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Beta-blockers reduce intestinal permeability and early mortality following traumatic brain injury in Drosophila.

Amanda R Scharenbrock, Rebeccah J Katzenberger, Megan C Fischer, Barry Ganetzky, David A Wassarman,

Traumatic brain injury (TBI) frequently leads to non-neurological consequences such as intestinal permeability. The beta-blocker drug labetalol, which inhibits binding of catecholamine neurotransmitters to adrenergic receptors, reduces intestinal permeability in a rat TBI model. Using a <i>Drosophila melanogaster</i> TBI model, we previously found a strong positive correlation between intestinal permeability ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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The conserved MASRPF motif in the Attractin homolog, Distracted, is required for association with Drosophila E3-ligase Mgrn1.

Vindhya Nawaratne, Sirisha Kudumala, Priyanka Prakash Kakad, Tanja A Godenschwege,

In rodents, all three paralogs of the Attractin (Atrn) transmembrane protein family exhibit strong phenotypic overlap and are implicated in the regulation of the same G-protein coupled receptors (GPCR) as E3-ligase Mahogunin ring finger 1 (Mgrn1). Recently it was shown that the highly conserved intracellular MASRPF motif in mammal Multiple ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Rapid degeneration of Drosophila olfactory neurons in Orco mutant maxillary palps.

Darya Task, Christopher J Potter,

<i>Drosophila melanogaster</i> vinegar flies have two olfactory organs: the antenna and maxillary palp. Olfactory neurons in these tissues respond to odorants via odorant receptors. Insect odorant receptors are heterotetramers of two proteins: an odorant binding OrX subunit and an Odorant Receptor Co-Receptor (Orco). Mutation of <i>Orco</i> disrupts odorant receptor formation, ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Expression of an endosome-excluded Cd63 prevents axis elongation in Xenopus.

Jennifer Kreis, Ramona Bonß, Kerstin Feistel, Philipp Vick,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Zebrafish Trak proteins 1a and 2 localize to the mitochondria.

Kelsey A Oonk, Lauren B Bienvenu, Paxton S Sickler, Christine Martin, Emily Nickoloff-Bybel, Albert Matthew Volk, Douglas C Weiser, Susan Walsh,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Single-cell resolution long-term luciferase imaging in cultivated Drosophila brains.

Frank K Schubert, Charlotte Helfrich-Förster, Dirk Rieger,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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A toolkit of tagged glp-1 alleles reveals strong glp-1 expression in the germline, embryo, and spermatheca.

Erika B Sorensen, Hannah S Seidel, Sarah L Crittenden, Joseph H Ballard, Judith Kimble,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 1 time

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C. elegans VWA-8 is a mitochondrial protein.

Ming Zhu, Andrew D Chisholm, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Role of GLD-3 in suppression of the germline stem cell fate.

Ariz Mohammad, Jian Chen, Tim Schedl,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Difference in phenotypic severity of presumed null alleles of capg-1.

Sarah VanDiepenbos, Györgyi Csankovszki,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Generation of sas-6::ha by CRISPR/Cas9 editing.

Mary Bergwell, Amy Smith, Holly Lakin, Rebecca Slay, Jyoti Iyer,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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2018 Update on Protein-Protein Interaction Data in WormBase.

Jaehyoung Cho, Christian Grove, Kimberly Van Auken, Juancarlos Chan, Sibyl Gao, Paul Sternberg,

MicroPubl Biol (microPublication biology)
[2018, 2018:]

Cited: 1 time

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Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling.

Haoyang Lu, Hui Xiao, Manyu Dai, Yangcheng Xue, Ren Zhao,

Ferroptosis was described as an important contributor to the myocardial ischaemia/reperfusion (MIR) injury, and britanin (Bri) was reported to exert antitumor and anti-inflammatory activities. Our study explores the effect and mechanism of Bri on MIR damage. The rat model of MIR was established by ligation of the left anterior descending ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):38-45]

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In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas.

Bo-Yan Liu, Jun-Li Xue, Qian-Qian Gu, Min Zhao, Meng-Yu Zhang, Ming-Yue Wang, Yun Wang, Shu-Cun Qin,

Medical effects of hydrogen have been reported in many studies. Due to difficulties in measuring hydrogen concentration in vivo after intake and high explosive risks of hydrogen, studies about dose-response relationships and tissue concentrations of hydrogen are few. Here, for the first time, we monitored real-time hydrogen concentrations in different ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(3):107-112]

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Neuroprotective effects of long noncoding RNAs involved in ischemic postconditioning after ischemic stroke.

Wei Ma, Chun-Yan Li, Si-Jia Zhang, Cheng-Hao Zang, Jin-Wei Yang, Zhen Wu, Guo-Dong Wang, Jie Liu, Wei Liu, Kuang-Pin Liu, Yu Liang, Xing-Kui Zhang, Jun-Jun Li, Jian-Hui Guo, Li-Yan Li,

During acute reperfusion, the expression profiles of long noncoding RNAs in adult rats with focal cerebral ischemia undergo broad changes. However, whether long noncoding RNAs are involved in neuroprotective effects following focal ischemic stroke in rats remains unclear. In this study, RNA isolation and library preparation was performed for long ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1299-1309]

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L4-to-L4 nerve root transfer for hindlimb hemiplegia after hypertensive intracerebral hemorrhage.

