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Enhanced pentylenetetrazole sensitivity in a C. elegans mutant associated with DNM1 encephalopathy.

Madeline A Vaji, Guy A Caldwell, Kim A Caldwell,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 0 times

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Phenotypic modulation of pentylenetetrazole-induced convulsive behaviors in C. elegans carrying a mutation associated with Alzheimer's disease.

Madeline A Vaji, Guy A Caldwell, Kim A Caldwell,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 0 times

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The muscarinic agonist arecoline suppresses motor circuit hyperactivity in C. elegans.

Katherine A McCulloch, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 1 time

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Application of the red-shifted channel rhodopsin Chrimson for the Caenorhabditis elegans cGAL bipartite system.

Mengyi Cao, Cynthia Chai, Jonathan Liu, Paul Sternberg,

MicroPubl Biol (microPublication biology)
[2018, 2018:]

Cited: 0 times

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Optogenetic Interrogation of ChR2-Expressing GABAergic Interneurons After Transplantation into the Mouse Brain.

Muhammad N Arshad, Gloster B Aaron, Janice R Naegele,

This paper describes research methods to investigate the development of synaptic connections between transplanted GABAergic interneurons and endogenous neurons in the adult mouse hippocampus. Our protocol highlights methods for retroviral labeling adult-born GCs, one of the few cell types in the adult brain to be continuously renewed throughout life. By ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2021, 2191:235-259]

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Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl.

Xia Wu, Gangfeng Yan, Shuzhen Han, Yingzi Ye, Xunjia Cheng, Hairong Gong, Hui Yu,

Balamuthia amoebic encephalitis has a subacute-to-chronic course and is almost invariably fatal owing to delayed diagnosis and a lack of effective therapy. Here, we report a 13-year-old girl with cutaneous lesions and multifocal granulomatous encephalitis. The patient underwent a series of tests and was suspected as having tuberculosis. She was ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1379-1387]

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1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy.

Barbara Kaproń, Robert Czarnomysy, Mariusz Wysokiński, Rudolf Andrys, Kamil Musilek, Andrea Angeli, Claudiu T Supuran, Tomasz Plech,

There are numerous studies supporting the contribution of oxidative stress to the pathogenesis of epilepsy. Prolonged oxidative stress is associated with the overexpression of ATP-binding cassette transporters, which results in antiepileptic drugs resistance. During our studies, three 1,2,4-triazole-3-thione derivatives were evaluated for the antioxidant activity and anticonvulsant effect in the ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):993-1002]

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The structure and function of TRIP8b, an auxiliary subunit of hyperpolarization-activated cyclic-nucleotide gated channels.

Ye Han, Kyle A Lyman, Kendall M Foote, Dane M Chetkovich,

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed throughout the mammalian central nervous system (CNS). These channels have been implicated in a wide range of diseases, including Major Depressive Disorder and multiple subtypes of epilepsy. The diversity of functions that HCN channels perform is in part attributable to differences in their ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):110-122]

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A de novo CACNA1D missense mutation in a patient with congenital hyperinsulinism, primary hyperaldosteronism and hypotonia.

María Carmen De Mingo Alemany, Luis Mifsud Grau, Francisca Moreno Macián, Belén Ferrer Lorente, Sara León Cariñena,

Congenital hyperinsulinemic hypoglycemia is the most frequent cause of persistent and recurrent hypoglycemia in the first years of life and in many patients rare genetic variants can be identified. Recently a case of congenital hyperinsulinemic hypoglycemia and a severe neurodevelopmental syndrome due to a mutation in the voltage-gated Cav1.3 Ca2+ ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):175-180]

Cited: 1 time

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3 receptor antagonists/inverse agonists containing triazole moiety.

Mingxia Song, Rui Yan, Yanhui Zhang, Dongfu Guo, Naiming Zhou, XianQing Deng,

Histamine H3 receptors (H3R) antagonists/inverse agonists are becoming a promising therapeutic approach for epilepsy. In this article, novel nonimidazole H3R antagonists/inverse agonists have been designed and synthesised via hybriding the H3R pharmacophore (aliphatic amine with propyloxy chain) with the 1,2,4-triazole moiety as anticonvulsant drugs. The majority of antagonists/inverse agonists prepared ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):1310-1321]

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RNA Editing in Neurological and Neurodegenerative Disorders.

