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Reperfusion Injury in Stroke

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XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition.

Yue-Ming Zhang, Xiao-Yu Qu, Li-Na Tao, Jing-Hui Zhai, Huan Gao, Yan-Qing Song, Si-Xi Zhang,

Context: XingNaoJing injection (XNJ), extracted from a traditional compound Chinese medicine Angong niuhuang pill, is well known for treating stroke in the clinic, but the specific effects and mechanisms remain unclear.Objective: We investigated the mechanistic basis for the protective effect of XNJ on cerebral ischaemia/reperfusion (I/R) injury.Materials and methods: Five ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):16-24]

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Taraxasterol protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activation of Nrf2 signalling pathway.

Yun He, Kaifu Jiang, Xue Zhao,

Cerebral ischemia/reperfusion (I/R) injury is a brain injury following ischaemic stroke that is associated with oxidative stress. Taraxasterol, a natural product, has been shown to have anti-oxidative and neuro-protective effects. However, the role of taraxasterol in cerebral I/R injury remains unknown. Primary hippocampal neurons were subjected to oxygen-glucose deprivation/reperfusion (OGD/R) ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):252-258]

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Apigenin-7-O-β-d-(6″-p-coumaroyl)-glucopyranoside reduces myocardial ischaemia/reperfusion injury in an experimental model via regulating the inflammation response.

Wei Quan, Shanbo Ma, Yanrong Zhu, Qing Shao, Jixing Hou, Xiaoqiang Li,

Context: Traditionally, Clematis tangutica Korsh. (Ranunculaceae) is used as a Tibetan herb for treating indigestion and blood stasis in China. Recently, a flavonoid glycoside, apigenin-7-O-β-d-(6″-p-coumaroyl)-glucopyranoside (APG), was isolated from the whole plant of C. tangutica.Objective: To investigate the cardioprotective effects of APG against myocardial ischaemia/reperfusion injury (MI/RI) and the possible ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):80-88]

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Renoprotective effect of vildagliptin following hepatic ischemia/reperfusion injury.

Iman O Sherif, Alaa A Alshaalan, Nora H Al-Shaalan,

Remote renal injury is a drastic consequence of hepatic ischemia/reperfusion (IR) injury. Vildagliptin (V) is a dipeptidyl peptidase-4 inhibitor that has a hepatorenal protective effect against models of liver and renal IR. This research was done to explore the protective role of vildagliptin against renal injury following hepatic IR injury ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):208-215]

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Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation.

Su Hwan Bae, Mi Ran Yoo, Ye Yeong Kim, In Kyung Hong, Mi Hee Kim, Seung Hak Lee, Dae Yul Kim,

Macrophage migration inhibitory factor (MIF) is a chemokine that plays an essential role in immune system function. Previous studies suggested that MIF protects neurons in ischemic conditions. However, few studies are reported on the role of MIF in neurological recovery after ischemic stroke. The purpose of this study is to ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1483-1489]

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Remote ischemic conditioning approach for the treatment of ischemic stroke.

Seyed Mohammad Seyedsaadat, David F Kallmes, Waleed Brinjikji,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1033-1034]

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Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy.

Chase Kingsbury, Matt Heyck, Brooke Bonsack, Jea-Young Lee, Cesar V Borlongan,

Stroke persists as a global health and economic crisis, yet only two interventions to reduce stroke-induced brain injury exist. In the clinic, many patients who experience an ischemic stroke often further suffer from retinal ischemia, which can inhibit their ability to make a functional recovery and may diminish their overall ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1014-1018]

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Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study.

Kamini Rakkar, Othman Othman, Nikola Sprigg, Philip Bath, Ulvi Bayraktutan,

Ischemic stroke is a devastating, life altering event which can severely reduce patient quality of life. Despite years of research there have been minimal therapeutic advances. Endothelial progenitor cells (EPCs), stem cells involved in both vasculogenesis and angiogenesis, may be a potential therapeutic target. After a stroke, EPCs migrate to ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1300-1307]

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Adrenomedullin: an important participant in neurological diseases.

Feng-Jiao Li, Si-Ru Zheng, Dong-Mei Wang,

Adrenomedullin, a peptide with multiple physiological functions in nervous system injury and disease, has aroused the interest of researchers. This review summarizes the role of adrenomedullin in neuropathological disorders, including pathological pain, brain injury and nerve regeneration, and their treatment. As a newly characterized pronociceptive mediator, adrenomedullin has been shown ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1199-1207]

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Outgrowth endothelial cells form a functional cerebral barrier and restore its integrity after damage.

Rais Reskiawan Abdulkadir, Mansour Alwjwaj, Othman Ahmad Othman, Kamini Rakkar, Ulvi Bayraktutan,

Breakdown of blood-brain barrier, formed mainly by brain microvascular endothelial cells (BMECs), represents the major cause of mortality during early phases of ischemic strokes. Hence, discovery of novel agents that can effectively replace dead or dying endothelial cells to restore blood-brain barrier integrity is of paramount importance in stroke medicine. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1071-1078]

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Selective brain hypothermia-induced neuroprotection against focal cerebral ischemia/reperfusion injury is associated with Fis1 inhibition.

