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Restless Legs Syndrome

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Tc-99m TRODAT-1 SPECT is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage.

Yi-Chou Hou, Yu-Ming Fan, Ya-Ching Huang, Ruei-Ming Chen, Cheng-Hsu Wang, Yi-Te Lin, Tzung-Hai Yen, Kuo-Cheng Lu, Yuh-Feng Lin,

Rationales: Restless leg syndrome (RLS) is a common complication in patients with end-stage renal disease (ESRD). However, there is a lack of biomarkers linking uremic RLS to dopaminergic neurons. Previous studies demonstrated that Tc-99m TRODAT-1 SPECT was a biomarker for RLS but the correlation between the physiologic parameter was lacking. ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(3):]

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The prevalence of insomnia and restless legs syndrome among Japanese outpatients with rheumatic disease: A cross-sectional study.

Kayoko Urashima, Kunihiro Ichinose, Hideaki Kondo, Takahiro Maeda, Atsushi Kawakami, Hiroki Ozawa,

The prevalence of symptomatic insomnia and the prevalence of restless legs syndrome (RLS) are known to be higher among patients with rheumatic diseases compared to the general population. The prevalences of insomnia and RLS reported in a questionnaire by Japanese patients with rheumatic diseases at an outpatient clinic were analyzed ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230273]

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Prevalence and predictors of restless legs syndrome in non-pregnant Saudi women of childbearing age.

Aljohara S Almeneessier, Maha Alzahrani, Aisha Alsafi, Raneem Alotaibi, Awad H Olaish, Ahmed S BaHammam,

PURPOSE:This study assessed the prevalence of restless legs syndrome (RLS) and its correlates and severity among non-pregnant Saudi women of childbearing age. METHODS:Consecutive non-pregnant female visitors (age 15-44 years) of the primary care centers of the female University campus at King Saud University (n = 1,136) were interviewed face-to-face to ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2020, :]

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Restless legs syndrome following the use of ziprasidone: a case report.

Cuizhen Zhu, Ran Bi, Yuliang Hu, Hui Zhou, Daomin Zhu, Brian Isaacson, Qingwei Li, Yezhe Lin,

Restless legs syndrome (RLS) is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity. Although there have been many case reports on antipsychotic-induced RLS, ziprasidone has never been reported as a cause of RLS. We present a case of ... Read more >>

Gen Psychiatr (General psychiatry)
[2020, 33(2):e100112]

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Presynaptic inhibition in restless legs syndrome.

Şule Aydin Türkoglu, Elif Sultan Bolac, Serpil Yildiz, Oya Kalaycioglu, Nebil Yildiz,

Introduction: Restless legs syndrome (RLS) is a condition that particularly urges at night in resting and causes the need to move the legs. Although the pathophysiology has not yet been clarified, dopamine and iron metabolism and spinal cord pathologies are blamed for causing the condition. There are few studies on ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-7]

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The influence of restless legs symptoms on musculoskeletal pain in depression.

Piritta Auvinen, Hannu Koponen, Hannu Kautiainen, Katariina Korniloff, Tiina Ahonen, Mauno Vanhala, Pekka Mäntyselkä,

Background and aims Restless legs syndrome is a sensorimotor disorder associated with mental health conditions notably depression. Restless legs symptoms and depression are commonly associated with pain. The study investigated the influence of restless legs symptoms on musculoskeletal pain in patients with depression or with increased depressive symptoms. Methods A ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2020, :]

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Creating cartoons to represent habitual leg movements.

Karla Carlos, Eleida Pereira Camargo, Mayara Menezes do Moinho, Amanda Moraes de Paula Souza, Melissa Haruka Kuroiwa, Gilmar Fernandes do Prado,

BACKGROUND:Many people have a habit of moving their legs and believe that this behavior is due to the restless legs syndrome (RLS), a highly prevalent neurological condition that greatly impairs the quality of life of affected individuals. This behavioral pattern, characterized by the habit of moving one's legs and feet, ... Read more >>

Arq Neuropsiquiatr (Arquivos de neuro-psiquiatria)
[2020, :]

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Sleep Disorders in Essential Tremor: Systematic Review and Meta-Analysis.

Félix Javier Jiménez-Jiménez, Hortensia Alonso-Navarro, Elena García-Martín, José A G Agúndez,

Sleep disorders are frequent in patients diagnosed with essential tremor (ET). The present review focuses on sleep disorders and the results of polysomnographic studies performed in patients with ET. For this purpose we performed a systematic review crossing the search term "essential tremor" with "sleep", "sleep disorders", "sleep disturbances" and ... Read more >>

Sleep (Sleep)
[2020, :]

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Sleep difficulties among South Sudanese former refugees settled in Australia.

