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Salicylate Toxicity

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A Case of Salicylate Toxicity Presenting with Acute Focal Neurologic Deficit in a 61-Year-Old Woman with a History of Stroke.

Tessa M Delaney, Jason T Helvey, Jason F Shiffermiller,

BACKGROUND Over-the-counter medications that contain aspirin are widely used, and patients generally regard them as safe. However, the side effects of salicylate toxicity can be severe, and delay in the diagnosis may increase the risk of mortality. Neurologic symptoms are a common presenting feature of salicylate toxicity in the elderly, ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e920016]

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Toxic stress-specific cytoprotective responses regulate learned behavioral decisions in C. elegans

Gábor Hajdú, Eszter Gecse, István Taisz, István Móra, Csaba Sőti,

Abstract Background Protection of organismal integrity involve physiological stress responses and behavioral defenses. Recent studies in the roundworm Caenorhabditis elegans have shown that pathogen and toxin exposure simultaneously stimulate cellular stress and detoxification responses and aversive behavior. However, whether a coordinate regulation exists between cellular and neurobehavioral defenses remains unclear. ... Read more >>

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Restoring colistin sensitivity in colistin-resistant E. coli: Combinatorial use of MarR inhibitor with efflux pump inhibitor.

Niranjana Sri Sundaramoorthy, Pavithira Suresh, Subramaniapillai Selva Ganesan, ArunKumar GaneshPrasad, Saisubramanian Nagarajan,

Antibiotics like colistin are the last resort to deal with infections by carbapenem-resistant Enterobacteriaceae (CREB). Resistance to colistin severely restricts therapeutic options. To tackle this dire situation, urgent measures to restore colistin sensitivity are needed. In this study, whole-genome sequencing of colistin-resistant E. coli strain was performed and the genome ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):19845]

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Educational Case: Ethylene Glycol Poisoning.

Matthew D Krasowski,

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and ... Read more >>

Acad Pathol (Academic pathology)
[2020, 7:2374289519900330]

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Effect of 10 UV filters on the brine shrimp Artemia salina and the marine microalgae Tetraselmis sp

Evane Thorel, Fanny Clergeaud, Lucie Jaugeon, Alice Rodrigues, Julie Lucas, Didier Stien, Philippe Lebaron,

Abstract The presence of pharmaceutical and personal care products’ (PPCPs) residues in the aquatic environment is an emerging issue due to their uncontrolled release, through grey water, and accumulation in the environment that may affect living organisms, ecosystems and public health. The aim of this study is to assess the ... Read more >>

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Common Toxidromes and the Role of Extracorporeal Detoxification.

Nikolas Harbord,

Extracorporeal modalities have been used for detoxification for decades, with hemodialysis the preferred and most commonly used modality. Salicylates, lithium, methanol, and ethylene glycol are the most common poisonings treated with dialysis. For each of these common poisonings, a description of the toxidrome including pharmacokinetics, clinical presentation, an overview of ... Read more >>

Adv Chronic Kidney Dis (Advances in chronic kidney disease)
[2020, 27(1):11-17]

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Drug-induced hearing loss: a case/non-case study in the French pharmacovigilance database.

Sylvie Favrelière, Paul Delaunay, Jean-Pascal Lebreton, Franck Rouby, Martine Atzenhoffer, Claire Lafay-Chebassier, Marie Christine Pérault-Pochat,

Hearing loss is defined as a decrease in the ability to perceive sounds which can occur suddenly or gradually and affects one ear or both. It is related to various etiologies, in particular drugs. The identification of all drugs that could be associated with hearing loss is essential for the ... Read more >>

Fundam Clin Pharmacol (Fundamental & clinical pharmacology)
[2020, :]

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Antidotes in Poisoning.

Binila Chacko, John V Peter,

Introduction:Antidotes are agents that negate the effect of a poison or toxin. Antidotes mediate its effect either by preventing the absorption of the toxin, by binding and neutralizing the poison, antagonizing its end-organ effect, or by inhibition of conversion of the toxin to more toxic metabolites. Antidote administration may not ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2019, 23(Suppl 4):S241-S249]

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Naproxen in the environment: its occurrence, toxicity to nontarget organisms and biodegradation.

