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Wound healing activity of neferine in experimental diabetic rats through the inhibition of inflammatory cytokines and nrf-2 pathway.

Juan Li, Haiyan Chou, Lei Li, Hao Li, Zhengjun Cui,

The diabetic foot ulcer (DFU) may be associated with late healing and septic manifestation, subsequently lead to amputation which is an overpriced incident. Neferine is an alkaloid found lotus. Neferine possesses many physiological functions such as anti-inflammatory, antioxidant, antimicrobial activity and anticancer effect. The aim of the present study was ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):96-106]

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Antidepressant effect of Gentiana olivieri Griseb. in male rats exposed to chronic mild stress.

Ahmet Berk, İsmet Yılmaz, Nurettin Abacıoğlu, Mustafa Bahadır Kaymaz, Merve Gökşin Karaaslan, Ebru Kuyumcu Savan,

Background: The flowering parts of Gentiana olivieri, known as 'Afat' in the southeastern Anatolia region of Turkey, are used as a tonic, an appetizer, and for the treatment of several mental disorders, including depression. The purpose of this study is to investigate the antidepressant effect of G. olivieri ethanol extract ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2020, 15(1):1725991]

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Apigenin-7-O-β-d-(6″-p-coumaroyl)-glucopyranoside reduces myocardial ischaemia/reperfusion injury in an experimental model via regulating the inflammation response.

Wei Quan, Shanbo Ma, Yanrong Zhu, Qing Shao, Jixing Hou, Xiaoqiang Li,

Context: Traditionally, Clematis tangutica Korsh. (Ranunculaceae) is used as a Tibetan herb for treating indigestion and blood stasis in China. Recently, a flavonoid glycoside, apigenin-7-O-β-d-(6″-p-coumaroyl)-glucopyranoside (APG), was isolated from the whole plant of C. tangutica.Objective: To investigate the cardioprotective effects of APG against myocardial ischaemia/reperfusion injury (MI/RI) and the possible ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):80-88]

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Balancing in a black box: Potential immunomodulatory roles for TGF-β signaling during blood-stage malaria.

Lisa L Drewry, John T Harty,

Malarial disease caused by Plasmodium parasites challenges the mammalian immune system with a delicate balancing act. Robust inflammatory responses are required to control parasite replication within red blood cells, which if unchecked, can lead to severe anemia and fatality. However, the same inflammatory response that controls parasite replication is also ... Read more >>

Virulence (Virulence)
[2020, 11(1):159-169]

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Renoprotective effect of vildagliptin following hepatic ischemia/reperfusion injury.

Iman O Sherif, Alaa A Alshaalan, Nora H Al-Shaalan,

Remote renal injury is a drastic consequence of hepatic ischemia/reperfusion (IR) injury. Vildagliptin (V) is a dipeptidyl peptidase-4 inhibitor that has a hepatorenal protective effect against models of liver and renal IR. This research was done to explore the protective role of vildagliptin against renal injury following hepatic IR injury ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):208-215]

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Serum osteoprotegerin level is positively associated with peripheral artery disease in patients with peritoneal dialysis.

Wei-Chen Lin, Jen-Pi Tsai, Yu-Hsien Lai, Yu-Li Lin, Chiu-Huang Kuo, Chih-Hsien Wang, Bang-Gee Hsu,

Osteoprotegerin (OPG) is a potential biomarker of cardiovascular disease complications and severity. Peripheral arterial disease (PAD) is associated with an increased risk of death in patients on peritoneal dialysis (PD). Therefore, this study aimed to evaluate the relationship between serum OPG levels and PAD by measuring the ankle-brachial index (ABI) ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):131-136]

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Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity.

