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Retinopathy of Prematurity

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Lycium barbarum polysaccharides protects retinal ganglion cells against oxidative stress injury.

Lian Liu, Xiao-Yuan Sha, Yi-Ning Wu, Meng-Ting Chen, Jing-Xiang Zhong,

The accumulation of excessive reactive oxygen species can exacerbate any injury of retinal tissue because free radicals can trigger lipid peroxidation, protein damage and DNA fragmentation. Increased oxidative stress is associated with the common pathological process of many eye diseases, such as glaucoma, diabetic retinopathy and ischemic optic neuropathy. Many ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1526-1531]

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Incidence and Early Course of Retinopathy of Prematurity.

Earl A Palmer, John T Flynn, Robert J Hardy, Dale L Phelps, Cynthia L Phillips, David B Schaffer, Betty Tung, ,

In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% ... Read more >>

Ophthalmology (Ophthalmology)
[2020, 127(4S):S84-S96]

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Assessment of the G-ROP study criteria for predicting retinopathy of prematurity: results from a tertiary centre in Turkey.

Ozge Yabas Kiziloglu, Yesim Coskun, Ipek Akman,

PURPOSE:The postnatal growth and retinopathy of prematurity (G-ROP) study has proposed a new model for retinopathy of prematurity (ROP) prediction based on gestational age, birth weight and postnatal weight gain. The purpose of the current study is to assess the efficacy of the G-ROP model for predicting ROP among a Turkish ... Read more >>

Int Ophthalmol (International ophthalmology)
[2020, :]

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Retinopathy of Prematurity Incidence in Children.

William V Good,

Ophthalmology (Ophthalmology)
[2020, 127(4S):S82-S83]

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Telemedicine for Retinopathy of Prematurity.

Christopher J Brady, Samantha D'Amico, J Peter Campbell,

Background: Retinopathy of prematurity (ROP) is a disease of the retinal vasculature that remains a leading cause of childhood blindness worldwide despite improvements in the systemic care of premature newborns. Screening for ROP is effective and cost-effective, but in many areas, access to skilled examiners to conduct dilated examinations is ... Read more >>

Telemed J E Health (Telemedicine journal and e-health : the official journal of the American Telemedicine Association)
[2020, :]

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Contralateral effect of systemic absorption of low dose bevacizumab (Avastin) after unilateral intravitreal injection in severe retinopathy of prematurity (ROP).

Ayad Shafiq, Roxane Hillier, Richard Hearn,

An extremely premature baby boy born at 23 weeks' gestational age was treated with unilateral low dose of 0.16 mg/0.025 mL intravitreal bevacizumab in the left eye for aggressive retinopathy of prematurity (ROP). He developed photographically documented changes in his contralateral right eye on imaging 5 days later. Second eye treatment ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(3):]

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Population based retrospective cohort study on risk of retinopathy of prematurity in twins.

Hui-Chen Tseng, Fung-Chang Sung, Chih-Hsin Mou, Hsiang Yu Lin, Chun-Chi Chiang, Ning-Yi Hsia, Ya-Ling Tzeng,

BACKGROUND:Twin infants are likely at great risk for ROP, but studies reported conflicting findings and population studies examining the risk of retinopathy of prematurity (ROP) in twins is limited. We aimed to evaluate the ROP risk in the cohort of one of twins, comparing to singletons. MATERIAL AND METHODS:Using insurance ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230346]

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Neurodevelopmental outcomes following intravitreal bevacizumab injection in Japanese preterm infants with type 1 retinopathy of prematurity.

Mitsuru Arima, Masato Akiyama, Kohta Fujiwara, Yujiro Mori, Hirosuke Inoue, Eiko Seki, Takahito Nakama, Shoko Tsukamoto, Masayuki Ochiai, Shouichi Ohga, Koh-Hei Sonoda,

PURPOSE:The purpose of this study was to evaluate neurodevelopmental outcomes in 18-month old (corrected age) preterm infants who received an intravitreal bevacizumab (IVB) injection for the treatment of type 1 retinopathy of prematurity (ROP). METHODS:In this ten-year retrospective study, we reviewed the medical records of patients who underwent ROP screening ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230678]

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Immunological outcomes in infants with ROP after dexamethasone and aminophylline.

Larisa Balashova, Svetlana Bykovskaya, Ludmila Korobova, Yulia Kuznetsova, Elena Kantardgy, Vladimir Mukhin, Andrey Popov,

This research aims to improve anaesthesia services given to preterm infants by the use of dexamethasone and aminophylline administrated under sevoflurane, and to analyze its effect on the cell-mediated immunity (CD4+CD25+Foxp3+(Treg) and CD4+CD25highFoxp3+CD127low). We have examined 74 premature babies with retinopathy of prematurity (ROP) at the 3-5 stages during the ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Antenatal exposure to fenoterol is not associated with the development of retinopathy of prematurity in infants born before 32 weeks of gestation.

