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ARENA-based activity profiling of tau and TDP-43 transgenic C. elegans.

Heather N Currey, Anna Malinkevich, Penny Melquist, Nicole F Liachko,

(microPublication biology)
[2020, 2020:]

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Difference in phenotypic severity of presumed null alleles of capg-1.

Sarah VanDiepenbos, Györgyi Csankovszki,

(microPublication biology)
[2020, 2020:]

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unc-42 regulates the expression of ASH terminal fate markers.

Jordan Wood, Denise Ferkey,

(microPublication biology)
[2019, 2019:]

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Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19.

Sarita Choudhary, Karli Sreenivasulu, Prasenjit Mitra, Sanjeev Misra, Praveen Sharma,

Since its first report in December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly emerged as a pandemic affecting nearly all countries worldwide. As the COVID-19 pandemic progresses, the need to identify genetic risk factors for susceptibility to this serious illness has ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2021, 41(2):129-138]

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Accurate serology for SARS-CoV-2 and common human coronaviruses using a multiplex approach.

Sophie van Tol, Ramona Mögling, Wentao Li, Gert-Jan Godeke, Arno Swart, Barbara Bergmans, Afke Brandenburg, Kristin Kremer, Jean-Luc Murk, Josine van Beek, Bas Wintermans, Johan Reimerink, Berend-Jan Bosch, Chantal Reusken,

Serology is a crucial part of the public health response to the ongoing SARS-CoV-2 pandemic. Here, we describe the development, validation and clinical evaluation of a protein micro-array as a quantitative multiplex immunoassay that can identify S and N-directed SARS-CoV-2 IgG antibodies with high specificity and sensitivity and distinguish them ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1965-1973]

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Risks and features of secondary infections in severe and critical ill COVID-19 patients.

Haocheng Zhang, Yi Zhang, Jing Wu, Yang Li, Xian Zhou, Xin Li, Haili Chen, Mingquan Guo, Shu Chen, Feng Sun, Richeng Mao, Chao Qiu, Zhaoqin Zhu, Jingwen Ai, Wenhong Zhang,

Objectives Severe or critical COVID-19 is associated with intensive care unit admission, increased secondary infection rate, and would lead to significant worsened prognosis. Risks and characteristics relating to secondary infections in severe COVID-19 have not been described. Methods Severe and critical COVID-19 patients from Shanghai were included. We collected lower ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1958-1964]

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Validation of Age-specific Survival Prediction in Pediatric Patients With Blunt Trauma Using Trauma and Injury Severity Score Methodology: A Ten-year Nationwide Observational Study

Chiaki Toida, Takashi Muguruma, Masayasu Gakumazawa, Mafumi Shinohara, Takeru Abe, Ichiro Takeuchi, Naoto Morimura,

Abstract Background: In-hospital mortality in trauma patients decreased recently owing to improved trauma injury prevention systems. However, no study which evaluated the validity of Trauma and Injury Severity Score (TRISS) in pediatrics by detailed classification of patients’ age and injury severity in Japan. This retrospective nationwide study evaluated the validity ... Read more >>

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The incidence of geriatric trauma is increasing and comparison of different scoring tools for the prediction of in-hospital mortality in geriatric trauma patients.

Libing Jiang, Zhongjun Zheng, Mao Zhang,

PURPOSE:The study aimed to examine the changing incidence of geriatric trauma and evaluate the predictive ability of different scoring tools for in-hospital mortality in geriatric trauma patients. METHODS:Annual reports released by the National Trauma Database (NTDB) in the USA from 2005 to 2015 and the Trauma Register DGU® in Germany ... Read more >>

World J Emerg Surg (World journal of emergency surgery : WJES)
[2020, 15(1):59]

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Multicenter evaluation of two chemiluminescence and three lateral flow immunoassays for the diagnosis of COVID-19 and assessment of antibody dynamic responses to SARS-CoV-2 in Taiwan.

Shey-Ying Chen, Yu-Lin Lee, Yi-Chun Lin, Nan-Yao Lee, Chia-Hung Liao, Yuan-Pin Hung, Min-Chi Lu, Jhong-Lin Wu, Wen-Pin Tseng, Chien-Hao Lin, Ming-Yi Chung, Chun-Min Kang, Ya-Fan Lee, Tai-Fen Lee, Chien-Yu Cheng, Cheng-Pin Chen, Chien-Hua Huang, Chun-Eng Liu, Shu-Hsing Cheng, Wen-Chien Ko, Po-Ren Hsueh, Shyr-Chyr Chen,

This multicenter, retrospective study included 346 serum samples from 74 patients with coronavirus disease 2019 (COVID-19) and 194 serum samples from non-COVID-19 patients to evaluate the performance of five anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody tests, i.e. two chemiluminescence immunoassays (CLIAs): Roche Elecsys® Anti-SARS-CoV-2 Test (Roche Test) and ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):2157-2168]

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Emergency nurses' perceptions regarding the risks appraisal of the threat of the emerging infectious disease situation in emergency departments.

