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Schizophrenia

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MicroRNA-15a, microRNA-15b and microRNA-16 inhibit the human dopamine D1 receptor expression in four cell lines by targeting 3'UTR -12 bp to + 154 bp.

Xue Wu, Feng-Ling Xu, Xi Xia, Bao-Jie Wang, Jun Yao,

Background: The abnormal expression Dopamine D1 receptor (DRD1) gives rise to the dysfunction of dopaminergic neurotransmitter and may be associated with the occurrence of schizophrenia. MicroRNAs (miRNAs) can regulate the DRD1 expression by binding 3'UTR and be involved in the post-transcriptional regulation.Methods: We first constructed the pmirGLO-recombined vectors of series ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):276-287]

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An exploration of medical student attitudes towards disclosure of mental illness.

Ian Fletcher, Michael Castle, Aaron Scarpa, Orrin Myers, Elizabeth Lawrence,

Background: Medical students are reluctant to access mental health services, despite having high rates of anxiety and depression. This reluctance persists through residency and into practice. Physicians and trainees who are unwell deliver lower quality patient care, behave less professionally, communicate less effectively and are at an increased risk for ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1727713]

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Atypical antipsychotics, more than just an antipsychotic.

Hiram Tendilla-Beltran, Gonzalo Flores,

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1477-1478]

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Opioid use and schizophrenia.

Kevin J Li, Anderson Chen, Lynn E DeLisi,

PURPOSE OF REVIEW:To summarize the current literature regarding comorbid schizophrenia and opioid use disorder (OUD). RECENT FINDINGS:Epidemiological evidence is unclear on whether patients with schizophrenia have a higher rate of OUD. Patients with OUD have been shown to have a higher risk of developing schizophrenia. However, it is clear that ... Read more >>

Curr Opin Psychiatry (Current opinion in psychiatry)
[2020, 33(3):219-224]

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Anomalies in language as a biomarker for schizophrenia.

Janna N de Boer, Sanne G Brederoo, Alban E Voppel, Iris E C Sommer,

PURPOSE OF REVIEW:After more than a century of neuroscience research, reproducible, clinically relevant biomarkers for schizophrenia have not yet been established. This article reviews current advances in evaluating the use of language as a diagnostic or prognostic tool in schizophrenia. RECENT FINDINGS:The development of computational linguistic tools to quantify language ... Read more >>

Curr Opin Psychiatry (Current opinion in psychiatry)
[2020, 33(3):212-218]

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Do we need sex-oriented clinical practice guidelines for the treatment of schizophrenia?

Piyumi Fernando, Iris E C Sommer, Alkomiet Hasan,

PURPOSE OF REVIEW:Clinical practice guidelines (CPGs) do not usually offer a sex-specific approach for the management of schizophrenia. With this narrative review, we aim to give an integrated and synthesized overview of the current state of knowledge regarding sex-specific aspects in schizophrenia and how this topic may be adapted in ... Read more >>

Curr Opin Psychiatry (Current opinion in psychiatry)
[2020, 33(3):192-199]

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Cannabidiol as a treatment option for schizophrenia: recent evidence and current studies.

Julie Schoevers, Judith E Leweke, F Markus Leweke,

PURPOSE OF REVIEW:The most recent studies published or initiated in the last 18 months, investigating cannabidiol in the treatment of symptoms of schizophrenia and related conditions are summarized, including observed tolerability and reported side-effects. RECENT FINDINGS:Recent studies focused on patients with sub-acute psychotic syndromes of schizophrenia, clinical high-risk state for ... Read more >>

Curr Opin Psychiatry (Current opinion in psychiatry)
[2020, 33(3):185-191]

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Antipsychotics and the microbiota.

Anderson Chen, Tae Yang Park, Kevin J Li, Lynn E DeLisi,

PURPOSE OF REVIEW:The gut microbiota has been speculated to underpin metabolic changes associated with chronic antipsychotic use. The change in the gut microbiota can also cause abnormal absorbtion from the gut into the blood stream (leaky gut syndrome) that can lead to inflammatory reactions, and thus, secondary damage to the ... Read more >>

Curr Opin Psychiatry (Current opinion in psychiatry)
[2020, 33(3):225-230]

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Switching from clozapine to paliperidone palmitate-3-monthly improved obesity, hyperglycemia and dyslipidemia lowering antipsychotic dose equivalents in a treatment-resistant schizophrenia cohort.

Juan Andrés Martínez-Andrés, Juan Antonio García-Carmona,

Clozapine, an antipsychotic developed in 1958, is considered the gold standard and the treatment of choice in treatment-resistant schizophrenia despite its side effects and despite 40-70% of these patients not responding to clozapine. In the last decade, new antipsychotics, such as paliperidone palmitate (PP), have emerged as well as its ... Read more >>

Int Clin Psychopharmacol (International clinical psychopharmacology)
[2020, 35(3):163-169]

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A systematic review of studies with clinician-rated scales on the pharmacological treatment of delusional disorder.

