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Single Ventricle

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Coronary artery bypass grafting vs. drug-eluting stent implantation in patients with end-stage renal disease requiring dialysis.

Zhi Wang, Yanjun Gong, Fangfang Fan, Fan Yang, Lin Qiu, Tao Hong, Yong Huo,

Objectives: To evaluate the optimal revascularization strategy for patients with coronary artery disease (CAD) and end stage renal disease (ESRD) in the drug-eluting stent (DES) era.Methods: One hundred and twelve patients with ESRD treated with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) were enrolled from 2007 to ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):107-112]

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Diagnostic Efficacy of Cardiac Scintigraphy with 99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation.

Julia Ilyushenkova, Svetlana Sazonova, Konstantin Zavadovsky, Roman Batalov, Yuliya Rogovskaya, Yana Anfinogenova, Yurii Lishmanov,

Objectives:This work aimed to study the efficacy of hybrid 99mTc-Pyrophosphate SPECT/CT for diagnosis of latent inflammatory processes in the myocardium of patients with atrial fibrillation (AF). Methods:The study comprised 34 patients aged 44 ± 9 years with AF of unknown etiology referred for radiofrequency ablation. The data were acquired using hybrid 99mTc-Pyrophosphate ... Read more >>

Cardiol Res Pract (Cardiology research and practice)
[2020, 2020:5983751]

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Deep learning-based attenuation map generation for myocardial perfusion SPECT.

Luyao Shi, John A Onofrey, Hui Liu, Yi-Hwa Liu, Chi Liu,

PURPOSE:Attenuation correction using CT transmission scanning increases the accuracy of single-photon emission computed tomography (SPECT) and enables quantitative analysis. Current existing SPECT-only systems normally do not support transmission scanning and therefore scans on these systems are susceptible to attenuation artifacts. Moreover, the use of CT scans also increases radiation dose to ... Read more >>

Eur. J. Nucl. Med. Mol. Imaging (European Journal of Nuclear Medicine and Molecular Imaging)
[2020, :]

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Proceedings From the 2019 Stanford Single Ventricle Scientific Summit: Advancing Science for Single Ventricle Patients: From Discovery to Clinical Applications.

Sushma Reddy, Stephanie Siehr Handler, Sean Wu, Marlene Rabinovitch, Gail Wright,

Abstracts Because of remarkable advances in survival over the past 40 years, the worldwide population of individuals with single ventricle heart disease living with Fontan circulation has grown to ≈70 000, with nearly half aged >18 years. Survival to at least 30 years of age is now achievable for 75% of Fontan patients. On ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(7):e015871]

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6q25.1 (TAB2) microdeletion is a risk factor for hypoplastic left heart: a case report that expands the phenotype.

Andrew Cheng, Whitney Neufeld-Kaiser, Peter H Byers, Yajuan J Liu,

INTRODUCTION:Hypoplastic left heart syndrome (HLHS) is a rare but devastating congenital heart defect (CHD) accounting for 25% of all infant deaths due to a CHD. The etiology of HLHS remains elusive, but there is increasing evidence to support a genetic cause for HLHS; in particular, this syndrome is associated with ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):137]

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Incidental Detection of Inadvertent Pacing Lead Placement in the Left Ventricle by Myocardial Perfusion Imaging Study.

Robert T Tung,

Kans J Med (Kansas journal of medicine)
[2020, 13:43-45]

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Effects of levosimendan on ventriculo-arterial coupling and cardiac efficiency in paediatric patients with single-ventricle physiology after surgical palliation: retrospective study.

Roberta Iacobelli, Zaccaria Ricci, Eleonora Marinari, Roberta Haiberger, Arianna Di Molfetta, Alessandra Toscano, Luca Di Chiara,

OBJECTIVES:The use of levosimendan for paediatric patients with low cardiac output after congenital heart surgery has been recently described. We sought to evaluate ventriculo-arterial coupling (VAC) and other ventricular energetic parameters before and after 72 h from levosimendan start in infants with single-ventricle physiology and cardiac failure after palliation with Norwood ... Read more >>

Interact Cardiovasc Thorac Surg (Interactive cardiovascular and thoracic surgery)
[2020, 30(4):623-629]

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Impairment of myocardial perfusion correlates with heart failure severity in patients with non-compaction cardiomyopathy.

Andraz Cerar, Martina Jaklic, Sabina Frljak, Gregor Poglajen, Gregor Zemljic, Barbara Guzic Salobir, Maja Dolenc Novak, Monika Stalc, Rok Zbacnik, Mirta Kozelj,

AIMS:Non-compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potential correlation between myocardial ischemia and heart failure severity in NCM patients. ... Read more >>

ESC Heart Fail (ESC heart failure)
[2020, :]

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Norwood procedure with right ventricle to pulmonary artery conduit: a single-centre 20-year experience.