Hannes Hudalla, Thomas Bruckner, Johannes Pöschl, Thomas Strowitzki, Ruben-J Kuon,

PURPOSE:Despite safety concerns, β2-sympathomimetics are still widely used as tocolytic agents. β-Blockers in turn are used to treat vasculo-proliferative diseases of the newborn such as retinopathy of prematurity (ROP), which may lead to visual impairment and blindness. The scope of this study was to investigate whether antenatal exposure to the ... Read more >>

Arch. Gynecol. Obstet. (Archives of gynecology and obstetrics)
[2020, 301(3):687-692]

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ULTRA-WIDE-FIELD IMAGING AND INTRAVENOUS FUNDUS FLUORESCEIN ANGIOGRAPHY IN INFANTS WITH RETINOPATHY OF PREMATURITY.

Jianbo Mao, Yirun Shao, Jimeng Lao, Xueting Yu, Yiqi Chen, Caiyun Zhang, Hanxiao Li, Lijun Shen,

PURPOSE:To determine the feasibility of ultra-wide-field imaging and ultra-wide-field intravenous fundus fluorescein angiography (UWF-IV-FFA) in infants with retinopathy of prematurity (ROP) using Optos 200Tx. METHODS:We performed Optos 200Tx capturing on 32 premature infants (14 females) and UWF-IV-FFA with Optos 200Tx on 12 of the 32 infants between April 2017 and ... Read more >>

Retina (Philadelphia, Pa.) (Retina (Philadelphia, Pa.))
[2020, :]

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Antagonist of nucleolin, N6L, inhibits neovascularization in mouse models of retinopathies.

Marie Darche, Mélissande Cossutta, Laure Caruana, Claire Houppe, Maud-Emmanuelle Gilles, Damien Habert, Xavier Guilloneau, Lucile Vignaud, Michel Paques, José Courty, Ilaria Cascone,

Retinal vascular diseases (RVD) have been identified as a major cause of blindness worldwide. These pathologies, including the wet form of age-related macular degeneration, retinopathy of prematurity, and diabetic retinopathy are currently treated by intravitreal delivery of anti-vascular endothelial growth factor (VEGF) agents. However, repeated intravitreal injections can lead to ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, :]

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A pyruvate dehydrogenase kinase inhibitor prevents retinal cell death and improves energy metabolism in rat retinas after ischemia/reperfusion injury.

Kota Sato, Seiya Mochida, Daisuke Tomimoto, Takahiro Konuma, Naoki Kiyota, Satoru Tsuda, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa,

We aimed to assess the neuroprotective effect of a pyruvate dehydrogenase kinase (PDK) inhibitor, Nov3r after ischemia/reperfusion (IR) injury in rats. IR injury was induced by applying 150 mmHg of intraocular pressure for 50 min. Nov3r was orally administered (100 mg/kg) 3 h before and 24 h after IR injury. TUNEL-positive cells increased and immunoreactive ... Read more >>

Exp. Eye Res. (Experimental eye research)
[2020, 193:107997]

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Serum VEGF and Ang-2 Levels in Infants Before and After Laser Treatment for Retinopathy of Prematurity.

Xiaofeng Yang, Junping Wang, Chao Chen,

Objectives: To investigate VEGF and Ang-2 level changes in the systemic circulation after laser photocoagulation in premature infants with ROP. Methods: Eleven infants (4 girls and 7 boys) had serum levels determined for VEGF and Ang-2, collected 1 day prior to and 7 days after ROP laser therapy. Serum levels of VEGF ... Read more >>

Fetal Pediatr Pathol (Fetal and pediatric pathology)
[2020, :1-7]

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Risk factors and pregnancy outcomes associated with retinopathy in patients presenting with severe preeclampsia: A retrospective cohort study.

Lei Ye, Meng-Dan Shi, Yan-Ping Zhang, Jia-Shuo Zhang, Cai-Rong Zhu, Rong Zhou,

The visual system was reported to be affected in over half of patients with preeclampsia (PE), though fundus examination was performed only among patients complaining of visual symptoms. Delayed diagnosis and treatment of PE-related retinopathy may lead to permanent visual impairment. Therefore, we hypothesize that some clinical or laboratory parameters ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(11):e19349]

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Artificial Intelligence and Ophthalmology

Kadircan Keskinbora, Fatih Güven,

Artificial intelligence is advancing rapidly and making its way into all areas of our lives. This review discusses developments and potential practices regarding the use of artificial intelligence in the field of ophthalmology, and the related topic of medical ethics. Various artificial intelligence applications related to the diagnosis of eye ... Read more >>

Turk J Ophthalmol (Turkish journal of ophthalmology)
[2020, 50(1):37-43]

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Practice Guidelines for Ocular Telehealth-Diabetic Retinopathy, Third Edition.

