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Full Text Journal Articles about
Sarcoidosis

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Histopathological Features of Subcutaneous Sarcoidosis.

Joaquim Marcoval, Rosa M Penín, Juan Mañá,

Only a few series of patients with systemic sarcoidosis and specific subcutaneous lesions have been reported. We reviewed our patients with systemic sarcoidosis with specific subcutaneous lesions to analyze their histopathological features and their relationship with clinical features of the systemic disease. Patients with systemic sarcoidosis with predominantly subcutaneous sarcoid ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2020, 42(4):233-243]

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Delayed diagnosis of lung cancer due to misdiagnosis as worsening of sarcoidosis: a case report.

Hong-Joon Shin, Min-Seok Kim, Bo Gun Kho, Ha Young Park, Tae-Ok Kim, Cheol-Kyu Park, In-Jae Oh, Yu-Il Kim, Young-Chul Kim, Yoo-Duk Choi, Sung-Chul Lim,

BACKGROUND:The concurrence of sarcoidosis and primary lung cancer is very rare. We report a very rare case with a delayed diagnosis of primary lung cancer due to its misdiagnosis as worsening of pulmonary sarcoidosis. CASE PRESENTATION:A 68-year-old man presented to the outpatient department for evaluation of a mass in the ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):71]

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18F-FDG PET/CT in bone sarcoidosis: an observational study.

Lucie Demaria, Raphael Borie, Khadija Benali, Eve Piekarski, Julia Goossens, Elisabeth Palazzo, Marine Forien, Philippe Dieudé, Bruno Crestani, Sébastien Ottaviani,

OBJECTIVE:Bone sarcoidosis is usually rare. Imaging procedures such as fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) can reveal bone sarcoidosis with better sensitivity than conventional radiography. We aimed to describe bone sarcoidosis involvement detected with 18F-FDG PET/CT. METHODS:This was an observational retrospective study of individuals with pulmonary sarcoidosis who ... Read more >>

Clin. Rheumatol. (Clinical rheumatology)
[2020, :]

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Platelet-rich plasma injections and the development of cutaneous sarcoid lesions: A case report.

Nicole Izhakoff, Oben Ojong, Muneeb Ilyas, Rodrigo Guridi, Carolina Lobos, Patricia Apt Druck, Martin N. Zaiac,

JAAD Case Rep (JAAD Case Reports)
[2020, 6(4):348-350]

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In Which Patients with Sarcoidosis Is FDG PET/CT Indicated?

Ruth G M Keijsers, Jan C Grutters,

Sarcoidosis is a granulomatous disease of which the etiology remains unknown. The diverse clinical manifestations may challenge clinicians, particularly when conventional markers are inconclusive. From various studies, it has become clear that fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT aids in sarcoidosis care. In this article, an update on FDG PET/CT ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(3):]

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Relationship to Deployment on Sarcoidosis Staging and Severity in Military Personnel.

Damon A Forbes, Jess T Anderson, Joshua A Hamilton, Fredric A Rawlins, Carole Tinkelpaugh, Joseph H Abraham, Michael J Morris,

INTRODUCTION:Ongoing studies are investigating the potential link between deployment to Operation Iraqi Freedom and Operation Enduring Freedom and relationship to increases in pulmonary disease. While increases in certain diseases such as asthma and airway hyperreactivity are well established, data on other chronic pulmonary diseases such as sarcoidosis have not been ... Read more >>

Mil Med (Military medicine)
[2020, :]

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Clinical Characteristics and Organ System Involvement in Sarcoidosis: Comparison of the University of Minnesota Cohort and Other Cohorts

Maneesh Bhargava, Hok Sreng, David Perlman, Chetan Shenoy, Daniel Steinberger, Rebecca Cogswell, Henri Roukoz, Erik Peterson, Lin Zhang, Tadashi Allen,

<title>Abstract</title> <p> Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Clinical cohort studies of different populations are important to understand the high variability in clinical presentation and disease course of sarcoidosis. The aim of the study is to evaluate clinical characteristics, including organ involvement, pulmonary function ... Read more >>

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The Promise of JAK Inhibitors for Treatment of Sarcoidosis and Other Inflammatory Disorders with Macrophage Activation: A Review of the Literature.