Teng-Da Qian, Xi-Feng Zheng, Jing Shi, Tao Ma, Wei-Yan You, Jia-Huan Wu, Bao-Sheng Huang, Yi Tao, Xi Wang, Ze-Wu Song, Li-Xin Li,

There is no effective treatment for hemiplegia after hypertensive intracerebral hemorrhage. Considering that the branches of L4 nerve roots in the lumbar plexus root control the movement of the lower extremity anterior and posterior muscles, we investigated a potential method of nerve repair using the L4 nerve roots. Rat models ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1278-1285]

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Enriched environment for offspring improves learning and memory impairments induced by sevoflurane exposure during the second trimester of pregnancy.

Shao-Wei Yin, Yi-Lin Meng, Chuang Li, Yuan Wang,

Studies in animals indicate that sevoflurane exposure in the second trimester of pregnancy has harmful effects on the learning and memory of offspring. Whether an enriched environment can reverse the damage of sevoflurane exposure in the second trimester of pregnancy on the learning and memory of rat offspring remains unclear. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1293-1298]

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Selection of suitable internal controls for gene expression normalization in rats with spinal cord injury.

Wei Liu, Jie Yu, Yi-Fan Wang, Qian-Qian Shan, Ya-Xian Wang,

There is a lack of systematic research on the expression of internal control genes used for gene expression normalization in real-time reverse transcription polymerase chain reaction in spinal cord injury research. In this study, we used rat models of spinal cord hemisection to analyze the expression stability of 13 commonly ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1387-1392]

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Angiotensin-(1-7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson's disease.

Qing Gao, Rui Chen, Liang Wu, Qing Huang, Xi-Xi Wang, You-Yong Tian, Ying-Dong Zhang,

Abnormal accumulation of α-synuclein contributes to the formation of Lewy bodies in the substantia nigra, which is considered the typical pathological hallmark of Parkinson's disease. Recent research indicates that angiotensin-(1-7) plays a crucial role in several neurodegenerative disorders, including Parkinson's disease, but the underlying mechanisms remain elusive. In this study, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1138-1145]

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HOXA11-AS aggravates microglia-induced neuroinflammation after traumatic brain injury.

Xiang-Long Li, Bin Wang, Fu-Bing Yang, Li-Gang Chen, Jian You,

Long noncoding RNAs (lncRNAs) participate in many pathophysiological processes after traumatic brain injury by mediating neuroinflammation and apoptosis. Homeobox A11 antisense RNA (HOXA11-AS) is a member of the lncRNA family that has been reported to participate in many inflammatory reactions; however, its role in traumatic brain injury remains unclear. In ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1096-1105]

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Myelin-associated glycoprotein combined with chitin conduit inhibits painful neuroma formation after sciatic nerve transection.

Wei Pi, Ci Li, Meng Zhang, Wei Zhang, Pei-Xun Zhang,

Studies have shown that myelin-associated glycoprotein (MAG) can inhibit axon regeneration after nerve injury. However, the effects of MAG on neuroma formation after peripheral nerve injury remain poorly understood. In this study, local injection of MAG combined with nerve cap made of chitin conduit was used to intervene with the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1343-1347]

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Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury.

Rui Zhao, Xue Wu, Xue-Yuan Bi, Hao Yang, Qian Zhang,

Baicalin is a natural active ingredient isolated from Scutellariae Radix that can cross the blood-brain barrier and exhibits neuroprotective effects on multiple central nervous system diseases. However, the mechanism behind the neuroprotective effects remains unclear. In this study, rat models of spinal cord injury were established using a modified Allen's ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1080-1087]

Cited: 1 time

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Optical tissue clearing enables rapid, precise and comprehensive assessment of three-dimensional morphology in experimental nerve regeneration research.

Simeon C Daeschler, Jennifer Zhang, Tessa Gordon, Gregory H Borschel,

Morphological analyses are key outcome assessments for nerve regeneration studies but are historically limited to tissue sections. Novel optical tissue clearing techniques enabling three-dimensional imaging of entire organs at a subcellular resolution have revolutionized morphological studies of the brain. To extend their applicability to experimental nerve repair studies we adapted ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1348-1356]

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Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects.

Bo Wang, Chang-Feng Lu, Zhong-Yang Liu, Shuai Han, Pi Wei, Dian-Ying Zhang, Yu-Hui Kou, Bao-Guo Jiang,

Although autologous nerve transplantation is the gold standard for treating peripheral nerve defects, it has many clinical limitations. As an alternative, various tissue-engineered nerve grafts have been developed to substitute for autologous nerves. In this study, a novel nerve graft composed of chitin scaffolds and a small autologous nerve was ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1106-1114]

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Effects of amyloid precursor protein peptide APP96-110, alone or with human mesenchymal stromal cells, on recovery after spinal cord injury.

Stuart I Hodgetts, Sarah J Lovett, D Baron-Heeris, A Fogliani, Marian Sturm, C Van den Heuvel, Alan R Harvey,

Delivery of a peptide (APP96-110), derived from amyloid precursor protein (APP), has been shown to elicit neuroprotective effects following cerebral stroke and traumatic brain injury. In this study, the effect of APP96-110 or a mutant version of this peptide (mAPP96-110) was assessed following moderate (200 kdyn, (2 N)) thoracic contusive ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1376-1386]

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