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Pyrogallol induces oxidative stress defects in the fission yeast S. pombe.

Nafees Ahamad, Simmi Anjum, Shakil Ahmed,

Apart from the beneficial roles of pyrogallol in industries, it also tends to produce free radicals that trigger apoptosis in human cells. In this study, we checked the toxic effect of pyrogallol in fission yeast <i>S. pombe</i> cells. We observed that the wild type and <i>wat1/pop3</i> delete cells were unable ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Differential effects on neuromuscular physiology between Sod1 loss-of-function mutation and paraquat-induced oxidative stress in Drosophila.

Atsushi Ueda, Atulya Iyengar, Chun-Fang Wu,

Oxidative stress is thought to be a major contributor to aging processes. Here, we report differential effects on neurotransmission caused by loss-of-function mutations of <i>Superoxide dismutase 1</i> (<i>Sod1</i>) and by paraquat (PQ) feeding in <i>Drosophila</i>. We demonstrated alterations in <i>Sod1</i> mutants; the larval neuromuscular junction displayed supernumerary discharges and the ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Anti-oxidant MitoQ rescue of AWB chemosensory neuron impairment in a C. elegans model of X-linked Adrenoleukodystrophy.

Sanjib Guha, Aurora Pujol, Esther Dalfo,

X-linked Adrenoleukodystrophy (X-ALD) is a neurometabolic disorder caused by a defective peroxisomal ABCD1 transporter of very long-chain fatty acids (VLCFAs). We have characterized a nematode model of X-ALD with loss of the <i>pmp-4</i> gene, the worm orthologue of <i>ABCD1</i>. These mutants recapitulated the key hallmarks of X-ALD and importantly mitochondria ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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oxi-1 and fshr-1 are required for neuromuscular signaling under normal and oxidative stress conditions in C. elegans.

Barry Wei, Jennifer R Kowalski,

MicroPubl Biol (microPublication biology)
[2018, 2018:]

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The pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review.

Xiaojiang Qin, Xinrong Xu, Xiaomin Hou, Ruifeng Liang, Liangjing Chen, Yuxuan Hao, Anqi Gao, Xufeng Du, Liangyuan Zhao, Yiwei Shi, Qingshan Li,

<h4>Context</h4>Farrerol, a typical natural flavanone isolated from the traditional Chinese herb 'Man-shan-hong' [<i>Rhododendron dauricum</i> L. (Ericaceae)] with phlegm-reducing and cough-relieving properties, is widely used in China for treating bronchitis and asthma.<h4>Objective</h4>To present the anti-inflammatory, antioxidant, vasoactive, antitumor, and antimicrobial effects of farrerol and its underlying molecular mechanisms.<h4>Methods</h4>The literature was reviewed ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):9-16]

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Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases.

Serra Ozgen, Judith Krigman, Ruohan Zhang, Nuo Sun,

Mitochondria play a multidimensional role in the function and the vitality of the neurological system. From the generation of neural stem cells to the maintenance of neurons and their ultimate demise, mitochondria play a critical role in regulating our neural pathways' homeostasis, a task that is critical to our cognitive ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):741-747]

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Therapeutic potential of translocator protein ligands for age-related macular degeneration.

Xing Li, Zhiming He, Xinhua Shu,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):793-794]

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Iron, the endolysosomal system and neuroinflammation: a matter of balance.

Daniel A Borquez, Pamela J Urrutia, Marco T Núñez,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1003-1004]

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Perioperative melatonin in COVID-19 patients: benefits beyond sedation and analgesia.

Abhijit S Nair,

Cytokine storm in coronavirus disease 2019 (COVID-19) patients leads to acute lung injury, acute respiratory distress syndrome, multiorgan dysfunction, shock, and thrombosis thus contributing to significant morbidity and mortality. Several agents like steroids, ascorbic acid, vitamins (C, D, E), glutathione, N-acetylcysteine have been used and several studies are underway to ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(2):41-43]

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Noise-induced hippocampal damage: potential mechanisms.

Sonia Jazmín Molina, Laura Ruth Guelman,

Neural Regen Res (Neural regeneration research)
[2022, 17(3):563-564]

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Markers for Mitochondrial ROS Status.

Monika Ostaszewska-Bugajska, Anna Podgórska, Bożena Szal,

Mitochondria actively participate in oxygenic metabolism and are one of the major sources of reactive oxygen species (ROS) production in plant cells. However, instead of measuring ROS concentrations in organelles it is more worthwhile to observe active ROS generation or downstream oxidation products, because the steady state level of ROS ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2363:199-213]

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Mitochondrial dysfunctions in neurodegenerative diseases: role in disease pathogenesis, strategies for analysis and therapeutic prospects.

Federica Rey, Sara Ottolenghi, Gian Vincenzo Zuccotti, Michele Samaja, Stephana Carelli,

Fundamental organelles that occur in every cell type with the exception of mammal erythrocytes, the mitochondria are required for multiple pivotal processes that include the production of biological energy, the biosynthesis of reactive oxygen species, the control of calcium homeostasis, and the triggering of cell death. The disruption of anyone ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):754-758]

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Exercise Cuts Both Ways with ROS in Remodifying Innate and Adaptive Responses: Rewiring the Redox Mechanism of the Immune System during Exercise.

Anand Thirupathi, Yaodong Gu, Ricardo Aurino Pinho,

Nearly all cellular functions depend on redox reactions, including those of immune cells. However, how redox reactions are rearranged to induce an immune response to the entry of pathogens into the host is a complex process. Understanding this scenario will facilitate identification of the roles of specific types of reactive ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(11):]

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Oxidative stress in genetically triggered thoracic aortic aneurysm: role in pathogenesis and therapeutic opportunities.