Stanley Kam Ki Lam, Enid Wai Yung Kwong, Maria Shuk Yu Hung, Wai Tong Chien,

Purpose: Emerging infectious diseases are considered as a pressing challenge to global public health. Throughout public health response to emerging infectious diseases, emergency nurses are situated at the forefront of the healthcare system. The present study has explored emergency nurses' perceptions regarding the risks appraisal of the threat of the ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):e1718468]

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Biopsychosocial Model and Perceived Constipation Severity According to the Constipation Phenotype.

Michel Bouchoucha, Marinos Fysekidis, David Deutsch, Bakhtiar Bejou, Jean-Marc Sabate, Robert Benamouzig,

PURPOSE:Constipation is a frequent complaint of patients with functional bowel disorders. The present study aimed to evaluate the relationship between the perceived constipation severity with demographics, clinical, physiological, and psychological parameters in constipated patients. PATIENTS AND METHODS:Four hundred seven constipated patients were included and had clinical, physiological, and psychological evaluation. ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2020, :]

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The incidence of geriatric trauma is increasing and comparison of different scoring tools for the prediction of in-hospital mortality in geriatric trauma patients

Libing Jiang, Zhongjun Zheng, Mao Zhang,

Abstract Purpose: The study aimed to test the incidence of geriatric trauma is increasing and evaluate different scoring tools for the prediction of in-hospital mortality in geriatric trauma patients. Methods: Part 1: Annual reports released by the National Trauma Database (NTDB) in the United States from 2005 to 2015 and ... Read more >>

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Sex Hormone Relations to Histologic Severity of Pediatric Nonalcoholic Fatty Liver Disease.

Noel T Mueller, Tiange Liu, Elana B Mitchel, Katherine P Yates, Ayako Suzuki, Cynthia Behling, Joel E Lavine,

CONTEXT:Sex hormones have been linked with presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults, but it is unknown if they affect severity of pediatric NAFLD. OBJECTIVE:To examine associations of circulating SHBG, estrogens, and androgens with key histologic features of pediatric, biopsy-confirmed NAFLD. DESIGN:Baseline assessment of longitudinal cohorts ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, 105(11):]

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Effect of alcohol intake on the severity of injuries caused by slipping down.

Kyoung Sung Yun, Jin-Seong Cho, Yong Su Lim, Jae Ho Jang, Hyuk Jun Yang, Woo Sung Choi,

OBJECTIVE:Alcohol consumption is associated with an increased risk of injuries. However, its effects on injury severity and mortality remain unclear. Specifically, the effects of alcohol intake on the severity of slip injuries have not been thoroughly investigated. Therefore, our study aimed to investigate the effects of alcohol intake on injury ... Read more >>

Clin Exp Emerg Med (Clinical and experimental emergency medicine)
[2020, 7(3):170-175]

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The risk factors related to the severity of pain in patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome.

Jing Chen, Haomin Zhang, Di Niu, Hu Li, Kun Wei, Li Zhang, Shuiping Yin, Longfei Liu, Xiansheng Zhang, Meng Zhang, Chaozhao Liang,

BACKGROUND:Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a disease with diverse clinical manifestations, such as pelvic pain or perineal pain. Although recent studies found several risk factors related to the pain severity of CP/CPPS patients, results were inconsistent. Here, we aimed to identify novel risk factors that are closely related ... Read more >>

BMC Urol (BMC urology)
[2020, 20(1):154]

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Patient Coded Severity and Payment Penalties Under the Hospital Readmissions Reduction Program: A Machine Learning Approach.

Jun Li, Devraj Sukul, Ushapoorna Nuliyalu, Andrew M Ryan,

OBJECTIVE:The objective of this study was to examine variation in hospital responses to the Centers for Medicare and Medicaid's expansion of allowable secondary diagnoses in January 2011 and its association with financial penalties under the Hospital Readmission Reduction Program (HRRP). DATA SOURCES/STUDY SETTING:Medicare administrative claims for discharges between July 2008 ... Read more >>

Med Care (Medical care)
[2020, 58(11):1022-1029]

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Quantitative assessment on the severity degree of Alzheimer dementia by algebraic analysis on cortical thickness profiles of human brains

Sangyeol Kim, Seongjun Park, Iksoo Chang,

Alzheimer disease (AD) affects profoundly the quality of human life. Quantifying the severity degree of Alzheimer dementia for an individual person is critical for the early diagnose and prescription for delaying the further dementia progression. However, the quantitative diagnose for human subjects of the mild cognitively impairment (MCI) or AD ... Read more >>

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Diabetes mellitus association with coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis.