Dorothy Bruck, Santino Atem Deng, Bichok Kot, Michele Grossman,

This quantitative study investigated self-reported sleep, mental health and trauma related nocturnal behaviours among South Sudanese Australians (SSA), examined sex differences in their responses, and sought to determine risk factors for insomnia in this population. Comparisons were also made to a general Australian (AUS) sample of 1,512 respondents, obtained in ... Read more >>

Transcult Psychiatry (Transcultural psychiatry)
[2020, :1363461520903122]

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Characteristics of sleep/wake problems and delivery outcomes among pregnant Japanese women without gestational complications.

Shiho Umeno, Chiho Kato, Yuki Nagaura, Hideaki Kondo, Hiromi Eto,

BACKGROUND:Frequently observed sleep/wake problems among pregnant women need comprehensive evaluation. This study was conducted to clarify the sleep/wake problems among pregnant women without gestational complications during the second and third trimester and the effects of sleep/wake problems on delivery outcomes. METHODS:A total of 88 Japanese pregnant women participated in this ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2020, 20(1):179]

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The effect of vitamin D on restless legs syndrome: prospective self-controlled case study.

Mesude Tutuncu, Melih Tutuncu,

PURPOSE:To evaluate the effect of vitamin D on severity of restless legs syndrome in patients with idiopathic restless legs syndrome (RLS). METHODS:Patients with idiopathic RLS completed questionnaires including the International Restless Legs Severity Scale (IRLSS) and were evaluated for vitamin D deficiency. Patients with deficiency of vitamin D were treated ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2020, :]

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Determinants of ferritin response to oral iron supplementation in children with sleep movement disorders.

Lourdes M DelRosso, Troy Yi, Jeremy H M Chan, Joanna E Wrede, Carey T Lockhart, Raffaele Ferri,

STUDY OBJECTIVES:To identify children who respond to oral iron supplementation as evidenced by increased ferritin levels and to identify factors that correlate with improvement in ferritin levels in those who respond. METHODS:A retrospective chart review of the PLMS/RLS/RSD database at Seattle Children's Hospital was carried out. Data collected included nocturnal ... Read more >>

Sleep (Sleep)
[2020, 43(3):]

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Risk analysis of lurasidone in patients with schizophrenia and bipolar depression.

Harika Modugula, Anoop Kumar,

BACKGROUND:Lurasidone has been approved by the United States Food and Drug administration (FDA) for the treatment of schizophrenia as well as for the treatment of bipolar depression. However, various adverse drug reactions have been reported regarding the use of lurasidone. Thus, in this article, we have analyzed the risk profile ... Read more >>

CNS Neurol Disord Drug Targets (CNS & neurological disorders drug targets)
[2020, :]

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Vitamin D and sleep regulation: is there a role for vitamin D?

Fiammetta Romano, Giovanna Muscogiuri, Elea Di Benedetto, Vohla V. Zhukouskaya, Luigi Barrea, Silvia Savastano, Annamaria Colao, Carolina Di Somma,

BACKGROUND:Vitamin D exerts multiple pleiotropic effects beyond its role in calcium-phosphate metabolism. Growing evidence suggest an association between hypovitaminosis D and sleep disorders, thus increasing the interest on the role of this vitamin in the regulatory mechanisms of sleep-wake cycle. OBJECTIVE:To explore and summarize the current knowledge about the role ... Read more >>

Curr. Pharm. Des. (Current pharmaceutical design)
[2020, :]

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Selective serotonin reuptake inhibitors and the risk of restless legs syndrome: a symmetry analysis.

Ann-Cathrine Dalgård Dunvald, Daniel Pilsgaard Henriksen, Jesper Hallas, Mette Marie Hougaard Christensen, Lars Christian Lund,

PURPOSE:Largely based on case series, several drugs have been implicated in drug-induced restless legs syndrome (RLS) including selective serotonin reuptake inhibitors (SSRI). We aimed to assess the association between initiation of SSRIs and RLS in a self-controlled design. METHODS:We conducted a symmetry analysis, including Danish adults who filled in their ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Prevalence of Restless Legs Syndrome among Medical Students of Karachi: An Experience from a Developing Country.

M Ishaq, S U Riaz, N Iqbal, S Siddiqui, A Moin, S Sajjad, T Ali, S Jamali,

Background:Restless legs syndrome (RLS) is a neurological disorder characterized by an uncomfortable sensation in the legs which gets worse in the evening or night, relieved upon movement. The aim of this study was to specify the prevalence of RLS in the group of young medical students and to assess the ... Read more >>

Sleep Disord (Sleep disorders)
[2020, 2020:7302828]

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Restless legs syndrome among multiple sclerosis patients in Lebanon.

J Makhoul, N Ghaoui, G Sleilaty, S Koussa, S Abbas, C Azar, J El Helou,

BACKGROUND:Multiple sclerosis (MS) is often associated with fatigue, with an increased prevalence of sleep disorders compared to the general population, notably restless legs syndrome (RLS). The aim of this study was to evaluate the prevalence and severity of RLS as well the co-occurrence of spinal demyelination lesions in patients with ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 41:101997]

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Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes - Possible Link.