Danuta Wojcieszyńska, Urszula Guzik,

This article summarizes the current knowledge about the presence of naproxen in the environment, its toxicity to nontarget organisms and the microbial degradation of this drug. Currently, naproxen has been detected in all types of water, including drinking water and groundwater. The concentrations that have been observed ranged from ng/L ... Read more >>

Appl. Microbiol. Biotechnol. (Applied microbiology and biotechnology)
[2020, 104(5):1849-1857]

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Insecticidal activity of two essential oils used in perfumery (ylang ylang and frankincense).

Roman Pavela, Filippo Maggi, Cristiano Giordani, Loredana Cappellacci, Riccardo Petrelli, Angelo Canale,

Nowadays, only a little part of essential oils produced at an industrial level is employed for insecticidal formulations, while thousand tons are used for perfumery purposes. This research explores the insecticidal potential of two essential oils largely used in perfumery, ylang ylang (Cananga odorata) and frankincense (Boswellia spp.) on three ... Read more >>

Nat. Prod. Res. (Natural product research)
[2020, :1-7]

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Continuous infusion of physostigmine in patients with perioperative septic shock: A pharmacokinetic/pharmacodynamic study with population pharmacokinetic modeling.

Nadine Pinder, Johannes B Zimmermann, Silke Gastine, Gudrun Würthwein, Georg Hempel, Thomas Bruckner, Torsten Hoppe-Tichy, Markus A Weigand, Stefanie Swoboda,

BACKGROUND:In the context of the cholinergic anti-inflammatory pathway, the clinical trial Anticholium® per Se (EudraCT Number: 2012-001650-26, ClinicalTrials.gov NCT03013322) addressed the possibility of taking adjunctive physostigmine salicylate treatment in septic shock from bench to bedside. Pharmacokinetics (PK) are likely altered in critically ill patients; data on physostigmine PK and target ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2019, 118:109318]

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ACMT 2020 Annual Scientific Meeting Abstracts – New York, NY.

J Med Toxicol (Journal of Medical Toxicology)
[0, :1-53]

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Fundaments of Toxicology-Approach to the Poisoned Patient.

Chiarra Ornillo, Nikolas Harbord,

Management of the poisoned patient begins with supportive care, assessment of organ function and dysfunction, and consideration of known or suspected poisons. The possibility of multiple ingestions should be considered with intentional exposures or suicide attempts. Enteric decontamination involves treatment to prevent the absorption of toxins from the gastrointestinal system ... Read more >>

Adv Chronic Kidney Dis (Advances in chronic kidney disease)
[2020, 27(1):5-10]

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Efficacy of binary combinations between methyl salicylate and carvacrol against thrips Anaphothrips obscurus: laboratory and field trials.

Xiao-Peng Lu, Jia-Huan Liu, Hua Weng, Zhi-Qing Ma, Xing Zhang,

BACKGROUND:Thrips Anaphothrips obscurus are one of the cosmopolitan major pests feeding on cereals and other grasses. In order to develop alternatives of chemical insecticides for thrips control, based on fumigant activity screening and evaluation of 22 essential oil (EO) compounds against the thrips, the binary interactions of methyl salicylate and ... Read more >>

Pest Manag. Sci. (Pest management science)
[2020, 76(2):589-596]

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Impact of bacterial motility on biosorption and cometabolism of pyrene in a porous medium.

Ludovica Rolando, Joaquim Vila, Rosa Posada Baquero, Jose Carlos Castilla-Alcantara, Anna Barra Caracciolo, Jose-Julio Ortega-Calvo,

The risks of pollution by polycyclic aromatic hydrocarbons (PAHs) may increase in bioremediated soils as a result of the formation of toxic byproducts and the mobilization of pollutants associated to suspended colloids. In this study, we used the motile and chemotactic bacterium Pseudomonas putida G7 as an experimental model for ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 717:137210]

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Base Promoted Intumescence of Phenols.

Yu Ji, Qiang Yao, Weihong Cao, Yueying Zhao,

: The intumescent process of sodium (substituted) phenolates has been studied. The generation of hydrogen radical via a homolytic cleavage of the Ar-H bond and the subsequent hydroarylation of phenolates to cyclohexadienes along with cyclization and elimination reactions of cyclohexadienes are critical steps in the base promoted intumescence of phenols. ... Read more >>

Polymers (Basel) (Polymers)
[2020, 12(2):]

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Extracorporeal Removal of Poisons and Toxins.

Joshua David King, Moritz H Kern, Bernard G Jaar,

Extracorporeal therapies have been used to remove toxins from the body for over 50 years and have a greater role than ever before in the treatment of poisonings. Improvements in technology have resulted in increased efficacy of removing drugs and other toxins with hemodialysis, and newer extracorporeal therapy modalities have ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2019, 14(9):1408-1415]

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Intentional acetylsalicylic acid acute intoxication and its clinical management.

