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ifas-1 is upregulated by fungal infection in a GPA-12 and STA-2-independent manner in the Caenorhabditis elegans epidermis.

Shizue Omi, Xing Zhang, Nishant Thakur, Nathalie Pujol,

Skin infection with the fungus <i>Drechmeria coniospora</i> leads to a transcriptional response in the worm epidermis. This involves an increased expression of a group of antimicrobial peptide (AMP) genes including those in the <i>nlp-29</i> and <i>cnc-2</i> clusters. The major pathways leading to the expression of these AMP genes have been ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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B.2.16 is a non-lethal modifier of the Dark82 mosaic eye phenotype in Drosophila melanogaster.

Alysia D Vrailas-Mortimer, Nitish Aggarwal, Neha N Ahmed, Ian M Alberts, Masa Alhawasli, Ibrahim A Aljerdi, Brooke M Allen, Ahmad M Alnajar, Michael A Anderson, Ryan Armstong, Chace C Avery, Eric J Avila, Tyra N Baker, Soolmaz Basardeh, Natasha A Bates, Farrah N Beidas, Ashton C Bosler, Deja M Brewer, Ryan S Buenaventura, Natalie Jl Burrell, Alyn P Cabrera-Lopez, Amairani B Cervantes-Gonzalez, Raymond P Cezar, Joselyn Coronel, Corinne Croslyn, Konnor R Damery, Lucero Diaz-Alavez, Nupur P Dixit, Dilcia L Duarte, Amanda R Emke, Katherine English, Audrey A Eshun, Samuel R Esterly, Arnold J Estrada, Mark Feng, Meghan M Freund, Niko Garcia, Charandeep S Ghotra, Haddia Ghyasi, Christa Sa Hale, Luci Hulsman, Lindsey Jamerson, Austin K Jones, Madeline Kuczynski, Takailah N Lacey-Kennedy, Mindy J Lee, Tala Mahjoub, Molly C Mersinger, Alyssa D Muckerheide, David W Myers, Karen Nielsen, Paul J Nosowicz, Jacinda A Nunez, Amy C Ortiz, Tulsi T Patel, Natalie N Perry, W Storm A Poser, Deisy M Puga, Cathrine Quam, Paulina Quintana-Lopez, Piper Rennerfeldt, Nicholas M Reyes, Ian G Rines, Cally Roberts, Daniel B Robinson, Kalina M Rossa, Gloria J Ruhlmann, Jeremy Schmidt, John R Sherwood, Dimyana H Shonoda, Hannah Soellner, Juan C Torrez, Mayukah Velide, Zachary Weinzapfel, Alisa C Ward, Kayla L Bieser, Julie A Merkle, Joyce C Stamm, Richard L Tillett, Jacob D Kagey,

Genetic screens have been used to identify genes involved in the regulation of different biological processes. We identified growth mutants in a Flp/FRT screen using the <i>Drosophila melanogaster</i> eye to identify conditional regulators of cell growth and cell division. One mutant identified from this screen, <i>B.2.16</i>, was mapped and characterized ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 1 time

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Net, skin and flatten, ImageJ plugin tool for extracting surface profiles from curved 3D objects.

Housei Wada, Shigeo Hayashi,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Spontaneous neoplasia in the western clawed frog Xenopus tropicalis.

Makoto Suzuki, Takeshi Igawa, Nanoka Suzuki, Hajime Ogino, Haruki Ochi,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 0 times

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A novel mutation in unc-112/kindlin locus causes distal tip cell migration defects.

Aileen Park, Zhongqiang Qiu, Josh Bumm, Myeongwoo Lee,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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SapTrap Builder: a desktop utility for CRISPR edit design.

Matthew Schwartz, Erik Jorgensen,

MicroPubl Biol (microPublication biology)
[2018, 2018:]

Cited: 1 time

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Skin-specific knockdown of hyaluronan in mice by an optimized topical 4-methylumbelliferone formulation.

Emily H Steen, Walker D Short, Hui Li, Umang M Parikh, Alexander Blum, Natalie Templeman, Nadine Nagy, Paul L Bollyky, Sundeep G Keswani, Swathi Balaji,

Hyaluronan (HA) is abundant in the skin; while HA can be synthesized by the synthases (HAS1-3), HAS2 is the leading contributor. Dysregulation and accumulation of HA is implicated in the pathogenesis of diseases such as keloid scarring, lymphedema and metastatic melanoma. To understand how HA synthesis contributes to skin physiology, ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):422-432]

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Bullous pemphigoid in patients receiving peritoneal dialysis: a case series and a literature survey.

Kohkichi Morimoto, Tadashi Yoshida, Naoki Washida, Kiyotaka Uchiyama, Takashin Nakayama, Hiroshi Itoh, Mototsugu Oya,

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Although several cases of BP in end-stage renal disease patients receiving peritoneal dialysis (PD) or hemodialysis have been reported, the incidence of BP in these patients remains unknown. We recently experienced three PD patients diagnosed with BP. The skin injury was ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):651-657]

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Prediction of clinical prognosis in cutaneous melanoma using an immune-related gene pair signature.