Yasuyuki Kobayashi, Yasuhiro Kotani, Yosuke Kuroko, Takuya Kawabata, Shunji Sano, Shingo Kasahara,

OBJECTIVES:The aim of this study was to evaluate the long-term outcomes of the Norwood procedure with right ventricle-pulmonary artery (RV-PA) conduit for hypoplastic left heart complex. METHODS:A retrospective observational study was performed in 136 patients with hypoplastic left heart complex who underwent a Norwood procedure with RV-PA conduit between 1998 ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2020, :]

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The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload.

Xiaopu Wang, Junyu Pei, Xinqun Hu,

Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of acute heart failure syndrome triggered by intense psychological or physiological stress. TTS typically manifests as acute chest pain, dyspnea or syncope that mimics an acute myocardial infarction but does not involve coronary artery obstruction. The current understanding of ... Read more >>

Cardiol Res Pract (Cardiology research and practice)
[2020, 2020:4150291]

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Stress Echocardiography: Concept and Criteria, Structure and Steps, Obstacles and Outcomes, Focused Update and Review.

Antoine Kossaify, Elie Bassil, Mikhael Kossaify,

Stress echocardiography (SEC) is a technique established more than 35 years ago; however, it is still poorly implemented in many countries and institutions, and this reluctance may be related to many obstacles such as operator skills, lack of awareness or institutional policy. Stress echo was initially used for assessing coronary ... Read more >>

Cardiol Res (Cardiology Research)
[2020, 11(2):89-96]

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Heart Failure in Single Right Ventricle Congenital Heart Disease: Physiologic and Molecular Considerations.

Anastacia M Garcia, Jonathan-Thomas Beatty, Stephanie Jialing Nakano,

Due to remarkable surgical and medical advances over the past several decades, there are growing numbers of infants and children living with single ventricle congenital heart disease (SV), where there is only one functional cardiac pumping chamber. Nevertheless, cardiac dysfunction and ultimately heart failure is a common complication in the ... Read more >>

Am. J. Physiol. Heart Circ. Physiol. (American journal of physiology. Heart and circulatory physiology)
[2020, :]

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Heart Rate Expenditure Correlates with Right Ventricular Function.

Daniel J Lachant, Allison N Light, Maria L Mackin, Ronald G Schwartz, R James White,

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(3):372-375]

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The prognostic value of stroke work/end-diastolic volume ratio during stress echocardiography.

Tonino Bombardini, Lauro Cortigiani, Quirino Ciampi, Miodrag C Ostojic, Tamara Kovacevic-Preradovic, Eugenio Picano,

Background: The ventricular stroke work (SW) refers to the work done by the left ventricle to eject the volume of blood during one cardiac cycle. The cath-lab relationship between SW and end-diastolic volume (EDV) is the preload-recruitable SW (PRSW). Recently a non-invasive single-beat PRSW (SBPRSW) has been proposed. However, the ... Read more >>

Acta Cardiol (Acta cardiologica)
[2020, :1-12]

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Validation of automated whole-body analysis of metabolic and morphological parameters from an integrated FDG-PET/MRI acquisition.

P Guglielmo, S Ekström, R Strand, R Visvanathar, F Malmberg, E Johansson, M J Pereira, S Skrtic, B C L Carlsson, J W Eriksson, H Ahlström, J Kullberg,

Automated quantification of tissue morphology and tracer uptake in PET/MR images could streamline the analysis compared to traditional manual methods. To validate a single atlas image segmentation approach for automated assessment of tissue volume, fat content (FF) and glucose uptake (GU) from whole-body [18F]FDG-PET/MR images. Twelve subjects underwent whole-body [18F]FDG-PET/MRI ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5331]

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Myocardial perfusion abnormalities in Eisenmenger syndrome.

Anunay Gupta, Chetan Patel, Saurabh Kumar Gupta, S Ramakrishnan, Anita Saxena, Shyam S Kothari,

BACKGROUND:Compared to primary pulmonary hypertension (PPH), the right ventricular (RV) contractile function is preserved for a long time in patients with Eisenmenger syndrome and is likely the most important determinant of relatively higher survival. The differences in myocardial perfusion have been purported to explain this discrepancy. The exact prevalence of ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2020, 41(3):206-211]

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A 12-Lead ECG database to identify origins of idiopathic ventricular arrhythmia containing 334 patients.

Jianwei Zheng, Guohua Fu, Kyle Anderson, Huimin Chu, Cyril Rakovski,

Measurement(s)Ventricular arrhythmiaTechnology Type(s)electrocardiographyFactor Type(s)sexSample Characteristic - OrganismHomo sapiens Machine-accessible metadata file describing the reported data: 10.6084/m9.figshare.11926506 ... Read more >>

Sci Data (Scientific data)
[2020, 7:]

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Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease.

Anastacia M Garcia, Jessica C McPhaul, Genevieve C Sparagna, Danielle A Jeffrey, Raleigh Jonscher, Sonali S Patel, Carmen C Sucharov, Brian L Stauffer, Shelley D Miyamoto, Kathryn C Chatfield,

Despite advances in both medical and surgical therapies, individuals with single ventricle heart disease (SV) remain at high risk for the development of heart failure (HF). However, the molecular mechanisms underlying remodeling and eventual HF in patients with SV are poorly characterized. Cardiolipin (CL), an inner mitochondrial membrane phospholipid, is ... Read more >>

Am. J. Physiol. Heart Circ. Physiol. (American journal of physiology. Heart and circulatory physiology)
[2020, 318(4):H787-H800]

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A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation.