Gaurav Aggarwal, Giuseppe Lippi, Carl J Lavie, Brandon Michael Henry, Fabian Sanchis-Gomar,

Highlights There are ~ 2-fold increased odds of severe coronavirus disease 2019 (COVID-19) and a ~ 2-fold increased risk of odds of mortality in patients with history of diabetes mellitus compared to those without diabetes mellitus. Patients with a history of diabetes mellitus should be closely monitored if they get infected with COVID-19. Results ... Read more >>

J Diabetes (Journal of diabetes)
[2020, 12(11):851-855]

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Sensory Reactivity at 1 and 2 Years Old is Associated with ASD Severity During the Preschool Years.

Rebecca Grzadzinski, Kevin Donovan, Kinh Truong, Sallie Nowell, Helen Lee, John Sideris, Lauren Turner-Brown, Grace T Baranek, Linda R Watson,

Children with Autism Spectrum Disorder (ASD) often display atypical sensory reactivity within the first years of life, prior to a diagnosis. This study examined sensory reactivity patterns at 14 months, changes from 14 to 23 months, and later ASD severity at 3 to 5 years of age in children (n = 87) at elevated likelihood ... Read more >>

J Autism Dev Disord (Journal of autism and developmental disorders)
[2020, 50(11):3895-3904]

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Effects of disease severity on quality of life in patients with psoriasis.

Elif Burcu Yavuz Daglioglu, Dursun Cadirci, Mustafa Aksoy,

Psoriasis is one of the leading dermatological diseases that can result in degradation in quality of life (QOL). We aimed to evaluate the effects of disease severity on QOL in psoriasis patients living in our region. 59 female and 41 male patients diagnosed with psoriasis were included in the study. ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2020, :e14422]

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Correlation between Chest CT Severity Scores and the Clinical Parameters of Adult Patients with COVID-19 pneumonia

Ghufran Saeed, Waqar Gaba, Asad Shah, Abeer Al Helali, Emadullah Raidullah, Ameirah Al Ali, Mohammed Elghazali, Deena Ahmed, Shaikha Al Kaabi, Safaa Almazrouei,

Purpose Our aim is to correlate the clinical condition of patients with COVID-19 infection with the 25 Point CT severity score by Chang et al (devised for assessment of ARDS in patients with SARS in 2005). Material and Methods Data of consecutive symptomatic patients who were suspected to have ... Read more >>

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[Comparison of severity classification of Chinese protocol, pneumonia severity index and CURB-65 in risk stratification and prognostic assessment of coronavirus disease 2019].

X Wang, Z W Hu, Y Hu, Y Cheng, H Zhang, H C Li, J Ma, G F Wang, J P Zhao,

Objective: To investigate the application of severity classification according to the protocol on the Diagnosis and Treatment of coronavirus disease 2019(COVID-19)by the National Health Commission of China, pneumonia severity index(PSI) and CURB-65 in risk stratification and prognostic assessment of COVID-19. Methods: Clinical data of 234 in-hospital patients with COVID-19 were collected ... Read more >>

Zhonghua Jie He He Hu Xi Za Zhi (Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases)
[2020, 43(10):834-838]

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New method for quantification of severity of isolated scaphocephaly linked to intracranial volume.

Otto D M Kronig, Sophia A J Kronig, Léon N A Van Adrichem,

PURPOSE:The aim is to implement Utrecht Cranial Shape Quantificator (UCSQ) for quantification of severity of scaphocephaly and compare UCSQ with the most used quantification method, cranial index (CI). Additionally, severity is linked to intracranial volume (ICV). METHODS:Sinusoid curves of 21 pre-operative children (age < 2 years) with isolated scaphocephaly were created. Variables ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, :]

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Prediction of Depression Severity Scores Based on Functional Connectivity and Complexity of the EEG Signal.

Yousef Mohammadi, Mohammad Hassan Moradi,

BACKGROUND:Depression is one of the most common mental disorders and the leading cause of functional disabilities. This study aims to specify whether functional connectivity and complexity of brain activity can predict the severity of depression (Beck Depression Inventory-II scores). METHODS:Resting-state, eyes-closed EEG data were recorded from 60 depressed patients. A ... Read more >>

Clin EEG Neurosci (Clinical EEG and neuroscience)
[2020, :1550059420965431]

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Prediction of mortality in critically-ill elderly trauma patients: a single centre retrospective observational study and comparison of the performance of trauma scores.

Rebecca Egglestone, David Sparkes, Ahilanandan Dushianthan,

BACKGROUND:Trauma in the elderly (≥ 65 years) population is increasing. This study compares the performance of trauma scoring systems in predicting 30-day mortality among the traumatised elderly patients admitted to the intensive care unit in a major trauma centre. METHODS:We collected retrospective data for all elderly trauma patients admitted to our ... Read more >>

Scand J Trauma Resusc Emerg Med (Scandinavian journal of trauma, resuscitation and emergency medicine)
[2020, 28(1):95]

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