Mark B Horton, Christopher J Brady, Jerry Cavallerano, Michael Abramoff, Gail Barker, Michael F Chiang, Charlene H Crockett, Seema Garg, Peter Karth, Yao Liu, Clark D Newman, Siddarth Rathi, Veeral Sheth, Paolo Silva, Kristen Stebbins, Ingrid Zimmer-Galler,

Contributors The following document and appendices represent the third edition of the Practice Guidelines for Ocular Telehealth-Diabetic Retinopathy. These guidelines were developed by the Diabetic Retinopathy Telehealth Practice Guidelines Working Group. This working group consisted of a large number of subject matter experts in clinical applications for telehealth in ophthalmology. ... Read more >>

Telemed J E Health (Telemedicine journal and e-health : the official journal of the American Telemedicine Association)
[2020, :]

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Longitudinal neurodevelopmental outcomes in preterm twins.

Rhandi Christensen, Vann Chau, Anne Synnes, Ruth E Grunau, Steven P Miller,

BACKGROUND:Several factors contribute to neurodevelopmental outcomes in preterm infants. The aim of this study was to examine the genetic and environmental influences on long-term outcomes in preterm twins. METHODS:From a prospective cohort of 225 preterm neonates studied with MRI, 24 monozygotic and 52 dizygotic twins were included. Neurodevelopmental outcomes at ... Read more >>

Pediatr. Res. (Pediatric Research)
[2020, :]

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Recent developments in pediatric retina.

Sophie Cai, Anthony Therattil, Lejla Vajzovic,

PURPOSE OF REVIEW:Pediatric retina is an exciting, but also challenging field, where patient age and cooperation can limit ease of diagnosis of a broad range of congenital and acquired diseases, inherited retinal degenerations are mostly untreatable and surgical outcomes can be quite different from those for adults. This review aims ... Read more >>

Curr Opin Ophthalmol (Current opinion in ophthalmology)
[2020, :]

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Lutein supplementation and retinopathy of prematurity: a meta-analysis.

Francesco Cota, Simonetta Costa, Carmen Giannantonio, Velia Purcaro, Piero Catenazzi, Giovanni Vento,

Background: Retinopathy of prematurity (ROP) is a multifactorial retinal disorder characterized by an abnormal vascular development of the retina of the preterm infants. Carotenoids are natural pigments that are synthesized by all plants and some microorganisms where they play a role in photoprotection and coloration. Lutein and zeaxanthin (L/Z) are ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-6]

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Progression Patterns in Retinopathy of Prematurity Subtypes: Does It Matter?

Audina M Berrocal, Timothy G Murray,

Ophthalmol Retina (Ophthalmology. Retina)
[2020, 4(3):229-230]

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Peripheral Retinal Changes in Regressed Retinopathy of Prematurity.

Jessica Minjy Kang, Mariana A Flores Pimentel, Alejandra G de Alba Campomanes,

J Pediatr Ophthalmol Strabismus (Journal of pediatric ophthalmology and strabismus)
[2020, 57(2):136]

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The effect of desflurane on retinal angiogenesis in a mouse model of oxygen-induced retinopathy.

Hyun-Su Ri, Sun Sik Bae, Jung Min Ha, Hee Young Kim, Seung-Hoon Baek,

PURPOSE:Retinopathy of prematurity (ROP) is an ocular disorder that primarily occurs in premature infants and is the most common cause of vision impairment. This study examined the effect of desflurane on angiogenesis in a mouse model of oxygen-induced retinopathy (OIR). METHODS:Mice were randomly allocated to the control (C), ROP control ... Read more >>

J Anesth (Journal of anesthesia)
[2020, :]

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Intranasal fentanyl for pain management during screening for retinopathy of prematurity in preterm infants: a randomized controlled trial.

Mythily Sindhur, Haribalakrishna Balasubramanian, Lakshmi Srinivasan, Nandkishor S Kabra, Prachi Agashe, Ashish Doshi,

OBJECTIVE:To study the efficacy of intranasal fentanyl as an adjunct for pain management during screening for retinopathy of prematurity (ROP) in preterm infants. STUDY DESIGN:In this single center, double blinded, randomized controlled trial, preterm neonates between 30 and 34 weeks postmenstrual age received either intranasal fentanyl (2 mcg/kg) or intranasal normal ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, :]

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Predictive ability of neonatal illness severity scores for early death in extremely premature infants.

Genichiro Sotodate, Kotaro Oyama, Atsushi Matsumoto, Yu Konishi, Yukiko Toya, Nao Takashimizu,

Background: The predictive ability of neonatal illness severity scores for mortality or morbidity in extremely premature infants has not been extensively studied. We aimed to evaluate the ability of neonatal illness severity scores [Clinical Risk Index for Babies II (CRIB II), Score for Neonatal Acute Physiology II (SNAP-II), and SNAP-Perinatal ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-6]

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