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The "second wave" of the COVID-19 pandemic in the Arctic: regional and temporal dynamics.

Andrey N Petrov, Mark Welford, Nikolay Golosov, John DeGroote, Michele Devlin, Tatiana Degai, Alexander Savelyev,

This article focuses on the "second wave" of the COVID-19 pandemic in the Arctic and examines spatiotemporal patterns between July 2020 and January 2021. We analyse available COVID-19 data at the regional (subnational) level to elucidate patterns and typology of Arctic regions with respect to the COVID-19 pandemic. This article ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1925446]

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Indigenous women's reproductive health in the Arctic zone of Western Siberia: challenges and solutions.

Elena Bogdanova, Sergei Andronov, Andrey Lobanov, Ruslan Kochkin, Andrei Popov, Ildiko Asztalos Morell, JonØyvind Odland,

In the Russian Arctic, alarming trends (shortage of nomadic Indigenous women, high reproductive loss, child mortality rates) indicate long-term changes towards demographic decline. This study aimed at comparing some indicators of the reproductive health (childbirth rates, number of pregnancies, pregnancy loss) of Indigenous and non-Indigenous women in the exploration of ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1855913]

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Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status.

Marina Yurievna Maksimova, Alexander Vladimirovich Ivanov, Edward Danielevich Virus, Ksenya Alexandrovna Nikiforova, Fatima Ramazanovna Ochtova, Ekaterina Taymurazovna Suanova, Maria Petrovna Kruglova, Mikhail Aleksanrovich Piradov, Aslan Amirkhanovich Kubatiev,

<h4>Objective</h4>Acute brain ischemia is accompanied by a disruption of low-molecular-weight aminothiols (LMWTs) homeostasis, such as homocysteine (Hcy), cysteine (Cys), and glutathione (GSH). We investigated the redox balance of LMWTs in blood plasma and its influence on ischemic stroke severity and the functional outcome in patients with an acute period.<h4>Patients and ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):117-123]

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MercuNorth - monitoring mercury in pregnant women from the Arctic as a baseline to assess the effectiveness of the Minamata Convention.

Bryan Adlard, Mélanie Lemire, Eva C Bonefeld-Jørgensen, Manhai Long, Kristín Ólafsdóttir, Jon O Odland, Arja Rautio, Päivi Myllynen, Torkjel M Sandanger, Alexey A Dudarev, Ingvar A Bergdahl, Maria Wennberg, James Berner, Pierre Ayotte,

Exposure to mercury (Hg) is a global concern, particularly among Arctic populations that rely on the consumption of marine mammals and fish which are the main route of Hg exposure for Arctic populations.The MercuNorth project was created to establish baseline Hg levels across several Arctic regions during the period preceding ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1881345]

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Moral frameworks of commercial surrogacy within the US, India and Russia.

Marcin Smietana, Sharmila Rudrappa, Christina Weis,

In this paper, we draw on three ethnographic studies of surrogacy we carried out separately in different contexts: the western US state of California, the south Indian state of Karnataka, and the western Russian metropolis of St Petersburg. In our interviews with surrogate mothers, intended parents, and surrogacy professionals, we ... Read more >>

Sex Reprod Health Matters (Sexual and reproductive health matters)
[2021, 29(1):1-17]

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Dendritic spine density changes and homeostatic synaptic scaling: a meta-analysis of animal studies.

Thiago C Moulin, Danielle Rayêe, Helgi B Schiöth,

Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability in response to chronic changes in the network activity. This type of plasticity is essential for the maintenance of brain circuits and is involved in the regulation of neural regeneration and the progress of neurodegenerative disorders. One of the most ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):20-24]

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Emergence and spread of novel H5N8, H5N5 and H5N1 clade 2.3.4.4 highly pathogenic avian influenza in 2020.

Nicola S Lewis, Ashley C Banyard, Elliot Whittard, Talgat Karibayev, Thamer Al Kafagi, Ilya Chvala, Alex Byrne, Saduakassova Meruyert Akberovna, Jacqueline King, Timm Harder, Christian Grund, Steve Essen, Scott M Reid, Adam Brouwer, Nikolay G Zinyakov, Azimkhan Tegzhanov, Victor Irza, Anne Pohlmann, Martin Beer, Ron A M Fouchier, Sultanov Akhmetzhan Akievich, Ian H Brown,

Analyses of HPAI H5 viruses from poultry outbreaks across a wide Eurasian region since July 2020 including the Russian Federation, Republics of Iraq and Kazakhstan, and recent detections in migratory waterfowl in the Netherlands, revealed undetected maintenance of H5N8, likely in galliform poultry since 2017/18 and both H5N5 and H5N1. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):148-151]

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The prevalence of helminthiases in North-Western Siberia rural indigenous and long-term resident people in 1988-89 and 2018-19.

