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Modeling subcortical ischemic white matter injury in rodents: unmet need for a breakthrough in translational research.

Yuexian Cui, Xuelian Jin, Jun Young Choi, Byung Gon Kim,

Subcortical ischemic white matter injury (SIWMI), pathological correlate of white matter hyperintensities or leukoaraiosis on magnetic resonance imaging, is a common cause of cognitive decline in elderly. Despite its high prevalence, it remains unknown how various components of the white matter degenerate in response to chronic ischemia.This incomplete knowledge is ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(4):638-642]

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Global discovery of human-infective RNA viruses: A modelling analysis.

Feifei Zhang, Margo Chase-Topping, Chuan-Guo Guo, Bram A D van Bunnik, Liam Brierley, Mark E J Woolhouse,

RNA viruses are a leading cause of human infectious diseases and the prediction of where new RNA viruses are likely to be discovered is a significant public health concern. Here, we geocoded the first peer-reviewed reports of 223 human RNA viruses. Using a boosted regression tree model, we matched these ... Read more >>

PLoS Pathog (PLoS pathogens)
[2020, 16(11):e1009079]

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Cryopreservation and Transplantation of Laboratory Rodent Ovarian Tissue for Genome Banking and Biomedical Research.

Yuksel Agca, Cansu Agca,

Genetic modifications in combination with highly sophisticated assisted reproductive technologies such as in vitro oocyte maturation and development, in vitro fertilization, intracytoplasmic sperm injection, and in vitro embryo culture have opened many research avenues and treatment options for both animals and humans. The number of genetically modified (GM) rodent strains ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2180:469-483]

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CRISPR-Cas RNA Targeting Using Transient Cas13a Expression in Nicotiana benthamiana.

Veerendra Sharma, Wenguang Zheng, Jun Huang, David E Cook,

Application of the CRISPR-Cas prokaryotic immune system for single-stranded RNA targeting will have significant impacts on RNA analysis and engineering. The class 2 Type VI CRISPR-Cas13 system is an RNA-guided RNA-nuclease system capable of binding and cleaving target single-stranded RNA substrates in a sequence-specific manner. In addition to RNA interference, ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2170:1-18]

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An Introduction to Virus Infections and Human Cancer.

John T Schiller, Douglas R Lowy,

Approximately, 1.4 million virus-induced cancers occur annually, representing roughly 10% of the worldwide cancer burden, with the majority (> 85%) occurring in the lower- and middle-income countries. The viruses associated with the greatest number of cancer cases are human papillomaviruses (HPVs), which cause cervical cancer and several other epithelial malignancies, and ... Read more >>

Recent Results Cancer Res (Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer)
[2021, 217:1-11]

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Studying RNA-Protein Interaction Using Riboproteomics.

Sonali Chaturvedi, A L N Rao,

Protein-protein interactions (PPI) are vital in regulating the biological and physiological functions in a given cell or organism. Proteomics, in conjunction with bioinformatic tools, represents the study involving the characterization of the protein content of the genome of a given biological system. Like PPI, an interaction between either coding or ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2170:213-218]

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Cryosurgery of Periocular Moderately Aggressive Basal Cell Carcinoma.

Oscar Finskas, Oscar Zaar, Karin Svedberg,

Uncertainty exists regarding the results of treating basal cell carcinomas with a more aggressive growth pattern than nodular growth with cryosurgery. Over the years, some medium aggressive, well-defined basal cell carcinomas have been treated with cryosurgery at the combined ophthalmology-dermatology recipiency at Sahlgrenska University Hospital, Gothenburg in Sweden. The medical ... Read more >>

Acta Derm Venereol (Acta dermato-venereologica)
[2020, 100(18):adv00336]

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Evaluating recovery, cost, and throughput of different concentration methods for SARS-CoV-2 wastewater-based epidemiology

Zachary LaTurner, David Zong, Prashant Kalvapalle, Kiara ReyesGamas, Austen Terwilliger, Tessa Crosby, Priyanka Ali, Vasanthi Avadhanula, Haroldo Hernandez Santos, Kyle Weesner, Loren Hopkins, Pedro Piedra, Anthony Maresso, Lauren Stadler,

As the COVID-19 pandemic continues to affect communities across the globe, the need to contain the spread of the outbreaks is of paramount importance. Wastewater monitoring of the SARS-CoV-2 virus, the causative agent responsible for COVID-19, has emerged as a promising tool for health officials to anticipate outbreaks. As interest ... Read more >>

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Effects of microhabitat on rodent-mediated seed removal of endangered Kmeria septentrionalis in the karst habitat.