Yu Yang, Xuan Long, Guiyun Li, Xiaohong Yu, Yu Liu, Kun Li, Xiaobin Tian,

Cutaneous melanoma (CM) is a malignant and aggressive skin cancer that is the leading cause of skin cancer-related deaths. Increasing evidence shows that immunity plays a vital role in the prognosis of CM. In this study, we developed an immune-related gene pair (IRGP) signature to predict the clinical prognosis of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1803-1812]

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Transdermal iontophoresis delivery system for terazosin hydrochloride: an in vitro and in vivo study.

Changzhao Jiang, Xiumei Jiang, Xiumin Wang, Jiaxu Shen, Mengjie Zhang, Leilei Jiang, Rui Ma, Tingting Gan, Yingbiao Gong, Jincui Ye, Wenyan Gao,

This study aimed to construct a transdermal iontophoresis delivery system for terazosin hydrochloride (IDDS-TEH), which included a positive and negative electrode hydrogel prescription. Intact guinea pig skin was used as a model for the skin barrier function, and the current intensity, terazosin hydrochloride (TEH) concentration, pH, competitive salt, and transdermal ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):454-462]

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A polymer-lipid membrane artificial cell nanocarrier containing enzyme-oxygen biotherapeutic inhibits the growth of B16F10 melanoma in 3D culture and in a mouse model.

Yun Wang, Thomas Ming Swi Chang,

Melanoma is a deadly skin cancer. Surgery is effective for early stages but there may be remnant cells. Treatments of later stages are associated with severe side effects. Moreover, a dangerous type of melanoma cannot be detected early enough for surgery. There is an urgent need for treatment with less ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2021, 49(1):461-470]

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Methicillin-resistant Staphylococcus aureus from infected skin lesions present several virulence genes and are associated with the CC30 in Brazilian children with atopic dermatitis.

Fernanda Sampaio Cavalcante, Simone Saintive, Dennis Carvalho Ferreira, Adriana Barbosa Rocha Silva, Lorrayne Cardoso Guimarães, Beatriz Stofel Braga, Eliane de Dios Abad, Marcia Ribeiro, Kátia Regina Netto Dos Santos,

Atopic dermatitis (AD) is a chronic inflammatory skin disease and colonization by <i>Staphylococcus aureus</i> may affect up to 100% of these patients. Virulent and resistant isolates can worsen AD patient clinical condition and jeopardize the treatment. We aimed to detect virulence genes and to evaluate the biofilm production of <i>S. ... Read more >>

Virulence (Virulence)
[2021, 12(1):260-269]

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Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging.

Kristoffer Hendel, Anders C N Hansen, Liora Bik, Charlotte Bagger, Martijn B A van Doorn, Christian Janfelt, Uffe H Olesen, Merete Haedersdal, Catharina M Lerche,

Bleomycin (BLM) is being repositioned in dermato-oncology for intralesional and intra-tumoural use. Although conventionally administered by local needle injections (NIs), ablative fractional lasers (AFLs) can facilitate topical BLM delivery. Adding local electroporation (EP) can augment intracellular uptake in the target tissue. Here, we characterize and compare BLM biodistribution patterns, cutaneous ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):1141-1149]

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Screening the dermatological potential of plectranthus species components: antioxidant and inhibitory capacities over elastase, collagenase and tyrosinase.

Joana M Andrade, Eva María Domínguez-Martín, Marisa Nicolai, Célia Faustino, Luís Monteiro Rodrigues, Patrícia Rijo,

A series of <i>Plectranthus</i> spp. plant extracts (aqueous, acetonic, methanolic and ethyl acetic) obtained from eight different species, and previously isolated compounds (ranging from polyphenols, diterpenes and triterpenes), were assayed for <i>in vitro</i> inhibition of the skin-related enzymes tyrosinase, collagenase and elastase, and for studying their antioxidant properties. The ethyl acetic ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):257-269]

Cited: 1 time

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The genetic feature and virulence determinant of highly virulent community-associated MRSA ST338-SCCmec Vb in China.

Ye Jin, Wangxiao Zhou, Zhidong Yin, Shuntian Zhang, Yunbo Chen, Ping Shen, Jinru Ji, Weiwei Chen, Beiwen Zheng, Yonghong Xiao,

ST59 is the predominant pathotype of community-associated methicillin-resistant <i>Staphylococcus aureus</i> (CA-MRSA) in China. As a variant of ST59, there is relatively little known about the detailed information of ST338. To address this issue, here, we described thirteen ST338 CA-MRSA strains isolated from severe bloodstream infection cases, and focused on their ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1052-1064]

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Screening of the superior F1 segregating populations of barberry (Berberis spp.) for cultivation based on phenotypic characterizations

Amir Safari-Khuzani, Mehdi Rezaei, Ali Khadivi,

Iranian seedless barberry, with a long history in the human diet, is consumed as dried fruit and also has valuable medicinal properties. In the present study, morphological and pomological characters of the F1 interspecific progenies of barberry (Berberis spp.) were evaluated to select superior ones. There were significant variations among ... Read more >>

(Industrial crops and products.)
[2021, 158:Not Available]

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Impact of mono-culture vs. Co-culture of keratinocytes and monocytes on cytokine responses induced by important skin sensitizers.