Andrey Kozlov, Galina Vershubskaya,

The aim of this work was to compare the prevalence of opisthorchiasis, diphyllobothriasis, and ascariasis among the rural indigenous and long-term resident people of Khanty-Mansi Autonomous Okrug (KMAO) in the years 1988-89 and 2018-19. Helminth infections were identified by faecal microscopic examinations conducted during health check-ups. We analysed 399 medical ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1917270]

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Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis.

Maria N Zakharova, Anna A Abramova,

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive muscle wasting, breathing and swallowing difficulties resulting in patient's death in two to five years after disease onset. In amyotrophic lateral sclerosis, both upper and lower motor neurons of the corticospinal tracts are involved in the process of neurodegeneration, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):65-73]

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STXBP1 forms amyloid-like aggregates in rat brain and demonstrates amyloid properties in bacterial expression system.

A V Chirinskaite, V A Siniukova, M E Velizhanina, J V Sopova, T A Belashova, S P Zadorsky,

Amyloids are the fibrillar protein aggregates with cross-β structure. Traditionally amyloids were associated with pathology, however, nowadays more data is emerging about functional amyloids playing essential roles in cellular processes. We conducted screening for functional amyloids in rat brain. One of the identified proteins was STXBP1 taking part in vesicular ... Read more >>

Prion (Prion)
[2021, 15(1):29-36]

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Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses.

Alisa A Shaimardanova, Daria S Chulpanova, Valeriya V Solovyeva, Aleksandr M Aimaletdinov, Albert A Rizvanov,

Tay-Sachs disease and Sandhoff disease are severe hereditary neurodegenerative disorders caused by a deficiency of β-hexosaminidase A (HexA) enzyme, which results in the accumulation of GM2 gangliosides in the nervous system cells. In this work, we analyzed the efficacy and safety of cell-mediated gene therapy for Sandhoff disease and Sandhoff ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):122-129]

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Development of molecular tools for diagnosis of Alzheimer's disease that are based on detection of amyloidogenic proteins.

Konstantin Y Kulichikhin, Sergei A Fedotov, Maria S Rubel, Natalia M Zalutskaya, Anastasia E Zobnina, Oksana A Malikova, Nikolay G Neznanov, Yury O Chernoff, Aleksandr A Rubel,

Alzheimer's disease (AD) is the most common form of dementia that usually occurs among older people. AD results from neuronal degeneration that leads to the cognitive impairment and death. AD is incurable, typically develops over the course of many years and is accompanied by a loss of functional autonomy, making ... Read more >>

Prion (Prion)
[2021, 15(1):56-69]

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Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida®) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms.

Claudiu T Supuran, Alessio Nocentini, Elena Yakubova, Nikolay Savchuk, Stanislav Kalinin, Mikhail Krasavin,

The non-nucleoside reverse transcriptase inhibitor VM1500A is approved for the treatment of HIV/AIDS in its <i>N</i>-acyl sulphonamide prodrug form elsulfavirine (Elpida<sup>®</sup>). Biochemical profiling against twelve human carbonic anhydrase (CA, EC 4.2.1.1) isoforms showed that while elsulfavirine was a weak inhibitor of all isoforms, VM1500A potently and selectively inhibited human (h) ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1056-1060]

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Inhibition of neprilysin with sacubitril without RAS blockage aggravates renal disease in Dahl SS rats.

Iuliia Polina, Morgan J Spicer, Mark Domondon, Ryan S Schibalski, Elizaveta Sarsenova, Regina F Sultanova, Daria V Ilatovskaya,

Salt-sensitive (SS) hypertension is accompanied with severe cardiorenal complications. In this condition, elevated blood pressure (BP) resulting from salt retention is associated with counterintuitively lower levels of atrial natriuretic peptide (ANP). In plasma, ANP is degraded by the neprilysin; therefore, pharmacological inhibition of this metalloprotease (i.e., with sacubitril) can be ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):315-324]

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Magnesium acetyltaurate prevents retinal damage and visual impairment in rats through suppression of NMDA-induced upregulation of NF-κB, p53 and AP-1 (c-Jun/c-Fos).

Lidawani Lambuk, Igor Iezhitsa, Renu Agarwal, Puneet Agarwal, Anna Peresypkina, Anna Pobeda, Nafeeza Mohd Ismail,

Magnesium acetyltaurate (MgAT) has been shown to have a protective effect against N-methyl-D-aspartate (NMDA)-induced retinal cell apoptosis. The current study investigated the involvement of nuclear factor kappa-B (NF-κB), p53 and AP-1 family members (c-Jun/c-Fos) in neuroprotection by MgAT against NMDA-induced retinal damage. In this study, Sprague-Dawley rats were randomized to ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(11):2330-2344]

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Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists.

Alexey Lukin, Anna Bakholdina, Mikhail Chudinov, Oleksandra Onopchenko, Elena Zhuravel, Sergey Zozulya, Maxim Gureev, Mikhail Krasavin,

A set of 1,3,4-thiadiazole-2-carboxamides bearing a substituted biphenyl in the amide portion was synthesised and tested for agonistic activity towards free fatty acid receptor 1 (FFA1). The observed activity trends were impossible to rationalised based solely on the docking energy scores of Glide SP. On the contrary, when the phospholipid ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1651-1658]

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Catalase impairs Leishmania mexicana development and virulence.