Guohai Wang, Yang Pan, Guole Qin, Weining Tan, Changhu Lu,

Seed removal behaviors of rodents are largely influenced by microhabitat. Although the karst ecosystem is composed of a broad variety of microhabitats, we have no information on how they affect such behaviors. We investigated rodents' seed removal behaviors in four karst microhabitats (stone cavern, stone groove, stone surface, and soil ... Read more >>

PeerJ (PeerJ)
[2020, 8:e10378]

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Nutritive Value and Physical Properties of Neo-Tropical Rodent Meat-with Emphasis on the Capybara (Hydrochoerus hydrochaeris).

Anwar Jamaal Ali, Kegan Romelle Jones,

This review will focus on the nutritive characteristics of meat from neo-tropical rodents which have not yet been domesticated. These rodents include the capybara (<i>Hydrochoerus hydrochaeris</i>), agouti (<i>Dasyprocta leporina</i>), and the lappe (<i>Agouti paca</i>). Information about the meat characteristics of these rodents were obtained from peer reviewed journal articles. Literature ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2020, 10(11):]

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Smart Investment of Virus RNA Testing Resources to Enhance Covid-19 Mitigation

Hossein Gorji, Markus Arnoldini, David Jenny, Wolf-Dietrich Hardt, Patrick Jenny,

Covid-19 mitigation commonly involves contact tracing (CT) and social distancing. Due to its high economic toll and its impact on personal freedom, we need to ease social distancing and deploy alternative measures, while preventing further waves of infections. While reliable mass testing (for virus RNA) would require too many resources ... Read more >>

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A Novel Enzymatic Digestion Approach for Isolation and Culture of Rodent Bone Marrow Mesenchymal Progenitors.

Leilei Zhong, Lutian Yao, Ling Qin,

Bone marrow mesenchymal stem cells (MSCs) are promising therapeutic tools for tissue repair and treatment of a number of human diseases. As a result, there is substantial interest in characterizing and expanding these cells to uncover their therapeutic potential. Bone marrow mesenchymal progenitors, containing both MSCs and their proliferative progeny, ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2221:29-39]

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Glioma-Associated Oncogene-1 Expression in Basal Cell Carcinoma and Its Histologic Mimics.

Sarah E Gradecki, Mary V Eid, Patcharin Pramoonjago, Mark R Wick,

Basal cell carcinoma (BCC) is the most common skin cancer, and it has numerous histologic mimics with variable prognoses and treatments. Although some immunohistochemical stains can be used for the differential diagnosis of BCC, variability and overlap in results can complicate their interpretation. Immunohistochemical staining for glioma-associated oncogene-1 (Gli-1) was ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2020, :]

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[Surgical techniques in the treatment of basal cell carcinoma-a prospective investigation].

Lukas Kofler, Hans-Martin Häfner, Claudia Schulz, Martin Eichner, Katrin Kofler, Saskia Maria Schnabl, Helmut Breuninger,

BACKGROUND:Basal cell carcinomas are the most frequent epithelial skin tumors and a frequent indication for dermatological interventions. Despite the establishment of drug treatment options, surgery is still the treatment of choice. Various options are available ranging from curettage to complex dermatosurgical procedures. In addition to the main aspect of low local ... Read more >>

Hautarzt (Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)
[2020, 71(12):960-968]

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Hunger Pandemic: Urban Rodents' Boom and Bust During COVID-19

Miguel Bedoya-Pérez, Michael Ward, Max Loomes, Mathew Crowther,

Abstract Shortly after the enactment of restrictions aimed at limiting the spread of COVID-19, local governments and public health authorities around the world reported an increased sighting of rats. We combined multi-catch rodent station data, rodent bait stations data, and rodent-related residents’ complaints data to explore the effects that social ... Read more >>

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Are the Recommended Excision Margins for Basal Cell Carcinoma Too Defensive? A Retrospective Chart Study and Evaluation of the Dutch Guideline.

Eva van Loo, Patty J Nelemans, Corine Peters, Myrurgia Abdul-Hamid, Nicole W J Kelleners-Smeets,

Acta Derm Venereol (Acta dermato-venereologica)
[2020, :]

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Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities.