Alice Wang, Katelyn Singh, Wael Ibrahim, Brett King, William Damsky,

Certain inflammatory disorders are characterized by macrophage activation and accumulation in tissue; sometimes leading to the formation of granulomas, as in sarcoidosis. These disorders are often difficult to treat and more effective, molecularly targeted therapies are needed. Recent work has shown that overproduction of inflammatory cytokines, such as interferon gamma ... Read more >>

Yale J Biol Med (The Yale Journal of Biology and Medicine)
[2020, 93(1):187-195]

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Coexistence of diffuse panbronchiolitis and sarcoidosis revealed during splenectomy: a case report.

Tomohiro Akaba, Kiyoshi Takeyama, Mitsuko Kondo, Fumi Kobayashi, Asako Okabayashi, Tatsuo Sawada, Etsuko Tagaya,

BACKGROUND:Sarcoidosis is a systemic granulomatous disease caused by CD4+ cell-dominant inflammation. Meanwhile, diffuse panbronchiolitis is a chronic inflammatory respiratory disease predominantly caused by CD8+ lymphocytes and neutrophils. Herein, we report a rare case of sarcoidosis in which the clinical presentation had become evident as diffuse panbronchiolitis after splenectomy for sarcoidosis. ... Read more >>

BMC Pulm Med (BMC Pulmonary Medicine)
[2020, 20(1):77]

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Sarcoidosis with Small Syringotropic Granulomas Presenting Clinically as a Pigmented Purpuric Dermatosis: Inconspicuous Clinical and Histopathologic Clues to Systemic Illness.

Brian J Simmons, Xiaoying Liu, Marshall A Guill, Robert E LeBlanc,

Sarcoidosis is a multisystem granulomatous disease with a myriad of clinical manifestations and a predilection to involve the lungs, eyes, lymph nodes and skin. A 38 year old man presented to dermatology with a history of progressive dyspnea, pulmonary consolidations on chest x-ray, and hilar adenopathy on computed tomography (CT) scan. ... Read more >>

J. Cutan. Pathol. (Journal of cutaneous pathology)
[2020, :]

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Honeycomb lung-like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis.

Michiru Sawahata, Noriharu Shijubo, Takeshi Johkoh, Koichi Hagiwara, Satoshi Konno, Tetsuo Yamaguchi,

Gene expression profiles of patients with progressive sarcoidosis, most of whom had evidence of fibrosis on imaging, have been reported to be similar to those of patients with inflammatory hypersensitivity pneumonitis, while expression profiles in progressive sarcoidosis did not resemble those of idiopathic pulmonary fibrosis. However, it is not known ... Read more >>

Respirol Case Rep (Respirology case reports)
[2020, 8(3):e00539]

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Pharmacogenetics of antitumor necrosis factor therapy in severe sarcoidosis.

Heleen Crommelin, Adriane Vorselaars, Joanne van der Vis, Vera Deneer, Coline van Moorsel,

PURPOSE OF REVIEW:Antitumor necrosis factor (TNF) treatment is an effective third-line treatment option in severe sarcoidosis. But not all patients respond to treatment. Pharmacogenetics studies the influence of genetic variations on treatment response. RECENT FINDINGS:In sarcoidosis, only one study reported on a relationship between genetic variation in TNF and response ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, :]

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Association between sarcoidosis and cardiovascular comorbidity: A systematic review and meta-analysis.

Abdalla Reda Mahmoud, Abdullah Dahy, Mahmoud Dibas, Alzhraa Salah Abbas, Sherief Ghozy, Amr Ehab El-Qushayri,

Sarcoidosis with cardiovascular involvement is critical and is associated with morbidity and mortality of the affected patients, if not properly managed. In this systematic review and meta-analysis, we aimed to review the available literature to find the prevalence of cardiovascular comorbidities and their association with sarcoidosis. An electronic search was ... Read more >>

Heart Lung (Heart & lung : the journal of critical care)
[2020, :]

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Management of repository corticotrophin injection therapy for pulmonary sarcoidosis: a Delphi study.