Chaomin Li, Jing Li, Fang He, Kun Li, Xu Li, Yan Zhang,

Objective Matrix Gla protein (MGP) is a potent calcification inhibitor. Mgp-/- mice display increased proportion of brown adipose tissue. However, whether MGP is involved in fat metabolism remains unclear. This study aims to investigate the involvement. Methods Expression of adipocyte differentiation markers was examined by RT-qPCR. Adipocyte formation was assessed ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):68-76]

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Microenvironment derived from metanephros transplantation inhibits the progression of acute kidney injury in glycerol-induced rat models.

Kailin Li, Yuan Chen, Jianye Zhang, Yong Guan, Chao Sun, Xian Li, Xiaoshuai Xie, Denglu Zhang, Xin Yu, Tongyan Liu, Xufeng Zhang, Feng Kong, Shengtian Zhao,

Background: Embryonic metanephros is the mammalian renal anlagen, which is considered as a potential source for the regeneration of functional whole kidneys. Some studies reported that metanephros implanted into unilateral nephrectomized animals can develop into kidney tissue. However, kidneys are nephrotoxic in renal failure patients, and whether metanephros can grow ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):89-97]

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Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats.

Li-Jun Jiang, Zhen-Xing Xu, Ming-Fu Wu, Gai-Qin Dong, Li-Li Zhang, Jun-Yan Gao, Chen-Xi Feng, Xing Feng,

Secondary brain damage caused by hyperactivation of autophagy and inflammatory responses in neurons plays an important role in hypoxic-ischemic brain damage (HIBD). Although previous studies have implicated Toll-like receptor 4 (TLR4) and nuclear factor kappa-B (NF-κB) in the neuroinflammatory response elicited by brain injury, the role and mechanisms of the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1316-1325]

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Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases.

Jose A Fernández-Albarral, Rosa de Hoz, Ana I Ramírez, Inés López-Cuenca, Elena Salobrar-García, María D Pinazo-Durán, José M Ramírez, Juan J Salazar,

Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant, anxiolytic, hypolipidemic, anti-atherogenic, anti-hypertensive, antidiabetic, and anti-cancer properties. In addition, saffron has remarkable beneficial properties, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1408-1416]

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Expression of long non-coding RNAs in complete transection spinal cord injury: a transcriptomic analysis.

Lu Ding, Wen-Jin Fu, Hong-Yan Di, Xiao-Min Zhang, Yu-Tian Lei, Kang-Zhen Chen, Tao Wang, Hong-Fu Wu,

Long non-coding RNAs (lncRNAs) are abundantly expressed in the central nervous system and exert a critical role in gene regulation via multiple biological processes. To uncover the functional significance and molecular mechanisms of lncRNAs in spinal cord injury (SCI), the expression signatures of lncRNAs were profiled using RNA sequencing (RNA-seq) ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1560-1567]

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Comparison of microwave ablation treatments in patients with renal secondary and primary hyperparathyroidism.

Haoyang Ma, Chun Ouyang, Yaoyu Huang, Changying Xing, Chen Cheng, Wei Liu, Donglan Yuan, Ming Zeng, Xiangbao Yu, Haibin Ren, Yanggang Yuan, Lina Zhang, Fangyan Xu, Ying Cui, Wenkai Ren, Hui Huang, Hanyang Qian, Boqiang Fan, Ningning Wang,

Purpose: Microwave ablation (MWA) is feasible for severe renal secondary hyperparathyroidism (SHPT) and primary hyperparathyroidism (PHPT) patients ineligible for parathyroidectomy (PTX). Here we compared the clinical manifestations and characteristics of parathyroid glands in these two groups, and summarized the techniques, safety and efficacy of MWA.Methods: Baseline clinical characteristics, ablation-related techniques, ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):66-76]

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Modified trapdoor procedures  using autogenous tricortical iliac graft  without preserving the broken cartilage to treat osteonecrosis of the femoral head: A Prospective Cohort Study With Historical Controls

Fengchao Zhao, Qi Cheng, Shizhuang Xu, Li Zheng, Xin Zheng,

<title>Abstract</title> <p> Background The aim of the present study was to investigate clinical and radiological outcomes of autologous tricortical iliac graft through a window created at the femoral head, without suturing the opened articular cartilage to treat osteonecrosis of the femoral head (ONFH), called modified trapdoor procedures. Methods ... Read more >>

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Amelioration of adjuvant-induced arthritis by exposure to low dose gamma radiation and resveratrol administration in rats.