José Eduardo Muñoz-Negro, Francisco José Gómez-Sierra, Victor Peralta, Alexandre González-Rodríguez, Jorge A Cervilla,

To collect the best available evidence and to compare the first-generation antipsychotics (FGAs) vs. the second-generation antipsychotics (SGAs) in the treatment of delusional disorder (DD). Systematic review including studies evaluating treatment response in DD using clinician-rated scales appearing in PubMed and Web of Science databases from inception till September 2019. ... Read more >>

Int Clin Psychopharmacol (International clinical psychopharmacology)
[2020, 35(3):129-136]

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Affected neural networks as basis of disturbed motor function in schizophrenia.

Andrea Schmitt, Daniela Reich-Erkelenz, Peter Falkai,

Eur Arch Psychiatry Clin Neurosci (European archives of psychiatry and clinical neuroscience)
[2020, 270(3):279-280]

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Efficacy and safety of brexpiprazole in acute management of psychiatric disorders: a meta-analysis of randomized controlled trials.

Ayman Antoun Reyad, Eriny Girgis, Raafat Mishriky,

Brexpiprazole is a new atypical antipsychotic for schizophrenia management and as adjunct in major depressive disorder (MDD). We searched randomized controlled trials (RCT) to review brexpiprazole efficacy and tolerability in acute management of schizophrenia and MDD using PubMed, EUDRACT, ClinicalTrials.gov and Cochrane Central Register of Controlled Trials. A meta-analysis was ... Read more >>

Int Clin Psychopharmacol (International clinical psychopharmacology)
[2020, 35(3):119-128]

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Trace elements in schizophrenia: a systematic review and meta-analysis of 39 studies (N = 5151 participants).

Amene Saghazadeh, Maryam Mahmoudi, Shayan Shahrokhi, Maryam Mojarrad, Maedeh Dastmardi, Mona Mirbeyk, Nima Rezaei,

CONTEXT:The pathogenesis of schizophrenia appears to be multifaceted. OBJECTIVE:The aim of this meta-analysis of studies that investigated blood and hair concentrations of trace elements in people diagnosed with schizophrenia was to determine whether levels of trace elements in patients with schizophrenia differ from those in healthy individuals. DATA SOURCES:The PubMed, ... Read more >>

Nutr. Rev. (Nutrition reviews)
[2020, 78(4):278-303]

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Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia.

Rick A Adams, Daniel Bush, Fanfan Zheng, Sofie S Meyer, Raphael Kaplan, Stelios Orfanos, Tiago Reis Marques, Oliver D Howes, Neil Burgess,

Frontotemporal dysconnectivity is a key pathology in schizophrenia. The specific nature of this dysconnectivity is unknown, but animal models imply dysfunctional theta phase coupling between hippocampus and medial prefrontal cortex (mPFC). We tested this hypothesis by examining neural dynamics in 18 participants with a schizophrenia diagnosis, both medicated and unmedicated; ... Read more >>

Brain (Brain : a journal of neurology)
[2020, :]

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Cost to ambulatory care for schizophrenia in Family Medicine

Brian González-Pérez, Ricardo Salas-Flores, Raúl de León-Escobedo, Liliana Aurora Carrillo-Aguiar, Alejandra Salas-Galarza,

Background:The groups related to ambulatory care (GRAA, according to its initials in Spanish) are a classification of clinical diagnoses performed on patients receiving medical care in primary care; it is a comprehensive treatment for one year. Objective:To determine the costs of ambulatory care and sociodemographic characteristics of patients with schizophrenia ... Read more >>

Rev Med Inst Mex Seguro Soc (Revista medica del Instituto Mexicano del Seguro Social)
[2020, 57(4):213-217]

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Hearing Loss: The Silent Risk for Psychiatric Disorders in Late Life.

Dan G Blazer,

Hearing loss is among the most frequent problems experienced by older adults, yet psychiatrists and other clinicians often ignore the problem as an aggravation rather than recognizing that the problem might benefit from appropriate hearing health care. Many psychiatric disorders have been associated with hearing loss, including depression, schizophrenia and ... Read more >>

Clin. Geriatr. Med. (Clinics in geriatric medicine)
[2020, 36(2):201-209]

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Effects of country of origin and wave of immigration on prevalence of schizophrenia among first and second-generation immigrants: A 30-year retrospective study.

G Eger, Y Reuven, J Dreiher, P Shvartzman, M Weiser, D Aizenberg, A Weizman, S Lev-Ran,

OBJECTIVES:To compare the rates of schizophrenia among 1st and 2nd generation immigrants from two distinct backgrounds and across sequential periods of immigration. METHODS:A 30-years retrospective cohort study (187,184 individuals) of 1st and 2nd generation East-African immigrants (EAIs) and former Soviet-Union immigrants (FSUIs) who migrated to Israel between 1980 and 2012. ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, :]

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Quality of life and its association with current substance use, medication non-adherence and clinical factors of people with schizophrenia in Southwest Ethiopia: a hospital-based cross-sectional study.

Defaru Desalegn, Shimelis Girma, Tilahun Abdeta,

BackgroundSchizophrenia was ranked as one of the top ten illnesses contributing to the global burden of disease. But little is known about the quality of life among people with schizophrenia, in particular in low-income countries. This study was aimed to examine the association of quality of life with current substance ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2020, 18:]

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Rare and common variants analysis of the EMB gene in patients with schizophrenia.