Jovana Sádlová, Lucie Podešvová, Tomáš Bečvář, Claretta Bianchi, Evgeny S Gerasimov, Andreu Saura, Kristýna Glanzová, Tereza Leštinová, Nadezhda S Matveeva, Ľubomíra Chmelová, Denisa Mlacovská, Tatiana Spitzová, Barbora Vojtková, Petr Volf, Vyacheslav Yurchenko, Natalya Kraeva,

Catalase is one of the most abundant enzymes on Earth. It decomposes hydrogen peroxide, thus protecting cells from dangerous reactive oxygen species. The catalase-encoding gene is conspicuously absent from the genome of most representatives of the family Trypanosomatidae. Here, we expressed this protein from the <i>Leishmania mexicana Β-TUBULIN</i> locus using ... Read more >>

Virulence (Virulence)
[2021, 12(1):852-867]

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Nitrous anhydrase activity of carbonic anhydrase II: cysteine is required for nitric oxide (NO) dependent phosphorylation of VASP in human platelets.

Dimitrios Tsikas, Stepan Gambaryan,

The carbonic anhydrase (CA) family does not only catalyse the reversible hydration of CO<sub>2</sub> to bicarbonate, but it also possesses esterase and phosphatase activity. Recently, bovine CA II and human CA II have been reported to convert inorganic nitrite (O=N-O<sup>-</sup>) to nitric oxide (NO) and nitrous anhydride (N<sub>2</sub>O<sub>3</sub>). Given the ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):525-534]

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Sami dietary habits and the risk of cardiometabolic disease: a systematic review.

I K Dahl, C Dalgård,

This systematic literary review investigates if an association between Sami dietary habits and cardiometabolic outcomes exists, and examines the dietary characteristics and cardiometabolic status of the Sami population. Included were all articles assessing Sami dietary habits and cardiometabolic disease or risk factors. Embase, Medline and SweMed were searched on 26 ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1873621]

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Nuclear sphingomyelin in neurodegenerative diseases.

Elisabetta Albi, Alice V Alessenko,

Neural Regen Res (Neural regeneration research)
[2021, 16(10):2028-2029]

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Hypothesis: AA amyloidosis is a factor causing systemic complications after coronavirus disease.

Alexey P Galkin,

The severe course of COVID-19 causes systemic chronic inflammation and thrombosis in a wide variety of organs and tissues. The nature of these inflammations remains a mystery, although they are known to occur against the background of a high level of cytokine production. The high level of cytokines provokes overproduction ... Read more >>

Prion (Prion)
[2021, 15(1):53-55]

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Angiogenesis and nerve regeneration induced by local administration of plasmid pBud-coVEGF165-coFGF2 into the intact rat sciatic nerve.

Ruslan Masgutov, Alina Zeinalova, Alexey Bogov, Galina Masgutova, Ilnur Salafutdinov, Ekaterina Garanina, Valeriia Syromiatnikova, Kamilla Idrisova, Adelya Mullakhmetova, Dina Andreeva, Liliya Mukhametova, Adilet Kadyrov, Igor Pankov, Albert Rizvanov,

Vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) are well-known growth factors involved in the regeneration of various tissues and organs, including peripheral nerve system. In the present study, we elucidated the local and systemic effects of plasmid construct рBud-coVEGF165-coFGF2 injected into the epineurium of intact rat ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(9):1882-1889]

Cited: 2 times

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Homeostatic and endocrine responses as the basis for systemic therapy with medical gases: ozone, xenon and molecular hydrogen.

Eugene Iv Nazarov, Igor Alb Khlusov, Mami Noda,

Among medical gases, including gases used therapeutically, this review discusses the comparative physiological activity of three gases - ozone (O<sub>3</sub>), xenon (Xe) and molecular hydrogen (H<sub>2</sub>), which together form representatives of three types of substances - typical oxidizing, inert, and typical reducing agents. Upon analysis of published and proprietary data, ... Read more >>

Med Gas Res (Medical gas research)
[2021, 11(4):174-186]

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Synaptic mechanisms of cadmium neurotoxicity.

Andrei N Tsentsevitsky, Alexey M Petrov,

Neural Regen Res (Neural regeneration research)
[2021, 16(9):1762-1763]

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How Do Natural Gas, Oil, and Coal Consumption Contribute to Environmental Degradation? An Empirical Investigation in Russia

Orazaliyev Kanat, Zhijun Yan, Muhammad Mansoor Asghar, Zahoor Ahmed, Haider Mahmood, Dervis Kirikkaleli, Muntasir Murshed,

Environmental degradation sourced by conventional energy sources is not only a major factor behind climate change but also poses an adverse impact on human health. Undoubtedly, fossil fuels are major drivers of economic growth; however, their detrimental environmental impacts are of global scope, affecting the inhabitants of the whole world. ... Read more >>

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