Anna Brzecka, Natalia Madetko, Vladimir N Nikolenko, Ghulam M Ashraf, Maria Ejma, Jerzy Leszek, Cyryl Daroszewski, Karolina Sarul, Liudmila M Mikhaleva, Siva G Somasundaram, Cecil E Kirkland, Sergey O Bachurin, Gjumrakch Aliev,

There is increasing number of the patients worldwide with sleep disturbances and diabetes. Various sleep disorders, including long or short sleep duration and poor sleep quality of numerous causes, may increase the risk of diabetes. Some symptoms of diabetes, such as painful peripheral neuropathy and nocturia, or associated other sleep ... Read more >>

Curr Neuropharmacol (Current neuropharmacology)
[2020, :]

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Pramipexole in peritoneal dialysis patients with restless legs syndrome (RLS): a protocol for a multicentre double-blind randomised controlled trial.

Tian-Tian Ma, Zhikai Yang, Sainan Zhu, Jing-Hong Zhao, Yi Li, Fu-Yun Sun, Nan Zhao, Zu-Ying Xiong, Zi-Bo Xiong, Jie Dong,

INTRODUCTION:Restless legs syndrome (RLS) is a common neurological sensorimotor disorder among patients with end stage renal disease. This clinical trial aimed to provide evidence on the efficacy and safety of pramipexole in patients with uremic RLS receiving peritoneal dialysis (PD). METHODS AND ANALYSIS:This is a 12-week, multicentre, randomised, double-blind, placebo-controlled ... Read more >>

BMJ Open (BMJ open)
[2020, 10(2):e033815]

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The present and the future of Transcranial Magnetic Stimulation in Restless Legs Syndrome.

Giuseppe Lanza, Anna Scalise,

Sleep Med. (Sleep medicine)
[2020, :]

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Effects of repetitive transcranial magnetic stimulation in subjects with sleep disorders.

Raffaele Nardone, Luca Sebastianelli, Viviana Versace, Francesco Brigo, Stefan Golaszewski, Elke Pucks-Faes, Leopold Saltuari, Eugen Trinka,

In this review, we aimed at identifying the studies that have employed repetitive transcranial magnetic stimulation (rTMS) in patients with sleep disorders. Low-frequency (LF) rTMS stimulating the right dorsolateral prefrontal cortex (DLPFC) or the posterior parietal cortex (PPC) was found to be effective to reduce cortical hyperexcitability and improve the ... Read more >>

Sleep Med. (Sleep medicine)
[2020, :]

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Iron-deficiency and dopaminergic treatment effects on RLS-Like behaviors of an animal model with the brain iron deficiency pattern of the restless legs syndrome.

Richard P Allen, Christopher J Earley, Byron C Jones, Erica L Unger,

BACKGROUND:Brain iron deficiency (BID), especially for the substantia nigra (SN), without peripheral iron deficiency (ID) has been well documented as a ubiquitous finding for restless legs syndrome (RLS) patients. This close association suggests the biology of RLS BID can produce RLS symptoms. Association, however, cannot establish such a direct relationship. ... Read more >>

Sleep Med. (Sleep medicine)
[2020, :]

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Striatal histamine mechanism in the pathogenesis of restless legs syndrome.

Yuan-Yang Lai, Kung-Chiao Hsieh, Yu-Hsuan Cheng, Keng-Tee Chew, Darian Nguyen, Lalini Ramanathan, Jerome M Siegel,

STUDY OBJECTIVES:Restless legs syndrome (RLS) has been hypothesized to be generated by abnormal striatal dopamine transmission. Dopaminergic drugs are effective for the treatment of RLS. However, long-term use of dopaminergic drugs causes adverse effects. We used iron-deficient (ID) and iron-replacement (IR) rats to address the neuropathology of RLS and to ... Read more >>

Sleep (Sleep)
[2020, 43(2):]

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[Restless legs syndrome].

G Vellieux, M-P d'Ortho,

Restless legs syndrome, also called Willis-Ekbom disease, is a frequent sensorimotor disease, more often encountered in women than men. It is characterized by an urge to move legs, during the evening or the beginning of the night, increased by rest and relieved by movement. Two forms are classically distinguished: primary ... Read more >>

Rev Med Interne (La Revue de medecine interne)
[2020, 41(4):258-264]

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Restless legs syndrome and periodic limb movements of sleep.

David O'Regan, Kirstie N Anderson,

Restless legs syndrome describes a curious need to stretch and move in response to an unpleasant feeling in the legs. For most people who have this, as they are drifting off to sleep there is a twitch of the toe, foot and ankle followed by another and then another. The ... Read more >>

Br J Hosp Med (Lond) (British journal of hospital medicine (London, England : 2005))
[2020, 81(1):1-8]

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