Reza Soleimani, Karl Brousmiche, Julien Favresse, Vincent Haufroid, Damien Gruson, Philippe Hantson, Pierre Wallemacq,

In the last decade, our knowledge about OTC drug intoxication has been expanded much further relative to previous years, though the absence of antidotes in some cases results in healthcare professionals using symptomatic treatment. This case report reminds the reader of the importance of clinical and toxicology laboratories in the ... Read more >>

Clin Case Rep (Clinical case reports)
[2019, 7(9):1697-1701]

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Assessment of the effects of metribuzin, glyphosate, and their mixtures on the metabolism of the model plant Lemna minor L. applying metabolomics.

Sofia Kostopoulou, Georgia Ntatsi, Gerasimos Arapis, Konstantinos A Aliferis,

Chemical plant protection products (PPPs) is a major group of xenobiotics that are being released in the environment. Although the effects of individual active ingredients (a.i.) on organisms have been studied, information on those of mixtures, is fragmented. Aquatic environments are being polluted by PPPs, posing serious risks for the ... Read more >>

Chemosphere (Chemosphere)
[2020, 239:124582]

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Absence of the nahG-like gene caused the syntrophic interaction between Marinobacter and other microbes in PAH-degrading process.

Chongyang Wang, Yong Huang, Zuotao Zhang, Han Hao, Hui Wang,

In this study, Marinobacter sp. N4 isolated from the halophilic consortium CY-1 was found to degrade phenanthrene as a sole carbon source with the accumulation of 1-Hydroxy-2-naphthoic acid (1H2N). With the assistance of Halomonas sp. G29, phenanthrene could be completely mineralized. The hpah1 and hpah2 gene cluster was amplified from ... Read more >>

J. Hazard. Mater. (Journal of hazardous materials)
[2020, 384:121387]

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Diagnosis and management of metabolic acidosis: guidelines from a French expert panel.

Boris Jung, Mikaël Martinez, Yann-Erick Claessens, Michaël Darmon, Kada Klouche, Alexandre Lautrette, Jacques Levraut, Eric Maury, Mathieu Oberlin, Nicolas Terzi, Damien Viglino, Youri Yordanov, Pierre-Géraud Claret, Naïke Bigé, , ,

Metabolic acidosis is a disorder frequently encountered in emergency medicine and intensive care medicine. As literature has been enriched with new data concerning the management of metabolic acidosis, the French Intensive Care Society (Société de Réanimation de Langue Française [SRLF]) and the French Emergency Medicine Society (Société Française de Médecine ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2019, 9(1):92]

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Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning.

Shuichi Hara, Masamune Kobayashi, Fumi Kuriiwa, Hajime Mizukami, Toshiji Mukai,

Oxidative stress has been suggested to play a role in brain damage during carbon monoxide (CO) poisoning. Severe poisoning induced by CO at 3000 ppm, but not 1000 ppm, enhances hydroxyl radical (˙OH) production in the rat striatum, which might be mediated by NADPH oxidase (NOX) activation associated with Ras-related ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2602]

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[Diagnostics and treatment of selected clinically relevant, acute drug intoxications].

Julia Tschirdewahn, Florian Eyer,

Acute drug poisoning due to accidental or self-damaging overdoses is responsible for 5-10% of emergency medical interventions in Germany. The treatment of asymptomatic to life-threatening courses requires extensive expertise. On the basis of a selective literature search, this article gives an overview of selected clinically relevant, acute drug poisonings with regard ... Read more >>

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz)
[2019, 62(11):1313-1323]

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Reply to "In response to "Coagulopathy and bleeding associated with salicylate toxicity" ".

Benjamin W Hatten, Robert G Hendrickson,

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2019, :1]

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Recurrent Anion Gap Metabolic Acidosis.

Abin Sajan, Judah Horowitz, Noriyuki Murakami, Isabel M McFarlane,

Background:Metabolic acidosis refers to any process that increases the hydrogen ions in the body and reduces the bicarbonate concentration. Metabolic acidosis is subdivided based on presence of anion gap (AG), and AG metabolic acidosis is most often due to ketoacidosis, lactic acidosis, renal failure, or toxic ingestions. AG metabolic acidosis ... Read more >>

Am J Med Case Rep (American journal of medical case reports)
[2019, 7(9):200-202]

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