Juan Zhou, Chuanchuan Ma, Ke Wang, Xiuli Li, Han Zhang, Jianhua Chen, Zhiqiang Li, Yongyong Shi,

BACKGROUND:Recent genome-wide association study showed rs10940346 locus near EMB gene was significantly associated with schizophrenia and suggested that EMB gene is one of the potentially causal genes for schizophrenia, but no causal variant has been identified. Our study aims to further verify EMB gene is a susceptibility gene for schizophrenia ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):135]

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Inflammatory markers are associated with psychomotor slowing in patients with schizophrenia compared to healthy controls.

David R Goldsmith, Nicholas Massa, Bradley D Pearce, Evanthia C Wommack, Alaaeddin Alrohaibani, Neha Goel, Bruce Cuthbert, Molly Fargotstein, Jennifer C Felger, Ebrahim Haroon, Andrew H Miller, Erica Duncan,

Patients with schizophrenia exhibit psychomotor deficits that are associated with poor functional outcomes. One pathway that may be associated with psychomotor slowing is inflammation. Inflammatory markers have been shown to be elevated in patients with schizophrenia and are associated with psychomotor deficits in both animal and human studies. Forty-three patients ... Read more >>

NPJ Schizophr (NPJ schizophrenia)
[2020, 6(1):8]

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Understanding individuals' subjective experiences of negative symptoms of schizophrenia: A qualitative study.

Isabelle Butcher, Katherine Berry, Gillian Haddock,

OBJECTIVES:Individuals with a diagnosis of schizophrenia often experience both positive and negative symptoms. Negative symptoms can be disabling and have a serious impact on everyday functioning. Despite the range of clinician-rated measurement tools used to assess negative symptoms, very little is known about how individuals subjectively experience these symptoms. This ... Read more >>

Br J Clin Psychol (The British journal of clinical psychology)
[2020, :]

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Pitch and Duration Mismatch Negativity and Heschl's Gyrus Volume in First-Episode Schizophrenia-Spectrum Individuals.

Dean F Salisbury, Anna R Shafer, Timothy K Murphy, Sarah M Haigh, Brian A Coffman,

Background. The mismatch negativity (MMN) brainwave indexes novelty detection. MMN to infrequent pitch (pMMN) and duration (dMMN) deviants is reduced in long-term schizophrenia. Although not reduced at first psychosis, pMMN is inversely associated with left hemisphere Heschl's gyrus (HG) gray matter volume within 1 year of first hospitalization for schizophrenia-spectrum ... Read more >>

Clin EEG Neurosci (Clinical EEG and neuroscience)
[2020, :1550059420914214]

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The effect of gender on the long-term course and outcome of schizophrenia in rural Ethiopia: a population-based cohort.

Rosie Mayston, Derege Kebede, Abebaw Fekadu, Girmay Medhin, Charlotte Hanlon, Atalay Alem, Teshome Shibre,

BACKGROUND:Although some studies have suggested that women with schizophrenia are more likely to achieve positive outcomes, the evidence-base is fraught with inconsistencies. In this study we compare the long-term course and outcomes for men and women living with schizophrenia in rural Ethiopia. METHODS:The Butajira course and outcome study for severe ... Read more >>

Soc Psychiatry Psychiatr Epidemiol (Social psychiatry and psychiatric epidemiology)
[2020, :]

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Evaluation of the Efficacy of BI 425809 Pharmacotherapy in Patients with Schizophrenia Receiving Computerized Cognitive Training: Methodology for a Double-blind, Randomized, Parallel-group Trial.

Philip D Harvey, Christopher R Bowie, Sean McDonald, Jana Podhorna,

BACKGROUND AND OBJECTIVE: Cognitive impairments associated with schizophrenia (CIAS) predict poor functional outcomes, but there are currently no approved pharmacological treatments for patients with CIAS. Additional cognitive stimulation may be required for pro-cognitive medications to improve efficacy, and computerized cognitive training (CCT) can be used to increase cognitive activity. A trial ... Read more >>

Clin Drug Investig (Clinical drug investigation)
[2020, 40(4):377-385]

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A 2-year longitudinal study of neuropsychological functioning, psychosocial adjustment and rehospitalisation in schizophrenia and major depression.

Schaub Annette, Goerigk Stephan, Kim T Mueser, Hautzinger Martin, Roth Elisabeth, Goldmann Ulrich, Charypar Marketa, Engel Rolf, Möller Hans-Jürgen, Falkai Peter,

Neuropsychological functioning turns out to be a rate-limiting factor in psychiatry. However, little is known when comparing neuropsychological and psychosocial functioning in inpatients with schizophrenia or severe depression in their treatment pathways including add-on psychoeducation or the latter combined with cognitive behavioral therapy up to 2-year follow-up. To evaluate this ... Read more >>

Eur Arch Psychiatry Clin Neurosci (European archives of psychiatry and clinical neuroscience)
[2020, :]

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