Franck F Rahaghi, Nadera J Sweiss, Lesley Ann Saketkoo, Mary Beth Scholand, Joseph B Barney, Alicia K Gerke, Elyse E Lower, Mehdi Mirsaeidi, Lanier O'Hare, Mark J Rumbak, Lobelia Samavati, Robert P Baughman,

In patients treated with repository corticotrophin injection (RCI) for pulmonary sarcoidosis, effective management of adverse events may improve adherence. However, management of adverse events may be challenging due to limitations in real-world clinical experience with RCI and available published guidelines.We surveyed 12 physicians with a modified Delphi process using three ... Read more >>

Eur Respir Rev (European respiratory review : an official journal of the European Respiratory Society)
[2020, 29(155):]

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Clinical phenotyping: role in treatment decisions in sarcoidosis.

Robert P Baughman, Mary Beth Scholand, Franck F Rahaghi,

A variety of phenotypic categorisations have been developed for sarcoidosis. Phenotyping has been used for genetics studies and to guide treatment selection. The authors participated in a Delphi expert consensus panel to develop a proposed phenotype categorisation and treatment recommendations for pulmonary sarcoidosis patients. Panellists reached consensus that asymptomatic patients ... Read more >>

Eur Respir Rev (European respiratory review : an official journal of the European Respiratory Society)
[2020, 29(155):]

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The Promise of JAK Inhibitors for Treatment of Sarcoidosis and Other Inflammatory Disorders with Macrophage Activation: A Review of the Literature.

Alice Wang, Katelyn Singh, Wael Ibrahim, Brett King, William Damsky,

Certain inflammatory disorders are characterized by macrophage activation and accumulation in tissue; sometimes leading to the formation of granulomas, as in sarcoidosis. These disorders are often difficult to treat and more effective, molecularly targeted therapies are needed. Recent work has shown that overproduction of inflammatory cytokines, such as interferon gamma ... Read more >>

Yale J Biol Med (The Yale journal of biology and medicine)
[2020, 93(1):187-195]

Cited: 0 times

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Presence of Antibodies Binding to Negative Elongation Factor E in Sarcoidosis.

Niklas Baerlecken, Nils Pursche, Torsten Witte, Katja Kniesch, Marius Höpfner, Diana Ernst, Frank Moosig, Benjamin Seeliger, Antje Prasse,

Sarcoidosis is characterized by multiorgan involvement and granulomatous inflammation. Its origin is unknown and the potential role of autoimmunity has not been sufficiently determined. We investigated the presence of autoantibodies in sarcoidosis using protein array technology. The derivation cohort consisted of patients with sarcoidosis (n = 25) and controls including ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(3):]

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An amelanotic choroidal melanoma arising in a young man with tattoo-associated sarcoidosis.

Sean T Berkowitz, Anderson L Brock, David A Reichstein,

Purpose:To describe a patient with an amelanotic choroidal melanoma, originally misdiagnosed as a choroidal granuloma, following his systemic diagnosis of tattoo-associated sarcoidosis. Observations:The amelanotic choroidal tumor, suspected to be a granuloma, failed initial steroid treatment. Full-thickness chorioretinal biopsy demonstrated histologic presence of uveal melanoma and tumor genetics via GEP analysis ... Read more >>

Am J Ophthalmol Case Rep (American journal of ophthalmology case reports)
[2020, 18:100655]

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[Is hypoxia a factor in the progression of pulmonary sarcoidosis?]

F Jeny, J-F Bernaudin, D Valeyre, H Nunes, C Planès, V Besnard,

Sarcoidosis is a systemic granulomatous disease that can reduce life expectancy mainly due to pulmonary fibrosis resulting from granulomatous inflammation The lack of vascularization within pulmonary granulomas suggests that macrophages localized in the center of these structures are hypoxic. Hypoxia signaling pathways are known to be pro-inflammatory and pro-fibrotic in ... Read more >>

Rev Mal Respir (Revue des maladies respiratoires)
[2020, :]

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Pulmonary Rehabilitation in Patients with Pulmonary Sarcoidosis: Impact on Exercise Capacity and Fatigue.