Judith Marsman, Gregory Gimenez, Robert C Day, Julia A Horsfield, Gregory T Jones,

Abdominal aortic aneurysm (AAA) is a major cause of sudden death in the elderly. While AAA has some overlapping genetic and environmental risk factors with atherosclerosis, there are substantial differences, and AAA-specific medication is lacking. A recent meta-analysis of genome-wide association studies has identified four novel single-nucleotide polymorphisms (SNPs) specifically ... Read more >>

Hum. Mol. Genet. (Human molecular genetics)
[2020, 29(4):554-565]

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The role of flow rotation in the adult right atrium: a 4D flow cardiovascular magnetic resonance study.

Peter Dewhurst, Louise Coats, Jehill D Parikh, Kieren G Hollingsworth, Lian Gan,

OBJECTIVE:In healthy adults, the right atrium (RA) serves as a reservoir for the systemic flow return from the superior vena cava (SVC) and inferior vena cava (IVC), preparing the two flows to be transferred to the right ventricle (RV) and pulmonary circulation. This study aims to quantify the haemodynamics of ... Read more >>

Physiol Meas (Physiological measurement)
[2020, :]

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Wide frequency characterization of Intra-Body Communication for Leadless Pacemakers.

Mirko Maldari, Mohammad Albatat, Jacob Bergsland, Youcef Haddab, Chadi Jabbour, Patricia Desgreys,

Leadless Cardiac Pacemakers (LCP) have the potential to revolutionize Cardiac Rhythm Management (CRM). Current LCPs can only pace a single location of the heart limiting their use to patients requiring single-chamber stimulation. A Multi-node system of synchronized LCPs could be used in a significantly larger patient population. Synchronization using standard ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2020, :]

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Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure.

Marios Arvanitis, Emmanouil Tampakakis, Yanxiao Zhang, Wei Wang, Adam Auton, , Diptavo Dutta, Stephanie Glavaris, Ali Keramati, Nilanjan Chatterjee, Neil C Chi, Bing Ren, Wendy S Post, Alexis Battle,

Heart failure is a major public health problem affecting over 23 million people worldwide. In this study, we present the results of a large scale meta-analysis of heart failure GWAS and replication in a comparable sized cohort to identify one known and two novel loci associated with heart failure. Heart ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1122]

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Numerical Simulation of the Effect of Pulmonary Vascular Resistance on the Hemodynamics of Reoperation After Failure of One and a Half Ventricle Repair.

Yan Fu, Aike Qiao, Yao Yang, Xiangming Fan,

ObjectiveThe one and a half ventricle repair (1.5VR) is a common clinical choice for patients with right heart dysfunction. Considering the influence of blood circulation failure and reoperation in urgent need, this essay aims to explore the hemodynamic effects of different pulmonary vascular resistance (PVR) values on reoperation after 1.5VR ... Read more >>

Front Physiol (Frontiers in Physiology)
[2020, 11:]

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Autologous CXCR4+ Hematopoietic Stem Cells Injected Into the Scar Tissue of Chronic Myocardial Infarction Patients Normalizes Tissue Contractility and Perfusion.

José Luis Aceves, Rafael Vilchis López, Paúl Mondragón Terán, Carmen Martínez Escobedo, Mario A Marroquín Muciño, Guillermo García Castillo, Miriam Marmolejo Estrada, Fernando Rodríguez García, Guillermo Díaz Quiroz, Luis Felipe Montaño Estrada,

BACKGROUND:Chronic myocardial infarction (CMI), represents a public health and a financial burden. Since stem cell transplant is used to regenerate cardiac tissue after acute myocardial infarction. AIM OF THE STUDY:To determine if autologous CXCR4 stem cells could restore damaged myocardial tissue in patients with CMI lesions. METHODS:20 NYHA grade III ... Read more >>

Arch. Med. Res. (Archives of medical research)
[2020, :]

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Left-ventricular innervation assessed by 123I-SPECT/CT is associated with cardiac events in inherited arrhythmia syndromes.

Johannes Siebermair, Sebastian Lehner, Stefan M Sattler, Konstantinos D Rizas, Britt-Maria Beckmann, Alexander Becker, Julia Schiller, Corona Metz, Mathias Zacherl, Nadine Vonderlin, Tienush Rassaf, Dobromir Dobrev, Christoph Rischpler, Stefan Kääb, Marcus Hacker, Andrei Todica, Reza Wakili,

AIMS:Impaired myocardial sympathetic innervation assessed by 123Iodine-Metaiodobenzylguanidine (123I-MIBG) scintigraphy is associated with cardiac events. Since regional disparities of structural abnormalities are common in inherited arrhythmia syndromes (iAS), a chamber-specific innervation assessment of the right (RV) and left ventricle (LV) could provide important insights for a patient-individual therapy. Aim of this ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2020, :]

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