Pedro Henrique Costa Cruz, Yukio Kawahara,

The brain is one of the organs that are preferentially targeted by adenosine-to-inosine (A-to-I) RNA editing, a posttranscriptional modification. This chemical modification affects neuronal development and functions at multiple levels, leading to normal brain homeostasis by increasing the complexity of the transcriptome. This includes modulation of the properties of ion ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2021, 2181:309-330]

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Fyn gene silencing reduces oligodendrocytes apoptosis through inhibiting ERK1/2 phosphorylation in epilepsy.

Xinming Luo, Zhengyu Li, Jing Zhao, Yan Deng, Yuqin Zhong, Ming Zhang,

This study aimed to investigate the effect of Fyn gene silencing on the apoptosis of oligodendrocytes (OLs) in epileptic model in vitro and the involved mechanism. Primary oligodendrocyte pro-genitor cells (OPCs) were separated from rats and differentiated to OLs. Immunofluorescent labeling showed positive expression of A2B5 in OPCs and Olig2 ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):298-304]

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Social isolation and exclusion: the parents' experience of caring for children with rare neurodevelopmental disorders.

Genevieve Currie, Joanna Szabo,

Purpose: The experiences of parents caring for the complex care needs of children with rare neurodevelopmental disorders are not well understood. Parents struggle to meet their children's medical, behavioural, and social needs within and across health, social, and family systems. The purpose of this study was to explore the parents' ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1725362]

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Investigation of Cerebral O-(2-[18F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models.

Carina Stegmayr, Rainer Surges, Chang-Hoon Choi, Nicole Burda, Gabriele Stoffels, Christian Filß, Antje Willuweit, Bernd Neumaier, Alexander Heinzel, N Jon Shah, Felix M Mottaghy, Karl-Josef Langen,

PURPOSE:A recent study reported on high, longer lasting and finally reversible cerebral uptake of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) induced by epileptic activity. Therefore, we examined cerebral [18F]FET uptake in two chemically induced rat epilepsy models and in patients with focal epilepsy to further investigate whether this phenomenon represents a major pitfall in ... Read more >>

Mol Imaging Biol (Molecular imaging and biology)
[2020, 22(5):1255-1265]

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Brain calcification because of neurocysticercosis: a vast field to be explored.

Javier A Bustos, Christina M Coyle,

PURPOSE OF REVIEW:Neurocysticercosis is the most common helminthic infection of the central nervous system caused by the larval stage of the pork tapeworm, Taenia solium. Endemic regions include Latin American countries, sub-Saharan Africa, and large regions of Asia, including the Indian subcontinent and is a global health problem. Seizures are ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(5):334-338]

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Cannabidiol for Adjuvant Treatment of Seizures Associated with Lennox-Gastaut Syndrome and Dravet Syndrome: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

Ben Wijnen, Nigel Armstrong, Bram Ramaekers, Willem Witlox, Marie Westwood, Debra Fayter, Steve Ryder, Titas Buksnys, Gill Worthy, Kate Misso, Sabine Grimm, Jos Kleijnen, Manuela Joore,

GW Research Ltd. provided two separate, but similar, submissions to the National Institute for Health and Care Excellence (NICE) on the clinical and cost-effectiveness of cannabidiol (CBD) 10 mg/kg/day, trade name Epidyolex®, for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS). This paper highlights important ... Read more >>

Pharmacoeconomics (PharmacoEconomics)
[2020, 38(10):1043-1053]

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Acute Childhood Viral Encephalitis in Southern Brazil.

Daniel Almeida do Valle, Mara Lúcia Schmitz Ferreira Santos, Heloísa Ihle Garcia Giamberardino, Sonia Mara Raboni, Rosana Herminia Scola,

BACKGROUND:Viral meningoencephalitis is highly heterogeneous, varying by geographic location. The aim of this study was to characterize the etiology and reporting the clinical findings and outcome of viral encephalitis in children in southern Brazil. METHODS:A cross-Sectional study was conducted at Hospital Pequeno Príncipe, Curitiba, Brazil, between January 2013 and December ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, 39(10):894-898]

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Diagnostic Value of Electroencephalography with Ten Electrodes in Critically Ill Patients.