Ya-Nan Tang, Gao-Feng Zhang, Huai-Long Chen, Xiao-Peng Sun, Wei-Wei Qin, Fei Shi, Li-Xin Sun, Xiao-Na Xu, Ming-Shan Wang,

Selective brain hypothermia is considered an effective treatment for neuronal injury after stroke, and avoids the complications of general hypothermia. However, the mechanisms by which selective brain hypothermia affects mitochondrial fission remain unknown. In this study, we investigated the effect of selective brain hypothermia on the expression of fission 1 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):903-911]

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Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review.

Yazdan Naderi, Yunes Panahi, George E Barreto, Amirhosein Sahebkar,

To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models. By searching in the databases of PubMed, ScienceDirect, and Scopus, and considering the inclusion and exclusion criteria of the study. Studies were included if focal cerebral ischemia model was performed in mammals and including a control ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):773-782]

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Targeting protein tyrosine phosphatase PTP-PEST (PTPN12) for therapeutic intervention in acute myocardial infarction.

Chiu-Fen Yang, Yi-Yun Chen, Jai Prakash Singh, Shu-Fang Hsu, Yu-Wen Liu, Chun-Yi Yang, Chia-Wei Chang, Szu-Ni Chen, Rou-Ho Shih, Shang-Te Danny Hsu, Yuh-Shan Jou, Ching-Feng Cheng, Tzu-Ching Meng,

AIMS:The myocardial ischaemia/reperfusion (I/R) injury is almost inevitable since reperfusion is the only established treatment for acute myocardial infarction (AMI). To date there is no effective strategy available for reducing the I/R injury. Our aim was to elucidate the mechanisms underlying myocardial I/R injury and to develop a new strategy ... Read more >>

Cardiovasc. Res. (Cardiovascular research)
[2020, 116(5):1032-1046]

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Role of adiponectin in diabetes myocardial ischemia-reperfusion injury and ischemic postconditioning.

Chen Cao, Hui-Min Liu, Wei Li, Yang Wu, Yan Leng, Rui Xue, Rong Chen, Ling-Hua Tang, Qian Sun, Zhongyuan Xia, Qi-Zhu Tang, Di-Fei Shen, Qing-Tao Meng,

PURPOSE:Patients with diabetes are vulnerable to myocardial I/R (ischaemia/reperfusion) injury, but are not responsive to IPO (ischaemic post-conditioning). We hypothesized that decreased cardiac Adiponectin (APN) is responsible for the loss of diabetic heart sensitivity to IPO cardioprotecton. METHODS:Diabetic rats were subjected to I/R injury (30 min of LAD occlusion followed ... Read more >>

Acta Cir Bras (Acta cirurgica brasileira)
[2020, 35(1):e202000107]

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Cardioprotection, Autoretroperfusion, and Therapeutic Hypothermia.

Mohamed El Farissi, Nico H J Pijls,

JACC Basic Transl Sci (JACC. Basic to translational science)
[2020, 5(3):279-281]

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Neuroprotective effects of trilobatin, a novel naturally-occurring Sirt3 agonist from Lithocarpus polystachyus Rehd., mitigates cerebral ischemia/reperfusion injury: Involvement of TLR4/NF-κB and Nrf2/ Keap-1 signaling.

Jianmei Gao, Nana Chen, Na Li, Fan Xu, Wei Wang, Yaying Lei, Jingshan Shi, Qihai Gong,

AIMS:Neuroinflammation and oxidative stress are deemed the prime causes of brain injury after cerebral ischemia-reperfusion (I/R). Since Sirt3 pathway plays an imperative role in protecting against neuroinflammation and oxidative stress and has been verified as a target to treat ischemia stroke. Therefore, we desired to seek novel Sirt3 agonist and ... Read more >>

Antioxid. Redox Signal. (Antioxidants & redox signaling)
[2020, :]

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S100A12 promotes inflammation and apoptosis in ischemia/reperfusion injury via ERK signaling in vitro study using PC12 cells.

Xiang Zhang, Rui Shen, Zhongwen Shu, Quanbin Zhang, Zuoquan Chen,

S100A12 is a member of S100 calcium-binding proteins with effect to promote inflammation in brain damage and stroke. However, the role of S100A12 in ischemia/reperfusion (I/R) remains to be clarified. This study aimed to explore the effect of S100A12 on I/R and discover the possible mechanism. Oxygen-glucose deprivation and reperfusion ... Read more >>

Pathol. Int. (Pathology international)
[2020, :]

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Targeting Myeloid-Specific Integrin α9β1 Improves Short and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis And Inflammation.

