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Inhibition of SARS-CoV 3CL protease by flavonoids.

Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim,

There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):145-151]

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The different clinical characteristics of corona virus disease cases between children and their families in China - the character of children with COVID-19.

Liang Su, Xiang Ma, Huafeng Yu, Zhaohua Zhang, Pengfei Bian, Yuling Han, Jing Sun, Yanqin Liu, Chun Yang, Jin Geng, Zhongfa Zhang, Zhongtao Gai,

This study aims to analyze the different clinical characteristics between children and their families infected with severe acute respiratory syndrome coronavirus 2. Clinical data from nine children and their 14 families were collected, including general status, clinical, laboratory test, and imaging characteristics. All the children were detected positive result after ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):707-713]

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Emergency nurses' perceptions regarding the risks appraisal of the threat of the emerging infectious disease situation in emergency departments.

Stanley Kam Ki Lam, Enid Wai Yung Kwong, Maria Shuk Yu Hung, Wai Tong Chien,

Purpose: Emerging infectious diseases are considered as a pressing challenge to global public health. Throughout public health response to emerging infectious diseases, emergency nurses are situated at the forefront of the healthcare system. The present study has explored emergency nurses' perceptions regarding the risks appraisal of the threat of the ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):e1718468]

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Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China.

Yang Li, Ruihong Zhao, Shufa Zheng, Xu Chen, Jinxi Wang, Xiaoli Sheng, Jianying Zhou, Hongliu Cai, Qiang Fang, Fei Yu, Jian Fan, Kaijin Xu, Yu Chen, Jifang Sheng,

A woman with 2019 novel coronavirus disease in her 35th week of pregnancy delivered an infant by cesarean section in a negative-pressure operating room. The infant was negative for severe acute respiratory coronavirus 2. This case suggests that mother-to-child transmission is unlikely for this virus. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(6):]

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Community Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, Shenzhen, China, 2020.

Jiaye Liu, Xuejiao Liao, Shen Qian, Jing Yuan, Fuxiang Wang, Yingxia Liu, Zhaoqin Wang, Fu-Sheng Wang, Lei Liu, Zheng Zhang,

Since early January 2020, after the outbreak of 2019 novel coronavirus infection in Wuhan, China, ≈365 confirmed cases have been reported in Shenzhen, China. The mode of community and intrafamily transmission is threatening residents in Shenzhen. Strategies to strengthen prevention and interruption of these transmissions should be urgently addressed. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(6):]

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Potential Presymptomatic Transmission of SARS-CoV-2, Zhejiang Province, China, 2020.

Zhen-Dong Tong, An Tang, Ke-Feng Li, Peng Li, Hong-Ling Wang, Jing-Ping Yi, Yong-Li Zhang, Jian-Bo Yan,

We report a 2-family cluster of persons infected with severe acute respiratory syndrome coronavirus 2 in the city of Zhoushan, Zhejiang Province, China, during January 2020. The infections resulted from contact with an infected but potentially presymptomatic traveler from the city of Wuhan in Hubei Province. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(5):]

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COVID-19 in 2 Persons with Mild Upper Respiratory Symptoms on a Cruise Ship, Japan.

Takeshi Arashiro, Keiichi Furukawa, Akira Nakamura,

We describe 2 cases of COVID-19 in patients with mild upper respiratory symptoms. Both patients worked on a cruise ship quarantined off the coast of Japan. One patient had persistent, low-grade upper respiratory tract symptoms without fever. The other patient had rapid symptom cessation but persistent viral RNA detection. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(6):]

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Detection of Novel Coronavirus by RT-PCR in Stool Specimen from Asymptomatic Child, China.

An Tang, Zhen-Dong Tong, Hong-Ling Wang, Ya-Xin Dai, Ke-Feng Li, Jie-Nan Liu, Wen-Jie Wu, Chen Yuan, Meng-Lu Yu, Peng Li, Jian-Bo Yan,

We report an asymptomatic child who was positive for a 2019 novel coronavirus by reverse transcription PCR in a stool specimen 17 days after the last virus exposure. The child was virus positive in stool specimens for at least an additional 9 days. Respiratory tract specimens were negative by reverse ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(6):]

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Student nurses' ethical views on responses to the severe acute respiratory syndrome outbreak.