Anita Grongstad, Martijn A Spruit, Line Merethe Oldervoll, Nina Køpke Vøllestad, Anne Edvardsen,

BACKGROUND:There is limited evidence regarding the impact of multidisciplinary pulmonary rehabilitation (PR) on exercise capacity and fatigue in patients with pulmonary sarcoidosis. The aim of this study was to evaluate the impact on exercise capacity and fatigue following PR, and to examine whether baseline fatigue was related to change in ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2020, :1-9]

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Ustekinumab-induced sarcoidosis in a patient with psoriatic arthritis.

Senol Kobak, Huseyin Semiz,

Psoriatic arthritis(PsA) is a chronic inflammatory disease which may affect many different joints. Sarcoidosis is a Th-1 cell related chronic granulomatous disease characterized by non-caseating granuloma formation. The coexistence of both diseases is a rare entity. In addition to conventional DMARDs, biological agents are also used in the treatment of ... Read more >>

Curr Drug Saf (Current drug safety)
[2020, :]

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Lung CD4+ Vα2.3+ T-cells in sarcoidosis cohorts with Löfgren's syndrome.

Pernilla Darlington, Susanna Kullberg, Anders Eklund, Johan Grunewald,

BACKGROUND:Sarcoidosis is diagnosed by a combination of typical clinical and radiological findings together with biopsy proof of non-caseating epithelioid cell granulomas in affected tissues and/or the cell distribution in bronchoalveolar lavage fluid (BALF). We aimed at investigating the usefulness of measuring the proportion of T-cell receptor (TCR) CD4+ Vα2.3+ T-cells ... Read more >>

Respir. Res. (Respiratory research)
[2020, 21(1):61]

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Delphi consensus recommendations for a treatment algorithm in pulmonary sarcoidosis.

Franck F Rahaghi, Robert P Baughman, Lesley Ann Saketkoo, Nadera J Sweiss, Joseph B Barney, Surinder S Birring, Ulrich Costabel, Elliott D Crouser, Marjolein Drent, Alicia K Gerke, Jan C Grutters, Nabeel Y Hamzeh, Isham Huizar, W Ennis James, Sanjay Kalra, Susanna Kullberg, Huiping Li, Elyse E Lower, Lisa A Maier, Mehdi Mirsaeidi, Joachim Müller-Quernheim, Eva M Carmona Porquera, Lobelia Samavati, Dominique Valeyre, Mary Beth Scholand,

Pulmonary sarcoidosis presents substantial management challenges, with limited evidence on effective therapies and phenotypes. In the absence of definitive evidence, expert consensus can supply clinically useful guidance in medicine. An international panel of 26 experts participated in a Delphi process to identify consensus on pharmacological management in sarcoidosis with the ... Read more >>

Eur Respir Rev (European respiratory review : an official journal of the European Respiratory Society)
[2020, 29(155):]

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Prognostic value of cardiovascular magnetic resonance in patients with biopsy-proven systemic sarcoidosis.

Louis Flamée, Rolf Symons, Ganna Degtiarova, Tom Dresselaers, Olivier Gheysens, Wim Wuyts, Johan Van Cleemput, Jan Bogaert,

OBJECTIVES:As prognosis in sarcoidosis is determined by cardiac involvement, the objective was to study the added value of cardiovascular magnetic resonance (CMR) in risk stratification. METHODS:In 114 patients (48 ± 12 years/52% male) with biopsy-proven sarcoidosis, we studied the value of clinical and CMR-derived parameters to predict future events, using sustained ventricular tachycardia, ... Read more >>

Eur Radiol (European Radiology)
[2020, :]

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CD163-positive macrophage infiltration predicts systemic involvement in sarcoidosis.

Taro Isohisa, Jun Asai, Mai Kanemaru, Takahiro Arita, Miho Tsutsumi, Yuka Kaneko, Yukiyasu Arakawa, Makoto Wada, Eiichi Konishi, Norito Katoh,

BACKGROUND:Sarcoidosis is a chronic and systemic inflammatory disease, in which patients present with noncaseating epithelioid granulomas. Cutaneous lesions of sarcoidosis develop in 9% to 35% of all sarcoidosis patients and comprise various clinical subtypes. It usually affects multiple organs and has a variable clinical course; this is called systemic sarcoidosis ... Read more >>

J. Cutan. Pathol. (Journal of cutaneous pathology)
[2020, :]

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