Stefanie S Portelli, Brett D Hambly, Richmond W Jeremy, Elizabeth N Robertson,

<b>Background:</b> The primary objective of this review was to explore the contribution of oxidative stress to the pathogenesis of genetically-triggered thoracic aortic aneurysm (TAA). Genetically-triggered TAAs manifest substantial variability in onset, progression, and risk of aortic dissection, posing a significant clinical management challenge. There is a need for non-invasive biomarkers ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):45-52]

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pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer.

Chao Li, Yifan Wang, Shuo Zhang, Jiaojiao Zhang, Fang Wang, Yunhao Sun, Lirong Huang, Wen Bian,

Multidrug resistance (MDR) is one of the main reasons for tumor chemotherapy failure. Podophyllotoxin (PPT) has been reported that can suppress MDR cancer cell growth; however, effective delivery of PPT to MDR cancer cells is challenged by cascaded bio-barriers. To effectively deliver PPT to MDR cancer cells, a PPT polymeric ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):680-691]

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Set1-mediated H3K4 methylation is required for Candida albicans virulence by regulating intracellular level of reactive oxygen species.

Jueun Kim, Shinae Park, Sohee Kwon, Eun-Jin Lee, Jung-Shin Lee,

<i>Candida albicans</i> is an opportunistic human fungal pathogen that exists in normal flora but can cause infection in immunocompromised individuals. The transition to pathogenic <i>C. albicans</i> requires a change of various gene expressions. Because histone-modifying enzymes can regulate gene expression, they are thought to control the virulence of <i>C. albicans</i>. ... Read more >>

Virulence (Virulence)
[2021, 12(1):2648-2658]

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Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.

Qingmei Meng, Elena Karamfilova Zaharieva, Megumi Sasatani, Junya Kobayashi,

<b>Objectives:</b> High dose-rate ionizing radiation (IR) causes severe DSB damage, as well as reactive oxygen species (ROS) accumulation and oxidative stress. However, it is unknown what biological processes are affected by low dose-rate IR; therefore, the molecular relationships between mitochondria changes and oxidative stress in human normal cells was investigated ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):160-169]

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Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome.

Javier Toro-Pérez, Ramón Rodrigo,

<h4>Background</h4>The extent of the damage following surgery has been subject of study for several years. Numerous surgical complications can impact postoperative quality of life of patients and even can cause mortality. Although these complications are generally due to multifactorial mechanisms, oxidative stress plays a key pathophysiological role. Moreover, oxidative stress ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):35-44]

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Xanthohumol Induces ROS through NADPH Oxidase, Causes Cell Cycle Arrest and Apoptosis.

Chun-Ming Wang, Jun Chen, Jing Zhao, Shan-Shan Hu, Shu-Qiu Zhang, Xiang-Quan Mi, Xiang Shi, Xin-Hui Cao, Zhen Li,

Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely related to the site of generation. Xanthohumol (XN) is an important natural product of hops (<i>Humulus lupulus</i> L.) and was reported to induce ROS in mitochondria. While in the ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:9877170]

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Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate.

Elisabetta Catalani, Matteo Giovarelli, Silvia Zecchini, Cristiana Perrotta, Davide Cervia,

Melanoma originates from the malignant transformation of melanocytes and is one of the most aggressive forms of cancer. The recent approval of several drugs has increased the chance of survival although a significant subset of patients with metastatic melanoma do not show a long-lasting response to these treatments. The complex ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(22):]

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The Cross Talk Between ROS And NO In The Viability Decline of Cryopreserved Pollen From Paeonia Lactiflora

Ruifen Ren, Lingling Zhang, Hao Zhou, Xueru Jiang, Yan Liu,

Reactive oxygen species (ROS) and nitric oxide (NO), two common active molecules, are both involved in changes in viability after liquid nitrogen (LN) storage, but the relationship between these two molecules has not been examined in plant cryopreservation until now. In this study, the pollen of Paeonia lactiflora 'Fen Yu ... Read more >>

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ROS-induced dramatic lipid changes in Arabidopsis.

Tianlin Jin, Xue Wang, Zhuying Deng, Xiaofang Liu, Dacheng Liang,

<b>Objectives:</b> The beneficial role of ROS was probably in promoting intercellular communication by modifying membrane constituents [Liang D. A salutary role of reactive oxygen species in intercellular tunnel-mediated communication. Front Cell Dev Biol. 2018;6:2]. We investigated how the membrane lipids were responding to ROS and ROS inhibitors.<b>Methods:</b> To examine how ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):190-196]

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Involvement of glucose transporter overexpression in the protection or damage after ischemic stroke.

Iván Alquisiras-Burgos, Penélope Aguilera,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):783-784]

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Sestrin2 in hypoxia and hypoxia-related diseases.

Xiaojing Che, Jiagui Chai, Yan Fang, Xifeng Zhang, Anju Zu, Lin Li, Shibo Sun, Weimin Yang,

<b>Objectives:</b> Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases.<b>Methods:</b> A review was conducted through an electronic ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):111-116]

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Home-based exergaming training effects for two individuals with spinal cord injury: A case report.

Maziah Mat Rosly, Hadi Mat Rosly,

<h4>Introduction</h4>Exergaming is a type of serious game that requires active bodily movements for video gameplay. This game-based exercise is gaining interest as a form of leisure activity of moderate-vigorous dose intensity.<h4>Objective</h4>This case report sought to assess the effects of exergaming training (i.e. Move Boxing, Move Tennis, and Move Gladiator Duel) ... Read more >>

Physiother Theory Pract (Physiotherapy theory and practice)
[2021, :1-11]

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