Venkatanaidu Karri, Carola Lidén, Nanna Fyhrquist, Johan Högberg, Hanna L Karlsson,

Sensitization to a contact allergen brings with it a lifelong risk to develop allergic contact dermatitis. Inflammation is an important part of the skin sensitizing mechanism, and understanding how different haptens stimulate the immune system, as well as the role played by different cell types present in skin, may be ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2021, 18(1):74-84]

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Increasing prevalence of hypervirulent ST5 methicillin susceptible Staphylococcus aureus subtype poses a serious clinical threat.

Ying Jian, Lin Zhao, Na Zhao, Hui-Ying Lv, Yao Liu, Lei He, Qian Liu, Min Li,

<i>Staphylococcus aureus</i> (<i>S. aureus</i>) is a clinical pathogen of great significance causing metastatic or complicated infections. ST5 clonotype isolates have dominated <i>S. aureus</i> infections for more than 10 years in Shanghai, China, and the proportion of methicillin-susceptible <i>S. aureus</i> (MSSA) has remarkably increased in the past decades. By whole-genome sequencing ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):109-122]

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Bushen Yijing Decoction (BSYJ) exerts an anti-systemic sclerosis effect via regulating MicroRNA-26a /FLI1 axis.

Zixuan Cheng, Jialin Zhang, Wanying Deng, Shaojian Lin, Donghai Li, Ke Zhu, Qing Qi,

Systemic sclerosis (SSc) refers to a group of autoimmune rheumatic diseases. Bushen Yijing decoction (BSYJ) is used for treating SSc. However, its underlying mechanism remains unknown. The present study aims to investigate potential roles of Friend leukemia integration factor 1 (FLI1) and microRNA in the beneficial effects of BSYJ on ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1212-1225]

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Application of laser capture microdissection and PCR sequencing in the diagnosis of Coccidioides spp. infection: A case report and literature review in China.

Xinyu Yang, Yinggai Song, TianYu Liang, Qiqi Wang, Ruoyu Li, Wei Liu,

Coccidioidomycosis is endemic to California, Arizona, and Mexico. In recent years, the reported cases of coccidioidomycosis have increased in nonendemic regions. Here, we reported a case of imported pulmonary coccidioidomycosis in a Chinese patient. A 63-year-old man presented with dry cough and fatigue for 6 months, and a computed tomography ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):331-341]

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Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways.

Aimin Liu, Buxin Zhang, Wei Zhao, Yuanhui Tu, Qingxing Wang, Jing Li,

Psoriasis is a chronic inflammatory skin disease that affects approximately 2% of worldwide population, and causing long-term troubles to the patients. Therefore, it is urgent to develop safe and effective therapeutic drugs. Catalpol is a natural iridoid glucoside, that has several remarkable pharmacological effects, however, whether catalpol can alleviated psoriasis ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):183-195]

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Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer.

João Fevereiro, Alexandra G Fraga, Carlos Capela, Ghislain E Sopoh, Ange Dossou, Gilbert Adjimon Ayelo, Maria João Peixoto, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues, Jorge Pedrosa,

Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the <i>BCL2L11</i> gene). We here report the association of genetic variants in <i>BCL2L11</i> with ulcerative forms of the disease in a cohort ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):223-225]

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Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013-2017: a retrospective study at Thailand's largest national tertiary referral center.

Pakpoom Phoompoung, Nantaporn Pirogard, Amornrut Leelaporn, Nasikarn Angkasekwinai,

<h4>Objectives</h4>To determine the incidence of invasive Group B streptococcal (iGBS) diseases and the factors significantly associated with iGBS mortality in adult patients.<h4>Material and methods</h4>This retrospective study included adults with a positive culture for GBS isolated from a sterile site at Siriraj Hospital - Thailand's largest tertiary care hospital - during ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):715-721]

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Circulating microRNA profile unveils mechanisms of action of acitretin for psoriasis vulgaris.

Lin Chen, Jie Li, Ying Yao, Shanlong Wang, Shuangjin Zheng, Xinggang Ju, Bin Zhang,

Psoriasis vulgaris is a common chronic and recurrent inflammatory skin disease. In clinical practice, acitretin is the first-line treatment drug for psoriasis vulgaris. MicroRNAs (miRNAs) play a vital role in the initiation and development of psoriasis vulgaris. However few studies focused on the mechanisms of acitretin in the treatment of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1838-1850]

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Phialemoniopsis limonesiae sp. nov. causing cutaneous phaeohyphomycosis in an immunosuppressed woman.

D Alvarez Martinez, C Alberto, A Riat, C Schuhler, P Valladares, B Ninet, B Kraak, P W Crous, L W Hou, L Toutous Trellu,

Rare or opportunistic fungal infections are mostly described in immunosuppressed patients. We present a case of a cutaneous phaeohyphomycosis that developed on the dorsal foot in an immunosuppressed woman suffering from AIDS, caused by a novel <i>Phialemoniopsis</i> species. It clinically presented as an indurated violaceous plaque, surmounted by nodules exuding ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):400-406]

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