Joseph Km Kam, Eric Chan, Albert Lee, Vivian Wi Wei, Kin On Kwok, Dominic Lui, Robert Kn Yuen,

BACKGROUND:Fifteen years have passed since the outbreak of severe acute respiratory syndrome in Hong Kong. At that time, there were reports of heroic acts among professionals who cared for these patients, whose bravery and professionalism were highly praised. However, there are concerns about changes in new generation of nursing professionals. ... Read more >>

Nurs Ethics (Nursing ethics)
[2020, :969733019895804]

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Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) infection during late pregnancy: A Report of 18 patients from Wuhan, China

Jing Yang, Lu Zhang, Lan Dong, Lei Ming, Min Wei, Jun Li, Ruheng Hu,

<title>Abstract</title> <p> Background Compared with Severe Acute Respiratory Syndrome(SARS) and Middle East Respiratory Syndrome(MESR), Corona Virus Disease 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible. However, reports on pregnant women infected with SARS-CoV-2 were very limited. By sharing the clinical characteristics, treatments and outcomes of ... Read more >>

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Preparedness and Lessons Learned from the Novel Coronavirus Disease.

Sai Krishna Gudi, Komal Krishna Tiwari,

In a short span, a novel coronavirus (SARS-CoV-2) has captured global consciousness by significantly affecting the day-to-day life of humans and emerged as a public health emergency. Undoubtedly, it indicates that lessons learnt from the past epidemics of coronaviruses such as the Middle East Respiratory Syndrome (MERS) and Severe Acute ... Read more >>

Int J Occup Environ Med (The international journal of occupational and environmental medicine)
[2020, 11(2):108-112]

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Modeling of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Proteins by Machine Learning and Physics-Based Refinement

Lim Heo, Michael Feig,

Protein structures are crucial for understanding their biological activities. Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is an urgent need to understand the biological behavior of the virus and provide a basis for developing effective therapies. Since the proteome of the virus was determined, some ... Read more >>

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Novel coronavirus takes flight from bats?

Ashley York,

Nat. Rev. Microbiol. (Nature reviews. Microbiology)
[2020, 18(4):191]

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Identifying Locations with Possible Undetected Imported Severe Acute Respiratory Syndrome Coronavirus 2 Cases by Using Importation Predictions.

Pablo Martinez De Salazar, René Niehus, Aimee Taylor, Caroline O'Flaherty Buckee, Marc Lipsitch,

Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection exported from mainland China could lead to self-sustained outbreaks in other countries. By February 2020, several countries were reporting imported SARS-CoV-2 cases. To contain the virus, early detection of imported SARS-CoV-2 cases is critical. We used air travel volume estimates ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(7):]

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Immune Epitope Map of the Reported Protein Sequences of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Leonardo Guevarra, Gianne Ulanday,

<title>Abstract</title> <p> Identifying immunogenic sequences of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins is important in developing epitope-based vaccine and diagnostics. This step is critical in designing potent vaccines and highly specific diagnostic tools which can help prevent the spread of this disease. In this study, ... Read more >>

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Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies

Daniel Wrapp, Dorien De Vlieger, Kizzmekia Corbett, Gretel Torres, Wander Van Breedam, Kenny Roose, Loes van Schie, Markus Hoffmann, Stefan Pöhlmann, Barney Graham, Nico Callewaert, Bert Schepens, Xavier Saelens, Jason McLellan, ,

The pathogenic Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV-1) and COVID-19 coronavirus (SARS-CoV-2) have all emerged into the human population with devastating consequences. These viruses make use of a large envelope protein called spike (S) to engage host cell receptors and catalyze membrane fusion. Because ... Read more >>

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A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome.

Shibo Jiang, Shuai Xia, Tianlei Ying, Lu Lu,

Cell. Mol. Immunol. (Cellular and Molecular Immunology)
[0, :1-1]

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The SARS-CoV-2 Vaccine Pipeline: an Overview.