Nicholas J Collier, Lesley E Rhodes,

Photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC). BCC is the most common human cancer and also a convenient cancer in which to study PDT treatment. This review clarifies challenges to researchers evident from the clinical use of PDT in BCC treatment. It outlines ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(22):]

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The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

Jeremy Luban, Rachel Sattler, Elke Mühlberger, Jason D. Graci, Liangxian Cao, Marla Weetall, Christopher Trotta, Joseph M. Colacino, Sina Bavari, Caterina Strambio-De-Castillia, Ellen L. Suder, Yetao Wang, Veronica Soloveva, Katherine Cintron-Lue, Nikolai A. Naryshkin, Mark Pykett, Ellen M. Welch, Kylie O’Keefe, Ronald Kong, Elizabeth Goodwin, Allan Jacobson, Slobodan Paessler, Stuart Peltz,

Highlights • COVID-19 is typified by SARS-CoV-2 replication and excessive inflammatory response.• PTC299 is small orally available DHODH inhibitor that blocks pyrimidine synthesis.• PTC299 is potent inhibitor of the replication of SARS-CoV-2 and other RNA viruses.• PTC299 also reduces production of cytokines associated with COVID-19 inflammation.• PTC299 may be a ... Read more >>

Virus Res (Virus research)
[2020, :]

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Detection of Anaplasma spp. and Bartonella spp. from wild-caught rodents and their ectoparasites in Nakhon Ratchasima Province, Thailand.

Amonrat Panthawong, John Paul Grieco, Ratchadawan Ngoen-Klan, Chien-Chung Chao, Theeraphap Chareonviriyaphap,

The objective of this study was to investigate evidence of emerging anaplasmosis and bartonellosis in rodents from endemic areas of Nakhon Ratchasima, Thailand. Rodent trapping was undertaken in 13 sub-districts of Muang District. The live-capture traps were set up in three locations of selected scrub typhus patient houses for three ... Read more >>

J Vector Ecol (Journal of vector ecology : journal of the Society for Vector Ecology)
[2020, 45(2):241-253]

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The rocaglate CR-31-B (-) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo

Christin Müller, Wiebke Obermann, Nadja Karl, Hans-Guido Wendel, Gaspar Taroncher-Oldenburg, Stephan Pleschka, Roland Hartmann, Arnold Grünweller, John Ziebuhr,

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a betacoronavirus in the subgenus Sarbecovirus causes a respiratory disease with varying symptoms referred to as coronavirus disease 2019 (COVID-19) and is responsible for a pandemic that started in early 2020. With no vaccines or effective antiviral treatments available, and infection and ... Read more >>

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Evolutionary Selection of the Nuclear Localization Signal in the Viral Nucleoprotein Leads to Host Adaptation of the Genus Orthobornavirus.

Ryo Komorizono, Yukiko Sassa, Masayuki Horie, Akiko Makino, Keizo Tomonaga,

Adaptation of the viral life cycle to host cells is necessary for efficient viral infection and replication. This evolutionary process has contributed to the mechanism for determining the host range of viruses. Orthobornaviruses, members of the family <i>Bornaviridae</i>, are non-segmented, negative-strand RNA viruses, and several genotypes have been isolated from ... Read more >>

Viruses (Viruses)
[2020, 12(11):]

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Prediction of the incubation period for COVID-19 and future virus disease outbreaks.

Ayal B Gussow, Noam Auslander, Yuri I Wolf, Eugene V Koonin,

BACKGROUND:A crucial factor in mitigating respiratory viral outbreaks is early determination of the duration of the incubation period and, accordingly, the required quarantine time for potentially exposed individuals. At the time of the COVID-19 pandemic, optimization of quarantine regimes becomes paramount for public health, societal well-being, and global economy. However, ... Read more >>

BMC Biol (BMC biology)
[2020, 18(1):186]

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A Vismodegib Experience in Elderly Patients with Basal Cell Carcinoma: Case Reports and Review of the Literature.

Anna Passarelli, Giovanna Galdo, Michele Aieta, Tommaso Fabrizio, Antonio Villonio, Raffaele Conca,

Cutaneous basal cell carcinoma (BCC) is the most common type of human tumor, and its incidence rate is increasing worldwide. Up until a few years ago, therapeutic options have been limited for patients with advanced BCC (including metastatic and locally-advanced BCC). Over the last few years, promising systemic therapies have ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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Unbiased metagenomic next-generation sequencing of blood from hospitalized febrile children in Gabon.

José Francisco Fernandes, Florian Laubscher, Jana Held, Isabella Eckerle, Mylène Docquier, Martin Peter Grobusch, Benjamin Mordmüller, Laurent Kaiser, Samuel Cordey,

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1242-1244]

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Outsized effect of predation: Wolves alter wetland creation and recolonization by killing ecosystem engineers.

Thomas D Gable, Sean M Johnson-Bice, Austin T Homkes, Steve K Windels, Joseph K Bump,

Gray wolves are a premier example of how predators can transform ecosystems through trophic cascades. However, whether wolves change ecosystems as drastically as previously suggested has been increasingly questioned. We demonstrate how wolves alter wetland creation and recolonization by killing dispersing beavers. Beavers are ecosystem engineers that generate most wetland ... Read more >>

Sci Adv (Science advances)
[2020, 6(46):]

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