Mona A El-Ghazaly, Noha A Fadel, Doaa H Abdel-Naby, Hassan A Abd El-Rehim, Hala F Zaki, Sanaa A Kenawy,

Purpose Low dose radiation has been reported as an effective treatment for rheumatoid arthritis via multiple dose exposures. The present study was designed to increase the therapeutic efficacy of low dose radiation with the minimum exposure level in arthritic rats by concurrent administration of resveratrol (RSV) as an adjunctive therapy ... Read more >>

Int. J. Radiat. Biol. (International journal of radiation biology)
[2020, :1-36]

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Impact of Mouse Strain and Sex when Modeling Radiation Necrosis

Carlos Perez-Torres, Andrew Boria,

<title>Abstract</title> <p> <bold>Background:</bold> Murine models are among the most common type of preclinical animal models used to study the human condition, but a wide selection of different mice is currently in use with these differences potentially compromising study results and impairing the ability to reconcile interstudy results. Our ... Read more >>

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Ultrasound Stimulation Suppresses LPS-Induced Proinflammatory Responses by Regulating NF-κB and CREB Activation in Microglial Cells.

Jia-Wei Chang, Meng-Ting Wu, Wen-Shin Song, Feng-Yi Yang,

The purpose of this study was to investigate the effects and underlying mechanisms of low-intensity pulsed ultrasound (LIPUS) against lipopolysaccharide (LPS)-induced neuroinflammation. BV-2 microglia subjected to LPS administration (1 μg/mL) were treated with LIPUS stimulation. The levels of inflammatory mediators and brain-derived neurotrophic factor (BDNF) were quantified using the western blot. ... Read more >>

Cereb. Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, :]

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Leaky gut, dysbiosis, and enteric glia activation: the trilogy behind the intestinal origin of Parkinson's disease.

Luisa Seguella, Giovanni Sarnelli, Giuseppe Esposito,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1037-1038]

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High Failure Rate after Beta-tricalcium Phosphate Grafting for the Treatment of Femoral Head Osteonecrosis: a Retrospective Analysis

Wanshou Guo, Pei Liu, Xiao-hong Mu, Hua-chen Yu, Guan Jian-lei, Zhao-hui Liu, Wei-guo Wang, Qi-dong Zhang,

<title>Abstract</title> <p> Background: Non-vascularized bone grafting is a promising head-preserving technique for younger patients diagnosed as non-traumatic osteonecrosis of the femoral head (NONFH). Among the various types of bone grafting techniques, “light-bulb” procedure grafting with synthetic bone substitute is an attractive option. We aimed to assess the effectiveness ... Read more >>

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The effect of low-level laser radiation and doxycycline on the levels of osteoprotegerin and receptor activator of nuclear factor kappa-B ligand.

Shirin Zahra Farhad, Amir Siadat, Neda Sadeghian, Sourena Abrishamkar, Farshad Khosraviani, Pegah Khazaei, Amir Saberi-Demneh,

The present in vitro study was conducted to investigate the effect of low-level laser (LLL) radiation and doxycycline on the levels of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) derived from MG-63 osteosarcoma cell line. MG-63 cells were divided into four groups. In the first group, ... Read more >>

Lasers Med Sci (Lasers in medical science)
[2020, :]

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RIP3/MLKL-mediated neuronal necroptosis induced by methamphetamine at 39°C.

Li-Min Guo, Zhen Wang, Shi-Ping Li, Mi Wang, Wei-Tao Yan, Feng-Xia Liu, Chu-Dong Wang, Xu-Dong Zhang, Dan Chen, Jie Yan, Kun Xiong,

Methamphetamine is one of the most prevalent drugs abused in the world. Methamphetamine abusers usually present with hyperpyrexia (39°C), hallucination and other psychiatric symptoms. However, the detailed mechanism underlying its neurotoxic action remains elusive. This study investigated the effects of methamphetamine + 39°C on primary cortical neurons from the cortex ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):865-874]

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Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing.