M Brandon Westover, Kapil Gururangan, Matthew S Markert, Benjamin N Blond, Saien Lai, Shawna Benard, Stephan Bickel, Lawrence J Hirsch, Josef Parvizi,

BACKGROUND:In critical care settings, electroencephalography (EEG) with reduced number of electrodes (reduced montage EEG, rm-EEG) might be a timely alternative to the conventional full montage EEG (fm-EEG). However, past studies have reported variable accuracies for detecting seizures using rm-EEG. We hypothesized that the past studies did not distinguish between differences ... Read more >>

Neurocrit Care (Neurocritical care)
[2020, 33(2):479-490]

Cited: 2 times

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Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies.

Catherine A Christian, Doodipala Samba Reddy, Jamie Maguire, Patrick A Forcelli,

The epilepsies are common neurologic disorders characterized by spontaneous recurrent seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many cases, by associated comorbidities as well. The primary courses of treatment are pharmacological, dietary, and/or surgical, depending on several factors, including the areas of ... Read more >>

Pharmacol. Rev. (Pharmacological reviews)
[2020, 72(4):767-800]

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Triggers of Aggressive Behaviors in Intellectually Disabled Adults and Their Association with Autism, Medical Conditions, Psychiatric Disorders, Age and Sex: A Large-Scale Study.

Ira L Cohen, John A Tsiouris,

Aggressive behaviors in those with intellectual disability (ID) and autism (ASD) have been linked to a variety of factors including ID level, age, sex, psychiatric disorders, and medical conditions but these factors have not been studied, in large samples, in terms of how they affect the stimuli that trigger aggression. ... Read more >>

J Autism Dev Disord (Journal of autism and developmental disorders)
[2020, 50(10):3748-3762]

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Focal Neurological Seizure due to Hyperglycemic Hyperosmolar Non-Ketotic Syndrome in Undiagnosed Diabetes Mellitus

Alexander Muacevic, John R Adler, Mihir Odak, Steven Douedi, Vandan Upadhyaya, Mustafa Fadhel, James Cosentino,

Hyperglycemic hyperosmolar non-ketotic syndrome (HHNS) is a life-threatening complication of type 2 diabetes mellitus with a wide range of presenting symptoms. Neurological symptoms, such as coma, can also be part of the manifestation of HHNS; however, focal seizures remain a rare but notable association.  A 85-year-old male patient with no ... Read more >>

Cureus (Cureus)
[0, 12(8):]

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Two cases of Nicolaides-Baraitser syndrome, one with a novel SMARCA2 variant.

Kadri Karaer,

Nicolaides-Baraitser syndrome (NCBRS) (OMIM 601358) is an uncommon but well-recognized autosomal dominant entity that is characterized by sparse scalp hair, characteristic coarse facies, microcephaly, seizures, developmental delay, intellectual disability (ID) and prominence of the interphalangeal joints and distal phalanges. Seizures are also common finding besides developmental delay and ID, which ... Read more >>

Clin. Dysmorphol. (Clinical dysmorphology)
[2020, 29(4):189-192]

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Characterization of kindled VGAT-Cre mice as a new animal model of temporal lobe epilepsy.

Justyna Straub, Agnieszka Gawda, Pranav Ravichandran, Bailey McGrew, Elsa Nylund, Julianna Kang, Cassidy Burke, Iuliia Vitko, Michael Scott, John Williamson, Suchitra Joshi, Jaideep Kapur, Edward Perez-Reyes,

OBJECTIVE:Development of novel therapies for temporal lobe epilepsy is hindered by a lack of models suitable for drug screening. While testing the hypothesis that "inhibiting inhibitory neurons" was sufficient to induce seizures, it was discovered that a mild electrical kindling protocol of VGAT-Cre mice led to spontaneous motor and electrographic ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Seizure in patients with COVID-19

Amir Emami, Nima Fadakar, Ali Akbari, Mehrzad Lotfi, Mohsen Farazdaghi, Fatemeh Javanmardi, Tahereh Rezaei, Ali A. Asadi-Pooya,

Objective The purpose of the current study was to collect the data on the occurrence of seizures in patients with COVID-19 and to clarify the circumstances of the occurrence of seizures in these patients. Methods All consecutive patients who referred to healthcare facilities anywhere in Fars province (located in South ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :1-5]

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