Wen-Hsiang Chen, Ulrich Strych, Peter J Hotez, Maria Elena Bottazzi,

Purpose of ReviewThe goal of this review is to provide a timely overview on efforts to develop a vaccine for the 2019 novel coronavirus SARS-CoV-2, the causative agent of coronavirus disease (COVID-19).Recent FindingsPrevious research efforts to develop a severe acute respiratory syndrome coronavirus (SARS-CoV) vaccine in the years following the ... Read more >>

Curr Trop Med Rep (Current Tropical Medicine Reports)
[0, :1-4]

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COVID-19 pneumonia: infection control protocol inside computed tomography suites.

Kento Nakajima, Hideaki Kato, Tsuneo Yamashiro, Toshiharu Izumi, Ichiro Takeuchi, Hideaki Nakajima, Daisuke Utsunomiya,

A novel coronavirus (severe acute respiratory syndrome coronavirus 2) causes a cluster of pneumonia cases in Wuhan, China. It spread rapidly and globally. CT imaging is helpful for the evaluation of the novel coronavirus disease 2019 (COVID-19) pneumonia. Infection control inside the CT suites is also important to prevent hospital-related ... Read more >>

Jpn J Radiol (Japanese journal of radiology)
[0, :1-3]

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Clinical features and the maternal and neonatal outcomes of pregnant women with coronavirus disease 2019

Rui Nie, Shao-shuai Wang, Qiong Yang, Cui-fang Fan, Yu-ling Liu, Wen-cong He, Mei Jiang, Cheng-cheng Liu, Wan-jiang Zeng, Jian-li Wu, Kutluk Oktay, Ling Feng, Lei Jin,

BACKGROUND There is little information about the coronavirus disease 2019 (Covid-19) during pregnancy. This study aimed to determine the clinical features and the maternal and neonatal outcomes of pregnant women with Covid-19. METHODS In this retrospective analysis from five hospitals, we included pregnant women with Covid-19 from January 1 ... Read more >>

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Anesthetic Management of Patients Undergoing Aortic Dissection Repair With Suspected Severe Acute Respiratory Syndrome Coronavirus-2 Infection.

Hao He, Shuai Zhao, Linlin Han, Qi Wang, Haifa Xia, Xin Huang, Shanglong Yao, Jiapeng Huang, Xiangdong Chen,

Severe acute respiratory syndrome coronavirus-2 is still active in Wuhan, China, and is spreading to the rest of the world. Recently, perioperative anesthetic management in patients with suspected or confirmed coronavirus-2 has been reported. However, little has been reported on the anesthetic management of patients undergoing aortic dissection repair in ... Read more >>

J. Cardiothorac. Vasc. Anesth. (Journal of cardiothoracic and vascular anesthesia)
[2020, :]

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Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation.

Guangming Ye, Zhenyu Pan, Yunbao Pan, Qiaoling Deng, Liangjun Chen, Jin Li, Yirong Li, Xinghuan Wang,

OBJECTIVES:Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. However, limited data was available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reactivation. This study aimed to evaluate the clinical characteristics of the SARS-CoV-2 reactivation. METHODS:Clinical records, ... Read more >>

J. Infect. (The Journal of infection)
[2020, :]

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Double-Quencher Probes Improved the Detection Sensitivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by One-Step RT-PCR

Yosuke Hirotsu, Hitoshi Mochizuki, Masao Omata,

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerges in Wuhan City, Hubei Province, spreads worldwide, and threats the human life. The detection of SARS-CoV-2 is important for the prevention of the outbreak and management of patients. Real-time reverse-transcription polymerase chain reaction (RT-PCR) assay detected the virus in clinical laboratory. ... Read more >>

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Identifying and Interrupting Superspreading Events-Implications for Control of Severe Acute Respiratory Syndrome Coronavirus 2.

Thomas R Frieden, Christopher T Lee,

It appears inevitable that severe acute respiratory syndrome coronavirus 2 will continue to spread. Although we still have limited information on the epidemiology of this virus, there have been multiple reports of superspreading events (SSEs), which are associated with both explosive growth early in an outbreak and sustained transmission in ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(6):]

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SARS-CoV-2: What do we know so far?

Pratik Hemant Khedkar, Andreas Patzak,

We are living in times where a viral disease has brought normal life in much of the world to a halt. Named after its causative agent, coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus recently renamed as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 manifests as dry ... Read more >>

Acta Physiol (Oxf) (Acta physiologica (Oxford, England))
[2020, :e13470]

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