Mario Rothbauer, Gregor Höll, Christoph Eilenberger, Sebastian R A Kratz, Bilal Farooq, Patrick Schuller, Isabel Olmos Calvo, Ruth A Byrne, Brigitte Meyer, Birgit Niederreiter, Seta Küpcü, Florian Sevelda, Johannes Holinka, Oliver Hayden, Sandro F Tedde, Hans P Kiener, Peter Ertl,

Rheumatoid arthritis is a chronic, systemic joint disease in which an autoimmune response translates into an inflammatory attack resulting in joint damage, disability and decreased quality of life. Despite recent introduction of therapeutic agents such as anti-TNFα, even the best current therapies fail to achieve disease remission in most arthritis ... Read more >>

Lab Chip (Lab on a chip)
[2020, :]

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Photobiomodulation with 630-nm LED radiation inhibits the proliferation of human synoviocyte MH7A cells possibly via TRPV4/PI3K/AKT/mTOR signaling pathway.

Caiyun Meng, Qing Xia, Hao Wu, He Huang, Hailiang Liu, Yujun Li, Fengmin Zhang, Wuqi Song,

Phototherapy has been used to treat postoperative pain and inflammatory response in rheumatoid arthritis. Confidence in this approach, however, is impaired by lack of understanding of the light-triggered cellular and molecular mechanisms. The purpose of this study was to characterize the response of human synoviocyte MH7A cells to visible LED ... Read more >>

Lasers Med Sci (Lasers in medical science)
[2020, :]

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Benefits of CT Scanning for the Management of Hip Arthritis and Arthroplasty.

Hytham S Salem, Kevin B Marchand, Joseph O Ehiorobo, John M Tarazi, Chelsea N Matzko, Nipun Sodhi, Matthew S Hepinstall, Michael A Mont,

INTRODUCTION:Imaging studies for preoperative planning of total hip arthroplasty (THA) are typically obtained by two-dimensional (2D) anteroposterior radiographs. However, CT imaging has proven to be a valuable tool that may be more accurate than standard radiographs. The purpose of this review was to report on the current literature to assess ... Read more >>

Surg Technol Int (Surgical technology international)
[2020, 36:]

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The Possibility of Using Genotoxicity, Oxidative Stress and Inflammation Blood Biomarkers to Predict the Occurrence of Late Cutaneous Side Effects after Radiotherapy.

Samia Chaouni, Delphine Dumont Lecomte, Dinu Stefan, Alexandre Leduc, Victor Barraux, Alexandra Leconte, Jean-Michel Grellard, Jean-Louis Habrand, Marilyne Guillamin, François Sichel, Carine Laurent,

Despite the progresses performed in the field of radiotherapy, toxicity to the healthy tissues remains a major limiting factor. The aim of this work was to highlight blood biomarkers whose variations could predict the occurrence of late cutaneous side effects. Two groups of nine patients treated for Merkel Cell Carcinoma ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2020, 9(3):]

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Neuronal Calcium Sensor 1 is up-regulated in response to stress to promote cell survival and motility in cancer cells.

Henrike K Grosshans, Tom T Fischer, Julia A Steinle, Allison L Brill, Barbara E Ehrlich,

Changes in intracellular calcium (Ca2+ ) signaling can modulate cellular machinery required for cancer progression. Neuronal Calcium Sensor 1 (NCS1) is a ubiquitously expressed Ca2+ -binding protein that promotes tumor aggressiveness by enhancing cell survival and metastasis. However, the underlying mechanism by which NCS1 contributes to increased tumor aggressiveness has ... Read more >>

Mol Oncol (Molecular oncology)
[2020, :]

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