papma,

<h4>Objective</h4>To investigate the prevalence and trajectories of neuropsychiatric symptoms (NPS) in relation to cognitive functioning in a cohort of amyloid-<i>β</i> positive individuals across the Alzheimer's disease (AD) clinical spectrum.<h4>Methods</h4>In this single-center observational study, we included all individuals who visited the Alzheimer Center Amsterdam and had 1) a clinical diagnosis of ... Read more >>

Neurology (Neurology)
[2021, :]

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Longitudinal risk factors for developing depressive symptoms in Parkinson's disease.

Tarek Antar, Huw R Morris, Faraz Faghri, Hampton L Leonard, Mike A Nalls, Andrew B Singleton, Hirotaka Iwaki,

<h4>Background</h4>Despite the established importance of identifying depression in Parkinson's disease, our understanding of the factors which place the Parkinson's disease patient at future risk of depression is limited.<h4>Methods</h4>Our sample consisted of 874 patients from two longitudinal cohorts, PPMI and PDBP, with median follow-up durations of 7 and 3 years respectively. Risk ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2021, 429:117615]

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SORL1 mutation in a Greek family with Parkinson's disease and dementia.

Georgia Xiromerisiou, Thomas Bourinaris, Henry Houlden, Patrick A Lewis, Konstantin Senkevich, Monia Hammer, Monica Federoff, Alaa Khan, Cleanthe Spanaki, Georgios M Hadjigeorgiou, Sevasti Bonstanjopoulou, Liana Fidani, Aleksey Ermolaev, Ziv Gan-Or, Andrew Singleton, Jana Vandrovcova, John Hardy,

Whole exome sequencing and linkage analysis were performed in a three generational pedigree of Greek origin with a broad phenotypic spectrum spanning from Parkinson's disease and Parkinson's disease dementia to dementia of mixed type (Alzheimer disease and vascular dementia). We identified a novel heterozygous c.G1135T (p.G379W) variant in SORL1 which ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2021, :]

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