Nirav Dhanesha, Manish Jain, Amit Tripathi, Prakash Doddapattar, Mehulkumar Chorawala, Girish Bathla, Manasa K Nayak, Madankumar Ghatge, Steven R Lentz, Shigeyuki Kon, Anil K Chauhan,

Rationale: Currently, there is no effective intervention available that can reduce brain damage following reperfusion. Clinical studies suggest a positive correlation between the increased influx of neutrophils and severity of brain injury following reperfusion. Integrin α9β1 is highly expressed on activated neutrophils and contributes to stable adhesion, but its role ... Read more >>

Circ. Res. (Circulation research)
[2020, :]

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MRI of Reperfused Acute Myocardial Infarction Edema: ADC Quantification versus T1 and T2 Mapping.

Kevin Moulin, Magalie Viallon, William Romero, Alban Chazot, Nathan Mewton, Karl Isaaz, Pierre Croisille,

Background After acute myocardial infarction (AMI), reperfusion injury is associated with microvascular lesions and myocardial edema. Purpose To evaluate the performance of apparent diffusion coefficient (ADC) quantification compared with T1 and T2 values in the detection of acute myocardial injury. Materials and Methods In this prospective study conducted from June ... Read more >>

Radiology (Radiology)
[2020, :192186]

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Sphingosine 1-phosphate signaling in ischemia and reperfusion injury.

Zohaib Raza, Uzma Saleem, Zainab Naureen,

Ischemia and reperfusion injury is a complex hemodynamic pathological phenomenon that engages the metabolic to inflammatory machinery in development of disease conditions like heart failure, stroke and acute kidney failure. Target specific therapeutic approaches for ischemia reperfusion injury remains critical despite the extensive studies contributing to the understanding of its ... Read more >>

Prostaglandins Other Lipid Mediat. (Prostaglandins & other lipid mediators)
[2020, 149:106436]

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TAT-dextran-mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes.

Hideki Maeda, Daisuke Kami, Ryotaro Maeda, Yuki Murata, Jun-Ichiro Jo, Tomoya Kitani, Yasuhiko Tabata, Satoaki Matoba, Satoshi Gojo,

Acute myocardial infarction is a leading cause of death among single organ diseases. Despite successful reperfusion therapy, ischaemia reperfusion injury (IRI) can induce oxidative stress (OS), cardiomyocyte apoptosis, autophagy and release of inflammatory cytokines, resulting in increased infarct size. In IRI, mitochondrial dysfunction is a key factor, which involves the ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, :]

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SGLT2 inhibitors reduce infarct size in reperfused ischemic heart and improve cardiac function during ischemic episodes in preclinical models.

Ioanna Andreadou, Robert M Bell, Hans Erik Bøtker, Coert J Zuurbier,

The sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of effective drugs managing patients, who suffer from type 2 diabetes (T2D): Landmark clinical trials including EMPA-REG, CANVAS and Declare-TIMI have demonstrated that SGLT2 inhibitors reduce cardiovascular mortality and re-hospitalization for heart failure (HF) in patients with T2D. It is ... Read more >>

Biochim Biophys Acta Mol Basis Dis (Biochimica et biophysica acta. Molecular basis of disease)
[2020, :165770]

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Overexpression of Long noncoding RNA Oprm1 Attenuates Myocardial Ischemia/Reperfusion Injury by Increasing Endogenous Hydrogen Sulfide Production via Oprm1/miR-30b-5p/CSE axis

Tong Li, Xiaomin Hu, Bojiang Liu, Peng Wu, Yuheng Lang,

<title>Abstract</title> <p> <bold>Background:</bold> Ischemia/Reperfusion (I/R) Injury largely limits the efficacy of revascularization in acute myocardial infarction. Long noncoding RNA (lncRNA) Oprm1 is protective in cerebral I/R injury. However, the effect of lncRNA Oprm1 on myocardial I/R injury and its mechanism remains unknown. <bold>Methods:</bold> We ligated and then released ... Read more >>

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lncRNA ZFAS1 Improves Neuronal Injury and Inhibits Inflammation, Oxidative Stress, and Apoptosis by Sponging miR-582 and Upregulating NOS3 Expression in Cerebral Ischemia/Reperfusion Injury.

Yanyan Zhang, Yiping Zhang,

The interplay between lncRNAs and miRNAs was reported to be associated with cerebral ischemia reperfusion injury (CIRI). Besides, the lncRNA ZFAS1 was significantly downregulated in patients with ischemic stroke. However, the exact biological role of ZFAS1 and its mechanism in CIRI remain to be elucidated. The current study was designed ... Read more >>

Inflammation (Inflammation)
[2020, :]

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Evaluation of ATP-PostC protective effect on myocardial function: A speckle tracking echocardiography study in ischemia-reperfusion injury

Yujie Liu, Min Ren, Keting Li, Xuemei Liu, Hongyu Yang, Zhonghui Jiang, Xinyu Wu,

<title>Abstract</title> <p> Background: Ischemia-reperfusion injury (IRI) seriously affects the prognosis of patients. We sought to use speckle tracking echocardiography (STE) to accurately evaluate the effect of drugs. Methods: In this study, STE was used to quantitatively evaluate the changes of myocardial function before and after reperfusion in myocardial ... Read more >>

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